Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Benzalkonium Chloride Usp CAS 8001-54-5

Molecular Formula: C17H30ClN

Formula Weight: 283.88

ZSpharmac: Benzalkonium Chloride Usp Supplement

Product Name: Benzalkonium Chloride Usp
CAS No: 8001-54-5
Purity: 99%

Basic Info

Product Name:Benzalkonium Chloride Usp
Other Names:Benzalkonium Chloride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:Clear or White to Yellow Viscous Solution
EINECS No.:616-786-9
Storage:Store Below +30°C.
Provide:Benzalkonium Chloride Usp MSDS;
Benzalkonium Chloride Usp COA

What is Benzalkonium Chloride Usp?

Benzalkonium Chloride Usp is a quaternary ammonium-based cationic surfactant, a heterogeneous mixture of various even-numbered alkyl chain alkyl benzyl chlorides. English name: Benzalkonium Chloride, CAS number: 85409-22-9, molecular formula: C17H30ClN, molecular weight: 283.880. Benzalkonium Chloride Usp is a non-oxidizing fungicide with broad-spectrum and high-efficiency sterilization and algae killing ability, which can effectively control the reproduction of bacteria and algae in water and the growth of slime, Soluble in ethanol and acetone. Although slow to dissolve in water, aqueous solutions are easier to handle and are still preferred. Aqueous solutions should be neutral to slightly alkaline in color from colorless to pale yellow. Aqueous solutions foam when shaken and have a bitter and faint almond taste in concentrated solutions.

Benzalkonium Chloride Usp Properties:

Boiling point >100°C/760mmHg
density 0.98
storage temp. Store below +30°C.
solubility Very soluble in water and in ethanol (96 per cent). An aqueous solution froths copiously when shaken.
form Viscous Solution
color Clear or white to yellow, may contain yellow-white fragments


Benzalkonium Chloride Usp Uses

Benzalkonium Chloride Usp can be utilized as a fungicide, an anti-bacterial for medical surgical instruments. It dissociates into cationic energetic groups in liquid remedy, and has the features of cleaning, purification, emulsifying and solubilizing. It can be used as a leveling representative for cationic dyes, as a sanitation and also algaecide for industrial water, as a disinfectant as well as antifungal agent for livestock pens, grain stockrooms, jamsils, and also cash crops such as mushrooms and white fungus.

Benzalkonium Chloride Usp Preparation

In organic solvent, at 30-70 ℃, aliphatic alkyl dimethyl tertiary amine and benzyl chloride are carried out salification reaction to obtain aliphatic alkyl dimethyl benzyl ammonium chloride; described aliphatic alkane The base is dodecyl, tetradecyl or hexadecyl; the organic solvent is one or more of methanol, ethanol, n-propanol, isopropanol, acetone and acetonitrile [1].

Preparation of Dodecyl Dimethyl Benzyl Ammonium Chloride
In 1000L reactor, add the dodecyl dimethyl tertiary amine of 100.00kg (469.5mol), the benzyl chloride of 62.40kg (493.0mol) and the acetone of 400.00kg, stir 5h at 50 DEG C. Then cool down to 0°C. After the solid was precipitated, it was filtered and dried to obtain 145.88 kg of white solid with a total yield of 91.5%. Dodecyldimethylbenzylammonium chloride is 99.5% pure.

Preparation of tetradecyldimethylbenzylammonium chloride
Add 40.00kg (166.0mol) of tetradecyldimethyl tertiary amine, 19.96kg (157.7mol) of benzyl chloride and 200.00kg of acetonitrile in a 500L reactor, and stir at 60°C for 4h. Then cool down to -10°C. After the solid was precipitated, it was filtered and dried to obtain 53.50 kg of white solid with a total yield of 92.3%. The purity of tetradecyldimethylbenzylammonium chloride is 99.6%.

Preparation of Cetyl Dimethyl Benzyl Ammonium Chloride
In 50L reactor, add the hexadecyl dimethyl tertiary amine of 6.00kg (22.3mol), the benzyl chloride of 2.82kg (22.3mol) and the ethanol of 18.00kg, stir 6 minutes at 40 DEG C and then be cooled to- 5°C. After the solid was precipitated, it was filtered and dried to obtain 8.12 kg of white solid with a total yield of 92.1%. The purity of cetyldimethylbenzylammonium chloride is 99.4%.

Benzalkonium Chloride Usp Fungicide

Benzalkonium Chloride Usp, likewise known as Jieermin, and benzalkonium bromide are both cationic surfactant broad-spectrum bactericides frequently made use of in professional practice. They dissociate into cationic active groups in aqueous option, and also have cleansing, bactericidal results as well as solid antiseptic power. It is quick, has reduced toxicity, and is much less irritating to the skin and mucous membranes. It can change the leaks in the structure of microbial cytoplasmic membrane, make bacterial cytoplasmic compounds extravasate, impede its metabolic rate and also play a killing effect, as well as has a strong effect on Gram-positive bacteria., versus Pseudomonas aeruginosa, acid-fast bacilli, viruses and microbial spores. It can promptly combine with healthy protein, as well as its result is dramatically lowered in the visibility of blood, cotton, cellulose and also raw material. Clinically, it is mainly made use of for the disinfection of skin, wounds, mucous membrane layers and medical tools; it is also utilized as a bacteriostatic representative in liquid preparations.

Use as well as dose are as follows: made use of for sanitation of skin and also mucous membranes, digestive tract lavage and also as a bacteriostatic representative in some liquid medicines; soaked in 0.1% remedy for 5 mins prior to surgical procedure as well as for arm sanitation; 0.05% to 0.1% remedy for skin as well as mucous membrane disinfection; 0.02% ~ 0.05% option for vaginal lavage; 0.005% ~ 0.02% option for bladder as well as urethral lavage; 0.0025% service for retention lavage; 0.01% for bacteriostatic representative in eye declines; Soak in 0.1% remedy for 30min; store sterilized instruments with 0.02% service, and add 0.2% salt nitrite as a preservative.

Note: Benzalkonium Chloride Usp need to not be utilized at the same time with anionic detergents such as soaps and also artificial detergents, and need to not be utilized with inorganic salts (citrate, iodide, nitrate, permanganate, salicylate, zinc sulfate, Silver salts, tartrates and also alkaloids, and so on) compatibility; not ideal for disinfection of cystoscopes, ocular instruments, rubber, natural leather, etc, avoid the use of light weight aluminum containers. Conflict with light weight aluminum, salt fluorescein, hydrogen peroxide, kaolin, hydrous lanolin as well as some sulfonamides.

Benzalkonium Chloride Usp Side Effects

Although Benzalkonium Chloride Usp has actually been commonly used as a bactericide in ophthalmic drugs in history, it is poisonous and also annoying to the eyes. In order to satisfy the needs of customers, pharmaceutical firms have boosted the production of bactericide-free agents, or switched over to unsafe Smaller fungicide options.

Many mass-market inhalers and also nasal spray formulations include Benzalkonium Chloride Usp as a bactericide, although substantial evidence suggests that benzalkonium chloride may affect ciliary motility, ciliary transport, nasal mucosal tissue, neutrophil function in people, as well as Leukocyte adversely impact the feedback to neighborhood inflammation.

Although some studies have revealed no organization between making use of nasal sprays at focus listed below or not greater than 0.1% Benzalkonium Chloride Usp as well as drug-induced rhinitis, it has been suggested that Benzalkonium Chloride Usp should be avoided for nasal sprays.

Nasal steroid formulas in the United States that do not include Benzalkonium Chloride Usp consist of budesonide, triamcinolone acetonide, dexamethasone, Beconase, and Vancenase aerosol inhalers.

Benzalkonium Chloride Usp aggravates middle ear cells at regular usage concentrations and has actually been shown to be hazardous to the internal ear. Occupational direct exposure to Benzalkonium Chloride Usp is related to asthma.

In 2011 a large clinical trial was developed to review the efficacy of hand sanitizers based upon various active components in stopping virus transmission amongst schoolchildren to dismiss safety interest in Benzalkonium Chloride Usp-based hand sanitizers.

Benzalkonium Chloride Usp has actually been used as a pharmaceutical chemical and antimicrobial representative since 1940. Although earlier studies validated the corrosiveness and irritation of benzalkonium chloride, examinations of Benzalkonium Chloride Usp side effects as well as organizations with condition have only surfaced in the past thirty years.

Benzalkonium Chloride Usp Assay

A method for measuring Benzalkonium Chloride Usp in soil, comprising the steps:
(1) Remove impurities such as stones, plant roots, and residues in the soil to be detected, vacuum freeze-drying, and then grind and sieve to obtain a soil sample for testing;
(2) mixing formic acid, acetonitrile and ultrapure water to obtain an acidic extraction solution, adding it to the detection soil sample obtained in step (1), then placing it into a constant temperature shaker for vibration extraction, centrifuging and filtering out the supernatant, and the filter residue is repeated In the above extraction and separation steps, the two supernatants were combined and stored below 4°C;
(3) adding diatomaceous earth to the supernatant obtained in step (2), fully mixing and purifying the two with a vortex, and then centrifuging and filtering with a 0.22 μm filter to obtain a detection solution;
(4) UPLC-MS/MS is used to determine the content of benzalkonium chloride in the detection solution in step (3).

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Benzalkonium Chloride Usp Quotation