Zhishang Chemical

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Zhishang Chemical

Benzethonium Chloride CAS 121-54-0

Molecular Formula: C27H42ClNO2

Formula Weight: 448.08

ZSpharmac: Benzethonium Chloride Supplement

Product Name: Benzethonium Chloride
CAS No: 121-54-0
Purity: 99%

Basic Info

Product Name:Benzethonium Chloride
Other Names:BenzethoniuM Chloride, 97%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Medical Raw Materials
Appearance:White Liquid 
EINECS No.:204-479-9
Provide:Benzethonium Chloride MSDS;
Benzethonium Chloride COA

What is Benzethonium Chloride?

Benzethonium chloride is a new type of quaternary ammonium antibacterial agent, which is commonly used in daily chemicals as well as cosmetics industries. Additionally, as an antiseptic and also anti-bacterial representative, it likewise has important applications in the field of medicine and health. For example, it has actually been widely utilized in Western countries as a bacteriostatic element of eye decreases or as a bacteriostatic element of injection. In the manufacturing of heparin salt products, benzethonium chloride is an essential key intermediate.

Benzethonium Chloride Properties:

Melting point 162-164 °C (lit.)
density 0.998 g/mL at 20 °C
vapor pressure < 0.001 hPa @ 2°C
refractive index 1.5650 (estimate)
storage temp. 2-8°C
solubility H2O: 0.1 M at 20 °C, clear, colorless
form Liquid
color White
PH5.5-7.5 (25℃, 0.1M in H2O)
PH Range5.5 – 7.5
Water Solubility 1-5 g/100 mL at 18 ºC


Benzethonium Chloride Uses

  1. Benzethonium chloride products have a wide and also secure market in the fields of medicine, day-to-day chemicals, cosmetics and more. Amongst them, in the field of heparin salt alone, the yearly need for this product exceeds 200 heaps, which is mostly made use of for the purification of heparin salt, or for the manufacturing of low molecular weight heparin sodium and enoxaparin. In the everyday chemical market, anti-bacterial wipes are also using this item in huge amounts as a bactericidal ingredient, with a yearly dose of tens of lots, and the need for benzethonium chloride in the entire daily chemical industry is swiftly increasing, and also the dose will certainly rise quickly. In the field of cosmetics and also ecological sanitation, this product is additionally exceptionally popular, and also the extent of promotion and also application as well as market leads are extremely wide.
  2. Benzethonium chloride is used in the detection of cations in washing powder and also in titration of sulfonic acid anions. The general dosage is 4 grams per week. Low dosage can effectively eliminate numerous bacteria; it has the functions of sanitation and deodorization.
  3. Benzethonium chloride was used in studies to assess the minimum inhibitory concentration of methicillin-resistant Staphylococcus aureus (MRSA) isolated from Malaysia; in studies of biocomposite membranes using sodium alginate and modified clays.

The Synergistic Bactericidal Effect of Benzethonium Chloride and PHMB

1. When benzethonium chloride and PHMB are used alone, the sterilization rate is lower than that of mixed use, that is, the two fungicides have a synergistic sterilization effect. And when the mass fraction of benzethonium chloride was about 50%, the bactericidal rate reached the highest value, the bactericidal rate of the mixed bactericide against Escherichia coli was close to 80%, and the bactericidal rate against Staphylococcus aureus was close to 90%. That is, when the two fungicides are configured in a ratio of 1:1, the best synergistic effect can be exerted. The two fungicides showed a synergistic bactericidal effect. The possible reason is that both of them are cationic surfactants, but the relative molecular weights of the two fungicides are quite different. The relative molecular mass of benzethonium chloride is small, and the relative molecular mass of polyhexamethylene biguanide is high, so the sterilization mechanism of the two may be different. Therefore, when they are used in combination, the bacteria will be destroyed according to their respective sterilization mechanisms, and the overall mortality of the bacteria will increase.

2. The above explores the synergistic effect of the total mass fraction of mixed fungicides of 0.0005%. When the ratio of benzethonium chloride and PHMB is 1:1, the bactericidal rate of Escherichia coli and Staphylococcus aureus can reach 80% respectively. , 90%. In the actual production of sanitary products, the sterilization standard is 90%. Therefore, it is necessary to explore the synergistic effect of the total mass fraction of mixed fungicides higher than 0.0005%.

3. Benzethonium chloride and PHMB are configured in a ratio of 1:1 to achieve the best synergistic effect, then the ratio of the two in the mixed fungicide is determined to be 1:1, and the total mass fraction of the tested mixed fungicide is 0.001% and 0.005%. %.

When benzethonium chloride and PHMB are used alone, the bactericidal rates of the two against Escherichia coli and Staphylococcus aureus are both close to 100% when the mass fraction is 0.02%; the other two have synergistic bactericidal effect, and when the two are 1: 1: The best sterilization effect can be achieved when the proportion of 1 is used in a mixed configuration. Under the optimal ratio of the two (1:1), the sterilization rate of the above two bacteria is close to 100% when the total mass fraction of the mixed bactericide is 0.005%.

Synergistic Effect of Benzethonium Chloride and Polyhexamethylene Biguanide

Benzethonium chloride and polyhexamethylene biguanide (PHMB) are a kind of organic compounds with no odor, non-corrosiveness and high sterilization. In recent years, they have been used in daily chemical industry, aquaculture, food processing, medical and environmental Disinfection and other fields are widely used. However, fungicides are toxic and irritating to a certain extent due to the presence of chlorine in their chemical components. For example, they have obvious irritating effects on human skin, eyes and upper respiratory tract, which can cause asthma and allergic contact dermatitis. Causes allergies in some people. Therefore, it is necessary to reduce the amount of bactericide as much as possible under the condition of ensuring the bactericidal standard. Since the combined use of fungicides may have synergistic effects, quantitative evaluation of their synergistic sterilization efficacy will be of great practical significance for guiding sanitary product manufacturers to further reduce the amount of fungicides.
At present, the research on the bactericidal effect of benzethonium chloride and PHMB mainly focuses on the bactericidal effect of single-component and multi-component. For example, most manufacturers use benzethonium chloride with a mass fraction of 0.1% in related sanitary products to ensure good bactericidal effect on common bacteria such as Staphylococcus aureus and Escherichia coli.
Previous studies have also found that benzethonium chloride mixed with some organic solvents also has a good bactericidal effect, such as: disinfection wipes whose active ingredients are benzethonium chloride and isopropyl alcohol are used to clean the surfaces of commonly used prosthodontic instruments and materials. The disinfection effect is 100%. The oral disinfectant containing benzethonium chloride and isopropanol can not only kill common bacteria, but also inhibit hepatitis B virus. There are also studies that show that the combined use of fungicides can also enhance its efficacy (that is, have a synergistic effect), such as: PHMB with chlorhexidine acetate, dialkyldimethylammonium chloride (benzalkonium chloride), bisdecyl two The sterilization effect of mixed use of methylammonium chloride and polyhexamethylene monoguanidine is better than the effect of single use. Among them, the compound disinfectant composed of PHMB and bisdecyldimethylammonium chloride or chlorhexidine acetate is used for sterilization. The effect is better. Although previous studies have clarified the synergistic effect of compound fungicides, quantitative data such as the optimal concentration and ratio of each component in the compound fungicides have not been given. Therefore, it is necessary to conduct in-depth research on this.
We use the two most commonly used bactericides (ie: benzethonium chloride and PHMB) for compounding, and two commonly used experimental strains of Escherichia coli and Staphylococcus aureus as test bacteria. synergies were investigated. The main focus of the research is:
(1) To explore the bactericidal effect of the two fungicides on bacteria when used alone;
(2) to explore whether the two fungicides have synergistic bactericidal effect;
(3) When the two fungicides have a synergistic effect, determine the minimum concentration and optimal ratio of the two.
This study provides a basis for the dosage and ratio of pharmaceutical products related to hygiene manufacturers, and provides guidance for consumers to purchase products.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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