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Catechine CAS 7295-85-4

Molecular Formula: C15H14O6

Formula Weight: 290.27

ZSpharmac: Catechine Supplement

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Product Name: Catechine
CAS No: 7295-85-4
Purity: 99%

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Basic Info

Product Name:Catechine
Other Names:(+/-)-Catechin Hydrate
CAS:7295-85-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:230-731-2
Storage:Sealed in Dry,2-8°C
Provide:Catechine MSDS;
Catechine COA

What is Catechine?

So far, more than 700 known compounds have been isolated and identified in tea, including primary metabolite proteins, carbohydrates, lipids and secondary metabolites, such as polyphenols, pigments, theanine, alkaloids, aroma substances, saponins, etc.In recent years, a large number of studies at home and abroad have found that catechine has many functions such as scavenging free radicals in the body, anti-oxidation, inhibiting tumor growth, preventing radiation, antibacterial disinfection, losing weight and reducing blood pressure, reducing incense poisoning, preventing AIDS, preventing cardiovascular diseases and regulating immunity. physiological function. It has been widely used in the fields of medicine, daily chemical industry, food and oil industry as a raw material for health food, natural cosmetics or as an antioxidant and preservative for oil-containing food.

Catechine Property

Melting point ~200 °C (dec.)
Boiling point 630.4±55.0 °C(Predicted)
density 1.593±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka9.54±0.10(Predicted)
form Solid
color White to Off-White

 

Catechine Uses

1. Control excessive weight
Lipton Tea Study Institute additionally reported its study results: Catechine in eco-friendly tea has a significant result on human fat metabolic rate and also fat distribution, particularly the reduction of visceral fat. Consuming environment-friendly tea can reduce the danger of cardiovascular disease and also cancer cells, generally since eco-friendly tea is abundant in flavonoids, especially catechines. A a great deal of medical experiments have verified that catechins have cell regulation as well as antioxidant functions. Catechine is a general term for a class of extremely energetic flavonoids, which are located in high levels in green tea.

Two medical tests conducted by Unilever on the efficacy of high levels of catechin in eco-friendly tea discovered that mildly obese healthy and balanced Chinese men and women drank high catechin eco-friendly tea for 90 successive days without altering diet and also exercise. Body weight, waist area and natural fat were all substantially decreased, and also Catechine in environment-friendly tea might have details beneficial effects on body fat distribution, specifically stomach fat distribution, and also it has some result on the control of main obesity.

2. Pharmacological results
Catechine is a vital component of tea, which has numerous features such as prevention and also therapy of heart disease as well as cancer. D-catechin likewise has various results such as decreasing the permeability of capillaries, antidiarrheal, hemostasis, antiviral, fungicidal, ACE inhibition and gastric abscess avoidance.

Free extreme scavenging: Catechine is a natural lipid anti-oxidant with even more antioxidant task than vitamin E. And it can scavenge complimentary radicals created by the body to secure cell membrane layers. Anti-aging: Since it has the feature of scavenging cost-free radicals, it can reduce aging.

Prevent tooth decay: Due to the fact that tea consists of fluoride, it can make teeth have strong resistance to acid erosion. Additionally, medical trials have revealed that Catechine can dramatically reduce plaque and sluggish gum disease.

Modification the distribution of intestinal tract bacteria: Catechine can inhibit human pathogenic germs (such as botulinum contaminant) without hurting the reproduction of beneficial bacteria (such as lactic acid germs), so it has the feature of digestive tract regulation. Antibacterial result: It can prevent the germs that create human skin diseases, and has a great result on the treatment of dermatitis.

Deodorization: Catechine can remove the odor of methyl mercaptan, so it can remove the foul breath of cigarette smokers, and also minimize the odor of pig, poultry as well as human waste (due to the fact that catechin can withstand the germs in the human digestive tract that create odor).

Others: Some researches have actually revealed that Catechine likewise inhibits blood pressure (can decrease diastolic and also systolic high blood pressure) and also blood sugar (prevents glycolytic enzymes), decreases blood cholesterol and low-density lipoprotein (LDL), as well as raises high-density lipoprotein (HDL) (made use of in Japan to make low-cholesterol eggs), anti-radiation and also ultraviolet rays (the USA has made cosmetics to avoid ultraviolet rays), anti-mutation (it has actually been verified in bacteria, however there is no record of human trials) and also various other features.

3. Market
It is a decreasing polyphenolic substance, which is conveniently oxidized by air in aqueous remedy, as well as is frequently used as an anti-oxidant. It can additionally be utilized in dyestuff as well as tanning markets.

Catechine Monomer Separation Method

Due to the similar structure and physicochemical properties of the main components of catechines, it is difficult to effectively separate each catechine monomer. However, with the continuous deepening of the research on the pharmacological functions of catechins, the research on the separation and preparation of catechin monomers has become more prominent, and it has also attracted more and more attention. Up to now, the separation and purification methods of catechin monomers include fiber column chromatography, SephadexLH-20 column chromatography, silica gel column chromatography, high-speed countercurrent chromatography separation, adsorption resin column chromatography and other technologies.
1. Separation by fiber column chromatography
Vuataz et al. used the partitioning properties of cellulose for the separation of catechine monomers. Finally, crystallization and purification were carried out in water, methanol, dichloromethane, ethyl acetate and dichloromethane, respectively, to obtain each main catechin monomer.
2. SephadexLH-20 column chromatography separation
Gel column chromatography is a method that uses gel to separate substances according to their molecular size. In addition to the role of molecular sieves, gel column chromatography often plays the role of reverse partition chromatography. 3. Separation by silica gel column chromatography
Silica gel column chromatography uses the polarity of different substances to separate. Chan et al. obtained a novel patent for the separation and preparation of catechin monomers in 2007. The crude product of Catechine was acetylated, extracted, separated and eluted to obtain each esterified monomer, and then degreasing reduction and chromatography were performed to obtain Catechine. class of monomers.

Effects of Green Tea Catechine on Cells

Much less swelling is related to avoidance of carcinogenesis, especially in prostate cancer cells. While most research in this field to day has focused on epigallocate-3-O-gallate, we investigated epi-Catechine-3-O-gallate, the initial medicine with essential therapeutic prospective 2 abundant environment-friendly tea polyphenols to obtain even more details concerning their anti-tumor and anti-inflammatory results. Moreover, to improve the organic task of (-)-epicatechin-3-O-gallate, we manufactured a difluoro analog named (-)-5,7-difluoro-epicatechin-3-O-gallate. Both substances decreased cell spreading in human key inflammatory lymphocytes in an apoptosis-specific manner, whereas (-)-5,7-difluoro-epicatechin-3-O contrasted to the all-natural product (-)-epicatechin-3-O – gallate has substantially higher task -3-O-gallate. Treatment of low-metastatic LNCaP and also high-metastatic PC-3 prostate cancer cells with (-)-epicatechin-3-O-gallate and (-)-5,7-difluoro-epicatechin-3-O-gallate revealed reduced micromolar range-dependent inhibition of cell stability. These impacts recommend that (-)-epicatechin-3-O-gallate and also the a lot more powerful (-)-5,7-difluoro-epicatechin-3-O-gallate may be made use of therapeutically by minimizing inflammatory lymphoid Cells minimize the quantity of swelling triggered to inhibit tumorigenesis, promo and progression throughout tumorigenesis. Further studies are needed to show this in vivo experiments.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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