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Capryloyl Salicylic Acid CAS 78418-01-6

Molecular Formula: C15H20O4

Formula Weight: 264.32

ZSpharmac: Capryloyl Salicylic Acid Supplier

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Product Name: Capryloyl Salicylic Acid
CAS No: 78418-01-6
Purity: 99%

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Basic Info

Product Name:Capryloyl Salicylic Acid
Other Names:2-Hydroxy-5-(1-Oxooctyl)Benzoic Acid
CAS:78418-01-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Powder to Crystal
EINECS No.:417-790-1
Storage:Room Temperature
Provide:Capryloyl Salicylic Acid MSDS;
Capryloyl Salicylic Acid COA

What is Capryloyl Salicylic Acid?

Capryloyl Salicylic Acid, generally called β-LHA (β-lipohydroxyacid, long-chain aliphatic hydrocarbon-β-hydroxy carboxylic acid), is an energetic substance created abroad recently and used in cosmetics. β-LHA is a salicylic acid by-product formed by presenting a lipophilic hydrocarbon team on the phenyl ring of salicylic acid, and also its lipophilicity is boosted compared to salicylic acid. It not only maintains the result of salicylic acid on exfoliating aging cutin, yet additionally boosts the fondness with skin cells, as well as penetrates right into the follicle much more easily. It can be made use of as an external component in cosmetics to postpone aging and also deal with blackheads. With the short-term comparative research of 2% β-LHA and also aesthetic practical active ingredient additives 0.05% all-trans retinoic acid (RA) and 10% glycolic acid (GA), the outcomes show that β-LHA, like RA, has a clear fixing effect on photoaging skin degenerative changes.

Capryloyl Salicylic Acid Property

Melting point 115 °C
Boiling point 454.8±35.0 °C(Predicted)
density 1.144
vapor pressure 97.3Pa at 21℃
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
pka2.68±0.10(Predicted)
form powder to crystal
color White to Almost white
Water Solubility 29.7mg/L at 20℃

 

Application of Capryloyl Salicylic Acid

CN201710937443.7 reveals a salicylic acid drug-carrying system and also its prep work method and also application, in which the salicylic acid drug-carrying system consists of the adhering to parts in weight percent: Capryloyl Salicylic Acid 1-5%; fluid lipid 10-30%; strong lipid 5-15%; surfactant 4.5-10%; pentanediol 1-5%; lecithin 0.2-2%; The here and now development mixes liquid lipids as well as solid lipids as basic materials to install Capryloyl Salicylic Acid. This drug-carrying system is a drug-carrying system in oil-in-fat-in-water (O/F/W), which has high embedding price, high drug-loading capability, high security, reduced irritation, as well as good drug release features; the medical-cosmetic composition prepared by installing capryloyl salicylic acid with the drug-carrying system provided by the existing development assists to brighten skin color, eliminate dark spots, freckles, whiten, eliminate creases, Sterilizes as well as removes swelling, eliminates acne and inhibits the manufacturing of melanin.

Preparation of Capryloyl Salicylic Acid

1 Preparation of Octanoyl Chloride
Octanoyl chloride was prepared by standard techniques making use of n-octanoic acid as well as SOCl2 as resources as well as dichloromethane as solvent. The crude product was directly used in the next reaction without further purification.

2 Preparation of Capryloyl Salicylic Acid
Include 94.6 g (0.71 mol) of AlCl3 to 236mL of CH2Cl2, mix at 10 ° C for 0.5 h, after that slowly include octanoyl chloride 50.0 g (0.31 mol) and methyl salicylate 36.0 g (0.24 mol) dropwise in 79mL of CH2Cl2 within 2h. After the dropwise response was completed at 10 ° C for 5h, the temperature level was elevated to 30 ° C to proceed the reaction for 12h. The mix was poured into 600 mL of ice water containing 40 mL of concentrated hydrochloric acid as well as stirred, as well as the layers were separated. The aqueous layer was drawn out with CH2Cl2. The natural layers were combined, washed with water, as well as focused to dryness to acquire 60.8 g of beige solid. Suspend straight right into 300mL ethanol without filtration, after that include 500mL aqueous option liquified with 55g NaOH, mix as well as respond at 60 ° C for 6h, amazing to space temperature after response, add 115mL focused hydrochloric acid while mixing, awesome as well as precipitate a large quantity of white precipitate, filter, laundry with water 2-3 times, recrystallize with dichloromethane, completely dry to obtain 44.7 g of beige crystals, yield 70.5%.

About Products:
If you need Capryloyl Salicylic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Capryloyl Salicylic Acid manufacturer and supplier, ZSpharmac will provide Capryloyl Salicylic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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