Whether Caprylohydroxamic Acid is used as a chelating agent or a preservative in cosmetics, its safety is also of concern. As early as 2012, Australia’s National Industrial Chemicals Notification Assessment Service (NICNAS) assessed the human health hazard of octanoylhydroxamic acid. Bovine corneal opacity and permeability (BCOP) was used to test 20 % octanoylhydroxamic acid solution, and octanoylhydroxamic acid was not regarded as a corrosive or severely irritating substance under the test conditions. 100 % Capryloylhydroxamic acid is also proven to be non- or minimally irritating to the eye by the EpiOcular™ corneal model. Capryloylhydroxamic acid is not irritating to the eyes by two in vitro eye irritation tests. Chinese patent [4] CN 102920612 A has an octanoyl hydroxamic acid content of 8-12% in the compound preservative proposed by CN 102920612 A. The Draize test shows that when the usage amount is 1.2%, it is slightly irritating to the acute eye irritation of rabbits. , but it cannot be determined whether it is caused by octanoyl hydroxamic acid or phenethyl alcohol in the preservative. For this product, Xu Jinrong et al. also conducted an acute skin irritation test. The test showed that a single exposure of the sample to rabbits would not cause skin irritation. In June 2019, the US Cosmetic Ingredient Evaluation (CIR) also released the draft “Safety of Octanoyl Hydroxamic Acid for Cosmetics”. Although no final conclusion has been reached, many experimental data deserve attention. Capryloylhydroxamic acid was applied to the EpiDerm™ skin model reconstituted with keratinocytes, tested according to standard OECD TG 439, and capryloylhydroxamic acid is classified as a non-irritating substance.
At present, except for the Apobase containing Caprylohydroxamic Acid that was published in Finland to cause contact dermatitis, there are no other reports at home and abroad such as adverse reactions such as contact dermatitis caused by this substance. CIR has collected a number of reports and results using Caprylohydroxamic Acid to test the Human Repetitive Injury Patch Test (HRIPT), with varying concentrations ranging from 0.105 % minimum to 100 % undiluted capryloylhydroxamic acid Powder, volunteers also ranged from 52 to 109. During the test, some volunteers noticed scattered, transient, barely observable mild erythema, and occasional edema; the researchers said that in The results of testing in the same way, neither the number of positive reactions nor the degree of reaction are proportional to the dilution concentration. HRIPT test results show that octanoylhydroxamic acid is not an irritant or sensitizer.
NICNAS calculates the limit of exposure (MOE) by assuming that a 60 kg woman is exposed to 15 types of leave-on and rinse-off cosmetics containing a certain concentration of Caprylohydroxamic Acid and NOAEL every day. The acylhydroxamic acid does not pose a safety concern when the maximum concentration does not exceed 0.3 %.
With the gradual improvement of people’s requirements for cosmetics, safety and low irritation have become the basic elements of cosmetics, and substances with high irritation, high risk and low safety will be slowly replaced and eliminated. Caprylohydroxamic Acid has not been included in the list of preservatives or other prohibited or restricted use lists, whether domestically or abroad, so it will be subject to certain restrictions when it is listed as a preservative in the domestic cosmetics filing, and domestic reports on its safety are relatively low. few. Studies have shown that capryloylhydroxamic acid has no eye irritation, no skin irritation, and no potential sensitization. Although it is difficult to achieve a good bacteriostatic effect when used alone, it is similar to the low-irritant ethylhexylglycerol of the same natural source. , Glycerin caprylate can effectively inhibit the growth of microorganisms; when used in combination with traditional preservatives, it can effectively reduce the amount of traditional preservatives, thereby reducing the overall irritation, and effectively solve the problem of cosmetic safety. Has broad application prospects.
