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Benzophenon CAS 119-61-9

Molecular Formula: C13H10O

Formula Weight: 182.22

ZSpharmac: Benzophenon Cosmetic Raw Material Supplier

Product Name: Benzophenon
CAS No: 119-61-9
Purity: 99%

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Basic Info

Product Name:Benzophenon
Other Names:Benzophenone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Crystalline Powder
EINECS No.:204-337-6
Storage:Store Below +30°C
Provide:Benzophenon MSDS;
Benzophenon COA

What is Benzophenon?

Benzophenone is an anemic prismatic crystal with an enjoyable and climbed fragrance, a melting point of 47-49 ° C, a liked one density of 1.1146, and a refractive index of 1.6077. Soluble in all-natural solvents and monomers such as ethanol, ether, chloroform, and more, nevertheless insoluble in water. It is a cost-free extreme photoinitiator, primarily utilized in cost-free radical UV dealing with systems, such as treatments, inks, adhesives, etc.It is additionally an intermediate for organic pigments, medications, seasonings, and pesticides. In the pharmaceutical sector, it is mostly made use of to create dicyclohexane piperidine, benztropine hydrobromide, diphenhydramine hydrochloride, etc. This item is also a styrene polymerization inhibitor and seasoning fixative. It can give seasonings a pleasant smell and is commonly used in perfumes and soap tastes. Throughout storage space and transport, products ought to be protected from moisture, sun, and warm resources, and their temperature should not exceed 45 ° C.

Benzophenon Property

Melting point 

47-51 °C (lit.)

Boiling point 

305 °C (lit.)



vapor density 

4.21 (vs air)

vapor pressure 

1 mm Hg ( 108 °C)

refractive index 



>230 °F

storage temp. 

Store below +30°C.


ethanol: soluble100mg/mL, clear, colorless (80% ethanol)


Crystalline Powder or Flakes


White to off-white



Odor Type


Water Solubility 

insoluble (<0.1 g/100 mL at 25 ºC)


Benzophenon Application

Benzophenon series products have numerous ranges and have actually been thoroughly utilized in medication, chemicals, dyes, plastics, layers, day-to-day chemicals, electronic chemicals and different other fields. In various locations, it is commonly made use of as photoinitiator, ultraviolet absorber and pharmaceutical intermediate.

1. Photoinitiator
As an eco-friendly environmentally friendly innovation, light healing contemporary advancement has actually developed strongly lately and has in fact been extensively used in numerous fields such as treatments, inks, adhesives, electronic tools, and optical fiber products. Photoinitiator is the major component of the photocuring system, and it plays an essential obligation in the degree of level of sensitivity of the healing system. Photoinitiators are divided right into 3 teams: homolytic fragment kind, hydrogen transfer kind and cationic kind. Benzophenone hydrogen transfer photoinitiators have high quantum performance, quickly treating rate, absorption range selection matching the irradiation light, superb thermal security, no dark feedback, and are much better than monomers and prepolymers. Great compatibility. The light-cured film has no yellowing or staining, is cheap, and is risk-free to utilize, so it has really become one of the most popular photoinitiator in manufacturing. In 2000, the residential manufacturing of benzophenone alone got to 1420t. The significant benzophenone photoinitiators consist of benzophenone, 4-methylbenzophenone, 2-methylbenzophenone, 2,4,6-trimethylbenzophenone (EsacureTZT), and extra.

2. UV absorber
Benzophenone UV absorbers are just one of the most typically made use of and produced UV absorbers. Along with absorbing ultraviolet light of 290 to 400nm, it additionally soaks up part of visible light. It is generally utilized in plastics, inks, paints, cosmetics and various other markets as a result of its superb compatibility with numerous other products. There are large amounts of kinds of benzophenone UV absorbers, most of which are by-products of 2,4-dihydroxybenzophenone (UV-0), such as 2-hydroxy-4-methylchlorobenzophenone (UV-0). UV-9), 2-hydroxy-4-n-octoxybenzophenone (UV-531), 2-hydroxy-4-methoxy-5-sulfonate benzophenone (UV-30), and so on. International p-benzophenone collection UV absorbers are likewise called after BP-X, such as UV-0 called BP-1, UV-531 called BP-17, UV-30 called BP-4, and so on. Lately, research study in the fields of receptive benzophenone UV absorbers, benzophenone Ni substances and the development of brand-new selections has actually accomplished pleasing end results. With the conditioning of individuals’s understanding of ultraviolet security and the quick innovation of the polymer product market, Benzophenon collection items as ultraviolet absorbers will absolutely likewise get greater growth.

3. Drug intermediates
Benzophenon collection points are intermediates for numerous drugs. As an instance, Benzophenon is an intermediate for the anti-suspension medicine diphenhydramine, 2-amino-5-chlorobenzophenone is an intermediate for diazepam medicines, and 4-chlorobenzophenone is utilized for In the production of anti-allergic medicines Anqimin and more. As a circumstances, the incredibly reliable anti-inflammatory and analgesic medicine ketoprofen is made from m-methylbenzophenone with bromination, cyanation, hydrolysis, and methylation.

How to Make Benzophenon

1) Phosgene method: The phosgene technique is one of the essential approaches for manufacturing Benzophenon series products, such as: benzophenone, important intermediates of fundamental dyes such as tetramethylmyxone and tetraethylmyxone, etc. Chain reaction The formula is as follows:

2) Benzoyl chloride method. Benzophenon is prepared by the Freit-Crafts condensation reaction of benzene and benzoyl chloride in the presence of aluminum trichloride. Include the benzene and zinc chloride option into the glass-lined reaction pot, stir and heat to 70 ° C, include benzyl chloride dropwise, finish the enhancement, stir and respond at 70-75 ° C for 10 hours under reduced pressure (1.33 × 104Pa-2.66 × 104Pa). Allow stand and separate right into layers. Laundry the upper oily material twice with clean water to eliminate zinc chloride and hydrochloric acid, and after that clean it as soon as with 1% weaken alkali option. The oil layer is vaporized to eliminate benzene and low boiling issue below 150 ° C to get unrefined diphenylmethane. The return is 95%. Include diphenylmethane and several magnetic pieces into the glass-lined response pot in sequence, stir and heat to 100-115 ° C, and dropwise add nitric acid with a relative thickness of 1.4. After adding, maintain it at 106-116 ℃ for 8 hours. Separate the oil layer and wash it three times with hot water, and then clean it 3 times with 3% sodium carbonate remedy. Distillation under lowered pressure yields 145-180 ° C(666.5Pa-1199.7 ) or 160-210 ° C (1333Pa-2399.4 ) portions to get benzophenone. The yield is 90%.

Synthesis Method of Benzophenon

(1) Prepared from benzene
Add 642 kg of carbon tetrachloride and 140.7 kg of granular aluminum trichloride to an iron pot with a coat and a stirrer. Circulation 156 kg of thiophene-free benzene right into the material within 3-5 hours, and incredible with cold water to maintain the interior temperature level at 20 ° C. The launched hydrogen chloride is introduced right into a ceramic absorption tower and linked to a settling tank to recoup the carbon tetrachloride drew out.

The thick reaction combination was pressed into a ceramic filtration pot consisting of 400 L of water. It is warmed up to boiling temperature level and after that preserved at this temperature degree by the heat of reaction while the vapor is executed by means of an absorption tower. The response lasts for 2-3 hours, and the carbon tetrachloride is washed, dried out, and recycled.

The unrefined tar-like benzophenone is hoover distilled, and the 157-176 ℃/ 10-20 mmHg part is collected. Recrystallize, centrifuge, and completely dry. 152.9 kg Benzophenon was obtained in each pot, with a yield of 84%.

( 2) Prepared from benzoyl chloride
In an iron pot with blending, add 35 kg of ground aluminum trichloride to 120 kg of benzene and 35 kg of benzoyl chloride within 5-6 hours with consistent mixing and maintain the temperature level at 30 ° C under air conditioning. After the lightweight light weight aluminum trichloride is consisted of, the temperature degree is raised to 50 ° C and preserved at this temperature level till a great deal of the hydrogen chloride is launched, which takes about 3-4 hours. Consist of the dark brownish reaction blend to 250 kg of crushed ice under stirring, then add 10 kg of focused hydrochloric acid to divide the benzene layer from the water layer. After the benzene layer was cleaned with damage salt hydroxide service, benzene was distilled off. The down payment was vacuum distilled to acquire regarding 35 kg of benzophenone, which was colorless crystals and defrosted at 48 ° C.

( 3) Prepared from benzyl chloride
( 1) Condensation: Include 253 kg of benzene and 139 kg of zinc chloride service with a particular gravity of 1.92-1.96 right into the glass-lined activator, mix to 70 ° C, and include 100 kg of benzyl chloride dropwise. After the dropwise addition is finished, mix at 70-75 ° C for 6 hours. Allow it represent layering, and clean the oil layer twice with water. Eliminate zinc chloride and hydrochloric acid. Clean once more with 0.5% alkaline water. The oil layer was evaporated to eliminate benzene and low-boiling materials (listed here 150 ° C), and about 94.5 kg of crude diphenylmethane was acquired. The return is 95%.

( 2) Oxidation: Include raw diphenylmethane and a number of magnetic products right into the oxidation activator subsequently, raise the temperature to 106-116 ° C, and include dropwise 146 kg of nitric acid with a details gravity of 1.92-1.96. After the improvement, react at 106-116 ° C for 8 hours, different the oil layer, clean it 3 times with cozy water, and after that tidy it 3 times with 3% sodium carbonate service. Distill under reduced pressure, build up the fraction at 145-180 ℃/ 5-8 mmHg, and get 85 kg Benzophenon. The return is 90%.

About Products:
If you need Benzophenon, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Benzophenon manufacturer and supplier, our company, ZSpharmac, will provide Benzophenon raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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