Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Conazole CAS 67914-69-6

Molecular Formula: C27H30Cl2N4O5

Formula Weight: 561.46

ZSpharmac: Conazole Cosmetic Raw Material Suppliers

Product Name: Conazole
CAS No: 67914-69-6
Purity: 99%

Navigation Bar

Basic Info

Product Name:Conazole
Other Names:ELUBIOL
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
Provide:Conazole MSDS;
Conazole COA

What is Conazole?

Conazole is a derivative of ketoconazole (II), its chemical name is: cis-4- [4- [[ 2-( 2,4-dichlorophenyl) -2-( 1H-imidazole-1-ylmethyl base) -1,3- dioxolane-4-yl] methoxy] phenyl] -1- piperazinecarboxylic acid ethyl ester (I)

Conazole, like the typical imidazole anti-bacterial item ketoconazole, is a brand-new imidazole broad-spectrum antifungal item that can inhibit fungal ergosterol biosynthesis as well as change the composition of other lipid compounds in the cell membrane layer. It has antagonistic results versus Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides. However, compared to ketoconazole, the latter can not be utilized in individual treatment products, while neoconazole It has much better water solubility than ketoconazole and also is suitable for usage in the field of individual treatment products. It has actually been included in the scope of European individual treatment items and also has a very wide market prospect.

Conazole Property

Boiling point 734.8±60.0 °C(Predicted)
density 1.37
storage temp. under inert gas (nitrogen or Argon) at 2-8°C


Conazole Preparation

Conazole, like the traditional imidazole anti-bacterial product ketoconazole, is a brand-new imidazole broad-spectrum antifungal item that can prevent fungal ergosterol biosynthesis as well as transform the composition of various other lipid compounds in the cell membrane layer. It has hostile effects against Candida fungus, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides. Nonetheless, compared with ketoconazole, the latter can not be utilized in individual treatment items, while neoconazole It has far better water solubility than ketoconazole and is suitable for use in the field of personal treatment products. It has actually been included in the extent of European individual care products and also has a really broad market possibility.

The synthesis of Conazole is based on cis- [2-( 2,4-dichlorophenyl) -2-( 1H-imidazole-1-ylmethyl) -1,3- dioxolane- 4-yl] Methanol p-toluenesulfonate (III, active ester form) is used as basic material, as well as is obtained by condensation with 4-( 4-hydroxyphenyl) -1- piperazine carboxylic acid ethyl ester (IV).
In US4335125, neoconazole is recrystallized from 2-methyl-2-pentanone, and also the melting point of the neoconazole acquired is 112.2 ° C. In world license WO93/18743, the synthesis of neoconazole begins with ketoconazole. The raw materials are hydrolyzed, acylated, fine-tuned and also changed to acquire Kind I neoconazole.

The filtration technique is to utilize 2-methyl-2-pentanone to crystallize, the response as well as crystallization yield is 84.9%, and then utilize acetone to transform to type I, the makeover return is 82.1%, and the complete return of kind I is 69.7%. The melting point of type I neoconazole is 127.6 ° C

. In WO93/18743, the buildings of Conazole Type I as well as Type II are likewise pointed out. The optimum DSC height of Type I with high melting point goes to 127.6 ° C, while the optimum DSC height of Kind II with reduced melting point goes to 110.9 ° C. Kind I is smaller sized than II. It is much more steady and is favored for use in cosmetics for the body. In the above two patents, 2-methyl-2-pentanone is used for recrystallization, which is not just costly and also expensive, yet also ketone chemicals continue to be in the item, which is hazardous to human wellness. In the Chinese patent disclosure spec CN101665490A, it is stated that recrystallization with ethyl acetate is utilized, and the recrystallization yield is 69.8% to 84.5%. Ethyl acetate is used for recrystallization of organic matter, yet the yield is low, and the melting point of the product is not discussed.

CN201210075893.7 provides a brand-new approach for purifying Conazole. The technological option actions are as complies with:

Action (1 ). Make use of a combined service of water and lower alkanol to dissolve the unrefined neoconazole at a temperature of 5085 ° C. The ratio of water to lower alkanol in the mixed solution is 3/71/19;

The lower alkanols in the action (1) consist of methanol, ethanol, propanol, and also isopropyl alcohol; the weight ratio of the combined remedy of water and reduced alkanols to the crude new conazole is 10/ 12/1;

Step (2 ). In the mixed service in which the unrefined neoconazole is liquified, add triggered carbon for decolorization. After filtering system to get rid of the carbon, awesome to -515 ° C for condensation; after that filter and dry again. The web content of the improved neoconazole gotten is above 99.0%., HPLC pureness is above 99.5%, melting point is in between 127.6 ~ 130 ℃.

The useful effects of today development are as follows:
Today creation is used to purify Conazole. The technique is basic as well as inexpensive. The pureness of the product acquired after filtration is more than 99.5%, the content is more than 99.0%, the melting point is 127.6-130 ° C, the stability of the acquired product is good, and the complete molar return of the response is 89 ~ 91%.

Certain instances of purification operations are as follows:
Action (1 ). In the reaction kettle, placed 100KG of ketoconazole and also 110KG of 10% hydrochloric acid, react at 85 ° C for 20 hrs, as well as trendy to space temperature level; then include 400L of toluene, and then slowly include 96.5 KG of 50% hydroxide. Salt remedy, speed up crystalline solid, centrifuge, laundry with 40KG of water, filter and combine, spin dry, as well as completely dry to get 92.1 KG of hydrolyzate, with HPLC purity of greater than 99.5% and also yield of 100%.

Step (2 ). Place the 92.1 KG hydrolyzate obtained symphonious (1) right into the reaction kettle, then include 520KG methylene chloride and 36KG potassium carbonate, include 25KG ethyl chloroformate dropwise at area temperature, then mix for 3 hours as well as include 300KG water., take the organic phase by layering, boil down under minimized stress to recuperate methylene chloride to dry skin, and obtain crude new conazole.

Action (3 ). Add the gotten unrefined neoconazole into 400KG of water-ethanol blended service (weight proportion 25:75), heat to 75 ° C to liquify, include carbon to filter, cool, crystallize, filter, and also drain. After drying, 95.6 KG of new conazole was gotten, with HPLC purity of 99.6%, chemical titration material of 99.4%, melting point of 127.6 ~ 128.5 ° C, and total return of 90.5%.

Contact Us

About Products:
If you need Conazole as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
As an experienced Conazole manufacturer and supplier, our company, ZSpharmac, will provide Conazole raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Conazole Quotation