Cinnamon Oil Coles 0.45g, RH-40 0.99g, Span 80 0.33g, Isopropyl Alcohol 0.44g, IPM 0.39g, Deionized Water 2.2g. Take 0.45 g of cinnamon oil, 0.99 g of RH-40, 0.33 g of Span 80, 0.44 g of isopropanol, and 0.39 g of IPM in the same container, stir well under a magnetic stirrer, and add deionized dropwise at 40°C water, stirring while adding dropwise, adding 2.2 g of deionized water to obtain cinnamon oil microemulsion.
2. Cinnamon Oil Coles Dropping Pills
(1) preparation recipe: get 2 parts of cinnamon oil, mix with 9 parts of bases (weight ratio of bulk drug and base 2:9), wherein bases are polyethylene glycol 4000 and polyoxyl 40 stearate by weight Mixed in a ratio of 8:1.
(2) Melt the matrix in an oil bath at 100°C, then add cinnamon oil, and keep stirring in the same direction until the mixture is uniform.
(3) Put the well-stirred medicinal liquid into the dripping tank of the pill-dropping machine, control the parameters according to the conditions of the pill-dropping machine, fully stir evenly in the dripping tank, and wait until each control index of the pill-dropping machine reaches the The requirements are that the chassis temperature is 100 °C, the oil bath temperature is 100 °C, the liquid temperature is 100 °C, and the dripping temperature is 100 °C. After the parameters are stable, the dripping system starts.
(4) The dripping pills are prepared on a dripping pill preparation device (ie, a dripping pill machine) equipped with a closed storage tank, and the dripping pressure is controlled to be 0.01Mpa.
(5) Select dimethyl silicone oil 400 as the cooling liquid, control the temperature of the cooling liquid to be 11 °C, the dropping speed of the pellets is 18 grains/min, the nozzle temperature is 45 °C, and the dropping distance is 13 cm. , Take out, spin-dry the coolant, granulate, dry, and coat.