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Citronellyl Nitrile CAS 51566-62-2

Molecular Formula: C10H17N

Formula Weight: 151.25

ZSpharmac: Methylglyoxal Miel Supplement

Product Name: Citronellyl Nitrile
CAS No: 51566-62-2
Purity: 99%

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Basic Info

Product Name:Citronellyl Nitrile
Other Names:3,7-DiMethyloct-6-Enenitrile
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Liquid
EINECS No.:257-288-8
Storage:Store in An Airtight Seal Away From Light
Provide:Citronellyl Nitrile MSDS;
Citronellyl Nitrile COA

What is Citronellyl Nitrile?

Citronellyl Nitrile is almost colorless liquid; fresh lemon fruit aroma and green vegetable-like and earthy aroma, natural and powerful, soluble in 6 volume 70% ethanol and oils, soluble in ethyl phthalate, insoluble in water. Citronellyl Nitrile is a good spice for citrus flavors, it can be used to stabilize lemon flavors, and it is more suitable for lemon and cologne flavors. It can coordinate well with “privet aldehyde” and dihydromyrcenol. Slight use that can enhance fresh air. It also enhances geranonitrile-based fragrances for a more natural, more citral-like scent. The general dosage is 0.5 to 3%, and it can also reach 10%. It is unstable in strong acid medium (pH=0.5~2), stable in weak acid and alkaline medium, and no factors that cause discoloration have been found. Since Citronellyl Nitrile does not exist in nature, it needs to be prepared by chemical synthesis method.

Citronellyl Nitrile Properties:

Boiling point 91.5-92 °C(Press: 11 Torr)
density 0.8332 g/cm3


Citronellyl Nitrile Uses

  1. Citronellyl Nitrile is a good spice for citrus flavors, it can be used to stabilize lemon flavors, and it is more suitable for lemon and cologne flavors. The general dosage is 0.5%-3%.
  2. Citronellyl Nitrile is more stable to heat, light and acid and alkali than citronellal, and the aroma is milder, more durable and transparent than citronellal, so Citronellyl Nitrile can not only be used as a substitute for citronellal, but also It has a wider range of applications and is mainly used for the deployment of cosmetic essences. When using geranonitrile to formulate the fragrance, adding citronellonitrile can improve the fragrance and give the fragrance a more natural and more similar smell to citral. Citronellyl Nitrile can coordinate well with dihydromyrcenol and privetaldehyde to enhance the fresh aroma of the essence. Citronellyl Nitrile is an essential spice when blending lavender, gardenia, citrus, magnolia, longevity, honeysuckle, cologne, linden, hyacinth and other fragrances. In cosmetic fragrances such as soaps.

How to Make Citronellyl Nitrile

1) Synthesis of Citronellaldoxime
Add 92 g of hydroxylamine hydrochloride and 250 mL of water into a three-necked response flask outfitted with a stirrer, 2 going down funnels and a thermometer, as well as stir to dissolve. The temperature level was preserved at 40 ° C, as well as the hydroxylamine hydrochloride option was reduced the effects of to pH 6 with 10% sodium carbonate service under stirring. The temperature was purely regulated at 40 ° C, and under this condition, 180-240 g of lemon eucalyptus oil was included dropwise with a dropping channel, and 10% sodium carbonate solution was included dropwise from an additional dropping channel to keep the response combination. The pH worth is in between 6.5 as well as 7.0. After the enhancement of products, the mixing response was proceeded for 3 hours at 40 ° C. and also pH worth of 6.5 to 7.0, that is, the response was terminated. The reaction blend was poured into a separatory funnel, the liquid layer was divided, as well as the oil layer was cleaned 3 times with water. Then use 2XZ-1 rotating vane air pump to execute vacuum purification to remove impurities such as dampness, as well as gather 115-30 ° C/1.334 kPa portions to get regarding 120g of citronellal oxime.

2) Synthesis of Citronellyl Nitrile
108 g of acetic anhydride was added to a three-necked reaction flask outfitted with a thermostat, a stirrer, a going down channel and also a reflux condenser, and also warmed to 90 ° C. with mixing. Under this temperature problem, 120 g of citronellal oxime was gradually added dropwise via a dropping channel, and after the enhancement was finished, the temperature was increased to 100 ° C., and the reaction was continued to be mixed for 2 h to finish the response. Initially, acetic anhydride and also acetic acid in the response blend were recouped by purification under minimized pressure with water removal. Then, after the response mixture was cooled down, it was poured into a separatory funnel, the reaction mix was washed with a proper amount of water for 3 to 5 times, and the water layer was divided. Finally, 2XZ-1 rotary vane air pump was used to execute vacuum cleaner fractionation of the response blend, as well as the 90 ° C/0.667 kPa fraction was gathered to acquire about 75g of Citronellyl Nitrile item, which has a regular characteristic fragrance of citronellyl nitrile.

Evaluation of Citronellyl Nitrile

Organonitriles are extensively utilized as components in scents and also incorporated into client products, a variety of which are for topical human use. Some all-natural nitriles are conveniently metabolized to possibly hazardous not natural cyanides. Subsequently, looks into were executed to take a look at whether this would absolutely occur when three depictive fragrant nitriles, phenylacetonitrile, geranonitrile, and also citronellonitrile, were placed on the skin in rats. Nitriles (benzyl cyanide, 150 mg/kg; geranyl in addition to citronellyl nitrile, 400 mg/kg) were put on the cut back of rats as well as kept in a closed state for 24 human resources. Pee samples were collected at 0-24 hrs, 24-48 hours as well as also 48-72 hours from the really initial application. As previously specified (Potter, J., Smith, RL, Api, AM, 2000. Urinary system thiocyanate degrees as a biomarker for not natural cyanide generation from benzyl cyanide in rats. Food as well as also Chemical Toxicology 39, 141-146). When it involves benzyl cyanide, urinary thiocyanate levels are significantly boosted as a result of the launch of cyanide in the body. The amount of thiocyanate recovered amounted 37% of the male dose as well as 32% of the female dose. For geranonitrile, urinary system thiocyanate excretion was not substantially boosted, while Citronellyl Nitrile enhanced just somewhat, standing for 0.40% of the dosage executed in males and additionally 0.29% of the dose administered in ladies. In the case of benzyl cyanide, urinary thiocyanate levels are substantially improved as a result of the release of cyanide in the body. The amount of thiocyanate recuperated amounted 37% of the male dosage as well as 32% of the female dosage. For geranonitrile, urinary thiocyanate excretion was not drastically boosted, while Citronellyl Nitrile increased just a little, standing for 0.40% of the dose carried out in men along with 0.29% of the dosage performed in females. When it comes to benzyl cyanide, urinary system thiocyanate levels are significantly boosted as a result of the launch of cyanide in the body. The amount of thiocyanate recouped amounted 37% of the male dosage and also 32% of the ladies dose. For geranonitrile, urinary system thiocyanate discharging was not significantly boosted, while Citronellyl Nitrile boosted just a little, corresponding to 0.40% of the dose supplied in men as well as also 0.29% of the dosage supplied in women.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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