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Chrysin Supplement CAS 480-40-0

Molecular Formula: C15H10O4

Formula Weight: 254.24

ZSpharmac: Chrysin Supplement Supplier

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Product Name: Chrysin Supplement
CAS No: 480-40-0
Purity: 99%

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Basic Info

Product Name:Chrysin Supplement
Other Names:Chrysin
CAS:480-40-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Crystalline Powder
EINECS No.:207-549-7
Storage:Room Temperature
Provide:Chrysin Supplement MSDS;
Chrysin Supplement COA

What is Chrysin Supplement?

Chrysin (5,7-dihydroxy-2-phenyl-4H-chromen-4-one), English name chrysin, exists in the seeds and stem bark of Oroxylum indicum (L.) Vent.] The heartwood of Pinus mon-ticola Dougl., the heartwood of P.aristata Engelm. and also other plants in Pinaceae. Modern medicinal study shows that Chrysin Supplement has a large range of medicinal tasks, such as anti-tumor result; anti-allergic effect; anti-inflammatory effect; anti-viral result; anti-pathogenic bacterium impact and hypoglycemic effect and so forth. Medications with chrysin as the main active ingredient have been used in several countries and areas. A selection of by-products acquired by structurally modifying chrysin as the previous compound also reveal comparable or far better pharmacological activity.

Chrysin Supplement Property

Melting point 284-286 °C(lit.)
Boiling point 357.45°C (rough estimate)
density 1.2693 (rough estimate)
refractive index 1.4872 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka6.50±0.40(Predicted)
form Crystalline Powder
color Yellow

 

Efficacy and Function of Chrysin Supplement

1. Antibacterial and anti-inflammatory
Chrysin Supplement is a natural medicinal active ingredient. It is an active flavonoid substance drawn out from the traditional Chinese medicine Butterfly by using high-tech innovation. It has apparent repressive and also elimination impacts on a range of delicate microorganisms and also pathogenic bacteria in the human body., after the human body absorbs chrysin, it can dramatically enhance the body’s antibacterial and also anti-inflammatory capabilities.

2. Prevention as well as therapy of cancer cells
Chrysin Supplement is a medicinal ingredient with specifically strong anti-cancer as well as anti-cancer capacity. It can prevent the task of health hazards in the body, stop them from harming human cells, as well as prevent the expansion of cancer cells in the human body, which can cause human cancer to happen. The price is significantly minimized, and it can prevent the spread of human cancer.

3. Anti-radiation
Chrysin Supplement, a medical component, can not just boost the body’s anti-cancer capability, however likewise prevent the spread of cancer cells, and it additionally has very anti-radiation capability. Those individuals that currently have cancer obtain radiotherapy as well as chemotherapy. It will create damage to the body’s body immune system, and there will be evident negative effects. After taking anticancer drugs having chrysin, the damage to the body of radiotherapy and chemotherapy can be decreased.

4. Avoidance of thrombosis
Chrysin Supplement also has extremely solid anticoagulant ability, and also can boost the task of platelets in human blood, and also can promote blood flow. Individuals can secure cardio and prevent thrombosis after taking these drugs having chrysin. Poplar can additionally tidy up complimentary radicals in the body as well as stop the aging of human capillary, which is also a vital reason that it can avoid cardiovascular diseases.

Through the thorough introduction of chrysin over, everybody has a detailed understanding of the efficacy and feature of chrysin, understanding that it is a medicinal component with numerous features, and additionally understands the beneficial effects it will carry the human body. You can make better use it later on in your life.

The Preparation Method of Chrysin Supplement

Chrysin Supplement is a flavonoid compound with a wide range of pharmacological activities. It has various pharmacological effects such as anti-tumor, radiosensitization, inhibition of aromatase activity, anti-inflammation, anti-oxidation, and prevention and treatment of cardiovascular and cerebrovascular diseases. However, chrysin has poor water solubility and less intestinal absorption, and its 5 and 7 hydroxyl groups are easily metabolized by glycosylation in the body, resulting in reduced activity. Effective modification of chrysin structure, especially in antitumor, is of great significance for obtaining new drug candidates with high efficiency and low toxicity.

CN102465158A A method for preparing chrysin, characterized in that it comprises the following steps:

1) Crush the leaves of Begonia clover, add acidic aqueous solution to mix, add 2-5%. Biological enzymatic hydrolysis to obtain enzymatic raw materials;

2) Add 5-10 times the amount of the above-mentioned enzymatic hydrolysis raw materials to 80-90% ethanol solution for reflux extraction for 2-3 times, recover and concentrate the extract under reduced pressure to an alcohol concentration of 20-40%, and place it for crystallization;

3) Filter out the above-mentioned crystals, dissolve the polyamide in ethanol and mix the sample, evaporate the ethanol to dry the column, ethanol solution gradient elution, thin-layer detection, collect high-concentration fractions, concentrate under reduced pressure, place crystals, and filter out the crystals 90- Reflux 99% ethanol to dissolve the crystals, and dry the crystals to obtain high-content chrysin products.

Pharmacological Action of Chrysin Supplement

Report one
Su Bingfeng, Department of Cardiovascular Medicine, Taizhou Municipal Hospital, and others discussed the effect of Chrysin Supplement on improving cardiac function in rats with acute myocardial infarction and its effect on the expression of matrix metalloproteinase 2 (MMP-2)/mitogen-activated protein kinase (MAPK). Methods: 100 SD rats were randomly divided into 5 groups: normal control group, model group, positive control group (perindopril, 0.4 mg·kg-1), chrysin low-dose and high-dose groups (20, 40 mg·kg-1). kg-1), 20 rats in each group. Except for the normal control group, acute myocardial infarction models were established in the other groups, the positive control group, chrysin low-dose and high-dose groups were given intragastric administration of corresponding drugs after successful modeling, and the normal control group and model group were given equal volumes of normal saline, qd , Continuous administration for 2 weeks. After the experiment, changes in myocardial pathological structure were observed, routine cardiac function indexes and myocardial enzyme indexes were measured, and myocardial MMP-2 and MAPK were measured by real-time fluorescent quantitative polymerase chain reaction (qRT-PCR) and western blot. mRNA and protein levels. Results: Compared with the model group, the range of myocardial infarction in the perindopril group and the high-dose chrysin group was significantly smaller, the infarction focus and scar tissue were significantly reduced, and the infiltration of inflammatory cells was reduced; Fibroblasts and inflammatory cell infiltration were evident. Compared with the normal control group, the left ventricular end-diastolic internal diameter (LVIDd), left ventricular end-systolic internal diameter (LVIDs), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenation, and Enzyme (LDH), myocardial MMP-2, MAPK mRNA and protein expressions increased, and fractional shortening (FS) and ejection fraction (EF) levels decreased (P<0.05); compared with the model group, the perindopril group , LVIDd, LVIDs, CK, CK-MB, LDH, myocardial MMP-2, MAPK mRNA and protein expression decreased, FS, EF levels increased in chrysin low-dose group and chrysin high-dose group (P<0.05); Compared with the perindopril group, the chrysin low-dose group had statistically significant differences (P<0.05). Conclusion: Chrysin can significantly improve the cardiac function of rats with acute myocardial infarction, which may be related to the inhibition of myocardial MMP-2 expression by chrysin and the activation of MAPK signaling pathway.

Report two
Lin Qi, Department of Urology, Taizhou Central Hospital, and others explored the effect of chrysin on the invasion and migration of prostate cancer PC-3 cell line by regulating the Wnt/β-catenin (β-catenin) pathway. Methods: PC-3 cell group, 5-fluorouracil group, low-dose chrysin group and high-dose chrysin group were set up. In the 5-fluorouracil group, 5-fluorouracil was added to make the final concentration 80.0 μg/mL; in the chrysin low-dose and high-dose groups, Chrysin Supplement was added to make the final concentration 60.0 μg/mL and 120.0 μg/mL, respectively, and cultured for 72 h. Tetramethylazolium salt microenzyme reaction colorimetry (MTT) and crystal violet staining were used to determine the cell survival rate and the number of clones formed, the Transwell method was used to determine the level of cell invasion, and the annexinV-FITC/PI kit was used to determine the level of cell apoptosis. The levels of β-catenin gene and protein in cells were measured by RT-PCR and Western blot. Results: Compared with the PC-3 cell group, the cell survival rate, the number of colony formation, the number of membrane penetration, the expression levels of β-catenin mRNA and protein in the other three groups were all decreased (P<0.05), and the apoptosis rate was increased (P<0.05 ). Compared with the low-dose chrysin group, the high-dose chrysin group had decreased cells, survival rate, colony formation number, membrane penetration number, β-catenin mRNA and protein expression levels (P<0.05), and increased apoptosis rate (P<0.05 ). Compared with the 5-fluorouracil group, the low-dose chrysin group had increased cells, survival rate, cell clone formation number, membrane penetration number, β-catenin mRNA and protein expression levels (P<0.05), and decreased apoptosis rate (P<0.05 ); in the high-dose chrysinin group, the cells, survival rate, cell clone formation number, membrane penetration number, β-catenin mRNA and protein expression levels were decreased (P<0.05), and the apoptosis rate was increased (P<0.05). Conclusion: Chrysin can inhibit the proliferation and invasion of prostate cancer PC-3 cell line, and induce the apoptosis of prostate cancer PC-3 cell line. related to catenin pathway.

About Products:
If you need Chrysin Supplement, the cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Chrysin Supplement manufacturer and supplier, ZSpharmac will provide Chrysin Supplement raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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