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Zhishang Chemical

Cocamidopropyl Betaine Natural CAS 86438-79-1

Molecular Formula: C19H38N2O3

Formula Weight: 342.52

ZSpharmac: Cocamidopropyl Betaine Natural Supplier

Product Name: Cocamidopropyl Betaine Natural
CAS No: 86438-79-1
Purity: 99%

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Basic Info

Product Name:Cocamidopropyl Betaine Natural
Other Names:Cocamidopropyl Betaine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow Transparent Liquid
EINECS No.:203-490-6
Provide:Cocamidopropyl Betaine Natural MSDS;
Cocamidopropyl Betaine Natural COA

What is Cocamidopropyl Betaine Natural?

Cocamidopropyl Betaine Natural (Cocoamidopropylbetaine) is a mild and efficient multifunctional surfactant prepared from low-cost coconut oil. It is a widely used basic ingredient in current international popular shampoo and hair care products. At present, it is mainly used to prepare shampoo, bath agent, facial cleanser, baby care products and other detergents. Cocamidopropyl Betaine Natural belongs to amphoteric surfactants, which is the fastest growing type of surfactants in recent years. Although its output only accounts for about 1% of the total amount of surfactants, its annual growth rate reaches 6% to 8%. Its mild performance is superior to other amphoteric surfactants, and it can achieve a very ideal effect in shampoo products.

Cocamidopropyl Betaine Natural Application

1. Water solubility
Cocamidopropyl Betaine Natural is a colorless to light yellow liquid, stable in a wide pH range, fully compatible with anionic, cationic and nonionic surfactants, and has good solubilizing properties. It can also be used as a cloud point depressant for other surfactants, avoiding the use of cloud point depressants such as ethylene glycol, ethanol, etc., which will reduce the viscosity of the system and reduce foam.

2. Detergency and foaming properties
It has remarkable anti-hard water performance, can produce rich foam in soft water and hard water, and also shows good washing effect in cold water, and also has excellent decontamination and foaming ability in electrolyte or seawater. It especially has the characteristics of fast foaming, rich and delicate foam, and very stable. It is used in combination with anionic surfactants such as alcohol ether sulfate, and its foam performance is better.

3. Thickening and conditioning
In shampoo formula, Cocamidopropyl Betaine Natural has a synergistic effect with other surfactants, showing obvious thickening and conditioning effects. It is mixed with anionic surfactant, the mass fraction of active substance is 10%-30%, and a product with high viscosity can be obtained, and the viscosity decreases with the increase of pH value. After adding weak acid during preparation, the viscosity can be increased. Its superior conditioning performance enhances the softness of hair and skin, and can effectively reduce the friction coefficient between fibers and produce excellent softness. It not only makes the fabric hydrophobic, but also has obvious antistatic effect.

4. Mildness
A prominent feature of Cocamidopropyl Betaine Natural is its high safety and no allergic reaction to the human body. Betaine without amide groups is toxic to marine or aquatic organisms. Moreover, if the carboxyl group in betaine is replaced by a sulfonic acid group, it is also toxic. Only when the amide group and carboxyl group exist at the same time can low toxicity or non-toxicity be achieved. Cocamidopropyl Betaine Natural is an internal quaternary ammonium compound, similar to amino acid zwitterions, and similar in structure to proteins. It has minimal irritation to skin, hair, especially eyes (cornea), and relatively low toxicity. And it can effectively reduce the irritation of alkyl sulfates and alkyl alcohol ether sulfates in cosmetics and bottle washing products such as baby cosmetics

5. Other properties
Scher Chemical Company of the United States pointed out that an important application of Cocamidopropyl Betaine Natural is that it can complex and dissolve cations such as quaternary ammonium compounds in anion systems. If the quaternary ammonium compound is pre-dissolved in amide betaine, it can be easily added to the anionic formula for a true 2-in-1. Cocamidopropyl betaine has low salt content, which expands the adaptability of the product and improves the low temperature stability of the product. Cocamidopropyl Betaine Natural has a certain dispersion effect. In the dye T industry, the dye is treated to make it difficult to agglomerate and obtain better dispersion effect. At present, environmental pollution is attracting widespread attention from all over the world. Cocamidopropyl betaine is favored by users for its excellent biodegradability.

Preparation of Cocamidopropyl Betaine Natural

The synthesis of Cocamidopropyl Betaine Natural can be divided into many different synthesis processes according to different carbon chain sources. At present, domestic manufacturers generally adopt the synthesis process with coconut oil as the carbon chain source. This process has the advantages of low synthesis difficulty, high product purity, white color and simple synthesis equipment requirements, but the reaction time is long and the synthesis efficiency is low. There are also foreign manufacturers using a synthesis process using coconut oil as the carbon chain source. This process has cheap raw materials and simple synthesis equipment requirements, but the product has a darker color and contains about 2.2% glycerin. However, the synthesis process using methyl cocoate as the carbon chain source has the advantages of low raw material cost, short reaction time, high synthesis efficiency, methanol and N,N-dimethyl-1,3-propanediamine mixed solution released from the reaction It is easy to be reused after rectification and purification.

Cocamidopropyl betaine was synthesized from methyl cocoate, N,N-dimethyl-1,3-propylenediamine, chloroacetic acid and NaOH, and KOH as a catalyst. Investigate the influence of the feed ratio of N,N-dimethyl-1,3-propylenediamine and methyl cocoate, catalyst dosage, reaction temperature and time on the synthesis of cocamidopropyl dimethylamine, and use infrared spectroscopy , mass spectrometry and high performance liquid chromatography were used to characterize the target product in order to provide a reference for the industrial production of Cocamidopropyl Betaine Natural from methyl cocoate.

Cocamidopropyl Betaine Natural Experimental Portion

Main Reagents and Instruments

Methyl cocoate, industrial product, American Stepan Co., Ltd.; N, N-dimethyl-1,3-propylenediamine, industrial product, Guangzhou Tianci High-tech Materials Co., Ltd.; Chloroacetic acid, industrial product, Aksu Nobel Ltd. GS-1 magnetic drive autoclave, Weihai Chemical Machinery Co., Ltd.; LCQ Deca XP liquid mass spectrometer, Thermoelectric Corporation of America; LC-10AT high performance liquid chromatography, Shimadzu Corporation of Japan; IR 200 Fourier transform infrared spectrometer, American Nicholas Company.

Experimental method
Synthesis of Cocamidopropyl Dimethylamine

Add 2.875 mol of N,N-dimethyl-1,3-propylenediamine, 2.500 mol of methyl cocoate, and an appropriate amount of catalyst KOH to the magnetically driven autoclave, seal the reactor, and fill the reactor with nitrogen to replace the air , start magnetic stirring, heat to 210°C, and react for 25 minutes. After the reaction is completed, the excess N,N-dimethyl-1,3-propylenediamine and the methanol produced by the reaction are removed in vacuum.

Synthesis of Cocamidopropyl Betaine Natural

Add 0.600 mol of cocamidopropyl dimethylamine and appropriate amount of water to a 1L four-neck glass flask, stir and raise the temperature, and add the chloroacetic acid (0.618 mol) solution neutralized with NaOH solution in advance after reaching 80°C, and heat Keep at 80-90°C, and react at constant temperature for 3 hours. After the reaction, cool down to below 40°C, and add hydrochloric acid or NaOH to adjust to the required pH.

Determination of conversion rate of fatty acid methyl ester

With reference to the method for measuring the average relative molecular mass of free amines (i.e. fatty amidopropyl dimethyl tertiary amine) by gas chromatography in QB/T4082-2010, the unreacted coconut oil in cocoamidopropyl dimethylamine is determined by gas chromatography acid methyl ester to obtain its conversion.

About Products:
If you need Cocamidopropyl Betaine, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Cocamidopropyl Betaine manufacturer and supplier, ZSpharmac will provide Cocamidopropyl Betaine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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