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Zhishang Chemical

Caprylohydroxamic Acid CAS 7377-03-9

Molecular Formula: C8H17NO2

Formula Weight: 159.23

ZSpharmac: Caprylohydroxamic Acid Supplement

Product Name: Caprylohydroxamic Acid
CAS No: 7377-03-9
Purity: 99%

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Basic Info

Product Name:Caprylohydroxamic Acid
Other Names:Octanoyl Hydroxamic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:230-936-7
Storage:Room Temperature
Provide:Caprylohydroxamic Acid MSDS;
Caprylohydroxamic Acid COA

What is Caprylohydroxamic Acid?

Caprylohydroxamic Acid is an optimal bacteriostatic natural acid. Effective and also selective chelation of ferric and ferric ions, and also mold and mildew growth is restricted in ferric-limited environments. At the same time, it has the ideal carbon chain length that can advertise the degradation of cell membrane layer framework. As a result, it has solid anti-bacterial ability as well as is a brand-new replacement for preservatives. Octylhydroxamic acid is used to prepare octylhydroxamic acid.

Caprylohydroxamic Acid Property

Melting point 78°C
density 0.970
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White


Application Status of Caprylohydroxamic Acid in Cosmetics

Cosmetics are rich in nutrients, such as water, various oils, and various functional additives, which can provide rich carbon and nitrogen sources for microorganisms, so it is easy to cause microbial contamination, affecting product quality and even consumer safety and health. In order to prevent primary or secondary pollution of cosmetics, it is necessary to add preservatives to cosmetics to inhibit the growth and reproduction of microorganisms in the product and prolong the shelf life of the product. According to the US FDA and CTFA reports, there are about 100 kinds of preservatives allowed in cosmetics. my country’s 2015 edition of “Cosmetics Safety Technical Specifications” includes 51 permitted preservatives, and limits the maximum usage, usage conditions and cosmetic types. As cosmetics regulatory authorities in various countries pay more and more attention to the issue of cosmetic preservatives, continue to revise relevant regulations, and consumers have increased product safety awareness, and the safety requirements for products are getting higher and higher. Cosmetics manufacturers also put forward higher requirements for preservatives .

Traditional preservatives can meet the requirements of products for antibacterial properties, but most traditional preservatives have certain safety risks. For example, methylisothiazolinone has been repeatedly reported to cause consumers to suffer from skin contact dermatitis, and EU consumers The Safety Science Committee (SCCS) has carried out safety risk assessments many times. On July 6, 2017, the European Union promulgated Regulation (EU) 2017/1224 to reduce the maximum concentration of methylisothiazolinone from 0.01% to 0.0015%. And it is forbidden to be used in resident cosmetics; formaldehyde is an excellent preservative, but its carcinogenic risk is high and its safety is extremely low, while formaldehyde sustained-release preservatives achieve bacteriostatic effect by releasing formaldehyde, which has potential Sensitization; Bropol is a decomposing sterilization, which is easy to form carcinogenic nitrosamines; halogen bacteriostatic agents are highly irritating and have a high sensitization rate. Therefore, safe and efficient preservatives or raw materials with antiseptic effect are more and more popular among manufacturers, such as p-hydroxybenzene derivatives, glycols, amphiphilic molecules with medium carbon chains, organic acids, antimicrobial peptides, etc.

Caprylohydroxamic Acid, also known as octanoyl hydroxamic acid, is a kind of organic acid with strong chelating ability to metal ions, so it is often used as a scavenger in the field of mineral flotation, and it is also found in animal feed as a scavenger. growth agent. In recent years, it has been widely used in cosmetics. In addition to being used as a chelating agent in cosmetics, it is also used in whitening products as a tyrosinase inhibitor, and even widely used in cosmetics as a preservative synergist.

Use of Caprylohydroxamic Acid in Cosmetics

In 2019, the US Food and Drug Administration VCRP data statistics show that there are currently 227 formulas containing Caprylohydroxamic Acid, which are used in eye products, lip products, baby products, washing products, and products that come into contact with mucous membranes. There are many cases in the open literature of the compound use of octanoylhydroxamic acid and other preservatives, and the compounded preservative system is used in a variety of formulations. Studies have shown that Caprylohydroxamic Acid can be compounded with other preservatives in a small amount to play a synergistic effect. The compound preservative system is comprehensively evaluated through the antiseptic challenge test and allergic patch test. The results show that the antiseptic system has antibacterial properties in lotion, O/W emulsion, O/W cream, and W/O cream formulations. The performance is good, and it is mild and non-irritating. Zhang Han et al. studied the microbial challenge test of Caprylohydroxamic Acid and glycerol caprylate compound antibacterial agent in five cosmetic formulations including water, cream, gel, shampoo, and hair care, and found that the compound antibacterial system has Good antiseptic effect. The chicken embryo chorioallantoic membrane blood vessel test was carried out on the mask essence containing the antiseptic system, and the results showed that there was no damage stimulation, and there was no bleeding damage to the capillaries at this time; while the results of the mask essence containing 0.1% MIT showed that it was relatively Severe traumatic stimulation, at this time more serious bleeding damage to capillaries occurs. In another literature report, a new compound moisturizing preservative composed of ethylhexylglycerol, glycerol caprylate, 1,2-hexanediol, caprylyl hydroxamic acid and 1,3-propanediol was explored in water preparation, The antibacterial effect of lotion, facial mask, cream and other skin care products. The results show that the compound antiseptic system can show good antibacterial effect in different formulations of cosmetics. Among them, the amount of Caprylohydroxamic Acid added to cosmetics is 0.045 %-0.063% can achieve synergistic effect with other preservatives. US Patent Nos. 110,351,523 and 10,407,528 also mention the use of capryloylhydroxamic acid or a mixture of caprylylhydroxamic acid and glycerol caprylate in sunscreen formulations as a preservative.

Cosmetic Safety Issues of Caprylohydroxamic Acid

Whether Caprylohydroxamic Acid is used as a chelating agent or a preservative in cosmetics, its safety is also of concern. As early as 2012, Australia’s National Industrial Chemicals Notification Assessment Service (NICNAS) assessed the human health hazard of octanoylhydroxamic acid. Bovine corneal opacity and permeability (BCOP) was used to test 20 % octanoylhydroxamic acid solution, and octanoylhydroxamic acid was not regarded as a corrosive or severely irritating substance under the test conditions. 100 % Capryloylhydroxamic acid is also proven to be non- or minimally irritating to the eye by the EpiOcular™ corneal model. Capryloylhydroxamic acid is not irritating to the eyes by two in vitro eye irritation tests. Chinese patent [4] CN 102920612 A has an octanoyl hydroxamic acid content of 8-12% in the compound preservative proposed by CN 102920612 A. The Draize test shows that when the usage amount is 1.2%, it is slightly irritating to the acute eye irritation of rabbits. , but it cannot be determined whether it is caused by octanoyl hydroxamic acid or phenethyl alcohol in the preservative. For this product, Xu Jinrong et al. also conducted an acute skin irritation test. The test showed that a single exposure of the sample to rabbits would not cause skin irritation. In June 2019, the US Cosmetic Ingredient Evaluation (CIR) also released the draft “Safety of Octanoyl Hydroxamic Acid for Cosmetics”. Although no final conclusion has been reached, many experimental data deserve attention. Capryloylhydroxamic acid was applied to the EpiDerm™ skin model reconstituted with keratinocytes, tested according to standard OECD TG 439, and capryloylhydroxamic acid is classified as a non-irritating substance.

At present, except for the Apobase containing Caprylohydroxamic Acid that was published in Finland to cause contact dermatitis, there are no other reports at home and abroad such as adverse reactions such as contact dermatitis caused by this substance. CIR has collected a number of reports and results using Caprylohydroxamic Acid to test the Human Repetitive Injury Patch Test (HRIPT), with varying concentrations ranging from 0.105 % minimum to 100 % undiluted capryloylhydroxamic acid Powder, volunteers also ranged from 52 to 109. During the test, some volunteers noticed scattered, transient, barely observable mild erythema, and occasional edema; the researchers said that in The results of testing in the same way, neither the number of positive reactions nor the degree of reaction are proportional to the dilution concentration. HRIPT test results show that octanoylhydroxamic acid is not an irritant or sensitizer.

NICNAS calculates the limit of exposure (MOE) by assuming that a 60 kg woman is exposed to 15 types of leave-on and rinse-off cosmetics containing a certain concentration of Caprylohydroxamic Acid and NOAEL every day. The acylhydroxamic acid does not pose a safety concern when the maximum concentration does not exceed 0.3 %.

With the gradual improvement of people’s requirements for cosmetics, safety and low irritation have become the basic elements of cosmetics, and substances with high irritation, high risk and low safety will be slowly replaced and eliminated. Caprylohydroxamic Acid has not been included in the list of preservatives or other prohibited or restricted use lists, whether domestically or abroad, so it will be subject to certain restrictions when it is listed as a preservative in the domestic cosmetics filing, and domestic reports on its safety are relatively low. few. Studies have shown that capryloylhydroxamic acid has no eye irritation, no skin irritation, and no potential sensitization. Although it is difficult to achieve a good bacteriostatic effect when used alone, it is similar to the low-irritant ethylhexylglycerol of the same natural source. , Glycerin caprylate can effectively inhibit the growth of microorganisms; when used in combination with traditional preservatives, it can effectively reduce the amount of traditional preservatives, thereby reducing the overall irritation, and effectively solve the problem of cosmetic safety. Has broad application prospects.

About Products:
If you need Caprylohydroxamic Acid, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Caprylohydroxamic Acid manufacturer and supplier, ZSpharmac will provide Caprylohydroxamic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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