Clindamycin Phosphate Gel Price, trade name Cleocinphosphate, chemical name 6-(1-methyl-trans-1-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7( S)-Chloro-6,7,8-trideoxy-L-threo-α-D-galactopyranoside-2-dihydrogen phosphate, a semi-synthetic derivative of clindamycin, It rapidly hydrolyzes clindamycin in vivo and exhibits pharmacological activity. Compared with clindamycin, its effect has the characteristics of high antibacterial activity, fast absorption, strong lipid solubility and permeability, and less side effects. It is widely distributed in the body and has high tissue concentration, especially in bone tissue. It is a broad-spectrum antibiotic with both anti-anaerobic-aerobic effects. Except for Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans and most of Staphylococcus aureus methicillin-resistant strains, most anaerobic bacteria are effective. It is clinically used for abdominal and pelvic infections caused by anaerobic bacteria including Bacteroides fragilis, Clostridium perfringens, Actinomyces, etc., as well as respiratory tract, joint and soft tissue, bone tissue caused by sensitive Gram-positive bacteria. , biliary tract infection and sepsis, endocarditis and so on.
Clindamycin Phosphate Gel Rate Shot is an anemic or slightly yellow clear liquid. Primarily used for the complying with various infectious conditions brought on by Gram-positive microorganisms: 1) Tonsillitis, suppurative otitis media, sinus problems, etc 2) Acute respiratory disease, severe worsening of persistent respiratory disease, pneumonia, lung abscess as well as bronchiectasis made complex by infection, etc 3) Skin and also soft tissue infections: boils, carbuncles, abscesses, cellulitis, injuries, burns as well as post-operative infections. 4) Urinary system infection: intense urethritis, intense pyelonephritis, prostatitis, and so on Others: osteomyelitis, blood poisoning, peritonitis and dental infection. Female pelvic as well as genital infections: endometritis, non-gonococcal fallopian tube as well as ovarian abscesses, pelvic cellulitis and also infection after gynecological surgical procedure.
Clindamycin Phosphate Gel Price Preparation Method
Using lincomycin hydrochloride as raw material, selective chlorination without separation of Vilsmeier reagent, and precipitation of clindamycin alcoholate in ethanol-saturated hydrogen chloride solution, and then using triethyl orthoformate as hydroxyl group Protecting agent, and finally using phosphorus oxychloride (POCl3) as a phosphorylating reagent, after hydrolysis reaction, recrystallization to obtain the product clindamycin phosphate.
Synthetic route of Clindamycin Phosphate Gel Price Fig. 1 is the synthetic route of Clindamycin Phosphate Gel Price The operation steps are as follows: 1. Synthesis of clindamycin 2 in a dry 250ml three-necked flask, pass N2 protection, add 20ml DMF and 100ml 1,2-dichloroethane, cool to 0°C, add 20ml POCl dropwise with stirring, and place in an ice bath after dropping. After keeping the temperature for about 30min, add 20g lincomycin hydrochloride 1 in batches, after adding, control the temperature to react at about 10°C for 1h, and react at room temperature for 1h, and then increase the temperature at 5-6°C every hour under the oil bath until it reaches 65-70°C, The reaction was incubated for 10h, and there was no raw material detected by thin layer chromatography (TLC). Cool to room temperature. 2. Synthesis of clindamycin alcoholate 3 The above reaction solution was transferred to a 500ml beaker, cooled in an ice bath, and 18% NaOH solution was added dropwise with stirring to pH 10-11. Transferred to a separatory funnel, The lower organic phase was separated, the aqueous phase was extracted with ethyl acetate (40ml×3), the organic phases were combined, washed with saturated brine until neutral, and dried over anhydrous Na2SO4. The organic phase was concentrated to dryness, and 70ml of ethyl acetate was added to make it Dissolve, add dropwise 25ml of ethanol solution saturated with hydrogen chloride under cooling, and separate out a white solid. Filter with suction, wash twice with ethyl acetate, and dry at 70 ° C to obtain white clindamycin alcoholate 321g, yield 92%, Meltpoint (mp) 142～144℃. 3. Synthesis of cyclic orthoester 4 In a 500ml three-necked flask, add 200ml of acetone and 20g of clindamycin alcoholate 3 respectively, and after stirring for 30min, slowly add 40ml of triethyl orthoformate dropwise to the system, at room temperature. The reaction was stirred for 18-24 hours, and no raw material was detected by TLC. Filtration, the filter cake was dissolved in 10 ml of dichloromethane and 150 ml of water, left to stand for stratification, the organic phase was separated, and the aqueous phase was extracted with dichloromethane (30 ml × 3). Combined The organic phase was dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. 4. Synthesis of phosphoryl compound 5 In a dry 500ml three-neck flask, pass N2 protection, add 350ml dichloromethane, 40ml triethylamine respectively, stir at room temperature for 30min, cool with ice water to below 10 ℃, slowly add dropwise 8.5ml of phosphorus oxychloride (POCl3) was added dropwise and kept at room temperature for 1h, then the above-mentioned cyclic orthoester 4 dissolved in dichloromethane was added dropwise, and the reaction was carried out at room temperature for 4h. TLC detected no raw materials. The reaction solution was slowly cooled under an ice bath. It was added dropwise to a 10% Na2CO3 solution for neutralization, the organic phase was separated, the aqueous phase was extracted with dichloromethane (100ml×3), the organic phases were combined, dried with Na2SO4, and the organic phase was concentrated under reduced pressure to a viscous state. . 5. Synthesis of Clindamycin Phosphate 6 The above-mentioned viscous substance was dissolved in dichloromethane, dropped into cold water at 10°C, and adjusted to pH 2 to 3 with dilute hydrochloric acid, and then heated to 25 to 30°C for thermal insulation and hydrolysis. 4h, TLC tracked the reaction. After the hydrolysis was completed, the reaction solution was concentrated under reduced pressure, and then 50ml of absolute ethanol was added to azeotrope. Then 100ml of absolute ethanol was added, stirred, left to stand for cooling and crystallization, filtered, washed with a small amount of ethanol, and dried at 70°C. Dry to give 6 as a white solid.
Clindamycin Phosphate Gel Price Pharmacology, Toxicology and Pharmacokinetics
High blood concentration can be obtained immediately after injection, and then widely distributed in cells and also body liquids. High is its characteristic. However, the ability to penetrate the blood-cerebrospinal fluid barrier is poor, and the concentration in brain tissue is low. After this product enters the body, it is quickly hydrolyzed to clindamycin under the action of alkaline phosphatase in the blood. The pharmacokinetics of normal people show that: after a single intravenous infusion of 0.6g of this product, the clindamycin in the blood reaches the peak immediately, the concentration is 11.09±2.02mg/L, and the 8-hour blood concentration is 1.69±0.35mg/L . After a single intramuscular injection of 0.6g, the clindamycin in the blood reaches the peak within 1-2 hours, the concentration is 5.92±1.45mg/L, and the blood concentration in 8 hours is 2.51±0.91mg/L, and the effective blood concentration can be maintained for 8 hours above. After administration of this product, it is mainly metabolized in the liver and excreted through bile and feces. The antibacterial activity in the feces can last for 5 days after drug withdrawal. Partially excreted in urine. Intravenous infusion and intramuscular injection of 0.6 g of this product, the 8-hour excretion rates were 11.72±1.33% and 10.51±2.68%, respectively.
Toxicology and Pharmacokinetics：
Clindamycin Phosphate Gel Price is a chemical semi-synthetic by-product of clindamycin, which has no antibacterial task in vitro, and also is swiftly hydrolyzed to clindamycin after entering the body to show its medicinal task.
Therefore, the antibacterial spectrum, antibacterial activity and therapeutic effect are the same as those of clindamycin, but its lipid solubility and permeability are better than those of clindamycin, and it can be administered by intramuscular injection and intravenous drip. Compared with lincomycin, this product has 4-8 times stronger antibacterial effect, good absorption, high bone concentration, and good curative effect on anaerobic infection.
The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.
“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.
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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.
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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
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Different quantity has different discount.
1. ≤50kg, Express delivery recommended, usually called as DDU service;
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