Zhishang Chemical

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Zhishang Chemical

Cantharone CAS 514-78-3

Molecular Formula: C40H52O2

Formula Weight: 564.85

ZSpharmac: Cantharone Supplement

Product Name: Cantharone
CAS No: 514-78-3
Purity: 99%

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Basic Info

Product Name:Cantharone
Other Names:Canthaxanthin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Dark Purple Crystalline Powder
EINECS No.:208-187-2
Provide:Cantharone MSDS;
Cantharone COA

What is Cantharone?

Cantharone is an all-natural pigment with terrific capacity of anti-oxidants.It is almost two times that of vitamin E, as well as fifty times that of vitamin E, likewise referred to as incredibly vitamin E. In 1984, FDA/WHO accepted Cantharone as a preservative and well established top quality criteria. Cantharidin has actually been widely utilized as colorant, nutrient and also anti-oxidant to be contributed to food, feed as well as cosmetics. All-natural Cantharone exists in certain mushrooms, shellfishes, fish, algae, eggs, blood as well as liver in really percentages, and some bacteria can also produce cantharidin.

Cantharone Property

Melting point 217~218℃
Boiling point 717.0±40.0 °C(Predicted)
density 1.003±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly)
form neat
color Very Dark Red to Black


Cantharone Uses

  1. Cantharone is used for edible orange coloring, used in beverages, ice cream, waffles and other unadulterated biscuits k sauces, processed tomato products, processed meat products, etc. Appropriate amount is added to the white cake pre-made powder, it can have apricot color, and the residual rate of pigment after baking can reach 96%. Adding 11 mg/kg to pork sausage can obtain the same color as beef products.

Pharmacological Effects of Cantharone

The rat dental cancer cells experiment verified that Cantharone has a considerable repressive impact on tumor proliferation and also can considerably lower the incidence of cancer cells. Supplementing cantharidin can minimize the incidence of breast tumors by 65%, as well as cantharidin can also lower the carcinogenicity of methyl nitroso urea, which has an excellent impact on decreasing the number and volume of methyl nitroso urea-induced breast lump cells. On top of that, feeding Cantharone can significantly hinder the occurrence of thymoma, melanoma, and fibrosarcoma. The toughness of this inhibitory effect is directly related to the feeding dose, feeding time and sex of speculative computer mice.

Cantharone is an exceptional photoprotectant and anti-oxidant. Many clinical tests have actually shown that the combination of cantharidin and beta-carotene is better than beta-carotene alone for the treatment of hematopoietic protoporphyrin (EPP) as well as complex light condition (PMLE) patients. The consumption of Cantharone can improve the activities of glutathione peroxidase, catalase, superoxide dismutase, etc, and properly manage the equilibrium of oxidation-antioxidant system in vivo, thus inhibiting cholesterol-induced oxidative anxiety.

Cantharone has immunomodulatory activity as well as functions as an immunomodulatory compound in human beings. Cantharidin can enhance the resistance of the body by boosting the phagocytic ability of macrophages, promoting the makeover of lymphocytes, raising the number of lymphocytes, and improving the vitality of natural killer cells.

Extreme exposure of unsafe skin to the sun can result in sunburn, which can cause light-induced oxidation, swelling, immunosuppression, aging, as well as also canceration of skin cells. Preclinical studies have revealed that normal dietary antioxidants can lower these damages. Cantharone has an excellent effect on genetic photodermatosis, especially in the treatment of polymorphic light eruption. It additionally blocks light-induced skin cancer cells and UV-induced immunosuppression.

Cantharone can properly protect and lower oxidative damage to osteoblasts, and afterwards secure osteoblast expansion by quenching free radicals and promote bone formation. Studies have discovered that canthaxanthin can effectively enhance osteoblast spreading as well as relieve distinction, suggesting that Cantharone might be involved in the governing activities associated with bone metabolic process. Coupled with its solid antioxidant ability, it might have a certain precautionary or adjuvant treatment value for aging-induced osteoporosis.

Cantharone Preparation

Method 1: Cantharone preparation: put 26.84g (0.05mol) β-carotene and 100ml of dichloromethane in a 500ml three-necked flask, stir to dissolve, and then add 1.36ml of 2wt% to the solution at a rate of 2 drops/s. Hydrogen peroxide and 1.66g KI aqueous solution, then slowly add 32.44g (0.2mol) m-chloroperoxybenzoic acid to the reaction system at a temperature of 25°C, and react for 7h to obtain Cantharone obtained by oxidation of β-carotene. Detected by ultraviolet spectrophotometer, the yield of product Cantharone is 81.1% after calculation.

Purification process: add 0.5g antioxidant to the mixture solution containing the target product Cantharone, the antioxidant is a tert-butylphenol-containing antioxidant, wash twice with 5wt% sodium thiosulfate solution, and then once with deionized water , and then the solvent was removed by rotary evaporation to obtain the crude product. The obtained crude product was heated to 60° C. in an ethanol solution, refluxed for 12 h, and then cooled for recrystallization. The solid obtained by recrystallization was put into a hydrothermal reactor, and the hydrothermal reaction was carried out at a temperature of 100 °C, and the transposition time was 16 h. The translocated solid was taken out and dried in a vacuum at 40° C. for 6 hours to obtain the product Cantharone, which was detected with an ultraviolet spectrophotometer, and the product purity was 93.2%.

Method 2: Add 6g β-carotene (99%, 0.01106mol) and 120ml dichloromethane to a 500ml four-necked flask, add 8g aqueous hydrogen peroxide solution (10%w/w, 0.02352mol) and 0.03g tetrabutyl bromide ammonium chloride, vacuum and nitrogen supplement three times, cool down to 0~5 ℃, very slowly dropwise add 27.6g of sodium hypochlorite aqueous solution pre-cooled to 5 ℃ (available chlorine content is 1.5wt%, 0.01166mol, pH value is adjusted to 7), dropwise The temperature during the addition is controlled at 0-5°C, after the dropwise addition, the temperature is kept at this temperature for 6 hours, and then the oil layer and the water layer are obtained by standing for stratification. After that, it was washed once with 100ml of 2% w/v sodium sulfite aqueous solution and once with 100ml of water, the oil layer was concentrated to dryness, 50ml of ethanol was added, isomerized at 70°C for 8h, cooled to room temperature, filtered, and dried in vacuo to obtain 5.52g of Cantharone with the content of 93.13%, the molar yield is 82.41%.

Biological origin of Cantharone

The extreme halophilic bacteria mutant TM was isolated in April 1996 from soil samples in a seawater evaporation pond in Egypt. containing 1% yeast
Cream, 0.75% casamino acid, 25% sodium chloride, 4% magnesium sulfate, 0.2% potassium chloride, pH 7.2 medium, cultured in shake flasks at 37 °C for 6 d, the mutant strain TM can 2.06 mg of total carotenoids/g stem cells were produced, including 0.06 mg of beta-carotene and 0.7 mg of canthaxanthin. The unique characteristics of the mutant TM are as follows: ① the concentration of sodium chloride in the medium is particularly high, which is beneficial to prevent contamination by other microorganisms, and because of this, no sterilization procedures are required; ② less than 10% sodium chloride The concentration induces cell autolysis. Therefore, cell lysis occurs automatically in fresh water, and no cell disintegration apparatus is required; ③ Moreover, the procedure for extracting and purifying carotenoids from mutant TM is simpler than from other sources, just as bacterial carotenoids are more The carotenoids should be easily isolated. Because of the above characteristics, mutant TM is one of the most promising sources of Cantharone for fish, poultry and food industries. By obtaining high-yielding mutants or isolating a cloned gene related to carotenoid biosynthesis from bacterial cells to increase production.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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