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Benzocaine Ointment CAS 94-09-7

Molecular Formula: C9H11NO2

Formula Weight: 165.19

ZSpharmac: Benzocaine Ointment Supplier

Product Name: Benzocaine Ointment
CAS No: 94-09-7
Purity: 99%

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Basic Info

Product Name:Benzocaine Ointment
Other Names:Benzocaine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:202-303-5
Provide:Benzocaine Ointment MSDS;
Benzocaine Ointment COA

What is Benzocaine Ointment?

Benzocaine is non-water-soluble anesthetic, benzocaine has the impact of calming pain as well as swelling. It is medically made use of for injury anesthetic, abscess surface area anesthetic, mucosal area anesthetic in addition to load anesthetic. Its medical influence is mostly to block nerve endings to reduce Discomfort as well as also itchiness.

Benzocaine Ointment Property

Melting point 88-90 °C
Boiling point 172 °C (12.7517 mmHg)
density 1.17
refractive index 1.5600 (estimate)
Fp 172°C/13mm
storage temp. 2-8°C
solubility alcohol: soluble1 gm in 5 ml
form Crystalline Powder
pka2.5(at 25℃)
color White
Water Solubility Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water


Benzocaine Ointment Application

  1. Benzocaine Lotion is an anesthetic, made use of for pain alleviation of injuries, ulcers and hemorrhoids, and also is also an intermediate for antitussives to ease coughing.
  2. Benzocaine Ointment is used for ultraviolet absorption of cosmetics, anesthetics, as well as discomfort alleviation for injuries, ulcers and hemorrhoids.

Benzocaine Lotion Preparation

Report one
The Benzocaine Ointment green prep work process has the adhering to actions:

① Add 80g of commercially readily available outright ethanol (1.74 mol) as well as 50g of p-nitrobenzoic acid (0.30 mol) into the reaction gadget under stirring, then gradually add 10g of dried concentrated sulfuric acid (0.10 mol) dropwise, After 15 minutes of dripping, the temperature was raised to 80 ± 2 ° C with stirring, and the reaction was refluxed for 6 hrs.

After the reaction mores than, ethanol is first distilled out under typical pressure, and when the temperature gets to 100 ± 2 ° C, the home heating is stopped, the layers are allowed to stand, and also the upper layer (concentrated sulfuric acid layer) is related to the following batch.

Amazing the material in the lower layer to 60 ± 2 ° C, adjust the pH worth to 8 with 5wt% sodium carbonate aqueous service, retest the pH after stirring for 0.5 h, and allow stand to different layers.

② Control the temperature level of the lower layer product (concerning 58g) at 60 ± 2 ° C, after that include it into 290g of water with mixing, then add 1g, 5wt% of Pd/C stimulant, replace it with nitrogen three times after including, and after that pass hydrogen to 0.6 MPa, as well as the catalytic hydrogenation reaction is carried out at a temperature level of 98 ± 2 ° C. When the stress no more goes down, after the catalytic hydrogenation reaction is finished, maintain it warm for 2 hrs, filter it while it is hot, and also cool the filtrate to 40 ° C. Suction filtration, centrifugation, The filter cake was dried at 60-70 ° C to acquire 48.5 g of white powdered benzocaine with a pureness of 99.6% (HPLC) as well as a two-step yield of 98.2%.

Report two
Add 500g of ethyl p-nitrobenzoate into a 1L autoclave, control the temperature level at 120 ° C, keep it cozy for 1h, then include 5g of activated Raney nickel catalyst, replace it with nitrogen three times, after that hydrogen 3 times, and then mix Pass hydrogen to 0.4 MPa, and also perform the hydrogenation response at a temperature level of 120 ° C. When the pressure no more goes down, after the hydrogenation reaction is finished, keep the temperature level for 4 hours, and also discharge the hydrogen gas to stop the response.

The GC analysis outcome of sampling evaluation: Benzocaine Ointment has a pureness of 99.98%, ethyl p-nitrobenzoate is not detected, et cetera are unidentified elements. Filter the material through a precision filter, press right into 500g of water for formation, stir till the temperature reaches 25 ° C, centrifuge to obtain a wet item, as well as vacuum cleaner dry for 12 hours to get 418.8 g of the final product with a yield of 98.99%.

Report three
The very first step, the synthesis of p-nitrobenzoic acid, in 250mL three-necked flask, include the p-nitrotoluene of 0.05 mol and also be 5% tetramethylammonium bromide and also 50mL distilled water about the molar fraction of p-nitrotoluene, Set up a reflux condenser, a thermostat, as well as a stirrer, start stirring, as well as after the temperature rises to 90 levels, include 0.125 mol KMnO4 in sets, the reaction temperature is 90-95 levels, and also mix for 2.5 hours;

In the second step, cool down the reaction liquid to room temperature level, remove the solid, clean the filter cake two times with hot water, combine the filtrates, acidify to pH= 2-3, precipitate the solid, filter, clean the filter cake with cold water, as well as dry to acquire light yellow Crystal p-nitrobenzoic acid;

The 3rd step is the synthesis of ethyl p-nitrobenzoate, add 0.015 mol p-nitrobenzoic acid, 25mL outright ethanol, and 2.5 mL focused sulfuric acid to a completely dry 100 mL single-neck round bottom flask, warm and stir on a water bathroom Reflux reaction for 1.5 h, put the reaction option right into a beaker with 100mL of ice water, precipitate crystals, filter with suction, clean the filter cake two times with water, after that move to a small beaker, add 10 mL of water to saturate, include mass portion under stirring It is 5% sodium carbonate remedy, as well as the pH of the solution is adjusted to 8 to acquire light yellow solid ethyl p-nitrobenzoate;

The fourth step, the synthesis of Benzocaine Ointment, in a 250mL round bottom flask, include an option constructed from 1.95 grams of ethyl p-nitrobenzoate as well as 100mL of ethanol, after that add 0.02 grams of Pd/C driver, feed hydrogen to mix the response, tender loving care tracking React up until the end of the response, filter with diatomaceous planet to remove the catalyst, spin dry to remove ethanol, as well as obtain white ethyl p-aminobenzoate.

About Products:
If you need Benzocaine Lotion, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Benzocaine Lotion manufacturer and supplier, ZSpharmac will provide Benzocaine Lotion raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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