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Choline Glycerophosphate CAS 28319-77-9

Molecular Formula: C8H20NO6P

Formula Weight: 257.22

Zhishang Chemical: Amrinone Supplement

Product Name: Choline Glycerophosphate
CAS No: 28319-77-9
Purity: 99%

Basic Info

Product Name:Choline Glycerophosphate
Other Names:Alpha-GPC
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Powder
EINECS No.:248-962-2
Provide:Choline Glycerophosphate MSDS;
Choline Glycerophosphate COA

What is Choline Glycerophosphate?

Choline Glycerophosphate is a water-soluble small molecule that normally exists in the human body and is the biosynthetic precursor of the important neurotransmitter acetylcholine (Acetylcholine). The most important role of GPC is that the choline it produces is a water-soluble vitamin B group, which plays an important role in the brain and nervous system. Studies have shown that GPC has an important role in the production of certain hormones and neurotransmitters such as acetylcholine and human growth hormone, This supports the functioning of the brain and nervous system.
In the body, the most important physiological function of GPC is to cross the blood-brain barrier and provide the necessary choline for the synthesis of acetylcholine and phospholipid (PC). Acetylcholine is an important neurotransmitter in the central nervous system, helping the brain to complete learning and memory. and cognitive activity, and can control light sleep and motor activity. Taking GPC directly can promote the formation of phosphoinositide in the brain, increase the synthesis of phospholipids in the brain, provide more phospholipid compounds for signal transmission in the central nervous system, and increase the synthesis of phosphatidylcholine in the body. Resists cell membrane damage and peripheral nerve function decline caused by aging. GPC was first listed in Italy. In recent years, GPC has attracted more and more attention in my country.

Choline Glycerophosphate Properties:

Melting point 142.5-143°
alpha D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
Fp 11 °C
storage temp. -20°C
form solid


Choline Glycerophosphate Uses

  1. Choline Glycerophosphate has been listed in Italy, Poland, Greece, Chile, South Korea, Brazil, Russia and other countries. Not only does it provide the high levels of choline that brain and nerve cells need, but it also protects their cell walls. Alzheimer’s patients are mainly manifested as memory and cognitive decline, and are accompanied by a variety of complications, such as inability to move, nervous system disorders and other functional impairments. Clinical pharmacological test results and clinical trials have confirmed that glycerophosphocholine is of great help to the cognitive ability and memory function of the brain.
  2. Choline Glycerophosphate can delay the decline of memory, and is used for the rehabilitation and prevention of stroke, cranial and brain injury patients. When the cell membranes of the human brain are damaged due to aging, the situation improves when the amount of acetylcholine and phosphatidylcholine synthesis in the body increases. Glycerophosphorylcholine can enter the structure of lipoproteins, and it can be administered not only orally but also intravenously. Pharmacokinetic studies have shown that glycerophosphocholine can be absorbed at the site of intravenous injection and small intestine, and then enter into various organs through blood circulation, and bind lipoproteins in the liver. It also has certain effects on the physical growth of adolescents, protecting the liver, resisting rheumatoid, improving the cognitive ability of the elderly, resisting arteriosclerosis, resisting the fat penetration of high-lipoprotein foods, and improving memory.
  3. Choline Glycerophosphate is a digestive system drug / liver disease adjuvant drug.

Preparation of Choline Glycerophosphate

At present, the preparation methods of GPC at home and abroad include direct extraction of animal organs, chemical synthesis, chemical hydrolysis, and phospholipase hydrolysis.
1) Direct extraction of animal organs
In order to obtain GPC, the method of extracting from bovine pancreas was first used. Crush the bovine pancreas, take 0.5 g of bovine pancreas tissue fluid, add 2 mL of purified water to obtain a tissue suspension, then add 40 mL of sodium hydroxide solution (0.1 mol/L), transfer it to a conical flask, add anhydrous Ethanol and ether (volume ratio 3:1) were extracted, and the ether layer was separated to obtain an anhydrous ethanol extract, which was boiled and filtered. The filtrate is added with petroleum ether for secondary extraction and separation, and the extract in absolute ethanol is suction filtered and dried to obtain the crude GPC product. This method has complicated operation process and low product yield, and has been replaced by other methods.
2) Chemical synthesis method
Applying the principle of epoxy ring-opening reaction, it is proposed to use ( R)-( + ) condensed glycerol ( ( R)-( + ) Glycidol) and phosphorylcholine for nucleophilic addition in the presence of isopropylamine, and then pass through the ion exchange resin layer The preparation of GPC by analysis is simple, but the total yield is less than 50%. In view of the instability of glycidol (2,3-epoxy-1-propanol), it needs to be frozen to avoid self-condensation, and its purity must be determined before use. , usually purified by distillation under reduced pressure. 2-Chloro-2-oxo-1,3,2-dioxaphosphalane was condensed with isopropylidene glycerol in an inert solvent at 0-10°C; the obtained condensate was condensed with triethylamine at room temperature Under the ring-opening condensation, the crude GPC is obtained; then it is concentrated by cation exchange resin, and then crystallized to obtain GPC.
3) Chemical hydrolysis method
GPC was prepared by alcoholysis of egg yolk phospholipid, the solvent was removed by rotary evaporation, and then extracted with ether to obtain a mixture of GPC and glycerophosphoryl ethanolamine, and then purified by silica gel column to obtain refined GPC. Using tetrabutylammonium hydroxide as a catalyst to hydrolyze lecithin to obtain relatively pure GPC, but it is necessary to remove the catalyst and recrystallize and purify the product. The whole process is complicated and the cost is high. The GPC was prepared by hydrolysis of lecithin, and the by-products were precipitated by mercuric chloride to achieve the purpose of purifying GPC. Excess mercury ions were removed by hydrogen sulfide and barium carbonate. This method was less efficient, and the obtained GPC not only contained unreacted eggs. Phospholipids, and a large amount of toxic mercury ions remain.
The egg yolk lecithin was dissolved in ether, stirred at room temperature for 2 h, the resulting precipitate was washed with ether, dissolved in methanol, and diatomite was added to make GPC diatomite mixed powder, which was mixed with 4- Dimethylaminopyridine was mixed, chloroform was added, cooled in an ice-water bath, sonicated at 50°C for 48 h, filtered to remove diatomaceous earth, the supernatant was concentrated and passed through a silica gel column, and the obtained active ingredients were sprayed with Hodamine 6G and DittmerLester-reagent After color development, concentrated and purified by Sephadex column to obtain high-purity GPC.
4) Phospholipase hydrolysis method
The GPC is prepared by an enzymatic hydrolysis method, and belongs to the technical field of lipid development and application. GPC was prepared by hydrolyzing soybean powder phospholipid with phospholipase A1 in an aqueous system, and the GPC yield reached 95%. Lipozyme IM and phospholipase A2 were used to co-catalyze the hydrolysis of phosphatidylcholine in a microemulsion system for 48 h to prepare GPC, and the highest yield was 94%. Phospholipase A1 catalyzed the hydrolysis of PC80, and the product GPC yield was 86% after 24 h. The adsorption method was used to prepare immobilized phospholipase A1 to catalyze the preparation of GPC from phosphatidylcholine, and the GPC yield of this method could reach 85%. reused many times.

Choline Glycerophosphate Tolerance

The use of Choline Glycerophosphate in patients with Alzheimer’s disease and multi-infarct dementia was investigated separately according to clinical trials in multiple centers. The course of Choline Glycerophosphate treatment for Alzheimer’s disease is 180 days, 0.4 g each time, three times a day. The results show that Choline Glycerophosphate has obvious curative effect in the treatment of Alzheimer’s disease, and patients have good tolerance to Choline Glycerophosphate; the research of Choline Glycerophosphate in the treatment of multiple cerebral infarction dementia, in the 120 Several cases of mildly ill patients with multiple cerebral infarction dementia were tested. The course of treatment was 80 days, and each intramuscular injection of Choline Glycerophosphate was 1 g.
The results show that Choline Glycerophosphate has a significant effect on multiple cerebral infarct dementia, and the patient’s tolerance is good. The use of Choline Glycerophosphate in the treatment of cerebral ischemic stroke, mild multiple cerebral infarction type dementia, mild Alzheimer’s disease, no major local or systemic adverse reactions. There were no clinically and statistically significant changes in vital signs (diastolic, systolic, and heart rate) nor any laboratory parameters. Therefore, Choline Glycerophosphate is well tolerated.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


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* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

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Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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