Zhishang Chemical

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Molecular Formula: C42H70O35

Formula Weight: 1134.99


CAS No: 7585-39-9
Purity: 99%

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Basic Info

Other Names:β-Cyclodextrin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:231-493-2
Storage:Room Temp


Cyclodextrin (CD), also known as Saltinger dextrin, is the second-generation supramolecular host compound, which is a chair-like conformation ring formed by D-glucopyranose linked by α-1,4 glycosidic bonds. Shaped oligosaccharides. Natural cyclodextrins include α-cyclodextrin, BETA-CYCLODEXTRIN and γ-cyclodextrin, which contain 6, 7, and 8 glucose monomers respectively, among which β-cyclodextrin is a cyclodextrin that can be commercialized on a large scale in industry. Dextrin products, its preparation method is simple, low cost, other commercially available β-cyclodextrin derivatives include carboxymethyl-β-cyclodextrin, glucosyl-β-cyclodextrin, ethylenediamine-β -cyclodextrin, hydroxyethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, sulfonate-β-cyclodextrin, quaternary ammonium-β-cyclodextrin and the like. Because of its rich hydroxyl structure, cyclodextrin has a good adsorption and wrapping effect on many organic molecules and inorganic heavy metals. It has the characteristics of safe raw materials, non-toxic, biodegradable, and good reusability. It is widely used in water treatment Research on the removal of organic and inorganic pollutants. According to the characteristics of water solubility and water insolubility, BETA-CYCLODEXTRIN and its derivatives can be used as flocculants, catalysts and adsorbents for water treatment, using the complexation, encapsulation, hydrogen bonding, electrostatic neutralization and catalytic degradation of target pollutants in aqueous solution systems function to achieve the purpose of removing the target pollutants.


Melting point 

290-300 °C (dec.) (lit.)

Boiling point 

844.96°C (rough estimate)


[α]D25 +159~+165° (c=1, H2O) (After Drying)


1.2296 (rough estimate)

refractive index 

1.7500 (estimate)

storage temp. 

room temp


1 M NaOH: 50 mg/mL








5.0-8.0 (1% in solution, Ph Eur)

optical activity

[α]20/D +162±3°, c = 1.5% in H2O

Water Solubility 

Soluble in water and ammonium hydroxide.



1. Using BETA-CYCLODEXTRIN in the pharmaceutical sector Using cyclodextrin to create inclusions (encapsulation) with medicines can maintain (1) unstable medications; (2) deliquescent, adhesive or liquid Medicine powdering; (3) Solubilization (solubilization) of poorly soluble or insoluble medications, etc 2. Using BETA-CYCLODEXTRIN in the pesticide industry Cyclodextrin inclusion stabilization, some pesticides can sustain storage space and enhance insecticidal effectiveness.
3. Use in the food industry Cyclodextrin is used in the food sector and also has the adhering to features: (1) Elimination and masking of details odors; (2) Enhancement as well as enhancement of food framework; (3) Alleviation of bitter preference as well as elimination; (4) anti-oxidation; (5) upkeep and also optimization of flavor.
4. Application of BETA-CYCLODEXTRIN in daily chemical industry Cyclodextrin can likewise be utilized as emulsifier and top quality improver in cosmetics manufacturing. It likewise has deodorizing (such as bad breath) as well as antiseptic impacts, and also can be made use of in the manufacture of tooth paste and also tooth powder.
5. Other uses of BETA-CYCLODEXTRIN can be made use of as a therapy representative for oily sewage in environmental protection. The aqueous option of cyclodextrin is utilized to cleanse the oil storage tank, and the waste fluid can be reused to get gas oil.
6. Use cyclodextrin in the field of chemistry Cyclodextrin is a valuable chemical reagent. When it exists, the fluorescence strength of the fluorochrome will increase significantly, so it can be taken advantage of in the evaluation of proteins as well as also amino acids; it can additionally be made use of to divide long-chain natural materials, racemates, and so forth. In addition to that, adsorbents made from cyclodextrins can be made use of as adsorbents for chromatographic evaluation.

BETA-CYCLODEXTRIN—Efficient Catalyst for Chemical Synthesis

1. BETA-CYCLODEXTRIN is the most efficient catalyst
The researchers first compared the catalytic effects of taurine, CTAB, TBAB, γ-cyclodextrin, and β-cyclodextrin catalysts, and found that β-cyclodextrin had the highest catalytic efficiency, while the same γ-cyclodextrin But dextrin has poor catalytic effect.

2. Select the most efficient concentration of BETA-CYCLODEXTRIN
Subsequently, the researchers compared the catalytic effects of 10mol, 20mol and 25mol of β-CD, and found that the catalytic effect was the best at the concentration of 20mol.

3. Find the most suitable reaction solvent and optimum reaction temperature
Next, the researchers compared the reaction effects in polar aprotic solvents (DMF, THF, and CH3CN) and polar protic solvents (H2O and EtOH), and found that in polar protic solvents H2O, EtOH:H2O (1 : 1) The medium reaction effect is the best.

In terms of reaction temperature, the reaction product yield is not high at room temperature, and when the temperature rises to 50 degrees Celsius, the reaction speed is the fastest and the reaction product yield is the highest.

4. Examining the Effect of Functional Groups
Meanwhile, the researchers tested the compatibility of various aromatic aldehydes with electron-withdrawing or electron-donating substituents with the reaction. The results show that the reaction can be carried out smoothly, and can tolerate a wide range of functional groups, such as chlorine, nitrobromide, fluorine, methyl, methoxyl, hydroxyl and phenyl, and the yield of products under the condition of electron-withdrawing substituents is relatively high. High, and slightly lower under the condition of electron-donating substituents, but both can obtain the corresponding products in good or excellent yields.

5. Examining Catalyst Reusability
Catalyst reuse can significantly reduce production steps and reduce production costs. At the end of the experiment, the researchers also studied the number of reuses of β-cyclodextrin. They found that BETA-CYCLODEXTRIN could be reused for 4 cycles, maintaining a high yield of 91%-84%. After 4 cycles, the reaction time increased and the product yield decreased.

Modification Method of BETA-CYCLODEXTRIN

BETA-CYCLODEXTRIN has relatively good solubility in water, and it is not easy to recycle when used in water phase, which greatly limits its application in water treatment. Cyclodextrin is a natural organic substance, safe, non-toxic and biodegradable. It is a better choice for cyclodextrin as adsorption, flocculation and photocatalytic materials. In order to improve solubility, dispersibility and long-term Stability, proper modification of β-cyclodextrin to make it have multifunctional, water-soluble or water-insoluble, high-dispersibility and other functional materials is very meaningful in water treatment. Usually, the methods of modifying cyclodextrin include chemical method and enzymatic method. Enzymatic method is mainly used to prepare branched cyclodextrin. Chemical method can use the outer alcoholic hydroxyl group of β-cyclodextrin to change its physical (solubility, mechanical strength, Size, specific surface area, etc.), chemical (chemical adsorption, complexation, electrical neutralization) and biological (antibacterial, degradable, etc.) properties, thus expanding its application in the field of water treatment. Chemically modified β-cyclodextrin can be classified into the following two categories:

1) Use the hydroxyl energy on the outer surface of BETA-CYCLODEXTRIN to react with multifunctional substances to generate various cyclodextrin derivatives with cyclodextrin as the skeleton to improve or reduce the concentration of β-cyclodextrin in water Solubility, it is mainly used as flocculant or coagulant in water treatment. It can play the role of moisture-proof, anti-oxidation and color protection in the food field. In the field of medicine, it can play the role of improving the solubilization of insoluble drugs. Analytical chemistry Domain can participate in the formation of stationary phase, play a role in molecular recognition and improve separation effect. β-cyclodextrin derivatives can be divided into cyclodextrin ethers, cyclodextrin esters, cyclodextrin-polymers and cross-linked cyclodextrins according to the chemical reaction of the introduction of new groups; The properties can be roughly divided into three types: hydrophilic, hydrophobic and ionic. Hydrophilic cyclodextrin derivatives include branched cyclodextrin, low molecular weight cyclodextrin polymer (molecular weight 3k ~ 6k), methyl cyclodextrin, hydroxyethyl cyclodextrin and hydroxypropyl cyclodextrin, etc. Hydrophobic cyclodextrin derivatives include ethyl cyclodextrin, acetyl cyclodextrin and polyacrylamide cyclodextrin, etc.; ionic cyclodextrin derivatives include quaternary ammonium or polyamine cyclodextrin, N- (2,3-Epoxypropyl)trimethylammonium chloride cyclodextrin, carboxymethyl cyclodextrin, alkylsulfonic acid cyclodextrin, phosphate ester cyclodextrin and sulfate ester cyclodextrin, etc.

2) Building BETA-CYCLODEXTRIN on other carriers can synthesize water treatment adsorbent materials with long service life, good mechanical properties or high dispersion properties. Carriers mainly include inorganic molecules, organic synthetic polymers and natural product polymers. Among them, inorganic carriers include graphene oxide, carbon nanotubes, SiO2 nanoparticles, magnetic Fe3O4 nanoparticles and zeolite, etc.; organic synthetic polymer carriers include polyethyleneimine, polyvinyl alcohol, polypropylene, polypropylene, polystyrene and Polymers such as polyester nanofibers; natural polymer carriers include cellulose and its derivatives, wood flour, chitosan, gelatin, sodium alginate, etc.

About Products:
If you need BETA-CYCLODEXTRIN this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of BETA-CYCLODEXTRIN, ZSpharmac will provide BETA-CYCLODEXTRIN raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.