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Carnosic Acid CAS 3650-09-7

Molecular Formula: C20H28O4

Formula Weight: 332.43

ZSpharmac: Carnosic Acid Cosmetic Raw Material Supplier

Product Name: Carnosic Acid
CAS No: 3650-09-7
Purity: 99%

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Basic Info

Product Name:Carnosic Acid
Other Names:Carnosic Acid Liquid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Sticky Yellow Powder
EINECS No.:609-253-7
Storage:Under -20°C
Provide:Carnosic Acid MSDS;
Carnosic Acid COA

What is Carnosic Acid?

Carnosic acid is a diterpene compound divided from the fallen leaves of the plant Rosmarinus officinalis. It is a white or yellow-white powder. It is quickly soluble in oils and organic solvents such as ethanol, ethyl acetate, acetone, and chloroform. It is insoluble in water. Carnosic acid appropriates for antioxidant usage in oil-soluble parts. Utilized in sauces, family pet food and feed, it has antioxidant and anti-aging results; has solid fat loss and lipid-lowering effects; treats cardiovascular disease and has anti-cancer results.
Rosemarinus is a herbaceous plant of the Lamiaceae member of the family. It is belonging to south European nations and has actually existed and grown in Hunan, Guizhou, Hainan, Guangxi, Guangdong and various other areas and cities in China. It has carnosic acid, rosmarinol, and rosmarinic acid., carnosol, epirosmanol, isorosmanol, rosmarinol and other energetic components. Among them, the very efficient antioxidant substances are carnosic acid, rosmanol and carnosol. Fat-soluble rosemary remove remains in the form of light yellow to yellow-brown powder or brown paste, insoluble in water, yet soluble in ethanol and oil; water-soluble rosemary significance continues to be in the sort of brown powder with the distinctive smell of rosemary. It has fantastic warm resistance (steady at 200 ℃) and UV resistance, and can properly stop the oxidation of grease.

Carnosic Acid Property

Melting point 190°C(lit.)
Boiling point 506.4±50.0 °C(Predicted)
density 1.184±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form powder
color yellow


Carnosic Acid Uses

1. Maintain grease and expand storage space time. Used in oil and fat-containing foods, it can protect against or delay the oxidation of oil or oil-containing foods, boost food stability and expand the storage space time of saved materials. Among our business’s partners, Infinite Chicken Wings, utilizes carnosic acid to prolong the shelf life of food without altering its taste.

2. As a flavoring for meat and fish. It can stop oxidation of meat items such as pork and sausage.

3. It can hinder the fishy smell of icy fish and meat items.

4. Prevent oxidation in high-temperature deep-fried foods and protect against light damage after packaging.

5. Carnosic acid is an all-natural antioxidant extracted from the rosemary plant. As a raw material for skin treatment products, it has actually long been sold in European and American countries.

Pharmacological Effects of Carnosic Acid

(1) Anti-bacterial outcome
Research research shows that Carnosic Acid has varying degrees of inhibitory results on Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Hansenula yeasts, and can be utilized as a food chemical.
( 2) Antioxidant impact
Carnosic Acid has excellent cost-free radical scavenging and antioxidant outcomes. Its DPPH, ABTS complimentary extreme scavenging capability and iron decreasing antioxidant ability are more powerful than VE, slightly weak than the man-made antioxidant TBHQ; its lowering capacity is more powerful than VE and TBHQ. Carnosic acid is fat-soluble and can properly prevent the development of peroxides in oils and the decay of polyene fats, hence expanding the life expectancy of oils. In addition, looks into have actually discovered that carnosic acid can appropriately eat oxygen cost-free radicals in computer mouse liver cells, minimize the production of lipid peroxides, therefore supporting cell membrane layers; carnosic acid can also inhibit the oxidation response of low-density lipoprotein, which can efficiently quit The occasion of atherosclerosis.
( 3) Other functions
Researches have found that carnosic acid has a repressive result on the dispersing of HL-60 cells and is anticipated to find to be a new medication for the therapy of hematological hatreds, heart problem and anti-cancer. Kaloustian et al. introduced that carnosic acid and various other rosemary gets rid of have particular healing effects on cardiovascular disease and respiratory system conditions, have antibacterial outcomes, and can also stop HIV infection. Ninomiya et al. reported that carnosic acid and various other rosemary essences can not just control people’s weight by efficiently controling fat absorption, thus acquiring the goal of weight loss, yet can furthermore treat swelling, treat aching throat, deal with indigestion, and avoid aging. Mental deterioration, dealing with diabetes mellitus, and promoting the manufacturing of nerve development variables, to name a few.

Study on The Antioxidant Mechanism of Rosemary

Initially, carnosic acid and carnosol are separated and detoxified as complies with:
500g of rosemary dried leaves were removed with ethanol at area temperature, and the remove was focused under minimized stress up until dry. The completely dry essence was mixed with 1L n-hexane, drawn out for 72 hours, filtered, and the filtrate was focused under reduced pressure to one-third of the initial quantity. Essence 3 times with 0.5 L 5% NaHCO3, combine the NaHCO3 extracts, and adjust the pH to 2.2 with H3PO4. Then essence once more with n-hexane, completely dry with Na2SO4, concentrate under minimized pressure until yellow-green crystals appear, filter to acquire carnosic acid crystals.
2kg of rosemary dried stems and leaves were crushed into 1cm pieces, removed with 8 times the quantity of petroleum ether under reflux three times (2h, 1h, 1h). The essence was filteringed system and focused to get 235g of oil ether essence, which was drawn out with 5% NaHCO3 solution., then acidified with 5% hydrochloric acid and drawn out with ethyl acetate to acquire 1.8 g of the remove. The extract underwent silica gel column chromatography and eluted with oil ether-acetone slope. 100mL of each section was gathered, and a total of 108 portions were gathered, of which 46 ~ 62 portions were integrated and subjected to silica gel column chromatography, eluting with chloroform-acetone (3:1), each portion was 100 mL, and a total amount of 52 fractions were gathered. The 21st to 23rd fractions were incorporated and recrystallized from acetone to acquire anemic needle-like carnosol. crystal.
The ESR method was made use of to examine the scavenging result of each monomer on superoxide anion free radicals, hydroxyl free radicals and lipid free radicals, and the chemiluminescence approach was utilized to analyze the scavenging effect of the monomer on superoxide anion totally free radicals and the protective impact on DNA damages. Speculative outcomes show that the tasks of the five compounds are concentration-dependent. The higher the concentration, the higher the task, and there is a saturation phenomenon. The order of IC50 worths of five substances for scavenging O2- · and lipid complimentary radicals is: for scavenging O2- · determined by ESR technique, carnosic acid > isorosmanol > rosmanol > epirosmanol > Carnosol; gauged by CL approach, isorosmanol > carnosic acid > rosmanol > epirosmanol > carnosol; for lipid free radicals, carnosic acid > isorosmarynol Arnosol > Rosmarinol > Epirosmanol > Carnosol.

About Products:
If you need the cosmetic raw material Carnosic Acid, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Carnosic Acid manufacturer and supplier, our company, ZSpharmac will provide Carnosic Acid raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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