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Bisoctrizole CAS 103597-45-1

Molecular Formula: C41H50N6O2

Formula Weight: 658.87

ZSpharmac: Bisoctrizole Supplier

Product Name: Bisoctrizole
CAS No: 103597-45-1
Purity: 99%

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Basic Info

Product Name:Bisoctrizole
Other Names:LOTSORB UV 360
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Orange to Green Neat
EINECS No.:403-800-1
Storage:Inert Atmosphere,Room Temperature
Provide:Bisoctrizole MSDS;
Bisoctrizole COA

What is Bisoctrizole?

Bisoctrizole, also known as 2, 2′-methylene-bis[4-teroctyl-6-(2H-benzotriazolyl-2)]phenol, is a benzotriazole UV absorber with excellent performance . Ultraviolet absorbers are a class of organic compounds that can selectively and strongly absorb solar ultraviolet rays that are harmful to polymers and have high light resistance themselves. Since the 1970s, benzotriazole has been listed by Ciba-Geigy, Switzerland. Because of its oil resistance, discoloration resistance, low volatility, and good compatibility with polymers, Bisoctrizole is widely used in various synthetic materials and products. , especially in automotive coatings is the most commonly used and most effective UV absorber. As the application fields of engineering and modified plastics continue to expand, there is demand and hope for UV absorbers.

Bisoctrizole Property

Melting point 197-199 °C(lit.)
Boiling point 771.6±70.0 °C(Predicted)
density d20 1.2
vapor pressure 0Pa at 25℃
Fp >200°C
storage temp. Inert atmosphere,Room Temperature
solubility almost transparency in THF
form neat
color White to Orange to Green
Water Solubility Insoluble < 5 ng/L at 25 °C


Bisoctrizole Uses

  1. Bisoctrizole is a high-efficiency UV absorber that can absorb 300-400nm UV rays as well as is extensively compatible with a range of resins. It has very reduced volatility and can be made use of along with other light stabilizers or antioxidants. It appropriates for acrylates, polyesters, polycarbonates, polyoxymethylene, polyamides, polyolefins, styrene polymers, elastomers, Adhesives, etc can be created by powder, solution or thaw extrusion, which can protect against crystal exudation and also sublimation, and also can likewise be used for spreading, thin-layer building of fibers, paper and also wallpaper.
  2. Bisoctrizole is a broad-spectrum UV absorber that absorbs both UVB as well as UVA. It is also a compound UV absorber, mirroring and spreading UV.

Bisoctrizole Preparation

Report one
(1) Synthesis of UV-360: Add 323g of UV-329, 4g of powdered sodium hydroxide, 128g of bis(di-n-propylamino)methane and 15g of four Butylammonium bromide was heated to 130°C with stirring, and reacted at this temperature and under vacuum (100mmHg) for 2h, while distilling off the generated di-n-propylamine. Turn off the heat and remove the negative pressure. During the reaction process, 108g of di-n-propylamine (122g in theoretical amount) was recovered, the recovery rate was 88.5%, and the content was 98.6%.

(2) Purification of UV-360: When the temperature drops to 110°C, slowly add 500g of toluene to dissolve all the materials. After the material is dissolved, lower the temperature to 90° C., slowly add 18% hydrochloric acid (about 40 g) by mass, and stir to fully neutralize the material to neutrality. Transfer the reactant to a beaker, cool and crystallize with ice water for 4 to 5 hours, then filter, wash the filter cake twice with 150mL×2 deionized water, then wash twice with 250g×2 methanol, and dry it at 100~ Dry at 110°C to obtain 266g of UV-360 (theoretical yield is 329g), the melting point of the product is 197-198°C, the yield is 80.9%, and the content is 99.6%.

Report two,
In a 500ml four-neck flask equipped with a stirring thermometer and a condenser, add 100ml of mesitylene, 8.0g of UV-32910, 28.0g of diethylamine, and 7.0g of paraformaldehyde, slowly raise the temperature to 140°C, keep it warm for 1 hour, and distill out the diethylamine at the same time. Ethylamine and water; then add 2.5g of sodium hydroxide, slowly raise the temperature to 170°C, keep the temperature for 2 hours, remove diethylamine and water at the same time, then cool down to 120°C, add glacial acetic acid to acidify to pH5-6, keep stirring for 30 minutes, add 120ml of methanol, heat to reflux, then cool to 10-15°C, keep warm for 60 minutes, filter, and dry the filter cake to obtain Bisoctrizole104.0g, yield 94.5% (in terms of UV-329), liquid chromatograph analysis content 99.77%.

Report three
1. Add 0.1 mol of 2-benzotriazole-4-tert-octylphenol, 0.09 mol of paraformaldehyde and 0.18 mol of di-n-propylamine into a four-necked flask, stir and heat, heat up to 120°C after melting the raw materials, and react for 2 hours ;

2. Cool down to 110°C, add 0.4g sodium hydroxide and 35g o-xylene, raise the temperature to 160°C, and react for 10h;

3. Cool down to 110°C, add 7.5g of glacial acetic acid, react for 0.5h, cool down to 60°C, add 40ml of methanol, react for 1h, filter, and recrystallize to obtain Bisoctrizole.

Report four
Add 30 grams (1 mole) of formaldehyde and 113 grams (1.5 moles) of N-methylethanolamine into the reaction flask, raise the temperature to 60°C and stir, and after the material liquid is clear and transparent, add 388 grams of dimethyl phthalate ( 2 moles) and 2-(2′-hydroxyl-5′-tertoctylphenyl) benzotriazole 323 grams (1 mole), the temperature was raised to 100 ° C for 2 hours, and then 693 grams of n-chlorotetradecane ( 3 moles) was heated to 160°C for 4 hours. Cool to 90°C, extract with 3 x 100ml of xylene, cool the extract to room temperature, crystallize, filter, and dry the filter cake at 100°C to obtain 270g of light yellow crystalline product with a yield of 82% and a melting point of 197-199°C.

About Products:
If you need Bisoctrizole as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Bisoctrizole manufacturer and supplier, ZSpharmac will provide Bisoctrizole raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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