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BOC-Glycine CAS 4530-20-5

Molecular Formula: C7H13NO4

Formula Weight: 175.18

ZSpharmac: BOC-Glycine Cosmetic Raw Material Suppliers

Product Name: BOC-Glycine
CAS No: 4530-20-5
Purity: 99%

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Basic Info

Product Name:BOC-Glycine
Other Names:Glutamine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:224-864-5
Storage:Room Temperature
Provide:BOC-Glycine MSDS;
BOC-Glycine COA

What is BOC-Glycine?

BOC-Glycine refers to N-tert-butoxycarbonylglycine, which is a derivative of glycine. A protecting group, tert-butoxycarbonyl (BOC), is added to the amino group of glycine, which is a commonly used amino acid protection strategy. As an important chemical reagent, BOC-Glycine plays a key role in peptide synthesis and organic synthesis.

BOC-Glycine Property

Melting point 86-89 °C(lit.)
Boiling point 306.47°C (rough estimate)
density 1.2843 (rough estimate)
refractive index 1.4353 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Powder
color White to off-white
Water Solubility soluble


BOC-Glycine Uses

Peptide synthesis: In solid-phase and liquid-phase peptide synthesis, BOC-Glycine is one of the basic units for building polypeptide chains. The BOC group serves as a temporary protective group for the amino group of amino acids, which can prevent unnecessary side reactions during the synthesis process, such as cross-coupling or self-coupling. Once the polypeptide chain is constructed, the BOC protecting group can be easily removed by acid treatment, exposing the free amino groups and preparing for the next coupling reaction.

Drug intermediates: BOC-Glycine serves as a precursor or intermediate for the synthesis of drug molecules and participates in the synthesis routes of various drugs. For example, when designing peptide drugs with specific biological activities, the introduction of glycine can adjust the hydrophilicity and flexibility of the peptide or serve as a linking group, affecting the bioavailability, stability and targeting of the drug.

Organic synthesis: In organic synthetic chemistry, BOC-Glycine can be used as a starting material for the synthesis of various nitrogen heterocyclic compounds, amino acid derivatives or other complex organic molecules. The flexibility of its structure makes BOC-Glycine play an important role in building molecular diversity and exploring new drug candidates or new materials.

Biochemical research: In biochemistry and molecular biology research, BOC-Glycine can be used for the design and synthesis of enzyme inhibitors, or as a tool molecule for studying protein structure and function. By replacing glycine at specific positions, scientists can study the effects of amino acid residues on protein conformation and function.

Materials Science: In the field of materials science, BOC-Glycine and its derivatives can be used as building blocks for the synthesis of polymer materials with special functions, such as smart polymers, biomedical materials, etc. Glycine’s hydrophilicity and small size make it ideal for preparing materials with specific physicochemical properties.

Outstanding Applications of BOC-Glycine in the Field of Cosmetics

Skin moisturizing and barrier repair: Glycine is a component of natural moisturizing factor (NMF), which can help the skin retain moisture and enhance the skin barrier function. Glycine obtained after removing the BOC protective group through chemical reaction can be used in moisturizing products to help maintain skin moisture and elasticity and reduce fine lines and roughness caused by dryness.

Antioxidant effect: Glycine and its derivatives have certain antioxidant properties and can help resist skin aging caused by free radicals. As part of the synthetic pathway, it can be converted into cosmetic raw materials with antioxidant functions.

Gentle exfoliation: Certain glycine derivatives are designed to gently remove dead skin cells from the skin’s surface, promoting cell renewal. BOC-Glycine serves as the starting point for the synthesis of these specific functional amino acids, indirectly supporting the development of exfoliating products in cosmetics.

Formula stabilizers: In cosmetic formulas, amino acids are sometimes used as pH regulators or stabilizers to help maintain product stability and appropriate pH to ensure the effectiveness of active ingredients. The mild nature of glycine makes it ideal for such applications, and BOC-Glycine can be converted into glycine suitable for cosmetic formulations through suitable chemical processing.

BOC-Glycine Advantages

High protection efficiency: The BOC group is an efficient amino protecting group that can stably protect the amino group of glycine and prevent it from participating in unnecessary reactions in complex synthetic environments. This is especially important for multi-step synthesis processes.

Selective deprotection: The removal conditions of the BOC group are relatively mild and selective, and can generally be achieved using acidic conditions such as trifluoroacetic acid (TFA) or hydrofluoric acid. This is very critical in peptide synthesis because it allows protection Precisely remove BOC protection while removing other sensitive functional groups.

Good stability: BOC-Glycine has better chemical stability than unprotected glycine, especially in chemical reactions that require long-term storage or under harsh conditions, which is important for large-scale production and long-term experimental plans Particularly important.

Strong compatibility: In peptide synthesis, BOC-Glycine is used together with other BOC-protected amino acids to form stable resin-bound or solution intermediates, which is beneficial to the synthesis of long-chain peptides and is compatible with a variety of coupling reagents and catalysts .

Easy to operate: The steps for BOC protection and deprotection have been highly standardized, relevant chemicals and equipment are easily available, and the operating methods are mature, making it easy to apply in laboratories and industrial scales.

Improve synthesis efficiency: The BOC strategy supports solid-phase synthesis, allowing rapid synthesis and convenient purification. Peptide and other nitrogen-containing compound libraries can be efficiently prepared through automated synthesizers, which is very important for drug screening and biochemical research.

Safety: Although all chemicals need to be handled with caution, BOC-Glycine, as a common laboratory chemical, is relatively safe and easy to handle, reducing risks in experimental operations.


National Center for Biotechnology Information. PubChem Compound Summary for CID 78288, Boc-glycine. https://pubchem.ncbi.nlm.nih.gov/compound/Boc-glycine. Accessed May 8, 2024.

As a company specializing in the production and supply of BOC-Glycine raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the BOC-Glycine raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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