Benzalacetone CAS 122-57-6

Today, the synthesis research of Benzalacetone mainly concentrates on enhancing or changing the driver. As an example, people such as Yang Xiuying propose to utilize potassium fluoride, aluminum oxide as well as various other metal oxides as stimulants to militarize the condensation of benzaldehyde and also acetone to generate Benzalacetone, making use of steel composite drivers, although The return of benzylidene acetone is raised to 90%, but the amount of stimulant made use of is big (acetone: stimulant=1:0.05), and the stimulant can not be reused and also used mechanically, causing a large quantity of waste residue as well as major pollution to the setting; Li Shanji It is reported in the literary works that polyvinyl chloride polyvinyl polyamine material is used as a phase transfer catalyst in a water-sodium hydroxide system to synthesize benzylidene acetone. In this reaction, a strong base is still utilized to make benzaldehyde prone to disproportionation React with Carmizzaro, only return is raised to 86.3%; Su Lihong, Chen Yanling, Qiu Ping are phase transfer driver with hexadecyltrimethylammonium bromide, return is brought up to 90%, however the intake of catalyzer is very Large, reaching 2. 5g/0. 1mol benzaldehyde, as well as non-recyclable; Ou Zhize et al. manufactured Benzalacetone with tributylamine aminated strongly basic anion exchange resin, and the yield was increased to more than 95%. However, the synthesis steps of the stimulant are numerous, and also the return is extremely low, so it is difficult to form a large production. On top of that, Cheng Jiahao researched the use of trimethylammonium, triethylammonium, tetraethylammonium bromide, benzyltrimethylammonium chloride, benzyltriethylammonium chloride, benzyldimethyldodecylammonium bromide Do phase catalyst, and return is between 80%～ 90%; Individuals such as Wang Feijun do stimulant with acidic material, and yield only has 46%. In the study of using stage transfer as a stimulant, the return has actually been improved to a specific level compared with the standard procedure; nonetheless, a solid base is still utilized, and also the base catalyst need to be reduced the effects of in the separation process after the response, resulting in a huge quantity of contaminant discharge and severe ecological influence. air pollution; second of all, several stage transfer stimulants are utilized in a large quantity and require to be manufactured, and also the synthesis steps are lots of, the return is low, as well as they can not be reused, making it difficult to promote the driver.

Individuals such as Zhu Zhiqiang suggested a technique for synthesizing benzylidene acetone in near-critical water (NCW refers to temperature 250 ° C ~ 300 ° C, pressure is the fluid water of 5MPiT10MPa), it is to benzaldehyde, acetone, and also deionized Water is included the small high-pressure response pot together, as well as after sealing, the reaction kettle is put into a salt bathroom storage tank with electric mixing, as well as the temperature level control of the salt bathroom is at 260 ° C. ± 2 ° C. After reacting Mi, trendy as well as accumulate the organic phase in the reaction mixture 2%。, Structural as well as compositional analysis, the return was 46.2%. The approach is characterized because the use of alkali stimulants such as NaOH in standard reactions is prevented and wastes such as neutralization salts are no more produced. However the deficiency of this approach is: the response time is long, and also the return of reaction is as well reduced, only has 46.2%; Make use of a large quantity of deionized water in the response, acetone and water miscible, and also benzaldehyde is likewise soluble in water, in the splitting up procedure There is fantastic difficulty; at the same time, the reaction is understood through an autoclave, which is a set response, and also the space-time return of the response is low as well as the energy intake is big. If the reaction is scaled up, there will be a big trouble in regards to equipment.