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Cordycepin Sigma CAS 73-03-0

Molecular Formula: C10H13N5O3

Formula Weight: 251.24

ZSpharmac: Cordycepin Sigma Supplier

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Product Name: Cordycepin Sigma
CAS No: 73-03-0
Purity: 99%

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Basic Info

Product Name:Cordycepin Sigma
Other Names:Cordycepin
CAS:73-03-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:200-791-4
Storage:Under -20°C
Provide:Cordycepin Sigma MSDS;
Cordycepin Sigma COA

What is Cordycepin Sigma?

Cordycepin Sigma was originally removed from Cordyceps fungi, for this reason the name cordycepin, also called cordycepin. Astonishingly, among the greater than 300,000 varieties of plants in nature, Cordycepin Sigma is only found in several category of Cordyceps. The magic of cordycepin was simply starting to be understood by human beings twenty years back.

Cordycepin Sigma Property

Melting point 225-229 °C
alpha D20 -47°; D27 -42°
Boiling point 394.4°C (rough estimate)
density 1.2938 (rough estimate)
refractive index 1.7610 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 25 mg/ml).
pka13?+-.0.60(Predicted)
form Powder
color White to Off-white

 

Cordycepin Sigma Uses

(1) Anti-tumor effect of Cordycepin Sigma:
Presently, researchers sum up the anti-tumor mechanism of cordycepin into two kinds: straight action as well as indirect activity.
The direct result indicates that the anti-tumor elements in cordycepin straight inhibit the expansion of tumor cells by disrupting the exchange of target cell nucleic acid, protein nucleic acid, as well as sugar. Cordycepin can act upon numerous cell signaling pathways, causing cell autophagy or apoptosis.
The indirect impact means that the anti-tumor active components in cordycepin can enhance the feature of immune cells by advertising the proliferation and also differentiation of human immune cells, therefore applying an anti-tumor effect.
 
( 2) Antiviral result of Cordycepin Sigma:
Cordycepin was first found and also examined as a nucleoside antibiotic. It has a variety of repressive results on microorganisms, fungi, viruses as well as other pathogenic microorganisms.
 
( 3) Anti-aging impact of Cordycepin Sigma:
Cordycepin can raise the activity of SOD enzyme in the liver, hinder the formation of superoxide substances, and also boost the activity of monoamine oxidase in the brain, which reveals that cordycepin has anti-aging effects.
 
( 4) Cordycepin Sigma decreasing blood fat and anticoagulant:
Cordycepin can likewise enhance the weight of the spleen, increase the revival price of nucleic acid and healthy protein in the liver, as well as has the effects of anti-hypoxia, raising myocardial dietary blood flow and reducing product cholesterol. It likewise avoids the development of embolism.
 
( 5) Cordycepin Sigma anti-inflammatory impact, immune guideline result:
A lot of literatures show that cordycepin has clear anti-infection, anti-inflammation, immune law and anti-tumor effects, as well as can additionally act upon oxidative damages, metabolic disorders and nerves illness.
The device of action of cordycepin is extremely made complex, however at the very least we know that the role of cordycepin is undisputed in the academic circle. On top of that, the functions of cordycepin for lowering blood sugar level, treating as well as protecting against weight problems, anti-aging, and also enhancing memory all show that cordycepin is an uncommon nutrient.

Cordycepin Sigma Pharmacological Action

It is presently recognized that a lot of Cordyceps fungi include Cordycepin Sigma, which undoubtedly plays an important role in the anti-tumor effect. Jagger thinks that there are three reasons why cordycepin in the Cordyceps fungus hinders tumorigenesis:
( 1) The free alcohol group of Cordycepin Sigma can be included right into the DNA of cancer cells to take effect.
( 2) Cordycepin Sigma can hinder the phosphorylation of nucleosides or nucleotides to generate diphosphate and triphosphate derivatives, consequently hindering the synthesis of nucleic acids in tumor cells.
( 3) Cordycepin can obstruct the amination of xanthylic acid right into guanylic acid.
In 1977, Müller et al. located that Cordycepin Sigma had a strong inhibitory impact on the spreading of L5718Y cells, with an ED50 of 0.27 μg; this inhibitory result could be terminated by adenine nucleoside, however not by 2′-deoxynucleoside; use tritium The classified Cordyceps test reveals that Cordycepin Sigma can permeate into RNA instead of DNA, as well as cordycepin can be phosphorylated into 3′-ATP in cells; 3′-ATP has a strong result on DNA-dependent DNA polymerase α and also β activities in L5718Y cells It has no result, however it has a solid repressive result on nuclear Poly(A) polysaccharides, which will certainly bring about mRNA growth problems, which can influence the formation of mRNA and protein synthesis. The anti-tumor impact of cordycepin may be associated with this system. In 1997, the United States has made use of cordycepin for Phase III scientific trials to deal with patients with acute pre-B and pre-T lymphocytic leukemia. At the same time, cordycepin also exhibits solid antifungal, anti-HIV infection and also discerning restraint of shuttle bus Germs task.
In 1985, Jiang Pingping made use of artificial insemination experiments to observe the cytotoxicity of Cordyceps sinensis as well as cultured mycelium (Qinghai) on ECA cells. Results For ECA cells cultured artificial insemination, the complete staining rate was 100% as well as 80% when the two minimum effective focus were 0.405 mg/ml and 25 mg/ml respectively, which indicated that the medicines had various cytotoxic results on ECA. Comprehensive in vivo experiments guess that the anti-tumor effect is associated with a specific amount of 3′-deoxynucleosides and also Cordyceps polysaccharides had in the medication, in addition to the immune law as well as maintenance of the relative balance of the immune function of the drug as a whole. Cordyceps sinensis has a certain cytotoxic result, which is consistent with the reported strong cytotoxic result of Cordycepin Sigma resistant to L1210.

Cordycepin Sigma Study Finds in Weight Loss and Obesity Prevention

About That Product:
If you need Cordycepin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Cordycepin, ZSpharmac will provide Cordycepin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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