Benzalkonium Chloride Usp, likewise known as Jieermin, and benzalkonium bromide are both cationic surfactant broad-spectrum bactericides frequently made use of in professional practice. They dissociate into cationic active groups in aqueous option, and also have cleansing, bactericidal results as well as solid antiseptic power. It is quick, has reduced toxicity, and is much less irritating to the skin and mucous membranes. It can change the leaks in the structure of microbial cytoplasmic membrane, make bacterial cytoplasmic compounds extravasate, impede its metabolic rate and also play a killing effect, as well as has a strong effect on Gram-positive bacteria., versus Pseudomonas aeruginosa, acid-fast bacilli, viruses and microbial spores. It can promptly combine with healthy protein, as well as its result is dramatically lowered in the visibility of blood, cotton, cellulose and also raw material. Clinically, it is mainly made use of for the disinfection of skin, wounds, mucous membrane layers and medical tools; it is also utilized as a bacteriostatic representative in liquid preparations.
Use as well as dose are as follows: made use of for sanitation of skin and also mucous membranes, digestive tract lavage and also as a bacteriostatic representative in some liquid medicines; soaked in 0.1% remedy for 5 mins prior to surgical procedure as well as for arm sanitation; 0.05% to 0.1% remedy for skin as well as mucous membrane disinfection; 0.02% ~ 0.05% option for vaginal lavage; 0.005% ~ 0.02% option for bladder as well as urethral lavage; 0.0025% service for retention lavage; 0.01% for bacteriostatic representative in eye declines; Soak in 0.1% remedy for 30min; store sterilized instruments with 0.02% service, and add 0.2% salt nitrite as a preservative.
Note: Benzalkonium Chloride Usp need to not be utilized at the same time with anionic detergents such as soaps and also artificial detergents, and need to not be utilized with inorganic salts (citrate, iodide, nitrate, permanganate, salicylate, zinc sulfate, Silver salts, tartrates and also alkaloids, and so on) compatibility; not ideal for disinfection of cystoscopes, ocular instruments, rubber, natural leather, etc, avoid the use of light weight aluminum containers. Conflict with light weight aluminum, salt fluorescein, hydrogen peroxide, kaolin, hydrous lanolin as well as some sulfonamides.