Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Caffeic Acid Sigma CAS 331-39-5

Molecular Formula: C9H8O4

Formula Weight: 180.16

ZSpharmac: Caffeic Acid Sigma Supplement

Product Name: Caffeic Acid Sigma
CAS No: 331-39-5
Purity: 99%

Navigation Bar

Basic Info

Product Name:Caffeic Acid Sigma
Other Names:Caffeic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow to Tan Powder
EINECS No.:206-361-2
Provide:Caffeic Acid Sigma MSDS;
Caffeic Acid Sigma COA

What is Caffeic Acid Sigma?

Caffeic Acid Sigma, also known as 3,4-dihydroxycinnamic acid or 3,4-dihydroxy-cinnamic acid (3,4-dihydroxy-cinnamic acid), yellow crystal, is an intermediate product of the phenylpropane metabolic pathway in tobacco, and is also a woody The metabolites of the glucoside synthesis pathway, mainly in the form of glucosides and esters, are phenolic substances in tobacco. Tobacco phenolic compounds are one of the important components that produce tobacco aroma. They not only directly affect the color of tobacco leaves, but also indirectly affect the quality and flavor of smoke. Their degradation products can also improve the smoking taste of tobacco products, which is an important indicator for measuring the quality of tobacco leaves. . Therefore, the determination of Caffeic Acid Sigma content in tobacco is of great significance for judging the quality and style characteristics of tobacco leaves.

Caffeic Acid Sigma Property

Melting point 211-213 °C (dec.) (lit.)
Boiling point 272.96°C (rough estimate)
density 1.2933 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. 2-8°C
solubility ethanol: 50 mg/mL
form powder
color yellow to tan
Water Solubility soluble in hot water


Caffeic Acid Sigma Uses

  1. Caffeic Acid Sigma is made use of as a reagent for organic synthesis.
  2. Caffeic Acid Sigma is utilized as an intermediate for caffeic acid. for organic synthesis.
  3. Caffeic Acid Sigma is a normally taking place phenolic acid substance in plants. It is an anti-oxidant that hinders the synthesis of leukotrienes (leukotrienes are involved in the guideline of resistance, swelling and also level of sensitivity), inhibiting Cu2+-generated oxidation of LDL.
  4. Caffeic Acid Sigma Antioxidant all-natural nutritional phenolic substances discovered in plants. Hinders the synthesis of leukotrienes associated with immune guideline, swelling as well as allergic reaction. Likewise prevents Cu2+-caused LDL oxidation.

Pharmacological study of Caffeic Acid Sigma

Sun Xiaomeng et al., from the Cancer Hospital of the First Affiliated Hospital of Henan University of Science and Technology, investigated the effects of Caffeic Acid Sigma on the biological behaviors of esophageal squamous cell carcinoma KYSE150 cells, including proliferation, migration, invasion, and the growth of subcutaneously transplanted tumors in nude mice. Methods: KYSE150 cells were treated with 0, 5, 10, 20, and 50 μmol/L caffeic acid for 12, 24, 48, 72, and 96 h, respectively, and the cell proliferation ability was detected by CCK-8 kit; KYSE150 cells were treated with 20 μmol/LCaffeic Acid Sigma. After 96 h of cells, the ability of cell migration and invasion was detected by Transwell chamber; KYSE150 cells labeled with luciferase were inoculated subcutaneously in nude mice, and after subcutaneous tumor formation, they were randomly divided into control group, low-concentration caffeic acid group and high-concentration caffeic acid group 5 rats in each group were given 100 μL 3 g/L sodium hydroxymethyl cellulose, 50 or 100 mg/kg Caffeic Acid Sigma intraperitoneal injection, once daily for 4 weeks. After 4 weeks, the growth of subcutaneous tumors was detected by small animal in vivo imaging method, and the nude mice were killed by de-neck method, and the subcutaneous tumors were stripped and weighed. Results: 5-50 μmol/L caffeic acid could inhibit the proliferation of KYSE150 cells (P<0.05), and the higher the concentration of caffeic acid, the stronger the inhibition. 20μmol/L caffeic acid could inhibit the migration and invasion ability of KYSE150 cells (P<0.05). The volume and mass of subcutaneous tumors in tumor-bearing mice in the low and high concentrations of caffeic acid groups were both lower than those in the control group (P<0.05). Conclusion: Caffeic Acid Sigma can inhibit the malignant biological behaviors of KYSE150 cells such as proliferation, migration, invasion and the growth of transplanted tumor in nude mice.

Preparation of Caffeic Acid Sigma

Caffeic Acid Sigma is generally made up of 3,4-dihydroxybenzaldehyde, 3-methoxy-4-hydroxybenzaldehyde, 3,4-dimethoxybenzaldehyde, 3,4-methylenedioxybenzaldehyde and substituted Cinnamate is prepared through equivalent chemical synthesis responses such as condensation reaction, demethylation response and also hydrolysis reaction.

Residential patent CN103804178A reported the synthesis of Caffeic Acid Sigma by alternative reaction, oxidation reaction and addition reaction making use of catechol as raw material. In the addition response, pyridine is made use of as the reaction solvent as well as the condensation driver. The solvent usage is big, the procedure is complicated, the production price is high, the item return is reduced (just around 70%), and the pureness is poor. As a result, its application is restricted. Amongst foreign patents, there is no patent for chemical synthesis of caffeic acid. They are generally drawn out and divided from plants by the method of typical Chinese medicine.

specific approach:
Preparation of unrefined Caffeic Acid Sigma

30 g of 3,4-dihydroxybenzaldehyde and also 60.0 g of malonic acid were taken as well as dissolved in 300 ml of N,N-dimethylformamide, after that 45 ml of pyridine was added, and the temperature was increased to 70 ° C. 9 mL of aniline was included, and the response was carried out for 1 hr. After the reaction, the response option was cooled to listed below 30 ° C, 1000ml of 2moL/L hydrochloric acid was added for mixing, and the mixture was stirred and also taken shape at space temperature for 2h. After suction filtration, the filter cake was washed two times with 300 ml of cleansed water. Coiffure at 50 ° C to get 36.50 g of yellow Caffeic Acid Sigma crude item, the yield is 93.60%, the pureness is 99.52%, as well as the content is 99.2%.

Caffeic Acid Sigma Improvement
Include 30g of Caffeic Acid Sigma crude product as well as 120ml of ethanol into a 500mL four-neck flask, heat up to 80 ° C, stir till liquified, add 1.5 g of turned on carbon to decolorize for 15min, and after that filter while warm. The filtrate was cooled to 5-10 ℃, stirred and crystallized for 2h. After suction purification, the filter cake was cleaned with 60 ml of cleansed water. After drying out at 50 ° C, 27.39 g of light yellow caffeic acid improved item was acquired, the return was 91.30%, the purity was 99.83%, as well as the material was 99.8%.

Clinical Application of Caffeic Acid Sigma

Sun Jinlin of Shandong Provincial Third Healthcare facility checked out the result of caffeic acid on leukopenia and thrombocytopenia in individuals with lung cancer after radiotherapy. Techniques: A total of 68 individuals with lung cancer cells that were hospitalized in our hospital from July 2018 to November 2019 were chosen as the topics, and also the individuals were separated into 2 teams according to whether the patients were offered caffeic acid therapy, the observation group as well as the control team, with 34 cases in each group. The degrees of WBC as well as platelets in the observation group and the control team were observed prior to treatment, 1 week, 2 weeks as well as 4 weeks after treatment. Results: There was a time result on WBC and also platelets in the monitoring group and the control team. Throughout the observation time, the WBC as well as platelet degrees in the observation group and also the control team showed a pattern of very first reducing and after that raising; the monitoring team and the control group had various degrees of WBC and platelets. After 1 week, 2 weeks as well as 4 weeks of treatment, the degrees of WBC as well as platelets in the monitoring group were greater than those in the control team; there was an interaction effect in between the patients in the observation team as well as the control team, and the degrees of WBC as well as platelets in the two teams raised with time. pattern, and also the observation group was greater than the control team. Verdict: Caffeic acid can enhance the trend of WBC as well as thrombocytopenia in patients with lung cancer cells after radiotherapy, and also help to restore the myelosuppression of individuals.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Caffeic Acid Sigma Quotation