Zhishang Chemical

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Zhishang Chemical

Collagenase II CAS 9001-12-1

Molecular Formula: C60H100N2

Formula Weight: 849.4494

ZSpharmac: Collagenase II Supplier

Product Name: Collagenase II
CAS No: 9001-12-1
Purity: 99%

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Basic Info

Product Name:Collagenase II
Other Names:Collagenase
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:light Brown Powder
EINECS No.:232-582-9
Provide:Collagenase II MSDS;
Collagenase II COA

What is Collagenase II?

Collagenase II, also known as collagenase, clostridial peptidase, English name collagenase, is a protease obtained from the fermentation of Clostridium histolyticum. Medical Collagenase II is refined from the culture fluid of Clostridium histolyticum ATCC21000. This enzyme has a high decomposing activity on the peptide bond of the gly-pro sequence. Due to the breakage of the original collagen molecules, it provides good conditions for the hydrolysis of other proteases, making it have a unique function of hydrolyzing collagen and denaturing collagen. The medical enzyme made with this enzyme has the ability to digest natural collagen and denatured collagen, has a strong digestion effect on necrotic tissue, and can promote the growth of granulation and epithelial cells. This product has no effect on globulin and fibrin, so it does not affect the normal blood vessels and muscle tissue of the human body. It can be used for debridement, scab removal, chronic skin ulcers and bedsores of second and third degree burns.

Collagenase II Property

storage temp. -20°C
solubility Soluble in aqueous buffers.
form powder
color light brown


Efficacy of Collagenase II

After taking Collagenase II, the human body will absorb enough protease needed, and the excess part will be excreted from the body. After supplementing protease, the local tissues of the body will quickly restore their original functions as if they were newly born. Collagenase II can give support to the fat tissue and skin elastic structure of the human body, and has an obvious change function. Its improvement effect is so good that it can be compared with the effect of surgery. It can effectively eliminate obesity, bloated face, sagging face, and skin Has a great firming and lifting effect.

The reason for choosing Collagenase II is that it has a high level of safety, good compatibility after being absorbed by the human body, and the effect is obviously natural, and its non-biological origin ensures that it will not cause dangerous symptoms such as allergies, and its own substances will participate in the human body The unique enzymatic effect of protease ensures its non-repelling property; the unique helical structure of protease has a lifting effect on aging and sagging skin, and is widely used in the field of beauty; the network physical structure of collagenase ensures that it will not be damaged due to severe Displacement or loss due to movement.

The main application fields of Collagenase II are industry, beauty and medicine. In the industrial field, leather factories are used more often. Producers use protease to depilate and soften leather products, which not only saves a lot of time, but also improves the working environment of leather factories to a large extent; in medicine Collagenase II has a certain medicinal value and can be used to treat bronchitis, indigestion and gastrointestinal discomfort, vasculitis and oral purification; in terms of beauty, intravenous injection can be used. Collagenase can replenish skin moisture, Smoothes wrinkles, fades scars and removes pigmentation, etc. However, excessive use can also cause side effects, which may cause symptoms of digestive system disorders such as diarrhea and abdominal pain; in daily life, Collagenase II is also closely related to us, it can be used To tenderize meat, clarify wine and degumming silk.

How to use Collagenase II

Classification and Source of Collagenase II

Collagenase II is originated from Clostridium histolyticum (Clostridium histolyticum), which is an enzyme crude remove that not just includes Collagenase II (a lot more accurately referred to as clostridiopeptidase A), it can break down all-natural collagen as well as reticular fibers. It additionally consists of some other proteases, polysaccharases, lipases, etc, which can successfully hydrolyze

Various other proteins, polysaccharides and lipids in the extracellular matrix of connective and also epithelial tissues make this product ideal for cells food digestion.

Currently commercially available microbial Collagenase II is mainly divided into 4 types based on the difference in Collagenase II task: Collagenase Kind I, Type II, Type III and Kind IV. There are some predispositions in application: 1) Collagenase I (Type I Collagenase): Has a relatively consistent activity of various enzymes (consisting of collagenase, caseinase, clostripain, trypsin activity). Typically made use of for the prep work of epithelial cells, liver, lung, fat and adrenal tissue cells; 2) Collagenase II (Type II Collagenase): has higher clostripain activity, normally made use of for heart, bone, muscle mass, thymus and also cartilage material 3) Collagenase III (Kind III Collagenase): includes low protease activity, as well as is frequently used in the preparation of breast cells; 4) Collagenase IV (Type IV Collagenase): contains low trypsin task, usually For the preparation of islet cells, or cell prep work experiments that require to preserve the integrity of the receptor.

About Products:
If you need Collagenase II, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Collagenase II manufacturer and supplier, ZSpharmac will provide Collagenase II raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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