Carbopol CAS 9007-20-9

Molecular Formula: C15H17ClO3

Formula Weight: 280.74668

ZSpharmac: Carbopol Supplier

Product Name: Carbopol

CAS No: 9007-20-9

Purity: 99%

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Basic Info

Product Name:	Carbopol
Other Names:	Carbomer
CAS:	9007-20-9
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Powder
EINECS No.:	618-435-5
Storage:	2-8°C
Provide:	Carbopol MSDS； Carbopol COA

What is Carbopol?

Polyacrylic acid, described as PAA, alias 2-acrylic acid homopolymer, acrylic material layer, acrylic material, acrylic monomer polymer, acrylic changed resin, acrylic material emulsion, is a water-soluble acrylic polymer, additionally soluble In some polar solvents, such as methanol, dioxane and ethylene glycol, etc. The ionization constant is 4.75. Due to the fact that the particle contains a lot of carboxyl groups, it can react with antacid, alcohols, as well as amines, as well as can also go through dehydration, deterioration, as well as complexation reactions. It can be made use of as thickener, dispersant, flocculant, glue as well as film-forming agent, etc. It is extensively made use of in industries such as finishes, plastics, papermaking, textiles, rubber, food, medicine, cosmetics as well as water treatment.

Physical and Chemical Properties of Carbopol

Carbopol of low molecular weight is a colorless and transparent strong. Its 20%-30% liquid remedy is light yellow or anemic thick liquid. The molecular weight is 500-5000, as well as the pH worth is 2-4. Therefore, Carbopol is a weak acid that is stronger than carbonic acid. It is normally secure to strong acids, solid alkalis, and oxidants, but under heat or long-lasting light, low-molecular-weight polyacrylic acid will certainly still repolymerize, making its molecular weight remain to increase, and also its viscosity will also enhance, and also lastly end up being a jelly state. A solid precipitated from the aqueous option. It is a chelating representative and a latticework distortion agent, which can create secure complexes with steel ions in water such as calcium and also magnesium. It also has great diffusion performance, and also can distribute amorphous bits such as crystalline compounds, soil, dust, harsh compounds and organic debris in water.

Carbopol Uses

Uses of Carbopol in Medicine
Carbopol is widely used in non-injectable formulations, especially topical liquid and semisolid formulations.

Carbomer resin has been studied for the preparation of sustained-release matrix pellets, as an enzyme inhibitor of intestinal protease in preparations containing polypeptides, as an adhesive for cervical patches and as microspheres for nasal administration, And magnetic granules that position drugs for delivery into the esophagus.

In addition, the value of Carbopol in medicine is far more than that, and its main medical value is divided into the following four aspects.

One is that it can be used as a sustained-release material to make controlled-release drugs for corresponding applications, such as ascorbic acid, aspirin, lithium carbonate, atropine sulfate, procaine hydrochloride, chlorpheniramine, quinine sulfate, theophylline, etc.

Second, it is used as a formula for external use, and can be used as a carrier matrix to make ointments, suppositories, gels, emulsions, etc.

The third is to make use of its gelling, adhesiveness, and film-forming properties. In the bioadhesive, it is used as a carrier matrix and a biopatch made of drugs. Because it is attached to the tissue mucosa for a long time, the bioavailability of the drug is improved. For example, mucous membranes are used as drug targets, including eye, nasal cavity, intestinal tract, vagina and rectal mucosa, etc.

The fourth is to use its suspending ability to effectively suspend the insoluble components to form a uniformly dispersed system, which is applied to oral suspensions, and has the characteristics of safety and effectiveness, avoiding taste, maintaining stability, and improving bioavailability.

Other Uses
In addition to medical treatment, Carbomer 951 is also used as a thickener in the preparation of double emulsion microspheres. Carbomers are also commonly used in cosmetics.

Carbopol is a stable and hygroscopic substance, and heating at 104°C for 2 hours does not affect its thickening properties.

However, exposure to excessively high temperatures can cause discoloration and reduced stability. It can be completely decomposed by heating at 260°C for 30 minutes.

And the safety of Carbopol is also there, and some grades can be used in oral preparations. It is generally believed that Carbopol is basically a non-toxic and non-irritating excipient.

There is no evidence of allergic reactions to topical application of Carbopol, but oral doses of 1 to 3 g of Carbopol can be used as a strong laxative.

Dissolution Method of Carbopol

1 The generally made use of approach is the dissolving technique the next day. If you want to use it the following day, saturate it the day in the past. Initially, include Carbopol in deionized water to liquify it according to the actual manufacturing demands. No demand to mix. Allow Carbopol soak up water naturally so that it can not be seen White powder on the surface shall prevail, after that include a neutralizer (triethanolamine or sodium oxide option), readjust the pH value to regarding 7, utilize a high-speed disperser, and mix equally at a reduced rate.

2 Usage a high-speed disperser to liquify and also add according to the real production ratio. If there is no white powder in the disperser, include a neutralizer to develop a gel, and after that make use of a vacuum cleaner emulsification pot to suck out the air in the gel. Filter again, as well as filter the undissolved Carbopol.

Preparation Method of Carbopol

Polymer acid is used as monomer to accomplish polymerization in the existence of initiator.
Polymer acid manufacturing method
a. The cyanoethanol approach utilizes chloroethanol as a resources, and cyanoethanol is obtained with sodium cyanide. Cyanoethanol is hydrolyzed at 175 ° C in the presence of sulfuric acid to obtain acrylic acid.

Figure 1 is the synthesis of polyacrylic acid by cyanohydrin method
b. Acrylonitrile hydrolysis method: Acrylonitrile is made use of as basic material to hydrolyze in the existence of sulfuric acid to create sulfate of acrylamide, and then hydrolyze to acquire acrylic acid.

Number 2 is the synthesis of polyacrylic acid by acrylonitrile hydrolysis
c. Reppy method and improved Reppy technique Liquify acetylene in tetrahydrofuran, measure and include in the reaction kettle. Pass carbon monoxide and also water in the presence of a catalyst composed of nickel bromide as well as copper bromide, and also respond at 200-225 ° C and also 7.8-9.8 MPa.

Number 3 is the synthesis of polyacrylic acid by Reppy method
d. Acrolein oxidation method Mix propylene, air, as well as water in a proportion of 1:10:6 (V), and after that pass it into the first ebullating bed. Stay at 370-390 ° C for 5.5 s, as well as the line rate is 0.6 m/s. Then go into the second ebullating bed, remain for 2.25 s under the catalysis of aluminum-vanadium= tungsten, and also manage the reaction temperature at 270-300 ° C. The space-time yield of acrylic acid is 55-60kg/ m · h. This technique is risk-free, light in pollution as well as low in expense. It is the main technique of manufacturing in your home as well as abroad.

Figure 4 is the synthesis of polyacrylic acid by oxidation of acrolein
Prep work of polyacrylic acid Include deionized water into the polymerization pot, warm at 60-100 ° C, and also start to go down the mixed remedy of ammonium persulfate and also acrylic acid (prepared with deionized water). After going down, remain to keep cozy and also stir for 3 to 4 hrs. Instant item Add 530kg of deionized water right into the polymerization kettle, include 41kg of Pingpingjia OS-15 and also mix to liquify. Then include 4kg of sodium dodecyl sulfate, stir to liquify and also add 68kg of mixed monomers (butyl acrylate, acrylonitrile) within 20 minutes. After mixing for 15 minutes, 30 kg of 1.5% ammonium persulfate aqueous service was added, and the enhancement was finished within 30 min. After continuing to mix for 15 mins, the temperature was slowly raised to 70 ° C, as well as the combined monomer (272kg) was included dropwise, as well as the decline was finished in regarding 1 hour. After the addition, keep stirring at 80 ° C. for 1 h.
After the reaction is completed, cool down to about 40 ° C, add 70kg of Pingpingjia OS-15, mix for 15 minutes as well as filter to eliminate impurities to obtain the item.
e. Adopt option polymerization method, usage acrylic acid as raw material, dilute with water, as well as polymerize under the action of initiator. The polymerization of acrylic acid is quick and exothermic. In order to recognize the control of the polymerization procedure, in the prep work of polyacrylic acid utilized for circulating water therapy, the acrylic acid is typically created right into a liquid solution of less than 40% for polymerization, and the polymerization temperature is typically controlled at 50-150 ° C. Generally used initiators are ammonium persulfate and sodium sulfite, and are commonly
Add a percentage (<5%) of mercaptosuccinic acid, isopropanol, and so on as a polymerization retarder, and also hydroquinone or catechol as a polymerization inhibitor. Include a specific stoichiometric quantity of deionized water into a reactor outfitted with an electrical stirrer, a reflux condenser, a going down funnel, and also a thermometer, begin mixing and raise the reaction temperature to concerning 80 ° C, add the gauged amount of thioglycolic acid or isopropyl Alcohol is contributed to the reactor to be miscible with water. Make a thin down solution of stoichiometric ammonium persulfate with determined water, area it in the dropping channel on the polymerization activator, mix the gauged acrylic acid (AA) monomer with a particular amount of water, as well as place it in the decline channel on the polymerization reactor right into an additional going down channel. When the water temperature level in the reactor gets to the temperature level needed for the response, start to drop the acrylic acid monomer liquid remedy and the initiator ammonium persulfate aqueous service, control the dropping price to keep the reaction temperature in between 85-90 ° C, as well as the polymerization response takes 3-5 hours. After the response is finished, cool down the polymerization fluid to room temperature, take samples as well as analyze numerous technological indicators, as well as pack them after fulfilling the demands.

About Products:
If you need Carbopol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Carbopol manufacturer and supplier, ZSpharmac will provide Carbopol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.