Zhishang Chemical

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Zhishang Chemical

Cardamom Cloves CAS 19309-14-9

Molecular Formula: C16H14O4

Formula Weight: 270.28

ZSpharmac: Cardamom Cloves Supplier

Product Name: Cardamom Cloves
CAS No: 19309-14-9
Purity: 99%

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Basic Info

Product Name:Cardamom Cloves
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
Storage:Room Temp
Provide:Cardamom Cloves MSDS;
Cardamom Cloves COA

What is Cardamom Cloves?

Cardamom Cloves (Cardamonin) is a yellow needle crystal, easily soluble in methanol, ethanol, ethyl acetate, diethyl ether, dilute alkali solution, hardly soluble in water, and reacts with lead acetate to form a yellow precipitate. Cardamonin can significantly inhibit the activity of tyrosinase, and at the same time, it can effectively inhibit the proliferation of melanocytes and the synthesis of melanin, and the effect is obviously better than that of other ingredients. Cardamom Cloves is derived from traditional Chinese herbal medicine in my country. It has good safety and resource advantages. It will have great market prospects for skin whitening and inhibition of skin pigmentation diseases (Chinese patent application number 200910055818.2). Pharmacological experiments found that the two have strong activity in inhibiting platelet aggregation, tumor formation, anti-inflammatory and antibacterial, and have low toxicity and good safety.

Cardamom Cloves Property

Melting point 199~200℃
Boiling point 484.5±45.0 °C(Predicted)
density 1.282±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥20mg/mL
form powder
color yellow


Cardamom Cloves Uses

  1. Cardamom Cloves has antibacterial, antiemetic and spleen invigorating effects.
  2. Cardamom Cloves are used for content determination/identification/pharmacological experiments, etc.

Cardamom Cloves Preparation

The extraction methods of Cardamom Cloves mainly include ethanol extraction, ether extraction, acetone extraction, chloroform extraction, etc., and silica gel column chromatography is used. Cardamomine obtained by these extraction and separation methods has low content, low yield and long extraction time, and is generally used as a small amount of preparation method in chemical composition research laboratories. Shi Daohua etc. impregnated with 95% ethanol for 3 days, refluxed 2 times with 8 times the amount of ethanol, 2 hours each time, recovered the ethanol under reduced pressure to obtain 600ml concentrated solution, made the concentrated solution into an aqueous suspension, and then used ethyl acetate, n-butanol Sequential extraction, the extract was decompressed to recover the solvent, concentrated to obtain 340g of extract, the extract was dissolved in an appropriate amount of acetone, the sample was mixed, and the column was wet-packed with silica gel equivalent to 5 times the amount of the solid, and eluted with petroleum ether-ethyl acetate system , collect the eluted fractions, spot on the same thin-layer plate as the reference substance, develop with toluene-ethyl acetate-methanol (15:4:1), chloroform-methanol (20:1) respectively, and UV light Observe under (wavelength 365nm), merge the fraction that appears dark spot in the corresponding position of reference substance, concentrate at normal pressure to obtain 13g mixed crystal. The mixed crystals were passed through a silica gel column, and the eluent was petroleum ether-ethyl acetate-acetone system. After concentration, 5 g of crystals were obtained. Take 100g of gel to swell overnight with methanol, put it on the column, dissolve the crystals in methanol, take 20ml and put it on the column, collect 3ml of each part, analyze by thin layer (TLC) and compare with the standard, combine the same fractions and concentrate to get orange needles Although this method has significantly improved than the acetone extraction method, the extraction rate is 0.084%, but the extraction rate is still very low, the extraction time is long, the organic solvent extraction extraction rate is low, and the loss is large.

CN201010235806.0 provides a method for extracting Cardamom Cloves with high extraction rate, short cycle and high purity.

Technical solution: In order to achieve the above object, the present invention provides a method for extracting Cardamom Cloves from Cardamom, which specifically includes the following steps: a. Extraction step: take an appropriate amount of Cardamom seeds, crush them to 20-60 mesh, and use cold infiltration , warm soaking or reflux extraction method, the cardamom seed powder is extracted with solvent for 1-3 times, the extracts are combined, concentrated under reduced pressure to obtain the extract; b. Organic solvent extraction step: extract the extract with petroleum ether until the extract is close to Colorless, discard the petroleum ether extract, keep the remaining extract; c. Separation and purification step: use column chromatography to separate the remaining extract, use water, methanol, ethanol, ethyl acetate, acetone, dichloromethane or their mixture The solution is eluted, monitored by high-performance liquid chromatography, and the effluent containing Cardamom Cloves is collected. After the effluent is concentrated, it is crystallized with an organic solvent to obtain high-purity cardamomine. Compared with the prior art, the extraction method of Cardamom Cloves provided by the method has the following advantages: (1) the route design of the method provided by the invention is reasonable, and the method is simple and easy to operate; (2) the method period provided by the invention is short and the extraction rate is high , the product has high purity; (3) the solvent used in the method provided by the invention and the column chromatography filler can all be recycled and recycled, which can reduce costs, and is a low-cost, cyclic process.

Detection Method of Cardamom Cloves

At present, the technical methods commonly used to determine the content of alpinol and Cardamom Cloves, the main components of cardamom, are: high performance liquid chromatography, thin layer chromatography and micellar electrokinetic capillary chromatography. Among these methods, the operating conditions of high performance liquid chromatography are not easy to control and are more cumbersome and take too long. Thin-layer chromatography uses a large amount of samples, and the separation procedures are troublesome, the separation time is long, and there may be interference from impurities. However, micellar electrokinetic capillary chromatography is prone to bubbles, easily broken columns, low detection sensitivity, and limited types of fillers. In order to solve these problems, it is necessary to improve the existing technology so that it has a simple, accurate, fast and feasible method. And in the production process of making cardamom into a modern traditional Chinese medicine preparation, fast and accurate determination of its concentration is a very important step, so the method provided by CN201510272183.7 can quickly complete this detection task.

The technical solution is: a method for determining the content of the main active components of Cardamom mesciens by ultraviolet spectrophotometry, including the preparation of standard sample solutions, the acquisition of standard curve linear regression equations, the preparation of samples to be tested, the ultraviolet detection and the calculation of concentrations. The preparation of the described sample to be tested, the calculation of ultraviolet detection and concentration comprise the following steps: a. the preparation of the sample to be tested: dry the cardamom sample, use a pulverizer to pulverize the rear mesh sieve respectively, accurately weigh 5 g of the cardamom powder, Add 95% ethanol to the reagent bottle to make up to 100mL, ultrasonically dissolve, then place overnight, filter, take the subsequent filtrate to pass through the microporous membrane, and the final filtrate is used for equipment; b. UV detection of samples to be tested: use UV spectrometry Photometrically measure the absorbance at 286nm and 346nm of the sample extract solution of cardamom sativa dissolved in 95% ethanol; c. Calculation of the concentration of the sample to be tested: the concentration of the sample solution of cardamom japonicus measured in step “b” at 286nm and 346nm respectively The average value of absorbance is used as the measured value of alpinol and Cardamom Cloves content, and is substituted into the linear regression equation of the standard curve to calculate the content of alpinol and Cardamom Cloves in the sample to be tested.

About Products:
If you need Cardamom Cloves, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Cardamom Cloves manufacturer and supplier, our company, ZSpharmac will provide Cardamom Cloves raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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