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Corsodyl Chlorhexidine Digluconate CAS 18472-51-0

Molecular Formula: C28H42Cl2N10O7

Formula Weight: 701.61

ZSpharmac: Corsodyl Chlorhexidine Digluconate  Supplement

Product Name: Corsodyl Chlorhexidine Digluconate
CAS No: 18472-51-0
Purity: 99%

Basic Info

Product Name:Corsodyl Chlorhexidine Digluconate
Other Names:Chlorhexidine Digluconate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless Liquid
EINECS No.:242-354-0
Provide:Corsodyl Chlorhexidine Digluconate MSDS;
Corsodyl Chlorhexidine Digluconate COA

What is Corsodyl Chlorhexidine Digluconate ?

Corsodyl Chlorhexidine Digluconate is a low-efficiency disinfectant, which can promptly kill purulent microorganisms, digestive tract microorganisms, usual microorganisms in medical facility infections, pathogenic microorganisms airborne and also pathogenic yeasts, suitable for hands as well as various other Long-lasting antiseptic security of the skin on the site.Corsodyl Chlorhexidine Digluconate is a low-efficiency broad-spectrum bactericide with quick-acting bactericidal effect, which can kill pyogenic coccus, intestinal pathogens, common pathogens of hospital infection, pathogenic bacteria in the air and pathogenic bacteria Yeast, suitable for long-term bactericidal protection of the skin at the injection site and the skin at the surgical site. The drug has no obvious toxic and side effects, and is mild in nature, easy to clean, has no peculiar smell, does not pollute clothes, and is non-irritating to the skin. The main components of the medicine are Corsodyl Chlorhexidine Digluconate and ethanol, which can volatilize quickly, and the disinfection effect can be achieved within 1 minute.

Corsodyl Chlorhexidine Digluconate Properties:

density 1.06 g/mL at 25 °C(lit.)
storage temp. 2-8°C
solubility water: soluble50% (w/v)
form Liquid
color Colorless
Sensitive Light Sensitive
Merck 14,2091


Corsodyl Chlorhexidine Digluconate Uses

  1. Corsodyl Chlorhexidine Digluconate has quick-acting bactericidal impact, is non-corrosive to steels and textiles, is slightly affected by organic matter, as well as has good security. From the toxicological examination on animals, chlorhexidine gluconate disinfectant has no stinging effect on skin and mucous membranes; the acute dental poisoning of rats is really non-toxic; it has no micronucleus effect on mouse bone marrow polychromatic erythrocytes; No poisonous impacts were observed in each dose group in the subacute poisoning test.
  2. Corsodyl Chlorhexidine Digluconate is utilized as an anti-bacterial as well as antibacterial. It has solid broad-spectrum antibacterial and also bactericidal results, and works against both Gram-positive as well as Gram-negative microorganisms. Sanitize external hands as well as skin, and wash the injury.

Preparation of Corsodyl Chlorhexidine Digluconate

A Corsodyl Chlorhexidine Digluconate is prepared from the following basic materials: 5.5 g of polysorbate 80, 1.2 g of original metronidazole powder, 220 g of ethanol, 2.0 g of banana essence, 40 g of pepper mint water, and also 0.7 g of sodium saccharin, lemon yellow pigment 0.025 g, glycerin 315g, polyethylene glycol 400 is 275g, chlorhexidine gluconate (mass portion is 5%) 125g, cleansed water is appropriate. The preparation method of the chlorhexidine gluconate compound gargle comprises the complying with steps:
A, obtain polysorbate 80, the former powder of metronidazole and include container An and stir, under the problem that stirring speed is 60 rev/min, continue mixing after 20 mins and get ethanol as well as include 5 times, the initial 4 times 40g each time, 60g for the fifth time, include banana essence as well as mint water to Chemicalbook as well as mix for 20 mins under the condition that the stirring speed is 60 rev/min to acquire material liquid A;
B, sodium saccharin is liquified in container B with 50ml purified water to get feed service B;
c, tartrazine is dissolved in container C with 50ml cleansed water to obtain feed solution C;
D, in container D, add 3700ml purified water, add glycerol, polyethylene glycol 400 successively while stirring under the condition that stirring speed is 60 rev/min, then add the chlorhexidine gluconate gluconate that mass fraction is 5%, Continue to stir for 5 minutes and stir to obtain material liquid D;
e. Mix the feed solution A, feed solution B, feed solution C and feed solution D evenly, configure to 5000ml with purified water, and stir evenly to obtain the cCorsodyl Chlorhexidine Digluconate.

Pharmacological Effects of Corsodyl Chlorhexidine Digluconate

Corsodyl Chlorhexidine Digluconate is a cationic surface area energetic preservative with broad-spectrum antibacterial result. Its mechanism of action is to modify the permeability of bacterial cell membranes. It is an anti-bacterial and also antiseptic.
Its antibacterial impact on Gram-positive and negative bacteria is more powerful than that of benzalkonium bromide as well as various other anti-bacterials. This product is still reliable in the visibility of serum, blood, and so on. The device of activity of this item is to adsorb on the osmotic barrier of bacterial cytoplasmic membrane layer, so that the cell contents leakage out and also play an anti-bacterial impact. Low concentration has bacteriostatic result, high focus has bactericidal impact.

Corsodyl Chlorhexidine Digluconate not be used in combination with sodium bicarbonate (baking soda) and potassium iodide. Drug interactions may occur if used concurrently with other drugs.

Corsodyl Chlorhexidine Digluconate Precautions

1 This product cannot be swallowed.
2 Avoid contact with eyes and other sensitive tissues with high concentration solutions; avoid using this product for bladder lavage.
3 The container that holds this product cannot use cork to prevent the product from being deactivated.
4 This product can be decomposed after long-term heat treatment, so the solution with higher concentration (above 1%) cannot be autoclaved; the autoclaved solution of dilute solution (below 0.1%) should not exceed 115 ℃ for 30 minutes.
5 This product is incompatible with soap, potassium iodide, etc. The 0.05% concentration of this product is incompatible with borax, bicarbonate, carbonate, oxide, citrate, phosphate and sulfate, because it can form low solubility salts that precipitate after 24 hours.
6. The use of drugs in pregnant and lactating women is not clear.
7 Children should use this product under the guidance of their parents to avoid swallowing. After drinking this product by mistake, symptoms of alcohol poisoning (such as slurred speech, lethargy, shaking gait, etc.) may occur, and should be sent to the emergency department immediately.

Corsodyl Chlorhexidine Digluconate Side Effects

1 Occasionally can cause contact dermatitis. High concentration solutions are highly irritating to the eye conjunctiva.

2 This product can stain the surface of the oral cavity, and the earliest one occurs about 1 week after use. After 6 months of use, about 50% of patients can stain their teeth, about 10% of patients are heavily stained, and those with more plaque deposits are more stained. Dentures can be permanently stained due to rough surfaces or edges.

3 Changes in taste can occur, which can be recovered with continued treatment.

4 Painless superficial oral scaling can occur in children and adolescents aged 10 to 18 years.

5 Rare local irritation and allergic reactions.

6 After drinking this product by mistake, children may experience symptoms of alcohol poisoning (such as slurred speech, lethargy, shaking gait, etc.), and should be sent to the emergency department immediately.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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