Zhishang Chemical

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Zhishang Chemical

Carboxymethyl Chitosan CAS 83512-85-0

Molecular Formula: C20H37N3O14

Formula Weight: 543.51948

ZSpharmac: Carboxymethyl Chitosan Supplier

Product Name: Carboxymethyl Chitosan
CAS No: 83512-85-0
Purity: 99%

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Basic Info

Product Name:Carboxymethyl Chitosan
Other Names:N-Carboxymethylchitosan
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White to Pale Beige Solid
EINECS No.:695-802-6
Storage:Room Temperature, Under Inert Atmosphere
Provide:Carboxymethyl Chitosan MSDS;
Carboxymethyl Chitosan COA

What is Carboxymethyl Chitosan?

Carboxymethyl chitosan is a water-soluble chitosan derivative, which is an amphoteric polyelectrolyte, which is formed by introducing a hydrophilic group -CH2COOH into the chitosan polymer chain. After radical modification, the water solubility is improved, especially the solubility in neutral and alkaline solutions is significantly enhanced, so that it has the characteristics of film formation, thickening, moisturizing, chelating, etc., so it is used in agriculture, medicine , health products, cosmetics, fresh-keeping, environmental protection and other aspects are widely used.

Carboxymethyl Chitosan Property

Melting point 600 °C
storage temp. Room Temperature, under inert atmosphere
solubility Aqueous Acid (Slightly, Heated, Sonicated), Water (Sonicated)
form Solid
color Off-White to Pale Beige


Carboxymethyl Chitosan Uses

The use of carboxymethyl chitosan as the only active ingredient in the preparation of products for the treatment of skin itching caused by histamine;

The number average molecular weight of the carboxymethyl chitosan is 2000~20000; the carboxymethyl chitosan is O-carboxymethyl chitosan; the preparation method of the carboxymethyl chitosan comprises The higher carboxymethyl chitosan raw material of average molecular weight is degraded by hydrogen peroxide, and the number average molecular weight of carboxymethyl chitosan in the higher carboxymethyl chitosan raw material of described number average molecular weight is 30~700,000; The degree of carboxymethyl substitution in the carboxymethyl chitosan raw material with higher average molecular weight is 0.8 to 1.3; the substitution degree of carboxymethyl O in the carboxymethyl chitosan raw material with higher number average molecular weight is 0.7 to 1.0 , the N-position substitution degree is not more than 0.3; when preparing products for treating itchy skin, the amount of carboxymethyl chitosan used is not less than 0.2%.

The Preparation Method of Carboxymethyl Chitosan

Add a solution of sodium hydroxide in isopropanol to the reaction flask, the concentration of sodium hydroxide is 40%.

Add chitosan with a degree of deacetylation of 15% to 45% into the reaction flask, and the mass ratio of chitosan to sodium hydroxide after adding is 1:4.8.

Slowly add the pre-dissolved isopropanone chloroacetic acid solution dropwise into the reaction flask under stirring, and continue to stir and react for 3 hours after the addition is complete. The mass ratio of chitosan to chloroacetic acid is 5:1.

After the reaction, add concentrated hydrochloric acid to the reacted material, adjust the pH value of the material to 6-7, filter with suction, wash the filter cake with absolute ethanol for 3 times, and dry the washed filter cake below 50°C to obtain a Carboxymethyl Chitosan.

Purification Method of Carboxymethyl Chitosan

The method for purifying Carboxymethyl Chitosan comprises the steps:

1) After dissolving 40Kg of carboxymethyl chitosan with a pH of 2.7 at the isoelectric point, a number average molecular weight of 40W, and a carboxymethyl substitution degree of 1.3 with 2 tons of water, adjust the pH of the carboxymethyl chitosan aqueous solution To 2.7, carboxymethyl chitosan is formed into a white flocculent precipitate, and centrifugal dehydration is obtained to concentrate carboxymethyl chitosan;

2) Repeatedly washing the concentrated carboxymethyl chitosan obtained in 1) with filtered water with a pH of 2.7 to remove the salt contained in the concentrated carboxymethyl chitosan to obtain desalted carboxymethyl chitosan;

3) The desalted carboxymethyl chitosan was repeatedly washed with 95% ethanol until the alcohol content of the supernatant was 95°, and the supernatant was removed and centrifuged to dry to obtain Carboxymethyl Chitosan with a purity of 99.3%.

Completing the above purification process, a total of 430Kg of ethanol with a concentration of 95% has been used. Compared with the need for 2 tons of 95% ethanol to purify 40Kg of the same Carboxymethyl Chitosan in the prior art, the consumption of ethanol is greatly saved, production costs are reduced, and The discharge of waste alcohol is avoided, and the damage to the environment is avoided.

About Products:
If you need Carboxymethyl Chitosan, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Carboxymethyl Chitosan, ZSpharmac will provide Carboxymethyl Chitosan raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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