Caprylyl hydroxamic acid is mainly used as an antibacterial agent and chelating agent in cosmetics and skin care products. It is relatively safe and can be used with confidence. It generally has no effect on pregnant women and has no acne-causing properties. Caprylyl hydroxamic acid is an ideal organic acid for antibacterial. It has high-efficiency and selective chelation ability for ferrous ions and ferric ions, and the growth of mold is limited in the environment with limited iron ions. At the same time, it has the optimal carbon chain length that can promote the degradation of cell membrane structure. Therefore, it has strong antibacterial ability and is a new substitute for preservatives.
Caprylyl hydroxamic acid can be used in cosmetics for anti-aging, moisturizing, anti-inflammatory, anti-oxidation, anti-acne, anti-wrinkle and other functions. It can help improve the elasticity of the skin, improve the fine lines of the skin, reduce wrinkles, improve the firmness of the skin, improve the pigmentation of the skin, improve the inflammation state of the skin, improve the antioxidant capacity of the skin, and improve the anti-acne ability of the skin , Improve the anti-aging ability of the skin, improve the anti-inflammatory ability of the skin, improve the antibacterial ability of the skin, improve the anti-sensitivity ability of the skin, etc.
Antiseptic and Antibacterial Efficacy of Caprylyl Hydroxamic Acid
Caprylyl hydroxamic acid is highly effective in inhibiting mold, and the minimum inhibitory concentration against Aspergillus niger is 0.078%. It has high safety and is widely used in Europe, the United States, Japan, and South Korea. As an organic acid, it can attack mold only when it is dispersed in the organism in an undissociated state. Therefore, caprylyl hydroxamic acid remains in an undissociated state from acidity to neutrality, and can effectively inhibit bacteria in this environment. Other preservative alternatives have no reasonable antiseptic efficacy in this environment
The Integrative Effects of Caprylyl Hydroxamic Acid
Caprylylhydroxamic acid has a highly efficient and selective chelation effect on Fe2+ and Fe3+. In iron ion-limited environment, the growth of mold is limited. Iron is a key element for microbial growth. Microorganisms release chelating agents (Siderophores), capture Fe3+ from the environment and convert it into Fe2+, and CHA has a high stability constant for chelating Fe3+, which can prevent mold from obtaining iron. It has high-efficiency chelation, inhibits the active elements required by mold, and limits the environment required for microbial growth.
Short-chain Epiactivation Effect of Caprylylhydroxamic Acid
Caprylyl hydroxamic acid, like caprylyl glycol, also has a carbon chain length (C8) that promotes the degradation of cell membrane structures. The microbial inhibition efficiency is related to the size of the alkyl carbon chain and the position of the hydroxyl group. Microorganisms with medium carbon chain length and ortho-hydroxy groups have better inhibitory effect. By interfering with the physiological environment of the inhibitory cell membrane, the short-chain structure selectively gathers on the water-oil interface in the oil-in-water emulsion system, making the food source of microorganisms in this area unfavorable to the growth of microorganisms and inhibiting the growth of microorganisms.
