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Zhishang Chemical

Best Diphenhydramine Hydrochloride CAS 147-24-0

Molecular Formula: C17H22ClNO

Formula Weight: 291.82

ZSpharmac: Diphenhydramine Hydrochloride Supplement

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Product Name: Best Diphenhydramine Hydrochloride
CAS No: 147-24-0
Purity: 99%

Basic Info

Product Name:Best Diphenhydramine Hydrochloride
Other Names:Diphenhydramine Hydrochloride
CAS:147-24-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:White Crystalline Powder or Adhering Crystals
EINECS No.:205-687-2
Storage:Ventilated Low Temperature Drying 2-8°C
Provide:Best Diphenhydramine Hydrochloride MSDS;
SigmaAldrich COA

What is Best Diphenhydramine Hydrochloride?

Best Diphenhydramine hydrochloride is just one of the common anticholinergic medicines. Anticholinergics are a course of drugs that treat a range of problems, consisting of allergic reactions, colds, hypertension, clinical depression, Parkinson’s disease, epilepsy, chronic obstructive lung disease, urinary system incontinence, and overactive bladder. A few of the best anticholinergic drugs consist of antihistamines, resting tablets, tricyclic antidepressants, and also medications for over active bladder. Diphenhydramine hydrochloride tablet is an anti-allergic over-the-counter drug, which is a medical insurance work-related injury drug. It is used for skin and mucous membrane allergies, such as urticaria, allergic rhinitis, skin pruritus, drug eruption, and is also effective for insect bites and contact rhinitis; The product can also be used to prevent and treat motion sickness, and has a strong antiemetic effect.

Best Diphenhydramine Hydrochloride Properties:

Melting point 168-172 °C
Boiling point 163-167 °C(Press: 3 Torr)
density 1.0489 (rough estimate)
refractive index 1.5800 (estimate)
Fp 9℃
storage temp. 2-8°C
solubility Very soluble in water, freely soluble in alcohol.
form Crystalline Powder or Adhering Crystals
color White
PHpH(100g/L, 25℃) 4.0~5.5
Water Solubility 1000 g/L

 

Best Diphenhydramine Hydrochloride Uses

  1. Finest Diphenhydramine hydrochloride works as an antihistamine by taking on histamine released from cells for H1 receptors on effector cells, thereby avoiding allergic reactions.
  2. Restraint of central nervous system task by Very best Diphenhydramine hydrochloride creates sedative-hypnotic outcomes.
  3. Best Diphenhydramine hydrochloride strengthens the effect of antitussives, and also has anti-dizziness and anti-paralysis effects.
  4. Best Diphenhydramine hydrochloride is used in pharmaceutical APIs.

Best Diphenhydramine Hydrochloride Applications and Side Effects

Application:

Diphenhydramine hydrochloride is mostly used for: skin and also mucous membrane layer allergic reactions, such as urticaria, angioedema, allergic rhinitis, pruritus, drug eruption, insect bites and call dermatitis; prevention as well as therapy of nausea, there are Solid antiemetic impact; Parkinson’s condition and also extrapyramidal signs and symptoms; sedative, hypnotic; reinforce the effect of antitussives, appropriate for the treatment of coughing triggered by colds or allergies.

Common side effects of diphenhydramine hydrochloride include drowsiness, poor orientation, and nausea, and it is not recommended for infants. The risks of use while pregnant are not known, but this medication is not recommended while breastfeeding.
As with other H1 antagonists, restless legs syndrome can be exacerbated at normal doses.
Diphenhydramine hydrochloride is also an anticholinergic agent that inhibits the parasympathetic nerves, causing side effects such as dizziness, dilated pupils, tachycardia, photophobia, confusion, and difficulty concentrating.
Taking too much diphenhydramine can be slightly psychologically addictive.
Although it has a sedative effect, due to the different adaptability of each person to the drug, there is a chance that an abnormal reaction will occur and instead become active.
Concomitant use of diphenhydramine hydrochloride with alcohol can cause drug interactions that can exacerbate drowsiness

Precautions for Best Diphenhydramine Hydrochloride

1. People with pyloric as well as duodenal blockage, pyloric constriction triggered by peptic ulcer, bladder neck stenosis, hyperthyroidism, heart disease, hypertension as well as lower respiratory system infection (consisting of asthma) should not utilize this item.
2. People who are very allergic to other ethanolamines might additionally dislike this item.
3. Avoid driving a lorry, operating at heights, or operating equipment after applying this medication.
4. In renal failure, the interval of management must be prolonged.
5. The antiemetic result of this item can trigger difficulties in the medical diagnosis of specific conditions.

Best Diphenhydramine Hydrochloride First Aid

Eyes: First check sufferer for contact lenses and eliminate if so. Flush sufferer’s eyes with water or saline for 20 to 30 minutes while calling medical facility or toxin control center. Do not put any kind of ointment, oil or medicine in the victim’s eyes without particular instructions from your doctor. Even if there are no signs (such as inflammation or irritability), the target needs to be required to the health center instantly after purging the eyes. Skin: Instantly flush influenced skin with water while eliminating as well as isolating all infected clothing. Gently and thoroughly clean all impacted skin areas with soap and water. If symptoms such as soreness or inflammation establish, call a medical professional immediately and also prepare to transfer the sufferer to a healthcare facility for therapy. Offer appropriate respiratory system security for rescuers going into unidentified environments. Whenever feasible, use self-contained breathing device (SCBA); if not available, utilize a degree of security higher than or equal to that advised in the protective apparel. Intake: Do not generate vomiting. If victim is conscious and also not shaking, offer 1 or 2 glasses of water to thin down chemical and call medical facility or toxin control center instantly. Be prepared to deliver the sufferer to the healthcare facility if recommended by your medical professional. If the target is shaking or loses consciousness, do not feed anything by mouth, make sure the sufferer’s respiratory tract is clear, and place the target on his side with his head lower than the body. Do not generate vomiting. Take the target to the hospital right away.

Best Diphenhydramine Hydrochloride Pharmacology and Toxicology

Diphenhydramine hydrochloride is a by-product of ethanolamine. Its antihistamine result is not just as good as that of promethazine, and its duration of action is likewise much shorter. The sedative result of the two drugs is the same, as well as it has regional anesthesia, antiemetic as well as anti-M choline-like impacts.
1. Antihistamine action, which takes on histamine released from cells for H1 receptors on effector cells, consequently preventing allergic reactions;
2. Restraint of main nervous system activity creates a sedative-hypnotic result;
3. Strengthens the effect of antitussives;
4. It also has anti-dizziness and anti-paralysis effects.

How to use Diphenhydramine Hydrochloride Tablets?

Diphenhydramine can be found in the form of tablets, swiftly degenerating (dissolving) tablet computers, capsules, liquid-filled capsules, dissolving bars, powders, and oral liquids. When diphenhydramine is utilized to soothe allergic reaction, cool, as well as coughing signs, it is normally taken every 4 to 6 hrs. When diphenhydramine is made use of to deal with motion sickness, it is normally taken 30 minutes before separation, and if required, before meals and at going to bed. When diphenhydramine is utilized to deal with insomnia, take it at going to bed (30 minutes prior to intended sleep). When diphenhydramine is used to treat uncommon motion, it is generally taken 3 times initial and afterwards 4 times. Follow the instructions on the package or on the prescription tag very carefully, as well as ask your physician or pharmacist to describe any kind of parts you do not understand. Take diphenhydramine specifically as guided. Do not take essentially or more frequently than prescribed by your medical professional or suggested on the tag.
Before utilizing two or even more items at the same time, thoroughly examine over the counter cough and also cold item tags. These products may include the same energetic components, and taking them with each other could create you to overdose. This is particularly vital if you are providing your kid cough and also cool medicine.
Over-the-counter cough and also cold mix products, including those including diphenhydramine, may cause significant adverse effects or death in children. Do not provide these products to children under the age of 4. If you are giving these products to children between the ages of 4 as well as 11, make use of with care as well as comply with package instructions very carefully.
If you are providing diphenhydramine or a combination product consisting of diphenhydramine to a child, reviewed the plan label meticulously to make certain the item appropriates for youngsters of that age. Do not give kids diphenhydramine items created grownups.

Best Diphenhydramine hydrochloride original research and reference preparation

1. Original research: 1946, USA, MCNEILCONSBenadry, capsule 25mg.
2. Japan: RESTAMINKOWATab.10mgVENATab.10Chemicalbookmg
3. UK: THEBOOTSCOMPANYPLC, BootsSleepeaze25mgTablets
4. Domestic: Specification: 25mg, with 54 production approvals.

Information on Bioequivalence Waiver of Best Diphenhydramine Hydrochloride

1. Dissociation constant (25℃): pKa=8.6 (for tertiary amino group, measured by titration method)

2. Solubility in each dissolution medium (37℃) pH1.2: 1.0g/ml or more. pH4.0: 1.0g/ml or more. pH6.8: 1.0mg/ml or more. Water: 1.0mg/ml or more.

3. Stability in each dissolution medium: water: not determined. In various pH dissolution media: Slow degradation in acidic dissolution media. Light: Slowly degrades.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Best Diphenhydramine Hydrochloride Quotation