Zhishang Chemical

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Zhishang Chemical

Betulin CAS 473-98-3

Molecular Formula: C30H50O2

Formula Weight: 442.72

ZSpharmac: Betulin Supplier

Product Name: Betulin
CAS No: 473-98-3
Purity: 99%

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Basic Info

Product Name:Betulin
Other Names:Betulinol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Powder
EINECS No.:207-475-5
Provide:Betulin MSDS;
Betulin COA

What is Betulin?

Betulin, also referred to as betulin, betulin, as well as betulin, is a course of triterpenoids drawn out from birch bark. Its use in bark is unidentified, yet it can be used as betulinic acid (carboxylic acid team Replaced alcohol team) and also various other precursors with even more biological practical substances.

Betulin Property

Melting point 256-257 °C(lit.)
Boiling point 493.26°C (rough estimate)
alpha D15 +20° (c = 2 in pyridine)
density 0.9882 (rough estimate)
refractive index 1.5045 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
form Off-white powder
color Pale Brown to Beige


Pharmacological Action and Application of Betulin

Betulin is a chemical medicine, plant essence, and also Chinese herbal medication essence. Research studies have actually located that betulin has moderate anticancer, antibacterial, antiviral as well as other organic activities, and also can likewise be used as a forerunner for the synthesis of betulin derivatives, betulinic acid as well as matching derivatives. Today, betulin is mostly used as a pharmaceutical intermediate. Betulin and its derivatives have actually revealed great potential as organic agents in the treatment of HIV and cancer.

1. Anti-HIV task
Mechanistically, although these substances of betulin as well as its by-products do not hinder HIV-1 reverse transcriptase, they inhibit nucleosome development at concentrations above the IC50 value. Consequently, it can be concluded that these betulin by-products function by interfering with the later stages of the virus life cycle, which belongs to infection entrance as well as growth and also growth.

2. Antitumor task
An experiment to study the anti-tumor impact and device of betulin in vivo showed that mouse liver cancer cells (H22) were used to develop a tumor-bearing mouse animal model. After intragastric management of betulin for 10 days, the growth restraint price, thymus index, spleen Index; MTr method was made use of to determine the makeover feature of computer mouse T lymphocytes as well as the killing activity of NK cells. Outcomes The 3 dosage teams of betulin and also the favorable control team all minimized the growth weight, and also the difference was statistically significant compared with the negative control group (P< 0.05), and also the difference in between the middle as well as high dosage teams as well as the adverse control group was also statistically significant (P< 0.05); when the effect-to-target proportion of the low-dose team was 25:1, the killing task of NK cells was more than that of the positive control group.

3. Anti-inflammatory activity
Most five-membered ring triterpenoids have anti-inflammatory residential properties, including betulinic acid as well as betulin. The anti-inflammatory residential or commercial properties of these 2 compounds have been confirmed in a variety of in vitro and also in vivo version systems. The outcomes showed that both betulin and betulinic acid had moderate anti-inflammatory homes at higher focus, as well as their anti-inflammatory residential properties were generally credited to the inhibition of non-neural gene paths.

4. Various other
Betulin can prevent the synthesis of cholesterol and also triglycerides, effectively protect against weight problems and atherosclerosis, betulin can boost insulin level of sensitivity, and has a great impact on kind diabetes. Betulin has anti-bacterial, antiviral, hinder healthy protein dissolution in hair fibers, enhance damaged hair appeal, advertise hair development as well as other activities.

Contents of The Invention of Betulin

The technical issue to be fixed by the present invention is to supply brand-new applications of betulin and betulinic acid for antidepressant and sedative hypnosis, which can offer a brand-new medication resource for the avoidance as well as treatment of sleeplessness as well as anxiety.

Technical scheme of the here and now invention is:
Application of betulin in the preparation of drugs for stopping and also treating sleeplessness and depression.

Application of betulinic acid in the preparation of medicines for protecting against and also treating sleeplessness as well as anxiety.

An anti-insomnia and also clinical depression pharmaceutical preparation consisting of betulin, the dose form is dental dosage kind or inhalation. The oral dosage type is a by mouth disintegrating tablet.

An anti-insomnia and depression pharmaceutical preparation including betulinic acid, the dose type is oral dosage type or breathing. The oral dose type is an orally disintegrating tablet.

In the here and now development, the betulin and also betulinic acid can be prepared by readily available or well-known techniques.

The pureness of where stated betulin, betulinic acid >=50%, is preferably >=80%, is a lot more ideally >=95%.

The benefits of today invention are: the present development divulges the impact of avoiding and treating sleep problems and also clinical depression. There are no imperfections such as excitement, tremor, and also dependency of standard antidepressants and sedative-hypnotic drugs. It is safe and also appropriate for long-term use. It can be utilized for conditioning treatment for individuals with clinical depression and insomnia, revealing that the two compounds have development and application leads.

Betulin and betulinic acid of the present creation can be used as a solitary element to prepare medications for protecting against as well as dealing with sleeplessness and anxiety, and also can be integrated with various other energetic ingredients (such as jujube saponin A, jujube saponin B, and also Li alkali) and also various other joint prescriptions to prepare multi-target antidepressant, sedative and also hypnotic drugs.

Preparation of Betulin

Method 1: Using birch bark as raw material, the extraction and purification process of betulin in birch bark was studied, and this process was suitable for the scale-up production of medicine. Crush the birch bark, extract with 10 times the amount of 95% ethanol under reflux for 5 hours, filter, and extract the filter residue with 8 times the amount of 95% ethanol under reflux for 3 hours, combine the filtrates, recover ethanol, pass through a diatomaceous earth column, and wash with ethyl acetate Ethyl acetate was recovered from the eluate to dryness, and 15 times of 95% ethanol was added to heat to dissolve, then cooled below 0~C, filtered, and dried, and the content of the dry product was above 98%.

Method 2: a method for preparing high-purity betulin, comprising:

1) The pulverized white birch bark is extracted by heating and refluxing with an aqueous ethanol solution, the extract is collected, then the extract is concentrated, the concentrate is cooled, the crude betulin solid is precipitated, and the crude product I is obtained by filtration;

2) Dissolving the crude betulin alcohol I obtained in step (1) in an aqueous ethanol solution, heating and stirring to dissolve, filtering while hot to remove insoluble impurities, adding an aqueous alkali solution, solid precipitation, cooling, and filtering the solid to obtain crude product II;

3) Dissolve the crude betulin alcohol II obtained in step (2) in an aqueous ethanol solution, heat to dissolve, filter to remove insoluble impurities, collect the filtrate, place and cool to precipitate crystals, filter to obtain a solid, and dry to obtain betulin with a purity greater than or equal to 99%. alcohol.

About Products:
If you need Betulin, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Betulin manufacturer and supplier, ZSpharmac will provide Betulin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Betulin Quotation