Civetone CAS 542-46-1

Molecular Formula: C17H30O

Formula Weight: 250.42

ZSpharmac: Civetone Supplier

Product Name: Civetone

CAS No: 542-46-1

Purity: 99%

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Basic Info

Product Name:	Civetone
Other Names:	9-Cycloheptadecen-1-One
CAS:	542-46-1
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Needle Crystal
EINECS No.:	208-813-4
Storage:	2-8°C
Provide:	Civetone MSDS； Civetone COA

What is Civetone?

Civet incense is also called fragrant cat incense. An animal spice, which is a secretion from the gonadal sac of civets (both male and female, male is preferred). About 30g can be collected once a month. It is light yellow liquid at the beginning, and turns from viscous liquid to brown solid after a long time. Freshly harvested secretions have an unpleasant odour, and after dilution they have a unique aroma. Insoluble in water, soluble in ethanol, benzene, chloroform. The main component of the aroma is civetone, which accounts for about 2% to 3%. In addition, it is also related to the special aroma of indole, benzyl trimethyl indole acetate and tetrahydro-p-methylquinoline. Like musk, it is an important fixative for high-end cosmetics. It was used in cosmetics before 1860, especially when musk was in short supply, and it was used instead of musk. The concentration of 4% Vaseline has no irritation and no feeling to the skin. No phototoxicity. Rat oral LD505000mg/kg.

Civetone is a scent compound. In 1915, Sack found that there were about 3% in all-natural civet scent. In 1926 Ruzicka determined the molecular structure as 9-cyclohexadecenone.
There are mainly cis-isomers separated from all-natural civet scent. Artificial items based on oleic acid are trans-body. Civetone can be utilized as a substitute for musk and is among the very best fixatives. It is mostly utilized in oriental scent type as well as floral scent kind progressed cosmetic significance.
Civetone has a strong animal-type musk aroma. Civetone is generated by Firm, Switzerland. The product specification is: fluid appearance, material not less than 90% (chromatographic technique, total amount of cis-trans isomers), d20200.923 ～ 0.940, n20D1.485 ～ 1.492, flash point > 100 ℃.
In spite of years of extensive research study work with the synthesis of civetone, a beneficial spice created in small tonnages, it has up until now been difficult to generate on a commercial range.
Civetone is generally made use of in high-end perfume flavor formulations, the dose is within 1%, as well as it can play an excellent effect even with a little dose (0.01%). IFRA has no limitations.
Civetone is taped in FEMA3425 in the United States; it is authorized by the FDA for food.

Civetone Property

Melting point	31-32°
Boiling point	bp742 342°; bp2 59°
density	d433 0.917
refractive index	nD33.4 1.4830

Civet ketone is also known as cycloheptadecen-9-one-1, 10-oxycyclohexadecene. It is the main component of civet aroma. Only about 3.5% civetone is contained in natural civet incense. White needle-like crystals. There are cis and trans. The relative molecular mass is 250.43. The relative density is 0.915～0.917 (33°C). The melting point is 32.5°C. The boiling point is 342°C (98.925×103Pa), 158～160°C (0.266×103Pa). Insoluble in water, soluble in organic solvents. The refractive index is 1.4830 (33.4°C). Rat oral LD50 is greater than 5000mg/kg. After release there is a strong and pleasant civet aroma. The threshold is 0.01×10-6～0.001×10-6.
Ciscatone is a naturally occurring civetone, the content of civetone is 2.5% to 3.5% in civet incense, and its musky smell becomes more pleasant when it is very dilute. Easy to evaporate with steam. It can be oxidized to 8-carbonopentadecane-1,15-dicarboxylic acid in benzene, which can be catalyzed by colloidal palladium in dilute alcohol to obtain dihydrocivet ketone, which can be catalyzed by platinum black to obtain dihydrocivet alcohol. Civet alcohol can be obtained by sodium reduction in boiling ethanol, and cycloheptadecene and a small amount of cycloheptadecane can be obtained by Clemmensen reduction method.

Civetone Uses

Civetone can bring vigor to the significance when it is utilized for fragrance, and has a strong capacity to fix fragrance. It is a really valuable fixative in Su Xinlan, oriental fragrance, citrus fragrance and numerous flower scents, such as Dagonghua jasmine, brandy, narcissus, climbed, and so on. It can be integrated with flower, vinegar, Su Xinlan, oriental Scent as well as pet fragrances are well collaborated. It is also an indispensable material for the prep work of fabricated civet scent. The general dose is 1-2%.
Civetone is used as a musk substitute. It has a strong ability to deal with scent and also is typically made use of as a fixative. It is made use of to blend top-quality essence, the dosage in fragrance is 0.04-0.4%, as well as the dose in balm as well as lotion is 0.003-0.02%.

Civetone Production Method

The natural civet scent contains about 3.5% civetone. After the civet incense is alkalized with 10% KOH alcohol, the neutral component undergoes vacuum fractionation, the portion at 130-170 ° C (0.2 kPa) is accumulated, and also it is made right into semicarbazone, separated and also refined, and after that disintegrated with oxalic acid to get civet ketone. Civetone is additionally included in the raffinate of apart civetone, which can be separated with phthalate and also alkalized, and after that oxidized with chromic acid to obtain civetone. The artificial technique can be gotten from 9,10,16-trihydroxyhexadecanoic acid drawn out from all-natural shellac as raw material, after halogenation, removal, thionyl chloride acid chlorination, condensation with ethyl acetoacetate, decarboxylation, esterification, iodine Chemical, cyclization, hydrolysis as well as likewise various other actions; it can similarly be prepared from oleic acid or undecylenic acid.

Civetone and Decanoic Acid as Candidate Pheromones of Giant Pandas

Chemicals present in urine are thought to play a crucial function in companion acknowledgment in solitary large pandas (Ailuropoda melanoleuca). Throughout reproducing season, ladies launch chemical signals to promote sexual understanding to prospective mates. The purpose of this study was to figure out whether specific volatile compounds located in ladies’s urine could be considered pheromones that elicit behavioral and physical feedbacks in males. Speculative synchronised option tests were carried out with restricted male large pandas (n = 3) housed at the Memphis Zoo, the San Diego Zoo, and the Atlanta Zoo. Octanoic acid, 1H-pyrrole-2-carbaldehyde, capric acid, and also civetone were selected as stimuli since previous research studies reported their altitude in pee throughout the breeding period. Guy’s behavioral choices for these volatile substances diluted in synthetic urine contrasted to without treatment synthetic urine identified male interest. Pee examples from men were collected 1 week in the past, throughout as well as 1 week after the experiment to assess changes in pee chemical composition and also urinary androgen concentrations. When stimuli were contrasted, there were no significant differences in study feedbacks (p =.395) or Fryman feedbacks (p =.600); nevertheless, decanoic acid and also civetone elicited much better behavioral choices than controls (feedback ratio > 0.5). The loved one wealth of 16 substances recognized in male urine was dramatically enhanced (p <.05) above standard values after direct exposure to the stimulus in men. Androgen levels were dramatically elevated (p <.05) in one man after exposure to 1H-pyrrole-2-carboxaldehyde, decanoic acid, and civetone. These information recommend that lycatone and capric acid in females’s pee may be sexually arousing in guys.

About That Product:
If you need Civetone, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Civetone manufacturer and supplier, ZSpharmac will provide Civetone raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.