Cordycepin Sigma CAS 73-03-0

It is presently recognized that a lot of Cordyceps fungi include Cordycepin Sigma, which undoubtedly plays an important role in the anti-tumor effect. Jagger thinks that there are three reasons why cordycepin in the Cordyceps fungus hinders tumorigenesis:
( 1) The free alcohol group of Cordycepin Sigma can be included right into the DNA of cancer cells to take effect.
( 2) Cordycepin Sigma can hinder the phosphorylation of nucleosides or nucleotides to generate diphosphate and triphosphate derivatives, consequently hindering the synthesis of nucleic acids in tumor cells.
( 3) Cordycepin can obstruct the amination of xanthylic acid right into guanylic acid.
In 1977, Müller et al. located that Cordycepin Sigma had a strong inhibitory impact on the spreading of L5718Y cells, with an ED50 of 0.27 μg; this inhibitory result could be terminated by adenine nucleoside, however not by 2′-deoxynucleoside; use tritium The classified Cordyceps test reveals that Cordycepin Sigma can permeate into RNA instead of DNA, as well as cordycepin can be phosphorylated into 3′-ATP in cells; 3′-ATP has a strong result on DNA-dependent DNA polymerase α and also β activities in L5718Y cells It has no result, however it has a solid repressive result on nuclear Poly(A) polysaccharides, which will certainly bring about mRNA growth problems, which can influence the formation of mRNA and protein synthesis. The anti-tumor impact of cordycepin may be associated with this system. In 1997, the United States has made use of cordycepin for Phase III scientific trials to deal with patients with acute pre-B and pre-T lymphocytic leukemia. At the same time, cordycepin also exhibits solid antifungal, anti-HIV infection and also discerning restraint of shuttle bus Germs task.
In 1985, Jiang Pingping made use of artificial insemination experiments to observe the cytotoxicity of Cordyceps sinensis as well as cultured mycelium (Qinghai) on ECA cells. Results For ECA cells cultured artificial insemination, the complete staining rate was 100% as well as 80% when the two minimum effective focus were 0.405 mg/ml and 25 mg/ml respectively, which indicated that the medicines had various cytotoxic results on ECA. Comprehensive in vivo experiments guess that the anti-tumor effect is associated with a specific amount of 3′-deoxynucleosides and also Cordyceps polysaccharides had in the medication, in addition to the immune law as well as maintenance of the relative balance of the immune function of the drug as a whole. Cordyceps sinensis has a certain cytotoxic result, which is consistent with the reported strong cytotoxic result of Cordycepin Sigma resistant to L1210.