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Beta Arbutin CAS 497-76-7

Molecular Formula: C12H16O7

Formula Weight: 272.25

ZSpharmac: Beta Arbutin Supplement

Product Name: Beta Arbutin
CAS No: 497-76-7
Purity: 99%

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Basic Info

Product Name:Beta Arbutin
Other Names:Arbutin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:207-850-3
Storage:Inert Atmosphere,Room Temperature
Provide:Beta Arbutin MSDS;
Beta Arbutin COA

What is Beta Arbutin?

Beta Arbutin is likewise referred to as arbutin, arbutin, arbutin, arbutin or myricetin, since it was initially stemmed from natural environment-friendly plants, it is a collection of “green”, “secure” as well as “efficient” ideas. Skin lightening active compound. Beta Arbutin is an excellent bleaching representative for lightening cosmetics. There are 2 optical isomers, namely α as well as ß types, as well as the biologically active ß isomer. It is white and also slightly yellow-colored powder at room temperature level. It is conveniently soluble in water, methanol, ethanol, propylene glycol and glycerin liquid solution. After liquifying, there is no precipitation liquid. It is added to several bleaching skin care items. It was called after it was found in the fallen leaves of the Rhododendron genus Ursopus, as well as was later discovered in the Rhododendron family members bilberry bilberry, the Rosaceae pear genus sand pear tree (Western pear, Xiaoshan pear), saxifrage It is found in the leaves of Saxifraga saxifrage, etc, and is made use of as a pharmaceutical and also aesthetic additive after extraction.

Beta Arbutin is one of the best and also most effective whitening basic materials prominent abroad, and also it is also the most affordable skin lightening as well as blemish removing energetic representative in the 21st century. In cosmetics, it can efficiently whiten and also eliminate freckles on the skin, slowly lighten and also eliminate blemishes, melasma, melanin, acne and also age spots. High safety and security, no irritability, sensitization and also opposite side results, excellent compatibility with different parts of cosmetics, and also steady ultraviolet radiation. Nonetheless, Beta Arbutin is conveniently hydrolyzed and must be made use of at a pH of 5-7. In order to stabilize the efficiency, an ideal amount of antioxidants such as salt bisulfite as well as vitamin E are normally added, so as to better achieve the impacts of whitening, freckle removal, hydrating, softening, crease removal as well as anti-inflammatory. It can be made use of to remove inflammation, advertise injury healing without scarring, and hinder the formation of dandruff.

Beta Arbutin Property

Melting point 195-198 °C
alpha -64 º (c=3)
Boiling point 375.31°C (rough estimate)
density 1.3582 (rough estimate)
refractive index -65.5 ° (C=4, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 50 mg/mL hot, clear
form neat
color White
optical activity[α]/D -64.0±2.0°, c = 3 in H2O
Water Solubility 10-15 g/100 mL at 20 ºC


Beta Arbutin Features and Efficacy


Beta Arbutin is additionally the main ingredient of the new type of melt and also scald medicine, which is defined by fast pain alleviation, strong anti-inflammatory power, rapid elimination of redness and also swelling, fast recovery, as well as no scarring. It does not generate poisonous, bothersome, animating and also other side impacts to melanocytes, as well as also has emollient, invasive, bactericidal and synergistic anti-inflammatory results. It is currently among the most safe and also most effective bleaching basic materials prominent abroad, as well as it is likewise the most affordable skin whitening and also freckle-removing energetic representative in the 21st century.

Beta Arbutin can hinder the activity of tyrosinase in the body and also prevent the manufacturing of melanin, thus minimizing skin pigmentation, eliminating pigmentation and freckles, and additionally has antiseptic and also anti-inflammatory results, which can dramatically prevent the production of tyrosinase in the cortex. Build-up, has a whitening effect on the skin, the impact is more powerful than kojic acid and ascorbic acid.


Beta Arbutin has the impact of brightening the skin, can quickly permeate right into the skin without impacting the skin cells, prevent the activity of tyrosinase to attain a whitening result, in addition, arbutin can additionally protect the skin from free radicals, hydrophilic As a result, it is frequently added to whitening products. There are two usual ones, α-arbutin as well as β-arbutin.

The preparation approach is different, and also there is one more called deoxyarbutin; also called D-arbutin.

In terms of bleaching results, the very best anti-melanin result is deoxy Beta Arbutin, which is dramatically greater than α-arbutin and β-arbutin;
The result of alpha-arbutin in hindering melanin production. It is 10 times stronger than β-arbutin, hence obtaining deoxyarbutin > α-arbutin > β-arbutin.

Is Beta Arbutin Suitable for Daytime Use?

Beta Arbutin decreases the production of melanin by hindering the activity of the melanin-producing enzyme tyrosinase, comparable to the whitening drug hydroquinone. Nonetheless, hydroquinone has negative effects, and there are several preventative measures. It must be utilized under the support and monitoring of a medical professional. The framework of arbutin has more sugar particles than hydroquinone, which is less annoying as well as can be openly added to skin treatment products with a focus restriction of as much as 7%.
The active particles of Beta Arbutin can penetrate the basal layer for deep blemish reduction. It has a solid therapeutic impact on melasma, dark areas, sun spots, and also pigmentation left over from drug allergies, however the focus is also reduced, as well as its impact is lasting. Sex will certainly be weakened, so 5% focus is the safest as well as most effective focus for spot lightening. The concentration of 5% is quicker than vitamin C to lighten places, and the perseverance of light areas is stable as well as does not trigger irritation to the skin.
Beta Arbutin will certainly be lowered to hydroquinone after being absorbed by the skin, which has brought about some individuals’s questions concerning the safety of arbutin, thinking that arbutin still has the possibility to generate adverse effects similar to hydroquinone. One of the most often listened to statement is that “the skin treatment products having arbutin can not be made use of throughout the day, otherwise lightening will certainly not be accomplished, but it will be darker”.
As a matter of fact, do not worry, the examination reveals that only arbutin with a concentration of greater than 7% might be sensitive to light, so 7% is a safety critical point. Within this concentration variety, arbutin is insufficient to create photosensitivity, and it is not needed to utilize it at night. Absorbed via the skin, disintegrated by light, it will be decreased to hydroquinone, resulting in a bleaching result. The focus of hydroquinone contained in arbutin skin treatment items is less than 20ppm (that is, 20 parts per million). Under such a low concentration restriction, hydroquinone will certainly not cause adverse effects such as skin anti-blackening.
If you dare not use it throughout the day even if the skin treatment product includes Beta Arbutin, then it is not required, unless the skin treatment item including arbutin additionally adds other upkeep components that require to be secured from light. In short, buy skin care items from reliable brands, and afterwards apply sunscreen during the day whatever you apply.

Preparation Method of Beta Arbutin

At present, there are many extraction sources and preparation methods of β-arbutin, including chemical industry synthesis, plant cell culture, enzymatic transformation and plant extraction. Among them, synthetic products dominate the market because of their high activity, light color and high purity. Regardless of the source or route to obtain arbutin, its quality depends on the purity, and the common Beta Arbutin on the market is 99% pure. 90% of the arbutin sold by our company is also synthetic. Lutianren also naturally extracted 98% of the natural beta Arbutin from red bean leaves. The price is 10 times as much as synthetic, 6,000 yuan/kg. The raw materials used in plant tissue culture and enzymatic methods are simpler, more efficient, and pollution-free in the production process.

The preparation technique of α-arbutin is obtained with sugar conversion by microbial enzymes, and also its stability, efficiency and security are much better than that of β-arbutin, and also the whitening result is 10 times that of beta. It has actually been widely used by many aesthetic brands on the planet.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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