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Bronopol CAS 52-51-7

Molecular Formula: C3H6BrNO4

Formula Weight: 199.99

ZSpharmac: Bronopol Supplier

Product Name: Bronopol
CAS No: 52-51-7
Purity: 99%

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Basic Info

Product Name:Bronopol
Other Names:2-Bromo-2-Nitro-1,3-Propanediol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow Crystals or Crystalline Powder
EINECS No.:200-143-0
Storage:Room Temperature
Provide:Bronopol MSDS;
Bronopol COA

What is Bronopol?

Roper, the chemical name is 2-bromo-2-nitro-1,3-propanediol, as well as other names include bronopol, bacteriostatic alcohol, and so on. International trade name: Bronopol. It is white crystalline powder, melting point: 122 ~ 130 ℃, conveniently soluble in water, ethanol, propylene glycol, ethyl acetate, etc, a little soluble in oil, hardly soluble in chloroform, acetone, and so on. In 1919, by E. Made by Schmidt and R.Wilkendorf, after that, the British Pharmacopocia Commission (British Pharmacopocia Commissionoin) announced its usual name Bronopol, which was made use of in farming to get a British patent in 1970.

Bronopol Property

Melting point 130-133 °C(lit.)
Boiling point 358.0±42.0 °C(Predicted)
density 2.0002 (rough estimate)
refractive index 1.6200 (estimate)
Fp 167°C
storage temp. Inert atmosphere,Room Temperature
solubility H2O: soluble100mg/mL, clear, colorless to faintly yellow
form Crystals or Crystalline Powder
color White to yellow
Water Solubility 25 g/100 mL (22 ºC)


Bronopol Uses

  1. Bronopol is a bactericide. It can appropriately manage a range of plant pathogenic bacteria. Cotton seeds can be taken care of to quit in addition to also handle cotton black arm issue along with microbial scabrous curse triggered by Xanthomonas cotton, as well as have no phytotoxicity to cotton.
  2. Bronopol is mainly used for cosmetics and also natural leather antisepsis, and also in farming for the control of rice bakanae illness.
  3. Bronopol is a biocide, primarily utilized in industrial flowing water, paper pulp, paint, plastics, cosmetics, timber, cooling down water circulation system, along with industrial sterilization, anti-mildew, anti-corrosion, algae and so on.
  4. Bronopol is a chemical for cosmetics. It is added to the handling of hair shampoos, balms and also creams and also various other cosmetics. The bactericidal focus in cosmetics is 0.01%-0.02%. It can likewise be used in cleaning agents, textile therapy representatives, etc.
  5. Bronopol is primarily used as a medical disinfectant, aesthetic chemical, as well as additionally as a pesticide treatment representative.

Bronopol Production Method

It is gotten by the reaction of nitromethane with formaldehyde and bromine, and also there are 2 operations. (1) Include nitromethane, 30% formaldehyde, calcium chloride and also sodium hydroxide in a molar ratio of 1:2:2:2 to the response device, stir, and decrease bromine and dichloroethane listed below 0 ° C to prepare The service. Included 1h, the amount of bromine and also nitromethane equimolar. The dichloroethane layer was separated, as well as the dichloroethane was distilled off. A white strong (unrefined product) was obtained. The aqueous layer of the reactant was drawn out with ether, and the ether in the ether extract was vaporized to get an additional part of the crude item. The crude items were integrated as well as recrystallized with ether to obtain the pure product. (2) First prepare 2-nitro-1,3-propanediol, add nitromethane and also 30% formaldehyde service into the reflux response device at a molar proportion of 1:2, after that include 2% potassium carbonate, heat and also reflux for 1 hour, cool and also precipitate crystallization. Removed with ether, dried out, distilled off ether, in 2-nitro-1,3-propanediol. After that dissolve it in methanol, include 20% sodium methoxide methanol option, stir at 20 ° C, and speed up 2-nitro-1,3-propanediol salt. Strain the sodium salt and also suspend in completely dry diethyl ether for bromination: add bromine dropwise to the diethyl ether suspension of 2-nitro-1,3-propanediol sodium listed below 0 ° C, as well as mix for 10 mins after the leaking is complete. Purification, distilled to diethyl ether, particularly Bronopol.

Safety of Bronopol's Preservatives

Actually, Bronopol preservatives do not belong to the “formaldehyde-releasing body” fungicides, and also the amount of formaldehyde launched is very tiny. It is extremely crucial to pick the proper detection approach to accurately measure the quantity of formaldehyde launched by Bropol. At present, acetylacetone spectrophotometry is extensively used in the sector to qualitatively identify formaldehyde material. The technique is based upon the discerning response of formaldehyde with Nash’s reagent (acetylacetone) in the visibility of ammonium acetate to produce yellow 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine. According to spectrophotometry, to determine the material of formaldehyde.

However not just formaldehyde responds with Nash reagent, Bronopol chemical particles can additionally undergo chain reactions to create displayed chemical compounds, which affect the last experimental results. For that reason, this technique is not appropriate for spotting the formaldehyde content in Bropol’s solution. Likewise, the test reagents in the pre-column derivatization method will likewise respond with Bropol particles, causing errors. The experiment shows that the non-destructive post-column derivatization method is more suitable for finding the formaldehyde content in the Bropol chemical option. For example, the post-column derivatization approach of high-performance liquid chromatography, the principle of which is to first different the possible formaldehyde in the sample by high-performance liquid chromatography, react with a derivatization reagent, and afterwards spot it.

Will the trace amount of formaldehyde created by Bronopol chemicals influence product safety because of hydrolysis? In fact, formaldehyde exists in humans as well as a great deal of typical foods. The formaldehyde material of less than 1ppm created by the hydrolysis of Bropol is less than the formaldehyde material in these typical foods. At the same time, China’s “Hygienic Criteria for Cosmetics (2007 )” specifies that Bropol can be used as a minimal preservative in cosmetics (the additive quantity ought to be less than 0.1%, while staying clear of the formation of nitrosamines), which also confirms that under appropriate use conditions The safety of Bropol for liquid washing products.

About Products:
If you need Bronopol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Bronopol manufacturer and supplier, ZSpharmac will provide Bronopol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Bronopol Quotation