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Zhishang Chemical

Chlorphenesin CAS 104-29-0

Molecular Formula: C9H11ClO3

Formula Weight: 202.63

ZSpharmac: Chlorphenesin Supplement

Product Name: Chlorphenesin
CAS No: 104-29-0
Purity: 99%

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Basic Info

Product Name:Chlorphenesin
Other Names:Chlorphenesin Chlorphenesin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:203-192-6
Storage:Sealed in Dry,Room Temperature
Provide:Chlorphenesin MSDS;
Chlorphenesin COA

What is Chlorphenesin?

Chlorphenesin is a secure, high-efficiency, broad-spectrum antifungal preservative. It has eliminating result on most Gram-positive and adverse bacteria and also fungi. It has no irritability and reduced toxicity. Fungal medicine. It has good chemical stability as well as will certainly not be deactivated under typical storage problems. It can be widely used in personal treatment items as an anti-mildew and antibacterial agent or in commercial fields such as glue, paint, fabric, and also paper production. Chlorphenesin is an antifungal medication in medication, suitable for antifungal, bacterial, vaginal mold and mildew, Trichomonas illness and more. In cosmetics, Chlorphenesin is commonly made use of as an antifungal representative in mix with other antibacterial preservatives. In the field of everyday chemical products where the amount of paraben is restricted and triclosan is banned.

The majority of people think that making use of preservatives is very poor for the skin. Actually, preservatives are not horrible. They also have the difference in between chemical preservatives, risk-free non-toxic preservatives and natural organic preservatives. As a safe and also reliable preservative included restricted quantities in cosmetics, chlorphenesin has a broad-spectrum antibacterial result on fungis and also microorganisms, and also can effectively stand up to Gram-positive and also unfavorable germs, specifically Aspergillus niger and also Penicillium pinophilia. Strong bactericidal task, has an excellent repressive impact on Yeast infection albicans as well as Saccharomyces cerevisiae.

Compared to other chemicals, chlorphenesin is made use of at a reduced concentration in cosmetics. The maximum use of chlorphenesin in the “Cosmetic Rules” is 0.3%, and 0.01% can play a preservative impact. It does not contain formaldehyde, also It is not a formaldehyde releaser, and will not denature proteins. It is a reliable as well as low-toxic anti-bacterial and antifungal representative, which can properly protect against the product from producing color and unpleasant smell brought on by microbial growth.

Chlorphenesin is a risk-free and also efficient chemical included restricted quantities in cosmetics. It has a broad-spectrum antibacterial impact on fungi and microorganisms, however it is very easy to have residues of p-chlorophenol in the preparation procedure, leading to a pungent smell. Taken in with the skin, it additionally has high volatility and is easily breathed in into the respiratory tract to create harm to the human body.

The even more natural skin treatment items are, the more they need the aid of chemicals to ensure their top quality. As long as it is a chemical that fulfills the guidelines, it is 100% safe if it is included percentage to the standard. There are numerous kinds of chemicals, which does not imply that they are bad. Several chemicals need to be made use of with each other to attain the very best antiseptic impact. Different types of chemicals do have differences in irritation. When acquiring, you can pick a low-concentration preservative such as chlorphenesin

Chlorphenesin Property

Melting point 77-79°C
Boiling point 290.96°C (rough estimate)
density 1.2411 (rough estimate)
refractive index 1.5470 (estimate)
RTECS TY4260000
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
form Solid
color White to Off-White
Water Solubility Slightly soluble in water.


Application Areas of Chlorphenesin

Chlorphenesin is mainly used as a muscular tissue depressant, as well as it works by obstructing nerve impulses from being sent to the mind. In cosmetics, it is made use of as a chemical as a result of its antifungal, anti-bacterial residential properties. As a chemical, it prevents different items from experiencing these issues, such as thickness modifications, pH adjustments, demulsification problems, noticeable microbial development, shade changes and unpleasant smells. In addition to dealing with nail issues brought on by fungis, the active ingredient is most frequently made use of in face creams, anti-aging serums, sunscreens, structures, eye creams, cleansers, mascara, as well as concealers.
In medicine, chlorphenesin-related prep work are antigen-related immunosuppressants that inhibit ige-mediated histamine release. Chlorphenesin is likewise an antifungal medicine, which is suitable for antifungal, bacteria, vaginal mold and mildew, Trichomonas illness, and also numerous medicine dose kinds. In cosmetics, chlorphenesin is used as a cosmetic fungicide in the “International Cosmetic Raw Materials Thesaurus and Handbook”. Chlorphenesin can successfully resist Gram-positive and also unfavorable bacteria, specifically for Aspergillus niger iml149007 and Penicillium pinophilia imi87160 (Fungi) has solid bactericidal task, as well as has a good inhibitory result on Candida fungus albicans ncpf3179 as well as Saccharomyces cerevisiae ncpf3275 (yeast).

Preparation of Chlorphenesin

A method for green and efficient selective synthesis of chlorphenesin, the specific operations are as follows:

In a 500ml three-necked flask, 55.25g (0.60mol) of glycerol, 25.3g (0.28mol) of dimethyl carbonate, 25.8g (0.20mol) of p-chlorophenol, and 0.8g (0.02mol) of sodium hydroxide were sequentially added. Wherein, the molar ratio of glycerol: diethyl carbonate: p-chlorophenol in the system is 3: 1.4: 1, and the molar ratio of p-chlorophenol to sodium hydroxide is 1: 0.1. During feeding, keep stirring at a low speed of 30 rpm, heat to 110 °C, and react for 11 h. After the reaction was completed, the temperature was lowered to 22°C, the supernatant of 552.5g of saturated sodium chloride solution was added to the above-mentioned obtained reaction solution for washing, and then 552.5g of dichloromethane was added, and the mixture was evenly mixed and allowed to stand, layered, and the organic phase was taken, Concentrated to obtain a yellow-white solid, which was recrystallized with dichloromethane and filtered with suction to obtain a pure white powder product. The solid powder was vacuum-dried at 45 °C to obtain 33.23 g of chlorophenyl glycerol, with a calculated yield of 82%, detected by HPLC The purity is 95.4%.

The Detection Method of Chlorphenesin

Chlorphenesin is a white to off-white crystalline powder. It is a broad-spectrum bacteriostatic agent and preservative. It has a good bacteriostatic and bactericidal effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, mold and other microorganisms. Currently, chlorphenesin is permitted in cosmetics as a preservative, but studies have shown that chlorphenesin may cause shortness of breath in infants. Therefore, infants are advised not to use chlorphenesin-containing products. Part 7: Finger Paints – Requirements and Measurement Methods” and the domestic GB 6675.14-2014 “Toy Safety Part 14: Finger Paint Requirements and Test Methods” allows chlorphenesin to be used as a restricted preservative, and specifies the maximum allowable use The concentration is 0.15%.

A liquid chromatographic detection method for chlorphenesin in a toy material, comprising the following steps:

(1) Prepare standard solution and fit standard curve equation

Weigh 0.05g (accurate to 0.0001g) of chlorophenesin, add methanol-water (50:50, v/v), dissolve by ultrasonic and transfer it to a 50mL volumetric flask, use methanol-water solution to make up to the mark, shake Evenly, prepare a standard stock solution with a mass concentration of 1000 mg/L;

Pipette 5.0mL of 1000mg/L standard stock solution into a 100mL volumetric flask, dilute to the mark with methanol-water (50:50, v/v) solution, shake well, and prepare an intermediate work with a mass concentration of 50mg/L standard solution;

Pipette 0.20, 1.00, 2.00, 10.0 mL of chlorphenesin intermediate working standard solution and 1.00, 2.50, 5.00 mL of standard stock solution into a 10 mL volumetric flask, and dilute with methanol-water (50:50, v/v) to the mark, shake well to obtain a series of concentration standard solutions with mass concentrations of 1.00, 5.00, 10.0, 50.0, 100, 250 and 500 respectively;

Taking the peak area as the ordinate (Y) and the mass concentration in the standard solution as the abscissa (X), perform linear regression, and the regression equation of chlorphenesin is Y=4.11(e+003)X-1.46(e+004) .

(2) Sample processing

Weigh 1.0g of the sample (accurate to 0.0001g) into a 10mL colorimetric tube with a stopper, add the extract (methanol-water (50:50, v/v)) to the mark and seal it with a parafilm, vortex for 1.0min , ultrasonically extracted for 20-35min, then filtered through a 0.22μm filter membrane, and the filtrate was used as the sample solution to be tested for later use;

(3) Chromatographic detection

Use methanol-water as mobile phase to carry out gradient elution according to Table 1, use C-18 column as chromatographic column (100mm×2.1mm, 1.7μm), use photodiode array (PDA) detector, detection wavelength 280nm (chlorophene The detection wavelength of ether), the flow rate is 0.2 mL/min, the column temperature is 30 °C, the injection volume is 1 μL, and the measured peak area is substituted into the regression equation of step (1) to obtain the mass concentration of chlorphenesin in the sample.

Table 1 Mobile phase gradient elution table

In the range of (1.000~500) mg/L, the peak area has a good linear relationship with the mass concentration, and the correlation coefficient is 0.9995. The spiked recoveries at different levels were 98.3%-104%, and the relative standard deviation (ie precision) was 0.51%-2.13%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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