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Betulin CAS 473-98-3

Molecular Formula: C30H50O2

Formula Weight: 442.72

ZSpharmac: Betulin Supplier

Product Name: Betulin
CAS No: 473-98-3
Purity: 99%

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Basic Info

Product Name:Betulin
Other Names:Betulinol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Powder
EINECS No.:207-475-5
Provide:Betulin MSDS;
Betulin COA

What is Betulin?

Betulin, the Chinese name is betulin, also known as betulin, betulin or betulin, is a natural compound extracted from white birch bark and belongs to the acyclic triterpenoids. Its molecular structure has certain uniqueness and can be dissolved in ethanol, ether, chloroform and benzene, but its solubility in solvents such as cold water and petroleum ether is low. Betulin appears as a white crystalline form with a well-defined melting point, approximately between 238°C and 251°C, depending on the solvent environment used.

Betulin has attracted attention for its various biological activities, including anti-inflammatory, antiviral, inhibiting the dissolution of proteins in hair fibers, improving the shine of damaged hair, and promoting hair growth. These properties make betulin a versatile chemical ingredient that is not only used in the cosmetic industry to make hair care and skin care products to improve skin conditions and hair health, but also finds applications in the pharmaceutical and food industries as a potential treatment or supplementary ingredients.

Betulin Property

Melting point 256-257 °C(lit.)
Boiling point 493.26°C (rough estimate)
alpha D15 +20° (c = 2 in pyridine)
density 0.9882 (rough estimate)
refractive index 1.5045 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
form Off-white powder
color Pale Brown to Beige


Pharmacological Action and Application of Betulin

1. Pharmaceutical industry
Anti-inflammation and immunomodulation: Betulin has a mild anti-inflammatory effect, can regulate the activity of the immune system and reduce inflammatory responses, and is suitable for the development of drugs for the treatment of inflammatory diseases such as arthritis.
Anti-tumor: Research shows that betulin has an inhibitory effect on a variety of cancer cell lines. Its mechanism may involve inhibiting cell proliferation, inducing apoptosis, etc., providing a new chemical raw material basis for cancer treatment.
Antibacterial and antiviral: Its antibacterial and antiviral properties make betulin potentially useful in the development of new antibiotics and antiviral drugs.

2. Cosmetics industry
Skin care: In skin care products, betulin is widely used in anti-aging products because it can promote skin cell regeneration, improve skin barrier function, and reduce fine lines and wrinkles.
Hair care: It can inhibit the dissolution of hair proteins, reduce damage, increase luster, and promote hair growth. It is an effective ingredient in high-end hair care products.
Anti-inflammation and repair: In care products for sensitive skin and problem skin, the anti-inflammatory properties of betulin help to relieve skin redness, itching and other symptoms.

3. Food industry
Although betulin’s direct application in the food industry is not as extensive as in the pharmaceutical and cosmetic fields, given its potential health benefits, such as antioxidant and anti-inflammatory effects, it may be developed as a functional food additive or dietary supplement in the future. Promote good health.

4. Materials Science
The special chemical structure of betulin and its derivatives may be explored for the development of new bio-based materials, such as biodegradable plastics, drug delivery carriers, etc., taking advantage of its biocompatibility and controllable physical and chemical properties.

5. Scientific research and biotechnology
As a chemical raw material for basic research, betulin is a precursor for the synthesis of other bioactive compounds such as betulinic acid and its derivatives, which may have wider biological activities and application potential.

Outstanding Applications of Betulin in Cosmetics

1. Strengthen skin barrier
Betulin can help strengthen the skin barrier function and enhance the skin’s resistance to external environmental factors (such as pollution, ultraviolet rays and climate change) by promoting the health of the stratum corneum. This is especially important for sensitive skin or easily damaged skin, helping to reduce water loss and maintain the skin’s water and oil balance.

2. Anti-inflammatory and soothing
Its mild anti-inflammatory properties make betulin an ideal ingredient for relieving skin redness, itching and inflammation. It is suitable for sensitive or inflammatory skin care products, such as anti-redness creams, soothing masks, etc.

3. Anti-aging effect
As a natural antioxidant, betulin can fight free radicals, reduce oxidative stress, and thus slow down the skin aging process. It can promote collagen synthesis, improve skin elasticity, and reduce fine lines and wrinkles. It is often used in various anti-aging skin care products, such as essences, night creams and eye creams.

4. Whitening and even skin tone
By inhibiting the activity of tyrosinase, betulin can reduce the production of melanin, help fade spots, even skin tone, and improve skin brightness and transparency, so it also has a place in whitening products.

5. Promote wound healing
Betulin has the property of promoting cell regeneration, which can accelerate the healing process of skin wounds and reduce scar formation. It is suitable for use in repair products, such as scar repair cream or regeneration essence.

6. Natural and gentle
As a plant extract, betulin complies with the current cosmetics market’s pursuit of natural, organic and mild ingredients, meets consumers’ expectations for safety and sustainability, and is suitable for creating a “clean beauty” product line.

7. Formula Compatibility
The good chemical stability of betulin is compatible with most cosmetic raw materials, making it easy to use in various formulations. It can be well integrated into both oil-in-water and water-in-oil systems, increasing its flexibility in cosmetic formulations.

Characteristics of Betulin

Structural characteristics: Betulin is a lupine-type pentacyclic triterpenoid compound, composed of 6 isoprene units, with a molecular formula of C30H50O2 and a relative molecular mass of 442.72. This structure gives it specific chemical and biological activities.

Physical properties: Betulin is usually in the form of white crystalline powder with a melting point between 252-257°C. This characteristic is beneficial to its handling and purification during the manufacturing process. It is easily soluble in organic solvents such as ethanol, ether, chloroform and benzene, and slightly soluble in cold water and petroleum ether, which indicates that its solubility and dispersion in cosmetic formulas need to be optimized through reasonable formula design.

Clear source: Mainly extracted from white birch bark, a sustainable natural resource, ensuring the renewable and eco-friendly nature of the raw materials.

Contact Us

As a company specializing in the production and supply of Betulin raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the Betulin raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Betulin Quotation