Zhishang Chemical

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Zhishang Chemical

Bronopol CAS 52-51-7

Molecular Formula: C3H6BrNO4

Formula Weight: 199.99

ZSpharmac: Bronopol Supplier

Product Name: Bronopol
CAS No: 52-51-7
Purity: 99%

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Basic Info

Product Name:Bronopol
Other Names:2-Bromo-2-nitro-1,3-propanediol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow Crystals Powder
EINECS No.:200-143-0
Storage:Room Temperature
Provide:Bronopol MSDS;
Bronopol COA

What is Bronopol?

Bronopol (English name Bronopol) is also known as bronopol, its scientific name is bronopol, 2-bromo-2-nitro-1,3-propanediol (2-Bromo-2-nitro-1,3-propanediol ), 2-bromo-2-nitropropane-1,3-diol (2-Bromo-2-nitropropan-1,3-diol), “Bronopol” is its common name, also called “Pi Lebao”, ” Rosinool”. At room temperature, it is white to light yellow, yellow-brown crystalline powder, odorless and tasteless, easily soluble in water, ethanol, propylene glycol, insoluble in chloroform, acetone, benzene, etc. It will slowly decompose in alkaline aqueous solution, and has a corrosive effect on some metals, such as aluminum.

Bropol can be compatible with most surfactants, but when substances containing -SH groups in cosmetic raw materials, such as cysteine, etc., the antibacterial activity of Bropol will be reduced.

Bronopol is poisonous, irritating to the eyes, skin, and mucous membranes, and can cause congenital abnormalities. When used in large quantities, it is harmful to the environment. It is mainly used as a preservative and bactericide for cosmetics, which can effectively prevent and control a variety of plant pathogenic bacteria.

Bronopol Property

Melting point 130-133 °C(lit.)
Boiling point 358.0±42.0 °C(Predicted)
density 2.0002 (rough estimate)
refractive index 1.6200 (estimate)
Fp 167°C
storage temp. Inert atmosphere,Room Temperature
solubility H2O: soluble100mg/mL, clear, colorless to faintly yellow
form Crystals or Crystalline Powder
color White to yellow
Water Solubility 25 g/100 mL (22 ºC)


Bronopol Uses

  1. Bronopol works versus a wide variety of phytopathogenic germs as well as is mainly utilized as a seed treatment representative, etc. In addition, due to its broad-spectrum antibacterial residential or commercial properties, it has been utilized as an anti-bacterial in medicine considering that the 1960s. With the boosting growth of cosmetics, combined with the broad-spectrum antibacterial and good water solubility of Bropol, it was utilized as an aesthetic chemical in the late 1980s as well as established extremely quick. In recent years, Bropol has been widely utilized in feed, paint, hair anti-corrosion, air-conditioning flowing water, oil area water injection, aircraft, lorry and also ship disinfection, etc, and the demand has raised swiftly.
  2. Bronopol has a spectrum of antibacterial activity. It has efficient antibacterial activity in solution products including surfactants in the pH series of 4 to 9, and in formulations with high focus of protein substances, particularly for Pseudomonas aeruginosa with strong anti-bacterial activity. Bacillus has special results; safe, non-irritating, and non-allergic. The quantity of this chemical used in cosmetics is 0.01% to 0.05%. The poisoning examination results show that this chemical is secure, and it is an aesthetic antiseptic approved by the US FDA. One of the agents; it has a collaborating result in the substance. According to the statistics of the US FDA, among all the chemicals utilized in cosmetics, Bronopol is made use of most frequently. It is the sharp rise in commercial need that advertises the research study and also commercial production of Bronopol.
  3. Bronopol can properly regulate a variety of plant pathogenic germs. Cotton seeds can be dealt with to stop and manage cotton black arm condition as well as bacterial scabrous blight brought on by Xanthomonas cotton, as well as have no phytotoxicity to cotton. It can additionally be utilized for rice bakanae condition. The advised focus is 800-1000mg/ L.
  4. Bronopol is generally used in industrial circulating water, paper pulp, paint, plastics, cosmetics, timber, cooling down water flow system, as well as commercial sterilization, anti-mildew, anti-corrosion, algae and so on.
  5. Bronopol is utilized as a chemical for cosmetics. It is included in the processing of shampoos, balms and also creams as well as other cosmetics. The antiseptic focus in cosmetics is 0.01%-0.02%. It can likewise be used in cleaning agents, textile treatment agents, and so on.

Bronopol Manufacturing Method

Bronopol can be obtained from nitromethane and formaldehyde as raw materials, under alkaline conditions, through a two-step reaction of alkane hydroxylation and bromination, and the reaction equation is as follows:




There are two operating procedures. (1) Add nitromethane, 30% formaldehyde, calcium chloride and sodium hydroxide in a molar ratio of 1:2:2:2 to the reaction device, stir, and drop bromine and dichloroethane below 0°C to prepare The solution. Added in 1h, the amount of bromine and nitromethane equimolar. The dichloroethane layer was separated, and the dichloroethane was distilled off. A white solid (crude product) was obtained. The aqueous layer of the reactant was extracted with ether, and the ether in the ether extract was evaporated to obtain another part of the crude product. The crude products were combined and recrystallized with ether to obtain the pure product. (2) First prepare 2-nitro-1,3-propanediol, add nitromethane and 30% formaldehyde solution into the reflux reaction device at a molar ratio of 1:2, then add 2% potassium carbonate, heat and reflux for 1 hour, cool and precipitate crystallization . Extracted with ether, dried, distilled off ether, in 2-nitro-1,3-propanediol. Then dissolve it in methanol, add 20% methanol solution of sodium methoxide d, stir at 20°C, and precipitate 2-nitro-1,3-propanediol sodium. Filter out the sodium salt and suspend in dry ether for bromination: Add bromine dropwise to the suspension of 2-nitro-1,3-propanediol sodium in ether below 0°C, and stir for 10 minutes after the drop is complete. Filtration, distilled to diethyl ether, namely Bronopol.

Synthesis of Bronopol

The organic synthesis technique of Bronopol mainly adopts following several: the one, nitromethane and formaldehyde are first condensed to generate intermediate 2-nitro-1,3-propanediol, then with bromine generation bromination reaction, obtain Bronopol product; Nitromethane is first brominated with bromine to produce bromonitromethane intermediate, and pure bromonitromethane is directly condensed with formaldehyde to obtain Bropol product.
Method 1: Condensation of nitromethane and formaldehyde first, and then bromination reaction with bromine to obtain the technical route of Bropol product. The process reaction mechanism is as follows:

Fig. 1 is Bronopol synthesis method one.
The report of using this principle to prepare Bropol was first seen in 1923. In absolute alcohol, in the presence of alkali metals, nitromethane and formaldehyde were reacted for condensation reaction, and the intermediate nitroalcohol produced was The basic salt is separated and placed in an organic solvent to obtain Bropol. Similar synthesis methods were reported in Germany and France in 1970.
Methods Dinitromethane was brominated with bromine to obtain bromopicrin intermediate, and the pure bromopicrin was directly condensed with formaldehyde to obtain Bronopol product. The technological principle of this method is:

Fig. 2 is Bronopol synthesis method two.
In 1990, the United States and the United States in 1991 successively proposed the preparation methods of halogenated nitro alcohols and bromo nitro alcohols. The method proposes to carry out bromination reaction of nitromethane and bromine to prepare a bromonitromethane intermediate, and then use the bromonitromethane to chemically react with formaldehyde to prepare a high-purity Bronopol product. The intermediate bromopicrin obtained by this method is very stable and easy to purify. The obtained product has less impurity content, simple post-treatment, and does not need any organic solvent in the crystallization process. The product Bronopol has large crystal size, good crystal form, and high purity, which meets the requirements of the British Pharmacopoeia BP2000 standard and can fully meet the needs of export. The process yield is about 88% to 90%.

About Products:
If you need Bronopol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Bronopol manufacturer and supplier, ZSpharmac will provide Bronopol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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