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Butylparaben CAS 94-26-8

Molecular Formula: C11H14O3

Formula Weight: 194.23

ZSpharmac: Butylparaben Supplement

Product Name: Butylparaben
CAS No: 94-26-8
Purity: 99%

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Basic Info

Product Name:Butylparaben
Other Names:Butyl 4-Hydroxybenzoate, 99%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Almost White Crystalline Powder
EINECS No.:202-318-7
Provide:Butylparaben MSDS;
Butylparaben COA

What is Butylparaben?

Butylparaben, also known as butylparaben, is a colorless fine crystal or crystalline powder that is almost odorless and slightly astringent in its pure form. It is a safe and effective paraben used internationally. preservative. Because its antiseptic effect is better than other paraben preservatives, it is widely used in food, medicine, cosmetics and other fields. The traditional production method of Butylparaben uses concentrated sulfuric acid as a catalyst, and uses p-hydroxybenzoic acid and n-butanol as raw materials to carry out an esterification reaction to obtain it. Practice has proved that this method has disadvantages such as poor catalyst selectivity, many side reactions, serious equipment corrosion, poor product color and serious environmental pollution. Therefore, research and development of new catalysts has become the key to solving the problem. In recent years, many researchers have done a lot of research on the synthesis of Butylparaben, and achieved certain results.

Butylparaben Properties:

Melting point 

67-70 °C(lit.)

Boiling point 

156-157 °C3.5 mm Hg(lit.)



refractive index 

1.5115 (estimate)



storage temp. 



Soluble in DMSO, ethyl acetate, methanol.


pKa 8.5 (Uncertain)


Crystalline Powder


White to almost white

Water Solubility 

<0.1 g/100 mL at 17 ºC


Butylparaben Uses

  1. Butyl parahydroxybenzoate is made use of for bacteriostasis as well as conservation of medications, cosmetics and food.
  2. Butylparaben is used as a preservative. As a result of its low solubility in water, it is typically formulated right into ethanol solution, acetic acid service or salt hydroxide remedy. To improve solubility, a number of different esters are usually used in mix. For example, three parts isobutyl ester, 4 parts isopropyl ester, three parts butyl ester are developed as a co-dissolving combination, as well as this mixture is used as an oil-in-water emulsifier. The preparation is convenient to be made use of in foods such as soy sauce, and its solubility can be raised by 2 to 3 times compared with the single use butyl ester. When utilized in soy sauce = oil, 20% to 25% of this item can be contributed to a 5% salt hydroxide service, and then slowly added to the soy sauce that has been warmed to concerning 80 ° C. Acetic acid services or ester emulsifiers can additionally be made use of. The dosage of anti-mildew for soy sauce is 0.05-0.10 g/L. Acetic acid or sodium hydroxide solution can be utilized in vinegar. Sodium hydroxide solution can be made use of in revitalizing beverages, however it is usually made use of in mix with benzoic acid and dehydroacetic acid.
  3. Butylparaben is used in organic synthesis intermediates; antiseptic ingredients in medication, food, cosmetics, films and premium products; reagents. It is primarily utilized as a food preservative and bactericidal representative. Amongst the parabens, its antibacterial as well as bactericidal effect is the greatest. Due to its poor water solubility, it is usually used in combination with various other esters.
  4. Butylparaben is utilized as an antiseptic and disinfectant.

Applications of Butylparaben

CN201710644982.1 provides a phenoxyethanol-based preservative and a preparation method and application thereof. The phenoxyethanol-based preservative has excellent antibacterial effect and is mild to the skin so that it can be used as an antibacterial agent for skin care products, and the preparation method has the advantages of The process is simple and the raw materials are easy to obtain. In order to achieve the above object, the present invention provides a phenoxyethanol-based preservative, which is composed of phenoxyethanol, methylparaben, ethylparaben, propylparaben, The composition of butyl gold and solvent; wherein, the weight ratio of phenoxyethanol, methylparaben, ethylparaben, propylparaben, butylparaben and solvent is 20-30:40-50: 5-15:8-15:8-15:40-60.

The present invention also provides a preparation method of a phenoxyethanol-based preservative, the preparation method comprising:

1) Dissolving phenoxyethanol in a solvent to obtain a phenoxyethanol solution;

2) Methylparaben, Ethylparaben, Propylparaben, and Butylparaben were added to the phenoxyethanol solution to make a phenoxyethanol-based preservative.

The present invention makes the prepared preservative have excellent antibacterial effect and is mild to the skin through the synergistic action of each component, so that it can be used as an antibacterial agent for skin care products, and the preparation method has the effects of simple process and easy availability of raw materials.

CN201510562373.2 provides an anti-mildew and antibacterial agent for fabrics, so as to better realize the function of the anti-mildew and antibacterial agent for fabrics. It is composed of the following components in parts by mass: 26-30 parts of dimethylhydantoin, 28-32 parts of mancozeb, 24-28 parts of ethoxyquinoline, 28-32 parts of Butylparaben, dodecyl 24-28 parts of dimethylbenzyl ammonium chloride, 28-32 parts of tebuconazole, 24-28 parts of difenoconazole, 30-34 parts of berberine, 24-28 parts of methylene dithiocyanate , 28-32 parts of vinyl acetate, 24-28 parts of triethyl tin chloride, 28-32 parts of 8-hydroxyquinoline copper, 24-28 parts of chitosan propionic acid, 28-32 parts of Xinjieerfen, 24 parts of vermiculite powder ~28 parts, 28-32 parts of nitroethane, 24-28 parts of cloves, 28-32 parts of carnauba wax, 24-28 parts of polyglycerol, 28-32 parts of p-nitrophenol.

The preparation method steps are as follows:

(1) Dimethylhydantoin, mancozeb, ethoxyquinoline, Butylparaben, dodecyldimethylbenzyl ammonium chloride, tebuconazole, berberis Alkali, Methylene Dithiocyanate, Vinyl Acetate, Triethyltin Chloride, Copper 8-Hydroxyquinoline, Chitosan Propionic Acid, Neogel, Nitroethane, Clove, Carnauba Wax, Polyglycerol, The p-nitrophenol is mixed, and ultrasonically dispersed at high speed, the ultrasonic frequency is 20-40KHz, the dispersion speed is about 5000-5400r/min, and the dispersion time is 30-60min;

(2) adding the vermiculite powder in the mass fraction, ultrasonically dispersing at high speed, the ultrasonic frequency is 20~35KHz, the dispersion speed is about 4800~5200r/min, and the dispersion time is 30~50min;

(3) Add the difenoconazole in the mass fraction, disperse at high speed by ultrasonic, the ultrasonic frequency is 20~30KHz, the dispersing speed is about 4600~4800r/min, and the dispersing time is 20~40min; after mixing uniformly, the solid content is obtained It is about 20 to 70% of this product.

The beneficial effects of the invention are as follows: the preparation process of the fabric antifungal and antibacterial agent is simple, the prepared product has superior antifungal and antibacterial properties, is suitable for use in the field of clothing fabrics, and improves product performance.

CN201310460589.9 provides a method for producing sterilized paper, so as to obtain paper with excellent bactericidal and bacteriostatic effects. The following technical scheme is adopted: a production method of sterilized paper is to apply a composite antibacterial agent in the production process of the paper, and the main active components of the composite antibacterial agent are dithiocyanomethane, Butylparaben and thiabendazole. The weight ratio of thiocyanomethane, butylparaben and thiabendazole is 0.1:0.5-0.8:0.2-0.4.

The preparation process of the composite antibacterial agent is as follows: after dissolving dithiocyanomethane, Butylparaben and thiabendazole in ethanol, adding an emulsifier and stirring evenly; the emulsifier is composed of sorbitan fatty acid ester and sorbitan monooleic acid. The ester polyoxyethylene ether is prepared by mixing in a weight ratio of 1:4; the usage amounts of the organic solvent and the emulsifier are respectively 2 times and 4 times the total weight of dithiocyanomethane, butylparaben and thiabendazole; Compared with the prior art, the present invention has the following advantages: 1. The present invention selects a composite antibacterial agent to apply to the paper, and the main effective components of the composite antibacterial agent act synergistically to obtain excellent antibacterial synergy; After the antibacterial agent is dissolved in the organic solvent, it is mixed with the emulsifier, and then mixed with the sizing liquid. When the spraying method is used, it is more uniform and ensures the sterilization and bacteriostatic effect of the sterilized paper.

Physicochemical Weaknesses of Butylparaben and Ways to Overcome

There is no doubt that Butylparaben is an efficient, safe and broad-spectrum food preservative. The reason why it has not been promoted and used in the domestic food industry is related to the physical and chemical properties of this substance. Regarding the physical and chemical properties of parabens, most literatures have the following introductions: colorless fine crystals or white crystalline powders. Almost odorless, slightly numb. Melting point 69~72℃. Extremely insoluble in water (0.2g/L, 25℃). Easily soluble in ethanol (2.10g/mL), ether (2.10g/g), acetone (2.40g/g) and propylene glycol (1.10g/g). Insoluble in glycerol (0.002g/g). Among them, two properties of slight numbness and extremely insoluble in water constitute the two major physical and chemical weaknesses of Butylparaben, which directly hinder the selection of this substance by technical personnel in the food industry. The reasons are: first, common sense of life reminds people that for For most foods, numbness is an odor, unless a certain food needs a spicy flavor. Therefore, once a food preservative is told that it has a tingling sensation, the technicians of the food processing department will try to give up the selection of this variety, so as not to affect the flavor of the food. Secondly, according to biological principles, the growth and reproduction of microorganisms are not only dependent on suitable temperature, but active water is also a key factor. If a certain food is in a relatively dry state, even if it is contaminated with microorganisms, it is not easy to spoil. Therefore, most food preservatives need to be dissolved in water to be uniformly dispersed in all parts of the food, and make the moisture contained in the food unsuitable for the growth of microorganisms. Poorly water-soluble preservatives become unsuitable for most foods. Although Butylparaben is an efficient, safe and broad-spectrum food preservative, to be widely used in the food industry, it is necessary to find technical means that can overcome its physical and chemical weaknesses. The experimental results show that finding out the taste threshold of butylparaben and realizing the sodium salt of butylparaben is an effective way to overcome the two physical and chemical weaknesses of butylparaben.

Any substance that has a taste or smell has a concentration range of detection. When the taste or smell of a odorant is below a certain amount, individuals with normal sense of taste or smell cannot detect the presence of the odorant. Only if the taste or odor is above this amount will the odorant be perceived by most people. According to the threshold definition proposed by the American Society for Testing and Materials, the so-called taste threshold is the concentration of the most dilute aqueous solution of taste substances that people can taste. The taste threshold was measured by sensory tasting method, and the test results were processed by statistical method. For example, 0.08% saline solution is the lowest concentration at which 50% (or 75%) of the subjects can feel the salty taste, and is set as the threshold concentration of salt. Sensory tasting experiments showed that the taste threshold concentration of butylparaben was 0.012%. Accordingly, there are three ways to overcome the tingling sensation of butylparaben. First, the compound use of butylparaben and propylparaben can not only control the concentration of the former within 0.012%, but also synergize the two preservatives, improve the antibacterial strength of the preservatives, and expand the Bacteriostatic range of preservatives. The second is to use butyl hydroxybenzoate in combination with other acid-type preservatives, and the concentration of butyl hydroxybenzoate can also be controlled within 0.012%. Even if there is no synergistic effect between paraben preservatives and common acid preservatives, at least there will be no mutual masking. The third is to use butyl hydroxybenzoate in foods with obvious flavor characteristics, and use it as little as possible in light food occasions.

Although parabens are organic substances with relatively large molecular weights, they lack water solubility. However, because its molecular structure contains a highly active hydroxyl group, its properties are very close to benzoic acid and sorbic acid, and it is easy to neutralize with sodium hydroxide to be derived into sodium paraben, which becomes into a water-soluble substance. Its reaction formula is as follows:

The aqueous solution of sodium paraben is alkaline and is an unstable substance. If it is placed for a long time, the hydrolysis reaction of paraben will occur, and part of the paraben in the solution will be reduced to p-hydroxybenzoic acid. . In order to prevent the hydrolysis of parabens, the method adopted by Japanese companies in the early years was mainly to prepare and use the sodium paraben solution. Due to the promotion of spray drying technology in recent years, several domestic enterprises have rapidly dried the prepared sodium paraben solution into fine powder since the beginning of 2000, which not only overcomes the problem of poor water solubility of paraben, but also effectively avoids the need for parabens. Hydrolytic reduction of Potin esters. In short, the two major physical and chemical weaknesses of butylparaben have now found effective ways to overcome, and people do not need to follow the old concept and hold conservative opinions on the promotion and application of butylparaben.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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