Zhishang Chemical

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Zhishang Chemical

Betulin Sigma CAS 473-98-3

Molecular Formula: C30H50O2

Formula Weight: 442.72

ZSpharmac: Betulin Sigma Supplement

Product Name: Betulin Sigma
CAS No: 473-98-3
Purity: 99%

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Basic Info

Product Name:Betulin Sigma
Other Names:Betulin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Powder
EINECS No.:207-475-5
Provide:Betulin Sigma MSDS;
Betulin Sigma COA

What is Betulin Sigma?

White birch (Betulaplatyphylla Suk.) is a species of birch belonging to the family Betulaceae, which is rich in resources in northeastern my country. Birch bark has complex chemical composition and diverse pharmacological effects. Its extract has antibacterial, antiviral, antitumor, lipid lowering, choleretic and hepatoprotective effects. Betulin Sigma is a triterpenoid extracted from birch bark, which has the functions of bactericidal, antiviral, anti-ultraviolet, anti-inflammatory, fast healing of wounds, anti-allergic, etc. It can also improve the luster of damaged hair and promote hair growth. It is used in food, It is widely used in medicine, daily chemical industry and other fields. It is a very valuable natural substance that can be obtained from abundant plant resources.

Studies have found that Betulin Sigma has an inhibitory effect on esophageal cancer cells cultured in vitro. Betulinic acid can improve the proliferation of T cells, enhance the activity of NK cells, and increase the level of INF. The tumor-inhibiting mechanism may be related to directly or indirectly enhancing the body’s anti-tumor immunity. Betulin Sigma is cheap and widely available in nature, up to 30% of dry weight in birch bark, but this resource is not fully utilized. Because previous studies believe that betulin has no clear medicinal value. At present, people mainly use Betulin Sigma as raw material to manufacture betulinic acid, and betulinic acid has been proven to have antimalarial, anti-inflammatory, anti-melanoma and other tumor, anti-HIV and other effects. But the yield is low. High cost. Recently, Polish scholars proposed that Betulin Sigma has a significant protective effect on alcohol-induced liver cell damage.

Betulin Sigma Property

Melting point 256-257 °C(lit.)
alpha D15 +20° (c = 2 in pyridine)
Boiling point 493.26°C (rough estimate)
density 0.9882 (rough estimate)
refractive index 1.5045 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
form Off-white powder
color Pale Brown to Beige


Pharmacological Action and Application of Betulin Sigma

1. Anti-HIV activity
Mechanistic studies have shown that although these Betulin Sigma and its derivatives do not inhibit HIV-1 reverse transcriptase, they inhibit nuclear soma formation at concentrations above IC50 values. Therefore, it can be concluded that these betulin derivatives work by interfering with the later stages of the virus life cycle, and are related to virus entry and growth and maturation.

2. Antitumor activity
An experiment to study the anti-tumor effect and mechanism of Betulin Sigma in vivo showed that mouse liver cancer cells (H22) were used to establish a tumor-bearing mouse model. ; MTr method was used to determine the transformation function of mouse T lymphocytes and the killing activity of NK cells. Results The tumor weights of the three dose groups of betulin and the positive control group were reduced, and the difference was statistically significant compared with the negative control group (P<0.05). P<0.05); when the effect-target ratio of the low-dose group was 25:1, the killing activity of NK cells was higher than that of the positive control group.

3. Anti-inflammatory activity
Most five-membered ring triterpenoids have anti-inflammatory properties, including Betulin Sigma and betulin. The anti-inflammatory properties of these two compounds have been validated in a number of in vitro and in vivo model systems. The results show that both Betulin Sigma and betulinic acid have mild anti-inflammatory properties at higher concentrations, and that their anti-inflammatory properties are mainly attributable to inhibition of non-neural gene pathways.

4. Other
Betulin Sigma can inhibit the synthesis of cholesterol and triglycerides, and effectively prevent obesity and atherosclerosis. Betulin can improve insulin sensitivity and has a good effect on type II diabetes. Betulin has antibacterial, antiviral, inhibiting protein dissolution in hair fiber, improving damaged hair luster, promoting hair growth and other activities.

Betulin Sigma Preparation

Method 1: Using birch bark as raw material, the extraction and purification process of Betulin Sigma in birch bark was studied, and the process was suitable for medicinal scale-up production. The birch bark was crushed, extracted with 10 times the amount of 95% ethanol for 5 hours, filtered, the filter residue was extracted with 8 times the amount of 95% ethanol under reflux for 3 hours, the filtrates were combined, the ethanol was recovered, passed through a celite column, and washed with ethyl acetate Take off, recover ethyl acetate from the eluent to dryness, add 15 times of 95% ethanol to heat and dissolve, cool down below 0~C, filter, and dry, and the content of the dry product is above 98%.

Method 2: A method for preparing high-purity Betulin Sigma, comprising:

1) The pulverized birch bark is extracted by heating with aqueous ethanol solution, and the extract is collected, and then the extract is concentrated, and the concentrate is cooled, and the betulin crude product solid is separated out, and the crude product I is obtained by filtration;

2) the betulin crude product I obtained in step (1) is dissolved in an aqueous ethanol solution, heated and stirred to dissolve, filtered while hot to remove insoluble impurities, an aqueous alkali solution is added, the solid is separated out, cooled, and the solid is filtered to obtain the crude product II;

3) The betulin crude product II obtained in step (2) is dissolved in an aqueous ethanol solution, heated to dissolve, filtered to remove insoluble impurities, the filtrate is collected, placed to cool to precipitate crystals, filtered to obtain a solid, and dried to obtain Betulin Sigma with a purity greater than or equal to 99%. .

Lnvention Content of Betulin Sigma, Betulinic Acid

The technological trouble to be solved by the present creation is to supply the new functions of Betulin Sigma, betulinic acid antidepressant, sedative and hypnotic, as well as can supply a new medication resource for the prevention and treatment of sleep problems as well as anxiety.

The technological system of the here and now invention is:
Application of Betulin Sigma in the preparation of medicines for avoiding and also treating sleep problems and anxiety.

Application of betulinic acid in the prep work of medicaments for avoiding and dealing with sleeping disorders and also anxiety.

An anti-insomnia and also anxiety pharmaceutical prep work consisting of betulin, which remains in the type of a dental dose form or an inhalant. The dental dosage kind is an orally breaking down tablet computer.

An anti-insomnia as well as clinical depression pharmaceutical prep work comprising betulinic acid, which remains in the form of an oral dose form or an inhalation. The dental dosage type is an orally degenerating tablet computer.

In today invention, the Betulin Sigma and also betulinic acid can be prepared by commercially available or well-known methods.

The pureness of wherein said Betulin Sigma, betulinic acid > 50%, ideally > 80%, more preferably > 95%.

The advantages of the present creation are as follows: today creation reveals the features of protecting against and also treating sleep problems and also anxiety. There are no negative aspects such as exhilaration, trembling, dependency, etc. of standard antidepressants and also sedative-hypnotic drugs, and the safety and security is excellent, appropriate for long-lasting appropriateness, and also can execute conditioning treatment for clinical depression and also insomnia patients, revealing that both substances have development as well as application prospects.

Betulin Sigma and also betulinic acid of the present innovation can be prepared by utilizing a single part to prepare medications for stopping as well as treating sleep problems as well as anxiety, and can be combined with other active parts (such as jujube saponin A, jujube saponin B, acid plume and various other substances), etc. Usual formula to prepare multi-target antidepressant, sedative and hypnotic drugs.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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