Cineol Kaufen CAS 470-82-6

Molecular Formula: C10H18O

Formula Weight: 154.25

ZSpharmac: Cineol Kaufen Supplement

Product Name: Cineol Kaufen

CAS No: 470-82-6

Purity: 99%

Basic Info

Product Name:	Cineol Kaufen
Other Names:	1,8-Cineole
CAS:	470-82-6
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Flavors and Fragrances
Appearance:	Clear Colorless to Slightly Yellow Liquid
EINECS No.:	207-431-5
Storage:	2-8°C
Provide:	Cineol Kaufen MSDS； Cineol Kaufen COA

What is Cineol Kaufen?

Cineol Kaufen (1,8-Cineole; Cajeputol), also referred to as eucalyptol, eucalyptol, eucalyptol, etc, is a colorless oily transparent fluid, widely located in all-natural fragrant oils, and is the main component of eucalyptus oil. Cineol Kaufen has a camphor smell and also an amazing herbal taste. It has antiseptic and insecticidal impacts. It is mainly used in medication and also food seasonings, as well as is often used as a chemical.

Cineol Kaufen Properties:

Melting point	1-2 °C(lit.)
Boiling point	176-177 °C(lit.)
density	0.9225
FEMA	2465 \| EUCALYPTOL
refractive index	n20/D 1.457(lit.)
Fp	122 °F
storage temp.	2-8°C
solubility	3.5g/l
form	Liquid
color	Clear colorless to slightly yellow
Water Solubility	Soluble in water(3500 mg/L (at 21°C). Miscible with ether, alcohol, chloroform, glacial acetic acid, oils. Soluble in ethanol, ethyl ether; slightly soluble in carbon tetrachloride.

Cineol Kaufen Uses

Cineol Kaufen GB 2760-96 specifies that the food tastes are permitted to be used. Mainly used in throat lozenge, fabricated mints, and so on.
Cineol Kaufen is among the fundamental components of lavender oil and also spike lavender oil, as well as is a necessary scent for the preparation of these vital oils. Proper amount is made use of in natural flavors such as lavender, freshly cut yard and fragrant wilt, as well as it has the impact of boosting quality. Made use of in medicated soaps, sprays or cosmetic significances as well as various other hygiene items, such as tooth paste, and so on, it has an antiseptic impact. It can be made use of as a covering up representative for foul breath in industrial products. Additionally made use of in food tastes.
Cineol Kaufen is utilized in the preparation of dental tastes and in the manufacture of pharmaceutical items. As an artificial additive, Japan’s “Food Additives Official Publication” stipulates that the purity of cineol is greater than 85% as well as can not be used for functions besides flavor.
Cineol Kaufen is commonly utilized in medication, as well as it is likewise used in the prep work of tooth paste significance and so on.

Preparation of Cineol Kaufen

The method for synthesizing eucalyptolfrom Cineol Kaufen the steps:
1) with terpineol and methylene dichloride mass ratio of 1:13, terpineol and solid catalyst zinc triflate mass ratio of 1:10.4 to join in the reaction flask; under normal temperature and pressure, under nitrogen protection Stir with a stirrer for 4h, the rotating speed is 80 rev/min, and stand for 25min after the reaction is completed to obtain the reaction solution I;
2) adding methylene chloride to the reaction solution I, the mass ratio of terpineol to methylene chloride is 1:6, stirring with a stirrer for 1 h, and the rotating speed is 40 rev/min to obtain reaction solution II;
3) adding saturated sodium bicarbonate solution to reaction solution II for extraction, the mass ratio of terpineol to saturated sodium bicarbonate solution is 1:19, standing for stratification for 10min, and taking the lower layer solution to obtain reaction solution III;
4) Wash the reaction solution III with saturated brine, the mass ratio of terpineol to saturated brine is 1:14.4, and the washing is carried out in 3 times; add anhydrous sodium sulfate and dry, and the mass ratio of terpineol to anhydrous sodium sulfate is 1 : 9.6; use a rotary evaporator to spin dry to obtain a light yellow transparent liquid, namely eucalyptol solution. Through GC detection, the conversion rate of eucalyptol was calculated to be 65.5%.

The Role of Cineol Kaufen in Chronic Disease Management

Cineol Kaufen has anti-inflammatory and antioxidant activity and has been used to treat lung inflammation and respiratory diseases, including bronchitis, sinusitis, bronchial asthma, and chronic obstructive pulmonary disease. In addition, eucalyptol showed neuroprotective effects in an ischemic stroke model, anti-inflammatory effects in neurodegenerative diseases such as Alzheimer’s disease, and significantly reduced preoperative anxiety in patients undergoing surgery.

1. Contains the representative essential oil of Cineol Kaufen

Many essential oils contain Cineol Kaufen, representative of which are Eucalyptus (Eucalyptus) Essential Oil, Eucalyptol Rosemary Essential Oil (Rosmarinus officinalis CT Cineol), Agonis fragrans Essential Oil, Myrtus Essential Oil (Myrtus) communis), Melaleuca viridiflora

2. Physicochemical properties of Cineol Kaufen

Eucalyptol is a lipophilic molecule that disrupts intracellular lipids and increases drug penetration. Lipid-based microemulsion systems of eucalyptol have been used for transdermal delivery. Eucalyptol is metabolized to 2-exo-hydroxy-1,8-cineole by rat and human liver microsomal P450 enzymes and eliminated in urine. In addition, eucalyptol readily crosses the blood-brain barrier and may have direct effects on receptors and enzymes in the brain. Cineol Kaufen has been reported to have antibacterial, anti-inflammatory, antioxidant, analgesic and antispasmodic effects in a variety of diseases including colds, flu, other respiratory infections, rhinitis and sinusitis. 1) Cineol Kaufen, as a strong inhibitor of pro-inflammatory cytokines such as TNF-α and IL-1β, shows analgesic effects in inflammation models. 2) Cineol Kaufen significantly increases the beating frequency of nasal cilia in the mucosa and has a bronchodilatory effect. 3) In addition, it reduces the exacerbation of asthma, sinusitis and chronic obstructive pulmonary disease symptoms by inhibiting cytokine-induced airway mucus hypersecretion. 4) It exhibits antioxidant activity by scavenging free radicals and reduces Ca2+ influx through calcium channels in the myocardium.

3. Regulation of cell signaling pathways by Cineol Kaufen

Chronic diseases are closely related to chronic inflammation and oxidative stress. Lipopolysaccharide (LPS) plays an important role in the inflammatory process by activating NF-κB and MAPK signaling pathways. Eucalyptol was shown to inhibit lipopolysaccharide-induced cytokine production, reduce NF-κB activity, and increase IκBα protein levels. In the BALB/C mouse model, eucalyptol reduced the number of inflammatory cells, the expression of matrix metalloproteinase-9 (MMP-9) and cytokines including TNF-α and IL-6 as well as nitric oxide and NF -κB) production. In addition to the above effects, it was found that eucalyptol reduced OGD/R-induced ischemic injury by reducing oxidative stress in rat neurons and glia. In a cellular model of Alzheimer’s disease, pretreatment of PC12 cells with eucalyptol decreased mitochondrial membrane potential, as well as levels of ROS, NO, COX-2, NF-κB, and reduced Aβ25-35-induced Pro-inflammatory cytokines TNF-α, IL-β and IL-6

4. The role of Cineol Kaufen in chronic disease management

Cineol Kaufen has been shown to be effective in a variety of inflammatory diseases including respiratory disease, pancreatitis, cardiovascular disease and neurodegenerative diseases, as well as reducing colon damage. Cineol Kaufen as a mucolytic agent for inflammatory respiratory diseases. Compared with placebo, eucalyptol treatment significantly reduced dyspnea and enhanced lung function and quality of life in patients with stable COPD. Eucalyptol treatment also improved the condition of asthmatics by enhancing lung function and improving overall health. In addition, eucalyptol has been used to treat chronic bronchitis, sinusitis, and rhinitis. The protective effect of Cineol Kaufen against neurodegenerative diseases may be due to its anti-inflammatory activity. Eucalyptol also exhibits antihypertensive effects by increasing nitrite levels and reducing malondialdehyde activity. Eucalyptol has also been reported to lower heart rate through a parasympathetic mechanism and lower blood pressure through vasodilation.

5. Clinical studies of Cineol Kaufen

Cineol Kaufen has shown anti-inflammatory effects in various chronic respiratory diseases in clinical studies. In addition, Cineol Kaufen has also been found to have analgesic and anxiolytic effects in humans. Eucalyptus essential oil is mainly composed of eucalyptol, and inhalation of eucalyptus essential oil can effectively relieve pain in patients undergoing total knee replacement. A randomized clinical trial found that inhaled eucalyptol significantly reduced anxiety in patients before SNRB.

What is the Cineol Kaufen Assay?

Determination method of Cineol Kaufen content According to gas chromatography [Appendix VI E 3., according to liquid chromatography 3. (1) Determination. The chromatographic conditions and system suitability test used polyethylene glycol (PEG)-20M and silicone (OV-17) as fixatives, and the coating concentrations were 10% and 2%, respectively; The ratio (weight ratio) is loaded into the same column (PEG is at the injection port end); the column temperature is 110±5℃; the theoretical plate number is calculated according to the eucalyptol peak, and should not be less than 2500; The resolution of the peaks should meet the requirements. Determination of correction factor Take an appropriate amount of cyclohexanone, accurately weigh it, add n-hexane to dissolve and dilute to a solution containing 50mg per 1ml, as the internal standard solution. In addition, about 100 mg of eucalyptus olein reference substance was taken, accurately weighed, placed in a 10 ml measuring bottle, 2 ml of internal standard solution was added precisely, diluted to the mark with n-hexane, shaken up, and 1 μl was injected into the gas chromatograph, and injected continuously for 3 to 5 times, the correction factor is calculated based on the average peak area. Preparation and Determination of Test Solution Take about 100mg of this product, accurately weigh it, put it in a 10ml volumetric flask, accurately add 2ml of internal standard solution, dissolve it with n-hexane and dilute to the mark, shake well, and use it as the test solution. Take 1 μl and inject it into a gas chromatograph, and measure it.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.