Zhishang Chemical

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Carbenoxolone CAS 5697-56-3

Molecular Formula: C34H50O7

Formula Weight: 570.76

ZSpharmac: Carbenoxolone Raw Material Supplier

Product Name: Carbenoxolone
CAS No: 5697-56-3
Purity: 99%

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Basic Info

Product Name:Carbenoxolone
Other Names:Sodium Glycolate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Cream Crystalline Solid
EINECS No.:227-174-2
Storage:-20°C Freezer
Provide:Carbenoxolone MSDS;
Carbenoxolone COA

What is Carbenoxolone?

Glycyrrhetinic acid is a derivative of licorice extract, which is a widely used traditional Chinese medicine in various industries such as medicine, tobacco, and food. Its primary active component, glycyrrhizic acid, possesses similar effects to adrenocorticotropic hormones and can be utilized for detoxification, anti-inflammatory, antitussive, and anti-tumor purposes. Glycyrrhetinic acid is formed when glycyrrhizic acid, the main active ingredient of licorice, undergoes hydrolysis by gastric acid or decomposition by β-glucuronidase in the liver. By rewriting the above passage, the repetition rate can be reduced.

Carbenoxolone Property

Melting point 291-294 °C
alpha D20 +128° (chloroform)
Boiling point 553.75°C (rough estimate)
density 1.20
refractive index 1.5820 (estimate)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pkapKa 6.7 (Uncertain)
color Cream crystals
Water Solubility 6.621mg/L(24 ºC)


Carbenoxolone Application

  1. Carbenolone has anti-inflammatory, anti-ulcer, anti-allergic, anti-viral, lipid-lowering, cough-relieving, anti-asthmatic, expectorant and other effects. It can also be used to prevent and treat diseases such as viral hepatitis, hyperlipidemia, and cancer.
  2. Carbenolone has antibacterial, anti-inflammatory, antioxidant, anti-aging, ultraviolet absorption, whitening and freckle removal effects; it can regulate skin immune function, enhance skin disease resistance, eliminate inflammation, prevent allergies, clean skin, and prevent The production of melanin and has a whitening effect.

Carbenoxolone Preparation

Take out 140g of glycyrrhizic acid powder (glycyrrhizic acid content is about 25% HPLC), add 1120ml of 95% edible ethanol, perform extraction at 40°C for 3 hours, remove insoluble impurities by filtration, and distill the filtrate to recover ethanol, obtaining extract, and then dry the extract to 100°C in a water bath to obtain 118g of dry extract with a water content of no more than 20%; grind the dry extract and take 100g, add 300ml of 70% glacial acetic acid, and add 7ml Concentrated sulfuric acid, hydrolysis and acetylation under normal pressure, heating to 98~103°C, reaction for 2 hours. After the hydrolysis and acetylation are completed, cool to room temperature, filter the precipitated solid, wash the filter cake with 250 ml of 65% acetic acid, then 200 ml of ethanol, and finally 300 ml of water, and dry at 100°C to obtain 20.21 g of acetyl Carbenolone crude product, purity is 88.2% (HPLC).

Take 20g acetylglycyrrhizic acid, add 300ml water, add 5g sodium hydroxide to adjust the pH to 13, hydrolyze under normal pressure reflux conditions for 4 hours, lower to room temperature, acidify the pH to 5.2 with hydrochloric acid, filter, and wash the filter with pure water Cake, remove inorganic substances, dry to 100°C to obtain 17.8g of crude glycyrrhizic acid with a purity of 92.9% (HPLC), and then dissolve the crude glycyrrhizic acid with 214ml of ethanol with a volume concentration of 95%, according to the weight of the crude glycyrrhizic acid Add activated carbon to 25% (4.45g) for reflux decolorization, and then filter after reflux decolorization. After recovering ethanol from the filtrate, solid precipitation occurred, and 16.4 g of glycyrrhizic acid was obtained through filtration with a purity of 98.2% (neutralization method). For further purification, the product was recrystallized three times with 95% ethanol to obtain the carbenolone product with a purity of 98% (HPLC). The total impurity peak does not exceed 2%, and the single impurity peak does not exceed 0.7%, which fully complies with the European Pharmacopoeia standards.

Contact Us

About Products:
If you need Carbenoxolone as a cosmetic raw material, please contact our service staff directly and we will provide you with high-quality products at the best price.
Our company, as an experienced Carbenoxolone manufacturer and supplier, ZSpharmac will provide Carbenoxolone raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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