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Chlorphenesin CAS 104-29-0

Molecular Formula: C9H11ClO3

Formula Weight: 202.63

ZSpharmac: Chlorphenesin Supplier

Product Name: Chlorphenesin
CAS No: 104-29-0
Purity: 99%

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Basic Info

Product Name:Chlorphenesin
Other Names:3-(4-Chlorophenoxy)-1,2-Propanediol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:203-192-6
Storage:Sealed in Dry,Room Temperature
Provide:Chlorphenesin MSDS;
Chlorphenesin COA

What is Chlorphenesin?

Chlorphenesin is a preservative commonly made use of in cosmetics as well as is compatible with the majority of preservatives (including potassium sorbate, salt benzoate, methylisothiazolinone). It looks like white crystals, usually with a weak particular odor. The melting point is 77.0-80.5 ° C. A little soluble in water (around 0.5%). Soluble in ethers. Rather soluble in taken care of oil, insoluble in white mineral oil. Microbial control efficiency: can provide better broad-spectrum anti-bacterial job. It has the capability to avoid and eliminate G+, G-, Aspergillus niger, Penicillium pinophilum, Yeast fungus albicans in addition to Saccharomyces cerevisiae.

In medicine, chlorphenesin-related prep work are antigen-related immunosuppressants that inhibit IgE-mediated histamine launch. Chlorphenesin additionally functions as a muscle mass depressant. Chlorphenidin is likewise made use of in antifungal medicines, which appropriate for antifungal, microbial, genital mold and mildew, and also trichomonas illness, in addition to there are numerous medication dose kinds.

In cosmetics, chlorphenesin is made use of as an aesthetic fungicide in the “International Cosmetic Raw Products Thesaurus and Manual”. Chlorphenesin can successfully stand up to Gram-positive as well as adverse bacteria, especially for Aspergillus niger IMI 149007 as well as Penicillium pinophilum IMI 87160 has solid antibacterial task, as well as has an outstanding repressive impact on Yeast infection albicans NCPF 3179 and also Saccharomyces cerevisiae NCPF 3275.

Chlorphenesin Property

Melting point 77-79°C
Boiling point 290.96°C (rough estimate)
density 1.2411 (rough estimate)
vapor pressure 0Pa at 25℃
RTECS TY4260000
refractive index 1.5470 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
form Solid
color White to Off-White
Water Solubility Slightly soluble in water.


Application Areas of Chlorphenesin

Chlorphenesin is mostly utilized as a muscular tissue depressant, which works by blocking nerve impulses from being sent out to the mind. In cosmetics, it is utilized as a preservative as a result of its antifungal, antibacterial homes. As a chemical, it prevents various products from experiencing problems such as thickness adjustments, pH changes, demulsification troubles, noticeable microbial growth, color modifications and unpleasant odor advancement. Along with being used to treat nail troubles brought on by fungus, the active ingredient is most commonly made use of in facial creams, anti-aging serums, sunscreens, structures, eye creams, cleansers, mascaras, and concealers.

In medicine, chlorphenesin-related preparations are antigen-related immunosuppressants that prevent ige-mediated histamine launch. Chlorphenesin is additionally an antifungal medicine, which is suitable for antifungal, bacterial, vaginal mold and mildew, as well as trichomonas illness, and has several drug dosage forms.

In terms of cosmetics, chlorphenesin is utilized as an aesthetic fungicide in the International Dictionary as well as Handbook of Aesthetic Raw Materials. Chlorphenesin can successfully resist Gram-positive in addition to unfavorable germs, specifically for Aspergillus niger iml149007 as well as Penicillium pinophilum imi87160 (fungi) has solid disinfectant task, and has a great repressive impact on Yeast albicans ncpf3179 in addition to Saccharomyces cerevisiae ncpf3275 (yeast).

Chlorphenesin Preparation

A kind of method of green efficient selective synthesis of chlorphenesin, concrete operation is as follows:

In a 500ml three-necked flask, 55.25g (0.60mol) of glycerol, 25.3g (0.28mol) of dimethyl carbonate, 25.8g (0.20mol) of p-chlorophenol, and 0.8g (0.02mol) of sodium hydroxide were successively added. Wherein, the molar ratio of glycerin in the system: diethyl carbonate: p-chlorophenol is 3: 1.4: 1, and the molar ratio of p-chlorophenol and sodium hydroxide is 1: 0.1. When feeding, keep stirring at a low speed of 30 rpm, heat to 110°C, and react for 11 hours. After the reaction, cool down to 22°C, add 552.5g of the supernatant of saturated sodium chloride solution to the above-mentioned reaction solution for washing, then add 552.5g of dichloromethane, mix well and let stand, separate layers, take the organic phase, Concentrate to obtain a yellow-white solid, which is recrystallized with dichloromethane and filtered with suction to obtain a pure white powder product. The solid powder is vacuum-dried at 45° C. to obtain 33.23 g of chlorphenesin, and the calculated yield is 82%. HPLC detection The purity is 95.4%.

Chlorphenesin Detection Method

A liquid chromatography detection method for chlorphenesin in toy materials, comprising the following steps:

(1) Prepare standard solution and fit standard curve equation

Weigh 0.05g (accurate to 0.0001g) of chlorphenesin, add methanol-water (50:50, v/v), ultrasonically dissolve and transfer to a 50mL volumetric flask, dilute to the mark with methanol-water solution, shake Evenly, it was made into a standard stock solution with a mass concentration of 1000mg/L;

Pipette 5.0mL of 1000mg/L standard stock solution into a 100mL volumetric flask, dilute to the mark with methanol-water (50:50, v/v) solution, shake well, and make an intermediate working solution with a mass concentration of 50mg/L standard solution;

Pipette 0.20, 1.00, 2.00, 10.0mL of chlorphenesin intermediate working standard solution and 1.00, 2.50, 5.00mL of standard stock solution into 10mL volumetric flask, dilute with methanol-water (50:50, v/v) To the scale, shake well to obtain a series of concentration standard solutions with mass concentrations of 1.00, 5.00, 10.0, 50.0, 100, 250 and 500;

Take the peak area as the ordinate (Y), and the mass concentration in the standard solution as the abscissa (X) to carry out linear regression, and obtain the regression equation of chlorphenesin as Y=4.11(e+003)X-1.46(e+004) .

(2) Sample processing

Weigh 1.0g of the sample (accurate to 0.0001g) into a 10mL stoppered colorimetric tube, add the extraction solution (methanol-water (50:50, v/v)) to the mark and seal it with a parafilm, vortex shake for 1.0min , ultrasonically extracted for 20-35min, then filtered through a 0.22μm filter membrane, and the filtrate was used as the sample solution to be tested;

(3) Chromatographic detection

Carry out gradient elution with methanol-water as mobile phase according to Table 1, adopt C-18 column as chromatographic column (100mm * 2.1mm, 1.7 μ m), with photodiode array (PDA) detector, detection wavelength 280nm (chlorophenglycine Ether detection wavelength), flow rate 0.2mL/min, column temperature 30°C, injection volume 1 μL, and substitute the measured peak area into the regression equation of step (1) to obtain the mass concentration of chlorphenesin in the sample.

About Products:
If you need Chlorphenesin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Chlorphenesin manufacturer and supplier, ZSpharmac will provide Chlorphenesin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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