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Zhishang Chemical

Cetylpyridinium Chloride CAS 123-03-5

Molecular Formula: C21H38ClN

Formula Weight: 339.99

ZSpharmac: Cetylpyridinium Chloride Raw Material Supplier

Product Name: Cetylpyridinium Chloride
CAS No: 123-03-5
Purity: 99%

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Basic Info

Product Name:Cetylpyridinium Chloride
Other Names:HexadecylPyridinium Chloride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:HexadecylPyridinium Chloride
EINECS No.:204-593-9
Storage:Room Temperature
Provide:Cetylpyridinium Chloride MSDS;
Cetylpyridinium Chloride COA

What is Cetylpyridinium Chloride?

Cetylpyridinium chloride is a cationic quaternary ammonium compound as well as a really important surfactant as well as bactericide in life. Under the very same conditions of use, the item’s killing price against heterotrophic germs, iron germs and sulfate-unwilling germs is better than dodecyldimethylbenzyl ammonium chloride and also dodecyldimethylbenzyl bromide. Ammonium chloride and also other typically used quaternary ammonium salt fungicides.

Cetylpyridinium Chloride Property

Melting point 77°C
Boiling point 496.25°C (rough estimate)
density 0.9362 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.6000 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Freely soluble in water; very soluble in chloroform; very slightly soluble in ether; insoluble in acetone, acetic acid, and ethanol.
form White Crystalline Powder
Odorat 100.00?%. pyridine
Water Solubility 111g/L at 20℃


Cetylpyridinium Chloride Applications

Application 1.
CN201710550231.3 reveals an organic fungicide that is harmless to the human body, and consists of parts such as cresol, dehydroacetic acid, phenylethyl alcohol, chlorhexidine iodine, cetylpyridinium chloride, cinnamon oil, hexadienoic acid, Propyl paraben, the web content of each component of the biological fungicide harmless to the body is: partly by weight, 10-14 parts of cresol, 4-9 parts of dehydroacetic acid, as well as 2-9 parts of phenylethyl alcohol. 7 components, chlorhexidine iodine 9-13 components, Cetylpyridinium Chloride 2-6 components, cinnamon oil 1-6 components, hexadienoic acid 5-10 components, propyl paraben 3-11 components. Through the above approach, the biological antifungal agent harmless to the body of the present innovation can change the leaks in the structure of the cell plasma membrane, inhibit the removal of enzymes as well as metabolites in the cell body, as well as create the inactivation of the cells. It is reasonable to use as well as harmless to the human body. Dangerous, can be reduced to typical expenses, without affecting usage.

Application 2.
CN200710180019.9 divulges a composite deterioration prevention made use of in oil as well as gas field development as well as a prep work approach thereof. The composite deterioration inhibitor includes imidazoline phosphate, 2-phosphonobutane-1,2,4-tricarboxylic acid, thiourea, Cetylpyridinium Chloride, in which each part is proportioned partly by weight to get to the adjusted web content of each energetic compound. Preparation technique: Include 2-phosphonobutane-1,2,4-tricarboxylic acid to imidazoline phosphate; include thiourea to water to dissolve; mix the remedy ready step by step and include cetylpyridinium chloride, mix equally for 50-90 mins and keep the temperature range at 15-45 ° C to get. This composite deterioration prevention uses a range of chemicals to synergize to avoid scaling, kill or prevent bacterial development, has a little dosage, has a large range of applications, and can also exert exceptional efficiency under complicated water quality problems.

Cetylpyridinium Chloride Detection

The method for colorimetric discovery of Cetylpyridinium Chloride in copolymerized column 5 aromatics in CHCl3 system is as complies with:
Action 1. Synthesis of copolymerized column 5 aromatic hydrocarbon (compound DCP5-16).
1. Synthesis of intermediates: Hydroquinone (4.4 g, 40mmol), salt hydroxide (10g, 4mmol), potassium iodide (4g, 24mmol), hexadecane bromide (26.8 g, 88mmol) and also ethanol (300.0 mL) was included in a 500 mL round-bottomed flask, and also the response was stirred for 3 days (72 h). The solid precipitated as well as the intermediate was gotten. 1HNMR (400MHz, CDCl3, 298K) δ (ppm): 6.82 (d, 4H), 3.96 (t, 4H), 1.75 (t, 4H), 1.43 (t, 4H), 1.26 (t, 48H), 0.86 (s,6 H). The yield is 80%.

2. Synthesis of copolymerized column 5 fragrant hydrocarbons: Add the intermediate (2.79 g, 5mmol) and paraphenylene dimethyl ether (2.76 g, 20mmol) into 80mL of 1,2-dichloroethane to liquify; after that include paraformaldehyde (0.75 g, 25 mmol) and boron trifluoride ether (3.2 mL, 25 mmol) were added to the remedy, and also the reaction was stirred at area temperature level for 8 h. After the reaction, put the option right into methanol to precipitate, filter, liquify the precipitate with chloroform, extract with 30 ml of pure water x 3 times, dry, and separate the natural stage with column chromatography (oil ether/ethyl acetate = 50:1 v/v) to obtain White solid DCP5-12 (0.95 g), return 18%.

Action 2. Copolymerized pillar 5 aromatic hydrocarbon (DCP5-16) recognizes surfactant cetylpyridinium chloride.
Prepare DCP5-16 with CHCl3 to make a 2 × 10-3 mol/L main solution; take 0.5 mL of the major option right into 7 colorimetric tubes. Prepare 0.5 mL of various surfactants (cetylpyridinium chloride, cetylpyridinium bromide, cetyltrimethylamine bromide, trimethylamine ethanol option, triethanolamine, dodecylbenzene sulfonic acid). Salt) in chloroform (focus 0.01 mol/L) was made use of as the visitor option. Add the above visitor services to the seven colorimetric tubes respectively. If the fluorescence of the host option is quenched, it suggests that the visitor service is Cetylpyridinium Chloride; if the fluorescence of the host service does not change, it implies that the visitor solution is not cetylpyridinium chloride.

Production Method of Cetylpyridinium Chloride

In the blend of 48ml SOCl2 and 0.3 g HCON(CH3)2, regulate the temperature level to 30-35 ° C while mixing, and decline 81g of cetyl alcohol. After the dripping is completed, the mixture is boiled for thirty minutes, cooled down, and distilled to obtain a 138-140 ° C (stress 270 Pa) fraction, which is hexadecane chloride with a yield of 92.2%. Warmth 80g of hexadecane chloride and 32g of dry pyridine in an oil bathroom to 150-160 ° C, and react for 12-15 hrs. After the reaction is finished, include 80ml of completely dry acetone, heat as well as dissolve the mixture in a water bathroom, and afterwards cool it to get an item with a yield of 994%. Melting point is 87-88 ℃.

About Products:
If you need the cosmetic raw material Cetylpyridinium Chloride, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Cetylpyridinium Chloride manufacturer and supplier, ZSpharmac will provide Cetylpyridinium Chloride raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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