Ceramide 3 CAS 100403-19-8

Molecular Formula: C24H47NO3

Formula Weight: 397.63488

ZSpharmac: Ceramide 3 Cosmetic Raw Material Supplier

Product Name: Ceramide 3

CAS No: 100403-19-8

Purity: 99%

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Basic Info

Product Name:	Ceramide 3
Other Names:	Ceramides
CAS:	100403-19-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Crystal or Colorless Liquid
EINECS No.:	309-560-3
Storage:	Store at -20°C
Provide:	Ceramide 3 MSDS； Ceramide 3 COA

What is Ceramide 3?

Ceramide is a kind of phospholipid with ceramide as the skeletal system, typically consisting of ceramide phosphocholine and ceramide phosphoethanolamine. Phospholipids are the essential parts of cell membrane layers. 40% to 50% of the sebum in the stratum corneum is comprised of ceramide, Ceramide is a substantial part of the intercellular matrix and plays a vital function in preserving the stability of wetness in the stratum corneum. Ceramide has a solid capability to connect to water littles, and it maintains skin wetness by creating a network structure in the stratum corneum. As a result, ceramides have the feature of keeping skin hydrated.
Ceramide is the most up to day generation of cream established in existing times. It is a water-soluble lipid item that has a similar structure to the products that comprise the stratum corneum of the skin. It can rapidly penetrate right into the skin and include with the water in the stratum corneum to develop a A mesh framework secured wetness.
Ceramide is the significant component (> 50%) of the intercellular lipids existing in the outer stratum corneum of human skin. It plays a vital role in quiting moisture loss and securing versus exterior stimulations. It is accountable for protecting the skin and hydrating and moistening it. Function. There are likewise a number of research study reports describing that using topical lotions consisting of ceramides can stay clear of delicate skin diseases and prevent melanin and brown locations.

Ceramide 3 Property

storage temp.	Store at -20°C
solubility	Methanol: 25 mg/mL
form	A crystalline solid

Ceramide 3 Applications

1. Anti-tumor
The pathogenesis of a number of lumps is related to the resistance of cells to apoptosis. As a result, the therapy of growths typically includes creating apoptosis. Conventional cancer cells treatment generally trusts drug radiation treatment, that is, medications to create apoptosis. Ceramide therapy of developments is different from basic medicines. It can directly act on the apoptosis signaling course, therefore activating cell apoptosis. Therefore, Ceramide 3 opens a new recovery option versus lumps. Ceramides are split into endogenous ceramides and exogenous ceramides. In the process of dealing with lumps, the focus of intracellular ceramide can be enhanced by directly adding exogenous ceramide or promoting the synthesis of endogenous ceramide, generating cell apoptosis to accomplish the function of managing growths. When cells are promoted by different external troubles, endogenous ceramide starts to be made, which advertises a rise in intracellular ceramide concentration and may generate a collection of physical and pathological responses such as apoptosis. Because of that, ceramide is thought of a lipid that can prevent swelling cells.
2. Prevent and deal with cardiovascular disease
Vascular endothelial cells are the extremely initial obstacle of the cardio system. The stability and endocrine function of vascular endothelial cells belong to whether the function of the cardio system is typical. When the body stays in a disease state, the expression of a wide range of inflammatory consider the body will definitely enhance greatly. The overexpression of inflammatory components will certainly influence the stability and endocrine function of endothelial cells. In severe instances, it might even result in endothelial cell apoptosis. Ceramide 3 plays a considerable obligation in generating endothelial cell apoptosis. It can be seen that ceramide plays a truly vital duty in controling the integrity of endothelial cells and endocrine feature. Ceramide generates apoptosis of vascular endothelial cells through the Fas path. This course plays an actually vital function in examining the gadget of ceramide-induced apoptosis of vascular endothelial cells.
3. Anti-inflammation
TNF (lump fatality factor) is a favorable regulatory authority of inflammation. TNF can directly cause neutrophils. In current times, info has shown that elevating the amount of intracellular Ceramide 3 can improve the quantity of TNF in the body, consequently activating apoptosis of various cells. The result of ceramide on TNF, a favorable regulatory authority of inflammation, suggests that ceramide has an anti-inflammatory impact.

Effects of Ceramide 3 on Skin

1. Moisturizing result: Ceramide 3 is the main element of the lipids in the skin’s stratum corneum. It can help repair the skin barrier and make the skin soft and glossy. However, as we age, ceramides slowly decrease, and the skin will become dull and completely dry without it.

2. Obstacle function: Sufficient Ceramide 3 in the skin can stand up to external excitement, yet if it is missing or absent, the skin loses its all-natural safety feature and sheds its ability to resist all outside physical and organic injury. As an example, skin is a lot more prone to sunburn when revealed to the sunlight, and it becomes red easily when the weather gets cold, and so on

3. Anti-allergic result: This is great information for thin-skinned kids’s shoes. Ceramides can help enlarge the stratum corneum, boost the tolerance of the whole skin, protect versus the breach of unsafe external substances, stay clear of allergic reactions, and fixing red blood filaments.

4. On top of that, Ceramide 3 has great anti-aging, bleaching and antioxidant impacts.

Ceramide 3 Preparation Method

Ceramide 3 can be manufactured via three different pathways, particularly the afresh synthesis pathway, the sphingomyelinase pathway and the salvage pathway. The afresh synthesis pathway is formed by serine palmitoyl transferase catalyzing serine and palmitoyl CoA on the cytoplasmic surface of the endoplasmic reticulum. -Keto dihydrosphinganine (3-ketosphinganine), which is after that formed into dihydrosphinganine, which is after that acylated by ceramide synthase to create dihydroceramide, and ultimately dihydroceramide is dehydrogenated to develop Ceramide. The salvage pathway is that glycated sphingolipids and sphingomyelin type sphingosine under the activity of glycosidase, acid sphingomyelinase and acid ceramidase in lysosomes, and dihydrosphingosine can be absorbed right into the endoplasmic reticulum. Ceramide synthase acylates to create ceramide. Additionally, ceramide can also be created from the hydrolysis of sphingomyelin on the cell membrane via the sphingomyelinase (SMase) pathway.

About Products:
If you need Ceramide 3, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
Our company, as an experienced Ceramide 3 manufacturer and supplier, ZSpharmac will provide Ceramide 3 raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.