Carmed Carvacrol CAS 499-75-2

Molecular Formula: C10H14O

Formula Weight: 150.22

ZSpharmac: Carmed Carvacrol Supplement

Product Name: Carmed Carvacrol

CAS No: 499-75-2

Purity: 99%

Basic Info

Product Name:	Carmed Carvacrol
Other Names:	Carvacrol
CAS:	499-75-2
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Organic Chemical Raw Materials
Appearance:	White Powder
EINECS No.:	207-889-6
Storage:	-20°C
Provide:	Carmed Carvacrol MSDS； Carmed Carvacrol COA

What is Carmed Carvacrol?

Carmed Carvacrol is an isomer of thymol, and its aroma is similar to that of thymol, so it is also called isothymol. Carmed Carvacrol is naturally present in essential oils such as thyme oil, especially in Spanish thyme oil, which has a higher content of Carmed Carvacrol.

Thyme alias thyme. Origin Northeast, Hebei, Inner Mongolia, Gansu, Qinghai and Xinjiang and other provinces. Ingredients: The whole thyme plant contains about 0.15-0.5% volatile oil (mainly carvacrol, p-cymene, thymol in the oil), bitterness and tannin. The leaves contain free oleanolic acid, ursolic acid, caffeic acid, etc. Thyme can not only be used as a medicine for health care, but also as a seasoning, and it is also an excellent natural health care raw material for processed foods. Since the 1980s, herbal foods such as thyme have grown in popularity. Relevant studies have shown that the volatile oil contained in thyme can not only flavor and cure diseases, but also have antiseptic and antibacterial functions. Therefore, it can benefit eaters a lot as a food raw material. Because of this, thyme is naturally indispensable in European medicinal teas. For example, 10% of thyme leaves are included in the raw material of a medicinal tea with the effect of relieving cough and preventing bronchitis.

Carmed Carvacrol Properties:

Melting point	3-4 °C(lit.)
Boiling point	236-237 °C(lit.)
density	0.976 g/mL at 20 °C(lit.)
FEMA	2245 \| CARVACROL
refractive index	n20/D 1.522(lit.)
Fp	224 °F
storage temp.	-20°C
solubility	1.25g/l
pka	10.38±0.10(Predicted)
form	neat
Water Solubility	Insoluble

Carmed Carvacrol Uses

Carmed Carvacrol is generally used for the preparation of dill, clove, artemisia, meat, mint, vanilla essence and so forth.
Carmed Carvacrol is made use of to develop fragrances, fungicides as well as disinfectants, as a scent for daily necessities such as toothpaste, soap, as well as additionally as a food taste.
Carmed Carvacrol is made use of in spices, food additives, feed ingredients, anti-oxidants, hygiene fungicides, insect repellants, chemicals, antiperspirants, pharmaceutical intermediates.

"Carmed Carvacrol": A Natural Plant Essential Oil Bacteriostatic Agent

Carmed Carvacrol is naturally present in the essential oils of labiata plants such as oregano, thyme, and winter savory, and is a monoterpene phenolic compound. Current research has confirmed that carvacrol has anti-inflammatory, antioxidant and antibacterial biological activities, and is widely used in spices, food additives, feed additives, antioxidants and pharmaceutical intermediates. spectrum of natural bacteriostatic agents.
The USDA’s “Phytochemistry and Plant Speciation” background information shows that oregano contains more than 30 antibacterial compounds, the best antibacterial among these components are carvacrol and thymol, which can not only kill fungi or prevent Its growth can inhibit the growth of most bacteria at the same time, and this non-specific antibacterial effect will not make bacteria resistant to drugs. Carvacrol in oregano essential oil is the most important active ingredient in resisting harmful microorganisms and infections. It has a very strong bactericidal function, and its content can account for up to 80%.
Tests have shown that Carmed Carvacrol, thymol and thymol have inhibitory effects on the growth of 20 species of fungi such as Fusarium, Aspergillus and Penicillium, and can strongly inhibit the growth of fungi and the synthesis of mycotoxins. as a broad-spectrum antifungal agent.
Carmed Carvacrol has broad-spectrum antibacterial activity against fungi and bacteria. Therefore, Carmed Carvacrol has also been developed and applied to the field of agricultural disease control. This phenolic compound not only has a broad-spectrum and high-efficiency bactericidal effect, but also stimulates crop growth, enhances immunity, and improves yield.
At present, Chengdu New Chaoyang Crop Science Co., Ltd. was registered with the Drug Inspection Institute of the Ministry of Agriculture with 10% Carmed Carvacrol mother liquor in 2014, becoming the first registered production company of carvacrol mother liquor in my country. In 2015, 0.5% Carmed Carvacrol water was registered again in the Ministry of Agriculture for the control of botrytis on kiwifruit, powdery mildew on medlar, and rust on jujube trees. Control of these three diseases of crops.
The carvacrol of Chengdu Xinchaoyang is made of various aromatic plants such as oregano and thyme as raw materials. Pesticide preparations, in line with organic green production standards. These plant components synergistically exert antifungal effects in the form of mixtures, and have many targets, making it difficult for carvacrol to develop resistance to crop disease control.
thyme
Sterilization principle: Through its strong surface activity and lipid solubility, carvacrol in Chengdu Xinchaoyang inhibits the germination of pathogenic spores or rapidly penetrates the cell membrane of pathogenic microorganisms, causing the water imbalance of pathogenic microorganisms and death.
Indoor antibacterial test: 0.5% carvacrol water can effectively inhibit the growth of botrytis pathogen mycelium
Preventive and therapeutic effects: Carmed Carvacrol from Chengdu Xinchaoyang has a strong control effect on fungal diseases such as botrytis, powdery mildew, rust, anthracnose and leaf blight of crops: for example, the control effect of jujube rust is 80%~90%. %, Lycium barbarum powdery mildew control effect is 70%~85%, tomato gray mold control effect is 80%~90%; at the same time, Chengdu Xinchaoyang’s carvacrol also has nutritional therapeutic effect on crops, regulating plant growth and improving immunity It has a regulatory effect on enhancing disease resistance.

Effect of Carmed Carvacrol on Isolated Human Umbilical Arteries

Carmed Carvacrol is the main compound in essential oils extracted primarily from thyme and oregano plants. Its various biological activities are demonstrated: antioxidant, anti-inflammatory, antibacterial, antifungal, antitumor, antitumor and vasodilatory effects. Although carvacrol-mediated vasodilation has been described previously, the exact mechanism of its action has not been determined.Carvacrol resulted in a significant reduction in vascular tone in 5-HT-precontracted umbilical arteries with an EC50 of 442.13 ± 33.8 µM (mean ± standard error of the mean – SEM). At 300 µM, carvacrol shifted the 5-HT concentration-response curve downward with p < 0.001 for the four highest concentrations. At a concentration of 1 mM, carvacrol completely abolished the contraction induced by BaCl2 in Krebs-Ringer bicarbonate solution without Ca2+ (p < 0.001). The TRPV3 channel antagonist isopentenyl pyrophosphate was able to reduce the efficacy of carvacrol (p < 0.001).

The vasodilatory effects of Carmed Carvacrol appear to be related to blocking L-type Ca2+ channels on smooth muscle cells. However, a role for TRPV3 channels in carvacrol-induced HUA vasodilation cannot be ruled out. Carmed Carvacrol completely abolished BaCl2-induced shrinkage in Ca2+-free Krebs-Ringer bicarbonate solutions (p < 0.001). The TRPV3 channel antagonist isopentenyl pyrophosphate was able to reduce the efficacy of carvacrol (p < 0.001). The vasodilatory effects of carvacrol appear to be related to blocking L-type Ca2+ channels on smooth muscle cells. However, a role for TRPV3 channels in carvacrol-induced HUA vasodilation cannot be ruled out. Carmed Carvacrol completely abolished BaCl2-induced shrinkage in Ca2+-free Krebs-Ringer bicarbonate solutions (p < 0.001). The TRPV3 channel antagonist isopentenyl pyrophosphate was able to reduce the efficacy of carvacrol (p < 0.001). The vasodilatory effects of Carmed Carvacrol appear to be related to blocking L-type Ca2+ channels on smooth muscle cells. However, a role for TRPV3 channels in carvacrol-induced HUA vasodilation cannot be ruled out.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.