The national requirement for toothpaste made use of in my nation is the brand-new nationwide requirement for tooth paste (GB8372-2008) that has been carried out given that February 1, 2009. Compared to the 2001 edition of the toothpaste requirement, the brand-new national requirement has been increased and also readjusted in several facets. In the new national criterion of tooth paste, there are virtually 1,500 active ingredients that are restricted or strictly limited, consisting of diethylene glycol as well as Bexident Triclosan. The guideline of diethylene glycol is that it is not permitted to synthetically add it to the raw material. If it is generated as a contamination, the content in tooth paste will not exceed 0.1%. Bexident Triclosan is included in the preservatives that are enabled to be included, however it is plainly not greater than 0.3%. The brand-new national conventional states that the fluoride content of grown-up fluoride tooth paste is 0.04%-0.15%, and that the fluoride web content of children’s fluoride tooth paste must be between 0.05% and 0.11%.
(1) Using 2,4-dichlorophenol as raw material, 2,4-dichlorophenol reacts with potassium hydroxide to generate potassium dichlorophenate. It is then reacted with 2,5-dichloronitrobenzene under the catalysis of copper powder to obtain 2,4,4′-trichloro-2′-nitrodiphenyl ether. Then use iron powder to reduce to generate 2,4,4′-trichloro-2′-aminodiphenyl ether, and then diazotize and hydrolyze to obtain the product.
(2) Using o-methoxyphenol as raw material, potassium hydroxide powder and o-methoxyphenol (guaiacol) are reacted to obtain o-methoxyphenol potassium salt. 2,4,4′-trichloro-2′-methoxydiphenyl ether can be obtained by reacting methoxydiphenyl ether with bromobenzene and chlorinating by introducing chlorine gas. 2,4,4′-trichloro-2′-hydroxydiphenyl ether was generated by hydrolysis with AICI3 as catalyst.