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Climbazole CAS 38083-17-9

Molecular Formula: C15H17ClN2O2

Formula Weight: 292.76

ZSpharmac: Climbazole Supplier

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Product Name: Climbazole
CAS No: 38083-17-9
Purity: 99%

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Basic Info

Product Name:Climbazole
Other Names:Diazobutinone
CAS:38083-17-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Neat
EINECS No.:253-775-4
Storage:Inert Atmosphere,Room Temperature
Provide:Climbazole MSDS;
Climbazole COA

What is Climbazole?

Campanolin is a racemate composed of equimolar amounts of (R)- and (S)-campuladin. The IUPAC name is (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl- 3,3-Dimethylbutan-2-one, CAS Registry No. 38083-17-19. It is a topically applied antifungal agent used to treat fungal skin infections in humans.
It can be included in non-prescription anti-dandruff hair shampoo services and skin treatment frameworks to handle dandruff in addition to dermatitis where fungal infections are the reason. Climbazole is a normal azole fungicide, which mainly prevents the synthesis of lanosterol 14α-demethylase (furthermore referred to as fungal CYP51) in the P450 enzyme, thus stopping the essential procedure of plasma fungal cell membrane layer. Part of ergosterol biosynthesis, causing fungal cell death.

Climbazole Property

Melting point 96-100°C
Boiling point 447.5±40.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
vapor pressure 0.001Pa at 25℃
refractive index 1.54
storage temp. Inert atmosphere,Room Temperature
solubility Insoluble in water
pka5.66±0.22(Predicted)
form neat
color White to Almost white
Water Solubility 58mg/L at 25℃

 

Climbazole Uses

  1. Climbazole has broad-spectrum bactericidal residential properties, and also is mostly made use of in anti-itch as well as anti-dandruff conditioning shampoos as well as hair care shampoos, along with antibacterial soaps, shower gels, medicated toothpastes, mouth washes, and so on.
  2. Climbazole is used in shampoos, body laundries, as well as soaps.

Climbazole Pharmacokinetics

1 Absorption kinetics of Climbazole

As shown in Figure 1, the concentration of Climbazole in the fish reaches the maximum at the 72th hour of the absorption period (i.e. the 3rd day); the concentration of Climbazole in the fish body remains the same at the end of the 72h~168h exposure period of the absorption period (i.e. the 7th day). Stablize. The stable concentrations of campanolain in gills and liver, bile and plasma were 2.91 and 33.7ng/g, 4.84 and 2.58ng/mL, respectively. According to the curve nonlinear fitting results, the absorption kinetics of Campanola in fish gills, liver, bile and plasma all conform to the pseudo-first-order kinetic equation, and the correlation coefficients r2 of the equation fitting results are 0.75, 0.83, 0.90 and 0.96. Comparison shows that: Climbazole has the highest ku in the liver, an order of magnitude higher than the ku in the gills, 2 times and 5 times higher than the bile and plasma, respectively, indicating that compared with other parts, the liver of tilapia is more likely to absorb clambazole. Previous studies have pointed out that the concentration and absorption rate of hydroxyazepam, methocarbamol, and tetrabromobisphenol A in the fish liver are also higher than those in the brain, bile, gills, and muscles in the water body, which may be due to the liver as a detoxification organ. , more easily absorb exogenous pollutants.

2 Clearance kinetics of Climbazole

As shown in Figure 1, at the 72th hour of the washout period (i.e. the 3rd day), the concentration of Campanuin in the fish reached the lowest value; at the end of the experiment at 72h~168h of the washout period (i.e. the 7th day), the concentration of Campanile in the fish body remained Stable. The stable concentrations of Campanola in gills, liver, bile, and plasma are 0.10ng/g (<MQLs), 1.28ng/g, 0.26ng/mL (<MQLs) and 0.05ng/mL (<MQLs), respectively. After the 3-day clearance period, the residual amount of Climbazole in tilapia was relatively low. According to the nonlinear fitting results of the curve, the clearance kinetics of Climbazole in the gills, liver, bile and plasma of the fish all conformed to the pseudo-first-order kinetics equation, and the correlation coefficients r2 of the equation fitting results are 0.97, 0.98, 0.77 and 0.98, respectively. The kinetic equations of the clearance of Campanola in tilapia are shown in Table 3. Through the equation parameters, the kinetic constants ke of the clearance of Campanola in the gills, liver, bile and plasma of Tilapia are 0.033, 0.029, 0.082 and 0.060 respectively. h-1; according to the ke value, the half-life t1/2 of Campanola in tilapia gills, liver, bile and plasma can be calculated to be 21.1, 23.9, 8.51 and 11.6h respectively. t1/2 is the smallest, and t1/2 in gills and liver is 2-fold and 3-fold higher than that in bile, respectively. Compared with other parts, the metabolism rate of campanolain in bile is faster, indicating that enterohepatic circulation in bile is an important metabolic pathway for fish to excrete Climbazole.

3 Fish body enrichment rules of Climbazole

According to the method recommended by OECD, the kinetic bioconcentration factor logBCFK of tilapia gills, liver, bile and plasma was calculated to be 0.32, 1.45, 0.54 and 0.36 respectively; During the 7d absorption kinetics experiment, the average concentration of Campanola in exposed water was 0.92ng/mL. The steady-state bioconcentration factor logBCFss of tilapia gills, liver, bile and plasma were calculated to be 0.50, 1.56, 0.72 and 0.45, respectively. The kinetic bioconcentration factor logBCFK and the steady-state bioconcentration factor logBCFss of campanola in fish gills, liver, bile and plasma are relatively close. It shows that during the 7d absorption kinetics experiment, Campanile has reached the equilibrium of absorption/clearance kinetics in fish. The comparison shows that the bioaccumulation level of Campanuin in the liver is higher, and the bioaccumulation level in gills and plasma is lower. According to the previous investigation results, the average logBAF value of logBAF of campanola in the liver of wild tilapia in the Yangtze River and Pearl River basins was 2.42. In comparison, the bioaccumulation level of clambachia in tilapia under laboratory exposure conditions was lower than that in tilapia under field exposure. , wild fish take in passively through predation on lower aquatic animals and plants, and actively absorb these two ways through gill respiration, and at the same time, take in campanol from food and surface water. Due to the continuous excretion of campanol into the receiving environment, it persists in the environment and is continuously ingested by wild fish, while the organisms have a limited removal rate of pollutants, resulting in the continuous accumulation of campanol in the fish, which eventually leads to field investigations. The logBAF is higher than the logBCFss of Climbazole in fish exposed to a single water body in the laboratory.

Purification Method of Climbazole

Currently synthesized Climbazole generally has low purity and poor color. It is reported in the literature that the clambasu obtained by purifying methods such as toluene or cyclohexane has not yet reached the ideal level, and there are also problems of poor chromaticity and peculiar smell.

In order to overcome the above-mentioned shortcoming, CN1203062C recrystallizes the crude product of Campoline with a mixed solvent of a polar solvent and a non-polar solvent, or uses a polar solvent but uses two different polar solvents or a method for recrystallizing in two steps with a mixed polar solvent , that is, first recrystallize with a polar solvent, and then recrystallize with another polar solvent or mixed polar solvent different from the first polar solvent to obtain high-quality, nearly transparent prismatic crystals Climbazole has a purity of more than 99% (high pressure liquid chromatography, external standard method) and the product is white and has no peculiar smell.

About Products:
If you need Climbazole as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Climbazole, our company, ZSpharmac will provide Climbazole raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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