Carbenoxolone CAS 5697-56-3

Molecular Formula: C34H50O7

Formula Weight: 570.76

ZSpharmac: Carbenoxolone Supplier

Product Name: Carbenoxolone

CAS No: 5697-56-3

Purity: 99%

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Basic Info

Product Name:	Carbenoxolone
Other Names:	Carbenoxic Acid
CAS:	5697-56-3
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Cream Crystals Solid
EINECS No.:	227-174-2
Storage:	-20°C Freezer
Provide:	Carbenoxolone MSDS； Carbenoxolone COA

What is Carbenoxolone?

Carbenoxolone is just one of the deep processing products of licorice extract. Licorice is a frequently made use of standard Chinese medication, widely used in medicine, cigarette, food as well as other fields. Its primary energetic component, glycyrrhizic acid, has corticotropic hormone-like results and also can be used for detoxification, anti-inflammation, antitussive, anti-tumor, etc. In the human body, Carbenoxolone is hydrolyzed by gastric acid or disintegrated by β-glucuronidase in the liver to form glycyrrhetinic acid.

Carbenoxolone Property

Melting point	291-294 °C
alpha	D20 +128° (chloroform)
Boiling point	553.75°C (rough estimate)
density	1.20
refractive index	1.5820 (estimate)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	pKa 6.7 (Uncertain)
color	Cream crystals
Water Solubility	6.621mg/L(24 ºC)

Carbenoxolone Uses

Carbenoxolone has the functions of anti-bacterial as well as anti-inflammatory, anti-oxidation, anti-aging, taking in ultraviolet rays, bleaching as well as lightening up skin, and also freckle removal; it can manage skin immune function, boost skin resistance to illness, get rid of inflammation, avoid allergies, clean the skin and also protect against the production of melanin, and also has lightening impact.
Carbenoxolone has anti-inflammatory, anti-ulcer, anti-allergic, anti-viral, hypolipidemic, antitussive, antiasthmatic, expectorant effects, and can likewise be used to prevent and deal with viral hepatitis, hyperlipidemia, and cancer cells. my nation is the primary exporter of licorice, and also it is of great value to perform deep processing as well as extensive application of licorice.

Carbenoxolone Preparation

Take 140g of glycyrrhizic acid powder (the content of glycyrrhizic acid is about 25% HPLC), add 1120ml of 95% edible ethanol, extract at 40°C for 3 hours, filter to remove insoluble impurities, distill the filtrate to recover ethanol to obtain the extract, and dry the extract on a water bath at 100°C , to obtain 118g of dry extract with a moisture content of not more than 20%; after crushing the dry extract, take 100g, add 300ml of 70% glacial acetic acid, add 7ml of concentrated sulfuric acid, hydrolyze and acetylate under normal pressure, and heat up to 98-103°C, React for 2 hours, after hydrolysis and acetylation are completed, cool to room temperature, filter the precipitated solid, wash the filter cake with 250ml 65% acetic acid, wash with 200ml ethanol, and finally wash with 300ml water, dry at 100°C to obtain acetyl Glycyrrhetinic acid crude product 20.21g, purity 88.2% (HPLC).

Take 20g of acetylglycyrrhetinic acid, add 300ml of water, add 5g of sodium hydroxide to adjust the pH to 13, hydrolyze under normal pressure for 4 hours under reflux, cool down to room temperature, acidify the pH to 5.2 with hydrochloric acid, filter, wash the filter cake with pure water to remove inorganic Salt, dry at 100 DEG C, obtain 17.8gCarbenoxolone crude product, purity 92.9% (HPLC), then glycyrrhetinic acid crude product is 95% ethanol dissolving with 214ml volume percentage concentration, add gac by 25% (4.45g) of Carbenoxolone crude product weight Carry out reflux decolorization, filter after reflux decolorization, after the filtrate recovers ethanol, precipitate solid, filter to obtain glycyrrhetinic acid 16.4g, purity 98.2% (neutralization method). For further purification, recrystallize three times with 95% ethanol to obtain a glycyrrhetinic acid product with a purity of 98% (HPLC). The total impurity peak is no more than 2%, and the single impurity peak is no more than 0.7%, which fully meets the European Pharmacopoeia standard.

Carbenoxolone Preparations

A kind of coated Carbenoxolone liposome, calculated by weight percentage, each raw material composition and content are as follows:

The lecithin is soybean lecithin with a PC content of 25%, an industrial-grade product produced by Beijing Meiyasi Phospholipid Technology Co., Ltd.;

The glycyrrhetinic acid is a standard product with a purity of 98%, Shanghai Ronghe Pharmaceutical Technology Development Co., Ltd.;

Described water-soluble grease is PEG-6 octanoic acid caprate, Fu Platinum Chemical Co., Ltd.;

The polyol is 1,2-propanediol, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

The surfactant is polyoxyethylene sorbitan laurate, a chemical grade product produced by Sinopharm Chemical Reagent Co., Ltd.;

The inorganic salt is magnesium sulfate, an analytical-grade product produced by Sinopharm Chemical Reagent Co., Ltd.

A kind of preparation method of above-mentioned coating Carbenoxolone liposome specifically comprises the steps:

(1) dissolving lecithin in polyol at 20-80°C to obtain a uniformly dispersed organic phase component A;

(2) dissolving glycyrrhetinic acid in water-soluble oil at 100-300° C. to obtain a uniformly dispersed organic phase component B;

(3) Mix organic phase A and organic phase B uniformly to obtain organic phase C;

(4) Dispersing and dissolving surfactant and inorganic salt in water to obtain uniformly dispersed water phase components;

(5) Stir the aqueous phase component obtained in step (4) at a stirring speed of 300 to 800 rpm, and at the same time add the organic phase component C obtained in step (3) slowly and uniformly, and stir to obtain the Carbenoxolone liposome mixture suspension;

(6) The glycyrrhetinic acid liposome suspension obtained in step (3) was sonicated at 20% to 40% ultrasonic power for 1 to 8 minutes, stirred until the system was homogeneous and naturally cooled down to room temperature to obtain Carbenoxolone liposomes.

Carbenoxolone: A Review of its Pharmacological Properties in Peptic Ulcer Disease

Carbenoxolone sodium has been shown to quicken the recovery of gastric as well as duodenal abscess, but its general value in duodenal ulcers may be low due to the high price of natural remission of duodenal ulcers. Additional research study is needed to decide whether it should be used prophylactically to postpone abscess recurrence. Carbenoxolone might act by impacting the proliferative activity of stomach epithelial cells and also the mucus-producing differentiation of epithelial cells (as well as favorably altering the physicochemical homes of mucous as well as by reducing digestion task), aspects that may be associated with the prevention of acute stomach ulcers. Numerous studies have revealed that ketone enhances the effect of a hospital stay and also bed rest on abscess recovery. Whether bed rest provides a fringe benefit of the medicine’ impact on ulcer healing in outpatients is likewise unclear. There is no evidence that sped up recovery with glycoxolone is connected with boosted overall end results. In patients in whom hospitalization is not feasible or desired, gomboxolone has the best benefit in increasing gastric ulcer recovery, however it needs to be provided just with cautious as well as regular monitoring of lotion electrolytes (particularly potassium), high blood pressure, as well as body weight. Usage in outpatients is feasible as well as when it is recognized that the patient will go to normal follow-up gos to. Patients have to be enlightened on the proper use of drugs. If serious mineralocorticoid-like harmful results take place, such as sodium as well as water retention and also hypokalemia, which occur in a variable percentage of individuals yet a lot of frequently in people that got an overdose, glycooxydone ought to be terminated and Deal with problems; they react to thiazide diuretics and potassium supplements, and may react to amiloride given in mix with low-dose thiazide diuretics. For individuals with moderate negative effects, ketone therapy can be proceeded and diuretics can be made use of at the same time. The very best results in the treatment of belly ulcers with the fewest adverse effects are taken with 100 mg gomboxolone tablet computers 3 times a day for the very first week, followed by 50 mg 3 times a day after that, ideally before meals. Older grownups and people with liver, heart, or kidney disease require reduced doses. Barium dishes or ideally endoscopies should be done occasionally and treatment continued till the abscess heals. The dosage for duodenal ulcer is 50 mg 4 times daily in unique positioned launch capsules. These are best taken around 20 mins before dishes.

About Products:
If you need Carbenoxolone, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Carbenoxolone, ZSpharmac will provide Carbenoxolone raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.