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Carbopol 940 CAS 76050-42-5

Molecular Formula: (C3H4O2)n

Formula Weight: 0

ZSpharmac: Carbopol 940 Supplement

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Product Name: Carbopol 940
CAS No: 76050-42-5
Purity: 99%

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Basic Info

Product Name:Carbopol 940
Other Names:CARBOMER
CAS:76050-42-5
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:202-415-4
Storage:-20°C
Provide:Carbopol 940 MSDS;
Carbopol 940 COA

What is Carbopol 940?

Carbopol 940, additionally called carbopol, is a high molecular polymer cross-linked by acrylic acid and allyl sucrose ether or allyl pentaerythritol ether. The study on Carbopol started in the 1950s as well as was first established and produced by the American Goodrich Business. By the 1970s as well as 1980s, the study on Carbopol 940 had matured and was widely utilized, mainly for cosmetics and pharmaceuticals. in research study and production. Its appearance is white powder, soluble in water, ethanol as well as glycerol, as well as its glass shift temperature is 100 ~ 105 ℃.

The particle has 56%-68% carboxyl teams, revealing weak level of acidity, as well as the pH of 0.5% liquid diffusion is 2.7-3.5. After Carbopol 940 is reduced the effects of as well as the carboxyl group is ionized, because of the shared repulsion of adverse charges, the molecular chain is diffused as well as extended, as well as it remains in a state of wonderful growth and also thickness. Counteracted gels are not sensitive to UV direct exposure, are not impacted by temperature, and also do not support microbial mold and mildew development. Carbomer has excellent enlarging, suspending as well as emulsifying residential properties as well as is extensively used in the fields of medicine and cosmetics.

Only a percentage of Carbopol 940 can accomplish the called for thickness, the common dosage is 0.10%-0.50%, and also it has the impact of enlarging as well as maintaining, to make sure that it can prepare solutions with a wide variety of viscosity and also various rheological properties, Cream as well as gel items. And also other thickeners such as cellulose, xanthan periodontal, and so on are made use of in really high focus (about 2%) to achieve the same effect. With the enhancement of living standards, people pay an increasing number of interest to the maintenance of personal body, so the demand for cosmetics and medical and also healthcare products is raising, that makes the preparation and application of Carbopol 940 have wide prospects.

Classification of Carbopol 940

According to the various degree of polymerization, Carbopol 940 can be divided into different requirements, amongst which Carbopol 934, 940, 941 are one of the most extensively made use of. According to the various viscosity, residential carbomer is divided right into 3 specs: high thickness, tool thickness as well as reduced viscosity. Due to the fact that its molecular structure consists of 52% to 68% of acid groups, it has a certain level of acidity. The pH of a 1% aqueous diffusion is 2.5 to 3.0. It can be reduced the effects of with an alkaline option to develop a gel.

After Carbopol 940 is neutralized to ionize the C group, due to the common repulsion of adverse charges, the molecular chain is spread and stretched, and it remains in a state of wonderful expansion as well as thickness. The gel made from carbomer is simple to spread, non-greasy, has good bond and harmony, is non-irritating to skin as well as mucous membranes, does not pollute clothing, as well as makes the drug release no or near absolutely no. Control the launch of the drug to a certain degree and also boost the effectiveness of making use of the medicine.

Application of Carbopol 940

When Carbopol 940 is an anionic adhesive, it cannot be used in combination with divalent basic drugs to avoid precipitation. The bioadhesive drug delivery system (BDDS) acts on the epidermal cell mucosa or skin surface of various cavities, such as the gastrointestinal tract, vagina, oral cavity, nasal cavity, epidermis, etc. The dosage forms include tablets, films, gels doses, sticks, etc. Among them, gel is a new type of bioadhesive drug delivery system that has developed rapidly in recent years. It has good dispersibility, strong adhesion, good stability, long-lasting efficacy, convenient application, and can avoid first-pass effect and administration site. Advantages of high concentration.

1) Gastrointestinal bioadhesives

The sulpiride matrix sustained-release retention tablet made of Carbopol 940 can adhere to the surface of gastrointestinal mucin or epithelial cells to prolong the retention time and achieve the purpose of sustained release. In vivo studies in rabbits show that compared with oral solution and powder injection, the AUC of the sustained-release retention tablet can be increased by more than 1 times, the mean retention time (MRT) can be prolonged by 4 to 5 times, and the bioavailability is improved.

2) Vaginal bioadhesives

Gel of metronidazole liposomes and clotrimazole liposomes with carbomer 974NF in the treatment of vaginitis. The in vitro test showed that about 50% metronidazole and 30% clotrimazole remained in the gels after the two drug-containing liposome gels were released for 24 hours. And the stability test showed that carbomer 974NF could maintain two kinds of liposome particle size distribution, indicating that the bioadhesive liposome gel is suitable for local treatment of vaginal diseases. In order to avoid the removal of the uterus in patients with uterine cancer, the preparation based on Carbopol 940 can be administered through the vagina to make the drug adhere to the uterine mucosa, kill cancer cells without damaging normal cells, and avoid removal of the uterus.

Using an appropriate proportion of hydroxypropyl cellulose (HPC) and carbomer as an adhesive, bleomycin can be directly compressed into a tablet or made into a duckbill suppository, which can be adhered to the cervix, and the formulation can be seen after 24 hours. Therefore, it is speculated that the dosage form can achieve satisfactory results in the treatment of uterine cancer.

3) Oral bioadhesive

After the drug is absorbed through the oral mucosa, it can directly enter the systemic circulation to avoid the first-pass effect. The apparent release rate constant of felodipine oral mucoadhesive tablets prepared with hypromellose (HPMC) K4M and carbomer 974P as bioadhesive polymers was 3.3% h-1, and the average adhesive force was 131.08-181.35g. It has been verified by in vivo experiments that the preparation has suitable adhesion to the oral cavity and is less irritating to the oral mucosa. In order to obtain a good effect on the treatment of periodontitis, metronidazole oral adhesive tablets were prepared with carbomer 940 and hydroxyethyl cellulose (HEC). It can be slowly released in the oral cavity, and the drug concentration detected in 12h is higher than the minimum inhibitory concentration.

4) Nasal bioadhesives

Nasal administration can be used for special patients where oral and intravenous administration is inconvenient or difficult to implement. Using Carbomer 971P as an excipient, apomorphine nasal powder was developed. The research on its sustained release shows that the bioavailability of this dosage form is equivalent to that of subcutaneous injection, and it has a sustained release effect. Najafabadi et al [14] reported that insulin was made into a carbomer gel spray.

1) Solid preparation

The tablet made of Carbopol 940 as the hydrophilic gel skeleton gradually absorbs water and swells in the release medium, and the drug gradually diffuses to the surface of the tablet for release. As the gel content increases, the swelling layer thickens and the drug release rate gradually slows down.

2) Injection

In recent years, the development of sustained-release injection drug delivery systems has attracted the attention of many pharmaceutical researchers. The drug delivery system can be implanted at a fixed point, release the drug locally, and release the drug for a long time. It can reduce the adverse drug reaction and improve the compliance of patients. The cyclosporine liposomes modified with carbomer 941 were administered intravenously to rats, the results showed that the transport of cyclosporine to the spleen and liver and other organs was significantly increased, and the concentration ratio of cyclosporine in tissue/plasma was the same as that of ordinary liposomes 2 times.

In the heart transplantation test, the average survival time of the rats in the Carbopol 940-modified liposome group, the ordinary liposome group and the control solution group was 18.8, 14.2 and 7.6 days, respectively. According to Fick’s first law of diffusion, the viscosity of liposomes modified by Carbopol 940 increases, the diffusion rate of the drug is slowed down, and the residence time of the drug in the body is prolonged, thereby enhancing the targeted transport and immunosuppressive effects of the drug.

1) Gel for skin

The gel is used on the skin surface, with good spreadability, no greasy feeling, and no pollution to clothes. The transdermal absorption rate is faster than that of the cream. Compared with the external solution, the gel has a longer residence time on the skin surface. The clemastine fumarate gel prepared with 1% carbomer 940 has good uniformity and dispersibility, simple preparation process and controllable quality.

2) Eye gel

Many ophthalmic drugs are poorly absorbed, mainly due to the accelerated elimination of tears. The ophthalmic gel prepared with carbomer can prolong the residence time of the drug in the eye and increase the absorption of the drug.

3) Gel for teeth

The triclosan dental paste prepared with carbomer 974P showed a zero-order release pattern. There are other reports,

The use of carbomer gel matrix has good adhesion and film-forming properties, and the addition of protein coagulants containing desensitizing drugs formaldehyde and thymol can prolong the time that the drug stays locally on the teeth and enhance the desensitization effect.

The main function of carbomer for oral suspension is to thicken, improve system rheology, suspend and provide bioadhesion. Carbomer can form a uniformly dispersed skeleton system in water, and insoluble components can be wrapped in the skeleton gap of the system. The physical stability and stabilization mechanism of the resin microcapsule suspension were studied, and it was shown that the carbomer exerted a stabilizing effect through single-point or multi-point adsorption with the resin microcapsule to generate space bridges.

Using Carbomer 934 as the suspending agent to prepare the aluminum hydroxide suspension, after shaking and sub-packaging, the particles settle slowly, do not agglomerate after settling, and have good dispersibility, which overcomes the tendency of the gel to become sticky and agglomerated during storage, and it is not easy to dumping phenomenon. The clarithromycin dry suspension prepared with 0.3%-0.5% carbomer 974P NF as the suspending agent, the whole system is relatively uniform and stable, and the sedimentation ratio conforms to the provisions of the 2000 edition of the Chinese Pharmacopoeia.

Preparation of Carbopol 940

A carbomer material, consisting of the sticking to raw materials partly by mass: 10-110 parts of carboxylic acid monomers, 0.01-1.5 parts of cross-linking representative, 10-1000 parts of water; 0.01-5.0 parts of various other sustaining reps; the prep job approach makes up: Follow the actions listed here:
1) Include 10-110 parts of carboxylic acid monomers, 0.01-1.5 parts of cross-linking depictive monomers, 10-1000 parts of water, as well as also 0.01-5.0 parts of various other ingredients right into the container, as well as mix them consistently to acquire the material fluid to be polymerized. The feed liquid is irradiated under the electron beam of light at a certain rate, and the feed fluid quickly expands right into a gel.
2) Dry and also cut the gel in step 1) right into bits;
3) Pulverize the granules of step 2) right into a white fine powder of carbomer product.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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