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Zhishang Chemical

Climbazole CAS 38083-17-9

Molecular Formula: C15H17ClN2O2

Formula Weight: 292.76

ZSpharmac: Climbazole Supplement

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Product Name: Climbazole
CAS No: 38083-17-9
Purity: 99%

Basic Info

Product Name:Climbazole
Other Names:Diazobutanone
CAS:38083-17-9
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Plant Extracts
Appearance:Colorless Viscous Liquid
EINECS No.:253-775-4
Storage:Inert atmosphere,Room Temperature
Provide:Climbazole MSDS;
Climbazole COA

What is Climbazole?

Climbazole is a racemate containing equimolar quantities of (R)- and also (S)- Clambol and also has the IUPAC name (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl- 3,3-Dimethylbutan-2-one, CAS Reg. No. 38083-17-19. It is a topical antifungal agent used to deal with fungal skin infections in people. It can be included in non-prescription anti-dandruff hair shampoos and skin treatment structures to treat dandruff and eczema where the reason is a fungal infection. Climbazoleis a normal azole fungicide, which inhibits the essential function of plasma fungal cell membrane layers by non-competitively obstructing the synthesis of lanosterol 14α-demethylase (likewise called fungal CYP51) in P450 enzymes. Part of the biosynthesis of ergosterol, which creates fungal cell death.

Climbazole Properties:

Melting point 96-100°C
Boiling point 447.5±40.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
refractive index 1.54
storage temp. Inert atmosphere,Room Temperature
pka5.66±0.22(Predicted)
form neat

 

Climbazole Uses

Climbazole is a racemate consisting of equimolar amounts of (R)- and (S)-carbazine and has the IUPAC name (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl- 3,3-Dimethylbutan-2-one, is a topical antifungal agent used to treat fungal skin infections in humans. It can be included in over-the-counter anti-dandruff shampoo formulations and skin treatment compositions to treat dandruff and eczema where the cause is a fungal infection. Gambasu inhibits the biosynthesis of ergosterol, an important component of plasma fungal cell membranes, mainly by non-competitively blocking the synthesis of lanosterol 14α-demethylase (also known as fungal CYP51) in P450 enzymes, enabling fungal cells die.

Climbazole Environmental Effects

Climbazole is commonly added to personal care products such as shampoos as a bacteriostatic and anti-dandruff active ingredient. According to the survey, shampoos containing Climbazole are widely sold in China and European countries. The annual consumption of Climbazole in China is 3800t. Statistics show that the content of Climbazole in ordinary shampoos can reach up to 2.0%, and its mass concentration is about 15mg /mL. After the shampoo is used, most of the Climbazole in it enters the urban sewage treatment system with the domestic domestic wastewater. However, the commonly used sewage treatment processes in various sewage treatment plants cannot completely remove Climbazole, and its water phase removal rate is only 34%~76%. After entering the environment, Climbazole has different degrees of toxic effects on aquatic organisms at all levels, and its ecotoxicity has gradually attracted attention. Climbazole has growth or behavioral inhibitory effects on green algae (Pseudokirchneriella subcapitata), duckweed (Lemna minor), Daphnia magna, zebrafish embryos (Danio rerio), etc. EC50) as low as 0.087 µg/mL. Sustained discharge of Climbazole poses a threat to aquatic ecosystems.

Climbazole Pharmacokinetics

1 Absorption kinetics of Climbazole

As shown in Figure 1, the concentration of Climbazole in the fish reached the maximum at the 72nd hour of the absorption period (ie, the 3rd day); the concentration of Climbazole in the fish remained at the end of the exposure at the 72nd to 168th hours of the absorption period (ie, the 7th day). Stablize. The stable concentrations of Climbazole in gill and liver, bile and plasma were 2.91 and 33.7 ng/g, 4.84 and 2.58 ng/mL, respectively. According to the curve nonlinear fitting results, the absorption kinetics of Climbazole in fish gills, liver, bile and plasma are in line with pseudo-first-order kinetic equations, and the correlation coefficients r2 of the equation fitting results are 0.75, 0.83, 0.90 and 0.96. Comparison shows that: Climbazole has the highest ku in the liver, which is an order of magnitude higher than that in the gills, and 2 times and 5 times higher than that of bile and plasma, respectively, indicating that compared with other parts, the liver of tilapia is easier to absorb Gumbosu. Previous studies have pointed out that the concentration and absorption rate of hydroxydiazepine, methocarbamol, and tetrabromobisphenol A in the fish liver are also higher than those in the brain, bile, gills, muscles, etc., which may be due to the liver as a detoxification organ. , it is easier to absorb exogenous pollutants.

2 Clearance kinetics of Climbazole

As shown in Figure 1, the concentration of Climbazole in the fish reached the lowest value on the 72nd (ie, the 3rd day) of the clearance period; the concentration of Climbazole in the fish was maintained at the end of the experiment (ie, the 7th day) from the 72nd to the 168th hour of the clearance period (ie, the 7th day). Stable. The stable concentrations of Climbazole in gill, liver, bile and plasma were 0.10ng/g (<MQLs), 1.28ng/g, 0.26ng/mL (<MQLs) and 0.05ng/mL (<MQLs), respectively, indicating After the 3-day clearance period, the residual amount of Climbazole in tilapia was relatively low. According to the nonlinear curve fitting results, the clearance kinetics of Climbazole in fish gills, liver, bile and plasma were all in line with pseudo-first-order kinetics equation, the correlation coefficients r2 of the equation fitting results are 0.97, 0.98, 0.77 and 0.98, respectively. The kinetic equations of Climbazole in tilapia are shown in Table 3. The kinetic constants ke of Climbazole in tilapia gills, liver, bile and plasma can be obtained from the equation parameters, which are 0.033, 0.029, 0.082 and 0.060, respectively. h-1; according to the ke value, the half-lives of Climbazole in tilapia gills, liver, bile and plasma can be calculated as t1/2 of 21.1, 23.9, 8.51 and 11.6h, respectively. By comparison, it can be known that: Climbazole in tilapia bile t1/2 was the smallest, with t1/2 in gill and liver being 2-fold and 3-fold higher than that in bile, respectively. Compared with other parts, the metabolic rate of Climbazole in bile was faster, indicating that the enterohepatic circulation of bile was an important metabolic pathway for the excretion of Climbazole from fish.

3 The fish enrichment rule of Climbazole

According to the method recommended by OECD, the log BCFK values ​​of Climbazole in tilapia gills, liver, bile and plasma were calculated to be 0.32, 1.45, 0.54 and 0.36, respectively; The average concentration of Climbazole in exposed water was 0.92ng/mL during the 7-day absorption kinetics experiment. Thus, the logarithmic bioconcentration coefficients logBCFss of Kambaosu in tilapia gills, liver, bile and plasma were calculated to be 0.50, 1.56, 0.72 and 0.45, respectively. The kinetic bioconcentration factor logBCFK and the steady-state bioconcentration factor logBCFss of Climbazole in fish gills, liver, bile and plasma were relatively close. It indicated that during the 7d absorption kinetics experiment, Climbazole had reached the equilibrium of absorption/clearance kinetics in fish. The comparison showed that the bioaccumulation level of Climbazole in the liver was higher, and the bioaccumulation level in the gill and plasma was lower. According to the previous investigation results, the average value of logBAF of the log BAF in the liver of wild tilapia in the Yangtze and Pearl River basins was 2.42. In comparison, the bioaccumulation level of Cambium in tilapia under laboratory exposure conditions was lower than that in tilapia under field exposure. This may be due to the contamination of Cambium in surface water and algae. , Wild fish are passively ingested by predation of lower aquatic animals and plants, and actively absorbed by gill respiration, while ingesting calabasin from food and surface water. Due to the continuous excretion of Climbazole into the receiving environment, Climbazole persists in the environment and is continuously ingested by wild fish, while the removal rate of pollutants by organisms is limited, resulting in the continuous accumulation of Climbazole in fish, which eventually led to field investigations. The logBAF was higher than the logBCFss of Climbazole in fish exposed to a single water body in the laboratory.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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