Zhishang Chemical

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Zhishang Chemical

Cardamonin CAS 19309-14-9

Molecular Formula: C16H14O4

Formula Weight: 270.28

ZSpharmac: Cardamonin Cosmetic Raw Material Suppliers

Product Name: Cardamonin
CAS No: 19309-14-9
Purity: 99%

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Basic Info

Product Name:Cardamonin
Other Names:Cardamom
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
Storage:Room Temp
Provide:Cardamonin MSDS;
Cardamonin COA

What is Cardamonin?

Cardamonin is a yellow needle crystal, conveniently soluble in methanol, ethanol, ethyl acetate, ether, as well as water down alkali option, however insoluble in water. It reacts with lead acetate to form a yellow precipitate. Cardamomine can significantly hinder the activity of tyrosinase, as well as at the same time, it can successfully inhibit melanocyte expansion and melanin synthesis, as well as the impact is considerably far better than various other active ingredients. Cardamomine is originated from my nation’s traditional Chinese organic medicine and has excellent security as well as resource benefits. It has fantastic market potential customers for skin lightening and hindering skin coloring illness (Chinese patent application number 200910055818.2). Pharmacological experiments have actually discovered that both have solid task in inhibiting platelet aggregation, preventing growth development, and also anti-inflammatory and anti-bacterial impacts, and also have low toxicity and also great security.

Cardamonin Property

Melting point 28 °C (lit.)
Boiling point 217 °C/150 mmHg (lit.)
density 1.097 g/mL at 25 °C (lit.)
vapor density 3.6 (vs air)
vapor pressure <0.98 atm ( 100 °C)
refractive index n20/D 1.477(lit.)
Fp 280 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form Viscous Liquid or Low Melting Solid
color APHA: ≤15
Specific Gravity1.09
OdorMild ammoniacal; faint, fishy; characteristic.
PH11.0-12.0 (25℃, 1M in H2O)
pka8.88(at 25℃)
explosive limit2.1-10.6%(V)
Water Solubility MISCIBLE


Cardamonin Uses

  1. Cardamonin has anti-bacterial, antiemetic, as well as spleen-strengthening impacts.
  2. Cardamonin is made use of for web content determination/identification/pharmacological experiments, and so on.

Cardamonin Preparation

The extraction approaches of Cardamonin currently consist of ethanol extraction, ether extraction, acetone extraction, chloroform removal, and so on, using silica gel column chromatography. The cardamomine material obtained by these extraction as well as splitting up techniques is reduced, the yield is reduced, and the removal time is long. They are normally made use of as a small-scale preparation approach in chemical make-up lab. Shi Daohua et al. made use of 95% ethanol to soak for 3 days, refluxed with 8 times the amount of ethanol two times, 2 hours each time, recuperated the ethanol under lowered stress to get 600ml of concentrated liquid, and made the concentrated liquid right into a liquid suspension with ethyl acetate as well as n-butanol. Extract in turn, recuperate the solvent under reduced pressure of the essence, and get 340g of extract after concentration. Dissolve the remove in an ideal quantity of acetone, mix the example, and also wet-pack the column with silica gel equivalent to 5 times the quantity of solid, as well as elute with petroleum ether-ethyl acetate system., collect each eluted fraction, spot it on the same thin layer plate as the referral substance, create with toluene-ethyl acetate-methanol (15:4:1) and also chloroform-methanol (20:1) respectively, and make use of UV light (wavelength 365nm), integrate the portions with dark places at corresponding positions of the referral compound, as well as concentrate under typical pressure to get 13g of combined crystals. The mixed crystals were travelled through a silica gel column, and also the eluent was petroleum ether-ethyl acetate-acetone system. After concentration, 5 g of crystals were acquired. Take 100g of the gel and swell it with methanol overnight and also put it right into a column. After the crystals are liquified in methanol, take 20ml and also placed it on the column. Gather each section of 3ml. Examine by thin layer (TLC) and also contrast it with a standard. Integrate the exact same fractions and focus to obtain an orange-yellow needle. 4.2 g of crystals were acquired. Although this method is considerably enhanced than the acetone removal technique, with an extraction price of 0.084%, the extraction price is still very reduced, the extraction time is long, as well as the natural solvent extraction price is reduced as well as the loss is large.

CN201010235806.0 provides a technique for extracting Cardamonin with high extraction price, brief cycle and also high pureness.

Technical solution: In order to accomplish the above function, the invention supplies an approach for drawing out cardamomine from cardamom, which especially consists of the following actions: a. Removal step: take a suitable amount of cardamom seeds, crush them to 20-60 mesh, and also cool them. By seepage, cozy soaking or reflux removal method, cardamom seed powder is drawn out with solvent 1-3 times, the essences are integrated, and focused under minimized pressure to get an essence; b. Organic solvent removal action: extract the extract with oil ether up until the essence is obtained Nearly colorless, discard the petroleum ether essence and also maintain the staying extract; c. Splitting up and filtration action: Usage column chromatography to divide the continuing to be remove with water, methanol, ethanol, ethyl acetate, acetone, dichloromethane or their mixes The combined solution is eluted, kept track of by high performance liquid chromatography, as well as the effluent having Cardamonin is collected. The effluent is concentrated and then crystallized with an organic solvent to get high-purity cardamomine. Compared with the existing technology, the cardamomine extraction method provided by this technique has the adhering to benefits: (1) The approach course offered by the present development is reasonably developed, and the method is simple and also easy to run; (2) The method offered by the existing innovation has a brief cycle and high extraction price. High, item purity is high; (3) The solvent and column chromatography filler utilized in the approach provided by the creation can be recuperated and also reused, which can reduce prices as well as is a low-cost, reusing procedure.

Cardamonin Detection Method

Presently, the technical methods commonly utilized to figure out the content of cardamom and also cardamonin, the primary components of cardamom, are: high performance liquid chromatography, thin layer chromatography and micellar electrokinetic capillary chromatography. Amongst these techniques, the operating conditions of high-performance fluid chromatography are hard to control, are cumbersome, and take too long. Slim layer chromatography needs a big amount of sample, the splitting up treatment is troublesome, the separation time is long, as well as there may be interference from contaminations. Nevertheless, micellar electrokinetic capillary chromatography is prone to bubbles, the column is simple to break, the discovery level of sensitivity is reduced, and also the kinds of fillers are restricted. In order to address these issues, it is essential to improve the existing innovation to make it simple to operate, accurate, rapid and also viable. And in the production procedure of making modern-day Chinese medicine preparations from cardamom, fast as well as precise measurement of its concentration is a very vital action, so the technique provided by CN201510272183.7 can rapidly complete this discovery job.

The technological option is: a method for gauging the material of the major active components of cardamom utilizing ultraviolet spectrophotometry, consisting of the prep work of basic sample remedy, the procurement of the linear regression formula of the basic contour, the prep work of the example to be examined, ultraviolet discovery and concentration calculation. Those prep work of the example to be examined, UV discovery and concentration calculation include the following steps: a. Preparation of the example to be checked: dry the cardamom example, crush it with a grinder as well as travel through a mesh filter, precisely evaluate 5g of cardamom powder, Location it in a reagent bottle as well as add 95% ethanol to a volume of 100mL, dissolve it with ultrasound, leave it overnight, filter, take the continuing to be filtrate as well as pass it through a microporous filter membrane, as well as dispense the final filtrate for use; b. Ultraviolet detection of the sample to be checked: make use of ultraviolet spectroscopy. Photometric method establishes the absorbance at 286nm as well as 346nm of the sample essence of cardamom liquified in 95% ethanol; c. Estimation of the concentration of the example to be tested: The measured example service of cardamom in step “b” is determined at 286nm and 346nm respectively. The ordinary absorbance is made use of as the gauged worth of the material of towering and also cardamomine, as well as is substituted right into the linear regression formula of the typical curve to determine the content of towering and cardamomine in the sample to be tested.

About Products:
If you need Cardamonin as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
Our company, as an experienced Cardamonin manufacturer and supplier, ZSpharmac will provide Cardamonin raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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