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Cetrimide CAS 1119-97-7

Molecular Formula: C17H38BrN

Formula Weight: 336.39

ZSpharmac: Cetrimide Supplement

Product Name: Cetrimide
CAS No: 1119-97-7
Purity: 99%

Basic Info

Product Name:Cetrimide
Other Names:Myristyltrimethylammonium Bromide, 98%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White Fine Crystalline Powder
EINECS No.:214-291-9
Storage:Store Below +30°C.
Provide:Cetrimide MSDS;
Cetrimide COA

What is Cetrimide?

Cetrimide, also known as tetradecyltrimethylammonium bromide, is a quaternary ammonium salt and a class of cationic surfactants. High-purity quaternary ammonium salts are excellent phase transfer catalysts and play a key role in organic synthesis. Among them, halogenated quaternary ammonium salts (R1R2R3R4N+X-) series compounds are widely used in daily chemical industry, textile, printing and dyeing, mining, asphalt, construction, plastic processing, oil extraction, petrochemical and other fields, playing an important role.

Cetrimide Properties:

Melting point 245-250 °C(lit.)
density 1.1328 (rough estimate)
refractive index 1.5260 (estimate)
storage temp. Store below +30°C.
solubility H2O: 10 % (w/v)
form Fine Crystalline Powder
color White
PHpH (50g/l, 25℃ : 4.0~6.0
Water Solubility 20 g/100 mL


Cetrimide Uses

  1. Cetrimide is utilized as a surfactant as well as can be made use of in hair shampoo, rubber, paint as well as other sectors.
  2. Cetrimide is made use of as a cationic surfactant, as well as can be used as a stimulant, emulsifier, bactericide, disinfectant, antistatic representative, etc.
  3. Cetrimide is made use of in ion-pair chromatography, anionic detergents, antiperspirants, stimulants, emulsifiers, anti-bacterials, antiseptic bases, antistatic agents and also speculative use.

Other Applications of Cetrimide

CN201811216468.9 provides a surfactant composition applied to in vitro diagnostic reagents, belonging to the technical field of surfactants, and the components include: sucrose-glucose-6-sodium carboxylate-fructose-6-sodium carboxylate-1-(N – dodecylformamide), sodium perfluorooctanoate, N,N,N-trimethyl-1-tetradecylammonium bromide and Gemini surfactant 12-2-12, of which sucrose-glucose-6-carboxylate The content of sodium-fructose-6-carboxylate-1-(N-dodecylformamide) is 5-80mM, the content of sodium perfluorooctanoate is 10-100mM, the content of Cetrimide is The content is 10-100 mM, and the content of Gemini surfactant 12-2-12 is 0.1-2 mM. The invention can optimize the reaction system of the in vitro diagnostic kit, improve the performance indicators such as repeatability, inter-batch difference, accuracy, stability and the like of the kit, and help prolong the validity period of the in vitro diagnostic reagent.

Cetrimide Preparation

report one,
Weigh 400 kilograms of tetradecyl dimethyl tertiary amine and place it in 1000 liters of enamel reaction kettles, and pump 263 kilograms of hydrobromic acid, 125 kilograms of methanol and 0.4 kilograms of ionic liquid 1-ethyl- The mixture of 3-methylimidazole hydrobromide was stirred and reacted at 50° C., the reaction time was 3 hours, and the reaction was carried out under normal pressure in a nitrogen atmosphere. After the reaction product was vacuum-dried (the drying temperature was controlled at 80° C.), it was added to the 1000L autoclave, and after the reaction kettle was flushed with nitrogen three times, 168 kilograms of dimethyl carbonate and 80 kilograms of dimethyl carbonate were pumped in at a flow rate of 20 kilograms/hour. The methanol mixture was reacted in a closed manner, the reaction temperature was 175° C., the reaction pressure was 1.7 MPa, and the reaction was carried out under stirring for 12 hours. The reaction product was vacuum dried (the drying temperature was controlled at 80°C) to obtain about 553 kg of N,N,N-trimethyl-1-tetradecylammonium bromide with a yield of 99.1% and a purity of 99.1%.

report two,
Weigh 1000g of Cetrimide and place it in a beaker, add concentrated hydrochloric acid dropwise (HCl adds a total amount of about 151g), stir with magnetic force, and remove about 80% of the water with a constant temperature water bath after the neutralization reaction. Vacuum drying to obtain the product tetradecyl dimethyl ammonium chloride; weigh 1000g tetradecyl dimethyl ammonium chloride and 330g dimethyl carbonate respectively, add them to the 10L reactor in turn, and drive them away with nitrogen purging After the air in the kettle, the reaction is carried out in a closed state. The reaction temperature is 170 ° C. After the reaction temperature reaches 160 ° C, the stirring is started, and the reaction time is 20 hours. After the reaction is completed, N,N,N-trimethyl-1-tetradecane is prepared. ammonium bromide is about 1040g.

report three.
A preparation technique of ion-pair chromatography grade tetradecyl trimethyl ammonium bromide, the steps are as follows:
Put 180g of tetradecyltrimethylammonium bromide raw material into 720mL of solvent (the solvent is prepared from 540mL of anhydrous acetone and 180mL of anhydrous methanol); the obtained mixture is heated to 55°C, stirred for not less than 1h, and stopped Heating, adding 9 g of pretreated activated carbon with a particle size of 100 mesh to the obtained solution in batches under stirring (the activated carbon was soaked in hydrogen peroxide with a mass concentration of 30% for 8 hours, and after separation, soaked in a 6N nitric acid solution for 5 hours, and the solid-liquid separation was carried out. Washed with ionized water until neutral, vacuum dried at 100°C for 4h, vacuum degree was 0.001MPa), then heated to reflux and fully stirred for 3h, stopped heating, filtered under reduced pressure, the filtrate was cooled to room temperature, transferred to a crystallizer, left to stand and analyzed The crystallization temperature was -20 °C; the white crystals precipitated were separated by filtration, the filter cake was pressed dry, the crystals were collected, dried in vacuum, the drying time was 5 h, the temperature was 90 °C, and the vacuum degree was 0.001 MPa to obtain ion-pair chromatography grade N,N ,N-trimethyl-1-Cetrimide 142g, can be sealed and packaged under nitrogen protection.
The obtained product was made into an aqueous solution with a concentration of C=10%, and its ultraviolet absorption value at each wavelength λ was measured:
When λ=240nm, A=0.06;
When λ=250nm, A=0.02;
When λ=260nm, A=0;
When λ=500 nm, A=0.01.

The Role of Cetrimide in the Operation of Hydatid Cyst

Savlon (0.5% Cetrimide/0.05% chlorhexidine) is utilized as a rodenticide throughout hydatid cyst surgical procedure. It is thought about a risk-free and effective drug. However, there are no suggestions for suitable concentrations or does of these medicines. Severe metabolic acidosis has actually been previously reported, yet its results on the pulmonary system have actually not been discovered. We present a situation of acute lung injury and breathing distress along with severe cardiopulmonary distress, serious metabolic acidosis, and kidney failure used during medical removal of pulmonary hydatid cysts. This agent serves as a chemical sclerosing agent, causing lung parenchyma damage via the bronchial openings existing in the pericys. Till a secure dose limit is known, the use of this medicine ought to be limited, especially in huge or polycystic surgery.

Cetrimide for Hydatid Cysts?

Cetrimide has been efficiently evaluated versus hydatid protoscoria as an ascaris removal accessory to hydatid surgery. It was checked at four focus (0.05, 0.1, 0.5 and also 1%) on protosegments of hydatid cysts in sheep as well as livestock, and also at 0.1% in human beings. For each and every focus, 3 incubations of 1, 5 as well as 10 min direct exposure were carried out in vitro and in vivo for ovine as well as bovine cysts, as well as two consecutive incubations for 5 minutes exposure were done for human cysts. All experiments caused rapid death of protocephalus, as judged by their loss of mobility, preparedness to obtain important spots, and failure to create second hydatid cysts when inoculated right into albino mice. Reduced poisoning of cetrimide, quick action on protosegmentum.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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