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Caffeic Acid CAS 331-39-5

Molecular Formula: C9H8O4

Formula Weight: 180.16

ZSpharmac: Caffeic Acid Supplier

Product Name: Caffeic Acid
CAS No: 331-39-5
Purity: 99%

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Basic Info

Product Name:Caffeic Acid
Other Names:3,4-Dihydroxycinnamic acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials 
Appearance:Yellow to Tan Powder
EINECS No.:206-361-2
Provide:Caffeic Acid MSDS;
Caffeic Acid COA

What is Caffeic Acid?

Caffeic acid, also known as 3,4-dihydroxy-cinnamic acid or 3,4-dihydroxy-cinnamic acid, yellow crystals, is an intermediate product of the phenylpropane metabolic pathway in tobacco and is also lignin Synthetic pathway metabolites, mainly in the form of glucosides and esters, are phenolic substances in tobacco. Tobacco phenolic compounds are one of the important components that produce tobacco aroma. They not only directly affect the color of tobacco leaves, but also indirectly affect the quality of smoke and taste. Their degradation products can also improve the smoking taste of tobacco products and are important indicators for measuring the quality of tobacco leaves. . Therefore, the determination of caffeic acid content in tobacco has important significance for judging the quality and style characteristics of tobacco leaves.

Caffeic Acid Property

Melting point 211-213 °C (dec.) (lit.)
Boiling point 272.96°C (rough estimate)
density 1.2933 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. 2-8°C
solubility ethanol: 50 mg/mL
form powder
color yellow to tan
Water Solubility soluble in hot water


Biological Activities of Caffeic Acid and Its Derivatives

Caffeic acid and its derivatives belong to phenylpropionic acid components in terms of chemical structure, and are synthesized from cinnamon acid as a precursor in terms of biogenesis. These chemical components are widely distributed in the plant kingdom and are secondary metabolites formed during plant aerobic respiration. Caffeic acid, ferulic acid and their derivatives chlorogenic acid and salvianolic acid are widely distributed in the plant groups of Chinese medicine resources, and are important phenylpropanoid resource products in Chinese medicine. For example, cinnamon bark is rich in cinnamon acid, caffeic acid is one of the main active substances in dandelion medicinal materials, ferulic acid is the main component of various medicinal plants of Umbelliferae, and chlorogenic acid mainly exists in medicinal plants of Lonicera family Among them, salvianolic acid components are mainly distributed in the traditional Chinese medicine Salvia miltiorrhiza, sinapinic acid has a high content in citrus plants such as rapeseed oil and lemon, and caffeic acid derivatives such as chlorogenic acid are also contained in apples and hawthorns. These natural phenolic acid components have a variety of physiological activities in the body, and are very good drug lead compounds.

Application Prospect of Caffeic Acid and Its Derivatives

With the advancement of scientific research, the biogenesis path system of caffeic acid and also its derivatives is ending up being an increasing number of ideal. The structure-activity relationship of caffeic acid and its by-products has also been preliminarily understood. As an example, its organic task is carefully pertaining to the hydroxyl group on its benzene ring. When the hydrogen on the benzene ring is replaced by some electron-withdrawing teams, its biological activity is stronger. The synthetic approach transforms the substituents on the benzene ring to develop brand-new caffeic acid derivatives actively and also especially to boost their organic task.

Caffeic acid and also its derivatives have organic tasks such as anti-virus, antibacterial, anti-infection, therapy of cardio and also cerebrovascular illness, and anti-tumor. They have been used in the field of medicine. Some drugs for the therapy of cardio as well as cerebrovascular diseases consist of caffeic acid as well as Its derivatives, such as caffeic acid tablets, can be used to treat leukopenia, as well as salt ferulate can be utilized to treat atherosclerosis. Along with the application of caffeic acid and its by-products in the field of medication, the brand-new uses in various other fields have additionally become brand-new study hotspots. For instance, caffeic acid as well as its by-products have antioxidant task for food emulsification systems as well as can extend the shelf life of food. Caffeic acid as well as its ester derivatives play the role of antioxidants in the emulsification system formed by mayo, milk as well as fish oil. The antioxidant activity of caffeic acid and also its by-products makes it utilized as an additive in food conservation. As risk-free and reliable all-natural items, caffeic acid and its by-products have a selection of organic activities. It is believed that with the deepening of study, they can also be used as artificial additive in the food area in the future.

Preparation of Caffeic Acid

Caffeic acid is mainly composed of 3,4-dihydroxybenzaldehyde, 3-methoxy-4-hydroxybenzaldehyde, 3,4-dimethoxybenzaldehyde, 3,4-methylenedioxybenzaldehyde and substituted cinnamon Ester is prepared through corresponding chemical synthesis reactions such as condensation reaction, demethylation reaction and hydrolysis reaction.

Domestic patent CN103804178A reports the synthesis of caffeic acid by using catechol as raw material through substitution reaction, oxidation reaction and addition reaction. In the addition reaction, pyridine is used as the reaction solvent and the condensation catalyst, the solvent consumption is large, the operation is complicated and the production cost is high, the product yield is low (only about 70%), and the purity is poor. Therefore, its application is limited. Among foreign patents, there is currently no patent on the chemical synthesis of caffeic acid. They are usually extracted from plants by means of traditional Chinese medicine extraction.

About Products:
If you need Caffeic Acid you have a quality product.
As an experienced Caffeic Acid manufacturer and supplier, ZSpharmac will provide Caffeic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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