Capryloyl Salicylic Acid CAS 78418-01-6

Molecular Formula: C15H20O4

Formula Weight: 264.32

ZSpharmac: Capryloyl Salicylic Acid Supplier

Product Name: Capryloyl Salicylic Acid

CAS No: 78418-01-6

Purity: 99%

Navigation Bar

Basic Info

Product Name:	Capryloyl Salicylic Acid
Other Names:	2-Hydroxy-5-(1-oxooctyl)benzoic acid
CAS:	78418-01-6
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Almost White Powder to Crystal
EINECS No.:	417-790-1
Storage:	Sealed in Dry,Room Temperature
Provide:	Capryloyl Salicylic Acid MSDS； Capryloyl Salicylic Acid COA

What is Capryloyl Salicylic Acid?

Capryloyl salicylic acid, commonly known as β-LHA (β-lipohydroxyacid, long-chain aliphatic hydrocarbon-β-hydroxycarboxylic acid), is an active compound developed by foreign countries in recent years and used in cosmetics. β-LHA is a salicylic acid derivative formed by introducing a lipophilic hydrocarbon group on the phenyl ring of salicylic acid, and its lipophilicity is enhanced compared with salicylic acid. It not just keeps the effect of salicylic acid on scrubing aging cutin, yet additionally improves the affinity with skin cells, and penetrates into the follicle much more quickly. It can be made use of as an outside active ingredient in cosmetics to postpone aging and also deal with blackheads.Through a short-term comparative study of 2% β-LHA and cosmetic functional ingredient additives 0.05% all-trans retinoic acid (RA) and 10% glycolic acid (GA), the results show that β-LHA, like RA, has the same effect on photoaging skin Degenerative changes have a clear repairing effect, manifested as the correction of epidermal dysplasia, dyskeratosis and atrophy, the increase of hyaline keratin granules, the thickening of the granular layer, the thinning of the stratum corneum, and the reduction of melanosomes , Skin whitening.

Capryloyl Salicylic Acid Property

Melting point	115 °C
Boiling point	454.8±35.0 °C(Predicted)
density	1.144
vapor pressure	97.3Pa at 21℃
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	2.68±0.10(Predicted)
form	powder to crystal
color	White to Almost white
Water Solubility	29.7mg/L at 20℃

Application of Capryloyl Salicylic Acid

CN201710937443.7 discloses a drug-carrying system of salicylic acid and its preparation method and application, wherein the drug-carrying system of salicylic acid includes the following components by weight percentage: caprylyl salicylic acid 1-5%; liquid lipid 10-30%; solid lipid 5-15%; surfactant 4.5-10%; pentanediol 1-5%; lecithin 0.2-2%; the balance is water. The present invention mixes liquid lipids and solid lipids as raw materials to embed octanoylsalicylic acid, and this drug-carrying system is a drug-carrying system of oil-in-fat-in-water (O/F/W), which has High embedding rate, high drug loading, high stability, low irritation, and good drug release characteristics; the medical aesthetic composition prepared by embedding caprylyl salicylic acid with the drug loading system provided by the present invention , helps brighten skin tone, remove dark spots, freckles, whiten, wrinkle, sterilize and reduce inflammation, remove acne and inhibit the production of melanin.

Preparation of Capryloyl Salicylic Acid

Add 94.6g (0.71mol) of AlCl3 to 236mL of CH2Cl2, stir at 10°C for 0.5h, and slowly add 50.0g (0.31mol) of octanoyl chloride (0.31mol) and 36.0g (0.24mol) of methyl salicylate in 79mL of CH2Cl2 solution dropwise within 2h . After the dropwise reaction was completed at 10°C for 5h, the temperature was raised to 30°C to continue the reaction for 12h. The mixture was poured into 600 mL of ice water containing 40 mL of concentrated hydrochloric acid and stirred, and the layers were separated. The aqueous layer was extracted with CH2Cl2. The organic layers were combined, washed with water, and concentrated to dryness to obtain 60.8 g of off-white solid. Suspend directly into 300mL ethanol without purification, then add 500mL aqueous solution dissolved in 55g NaOH, stir and react at 60°C for 6h, cool to room temperature after reaction, add 115mL concentrated hydrochloric acid while stirring, cool and precipitate a large amount of white precipitate, filter and wash with water 2 to 3 times, recrystallized from dichloromethane, and dried to obtain 44.7 g of off-white crystals, with a yield of 70.5%.

About Products:
If you need Capryloyl Salicylic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Capryloyl Salicylic Acid manufacturer and supplier, ZSpharmac will provide Capryloyl Salicylic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.