Zhishang Chemical

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Zhishang Chemical

Ceramosides CAS 100403-19-8

Molecular Formula: C24H47NO3

Formula Weight: 397.63488

ZSpharmac: Ceramosides Supplier

Product Name: Ceramosides
CAS No: 100403-19-8
Purity: 99%

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Basic Info

Product Name:Ceramosides
Other Names:Ceramides
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Viscous Liquid
EINECS No.:309-560-3
Provide:Ceramosides MSDS;
Ceramosides COA

What is Ceramosides?

Ceramide is a type of phospholipid with Ceramosides as the skeleton, primarily consisting of ceramide phosphocholine and also ceramide phosphoethanolamine. Phospholipids are the primary elements of cell membrane layers. Ceramosides are a major part of the intercellular matrix as well as play an essential role in keeping the dampness equilibrium of the stratum corneum. Ceramides have a strong capacity to connect with water molecules and keep skin moisture by developing a network framework in the stratum corneum. For that reason, ceramides have the result of keeping skin dampness.

Ceramosides is the most recent generation of moisturizing agents established over the last few years. It is a water-soluble lipid compound. It has a similar structure to the product that makes up the stratum corneum of the skin. It can promptly penetrate right into the skin and also incorporate with the water in the stratum corneum to develop a kind of Mesh structure secure dampness.

Ceramosides are the major constituents (> 50%) of intercellular liposomes in the outer stratum corneum of human skin, which play a vital function in stopping water distribution and also protecting against outside stimulations, as well as are responsible for shielding the skin and moisturizing as well as hydrating. There are likewise several research study reports that making use of topical lotion items containing ceramides can attain the purpose of preventing allergic skin diseases and also inhibiting the result of melanin and also brown spots.

The Role of Ceramosides

Hydrating result of Ceramosides: Ceramide is the main part of the stratum corneum of the skin, which can help repair the skin barrier and also make the skin soft and shiny. The hydrating capacity is 16 times that of hyaluronic acid, as well as the moisturizing rate is 80% especially for senior completely dry skin. And also it is very easily soaked up by the skin, as well as can advertise the infiltration of various other nutrients. The above paragraph additionally said that with age, ceramide gradually loses as well as reduces, and the lack of it will make the skin plain and dry.

The barrier function of Ceramosides: adequate ceramides in the skin can stand up to outside stimulations, but if the skin is missing, the skin sheds its own all-natural protective function, and also external stimulations can straight damage the skin.

The anti-aging impact of Ceramosides: In addition to being abundant in collagen, the baby’s skin is elastic as well as tender, and also it is likewise loaded with ceramides. Lasting supplements of ceramides makes the skin plump and much less vulnerable to wrinkles.

Anti-allergic result: Ladies with delicate skin can choose to use it. Ceramide can repair and also enlarge the stratum corneum. To put it merely, it fills up the holes in the stratum corneum, improves the tolerance of sensitive muscular tissues, and also makes it much less vulnerable to sensitivity as well as soreness.

Using Ceramosides in cosmetics might be due to cost-effectiveness. Currently, it is just made use of for the face, including day lotion, evening lotion, facial significance, and so on.

Ceramosides are natural moisturizing elements that belong to the skin. If the skin has a moisturizing aspect, it can keep the moisture of the skin even in a completely dry setting without excessive loss.

Ceramosides can frequently regenerate keratin, can promote cell metabolism, as well as can transfer cell details. It is an anemic, transparent, fluid, water-soluble lipid. At the same time, ceramide can protect the skin’s hydrating and moisturizing functions, so it is an extremely vital active ingredient in everyday skin care.


Application of Ceramosides

1. Anti-tumor
The pathogenesis of lots of swellings is connected with the anti-apoptosis of cells. Subsequently, the treatment of developments is primarily to create apoptosis. The traditional lump therapy primarily trusts drug radiation therapy, that is, drug-induced apoptosis, while ceramide treatment of tumors is different from regular medicines, which can directly act upon the apoptosis signal transduction path, as a result triggering cell apoptosis. Therefore, Ceramosides open up a brand-new treatment option for anti-tumor. Ceramides are split right into endogenous ceramides and also exogenous ceramides. In the process of lump treatment, the focus of intracellular ceramide can be increased by directly adding exogenous ceramosides or by promoting the synthesis of endogenous ceramide, generating apoptosis and also acquiring the purpose of swelling treatment. When cells are improved by numerous exterior issues, endogenous ceramide starts to manufacture, which markets the increase of intracellular ceramide focus and also may induce a series of physical and also pathological responses such as apoptosis. Consequently, ceramide is believed to be a lipid that can prevent tumor cells.
2. Avoidance and additionally therapy of cardiovascular disease
Vascular endothelial cells are the first obstacle of the cardio system. The integrity and likewise endocrine feature of vascular endothelial cells relate to whether the function of the cardio system is regular. When the body remains in a state of disease, the expression of a wide variety of inflammatory consider the body will certainly boost dramatically, and likewise the overexpression of inflammatory components will certainly influence the honesty as well as endocrine function of endothelial cells, as well as also create endothelial cell apoptosis in severe situations. Ceramosides play a significant duty in the induction of endothelial cell apoptosis. It can be seen that ceramide plays an extremely important function in controling the security of endothelial cells and also endocrine function. Ceramosides create apoptosis of vascular endothelial cells with the Fas course, which is exceptionally vital for examining the system of ceramide-induced apoptosis of vascular endothelial cells.
3. Anti-inflammatory
TNF (development death element) is a beneficial regulatory authority of swelling. TNF can right trigger neutrophils. Lately, some information have actually revealed that raising the amount of intracellular Ceramosides can raise the quantity of TNF in the body, consequently setting off many cell apoptosis. The effect of ceramide on TNF, a positive regulator of swelling, advises that ceramide has an anti-inflammatory outcome.

Preparation Method of Ceramosides

Ceramosides can be synthesized by three different pathways, namely de novo synthesis pathway, sphingomyelinase pathway and salvage pathway. The de novo synthesis pathway is the cytoplasmic surface of the endoplasmic reticulum by serine palmitoyltransferase catalyzed by serine and palmitoyl CoA to form 3- Keto dihydrosphingosine (3-ketosphinganine), then form dihydrosphingosine, and then acylate dihydrosphingosine by Ceramosides synthase to generate dihydroceramide, and finally dehydrogenation of dihydroceramide to form ceramide . The salvage pathway is that glycosylated sphingolipids and sphingomyelin form sphingosine under the action of glycosidase, acid sphingomyelinase and acid ceramidase in lysosomes, and dihydrosphingosine can be absorbed by the endoplasmic reticulum. Ceramosides synthase acylates to form ceramides. In addition, ceramide can also be hydrolyzed from sphingomyelin on the cell membrane through the sphingomyelinase (SMase) pathway.

Uniqueness of Ceramosides

Ceramosides are very few ingredients that have a certain molecular weight and can enter the skin barrier through special channels. Through external application, the externally supplemented ceramide can be integrated with the ceramide contained in the skin barrier itself, participate in the regular metabolism of the skin, and help the skin barrier maintain a normal thickness. Therefore, ceramides are very popular in the skin care industry.

So, how should we choose skin care products that contain Ceramosides? Because we can not plainly recognize the content of the components in the item, thankfully, the components in the product ingredient list are prepared in descending order of web content.We can refer to whether the arrangement in the ingredient list is in the following order: Ceramide-cholesterol-free fatty acid.

About Products:
If you need Ceramosides, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Ceramosides, ZSpharmac will provide Ceramosides raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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