Bellflower Extract

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Bellflower Extract Supplier

Product Name: Bellflower Extract

CAS No: 0

Purity: 99%

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Basic Info

Product Name:	Bellflower Extract
Other Names:	RADIX PLATYCODI Extract
CAS:	0
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Yellow Viscous Liquid
EINECS No.:	NULL
Storage:	2-8°C
Provide:	Bellflower Extract MSDS； Bellflower Extract COA

What is Bellflower Extract?

Bellflower Remove is the dried out origin extract of Platycodonggrandiflorum (Jacq.) A.DC., a plant of the Campanulaceae family members. The main energetic ingredients are saponins, which additionally consist of flavonoids, polysaccharides and also anthocyanins, fatty acids as well as fatty oils, micronutrient as well as amino acids, etc. Anthocyanins have anti-oxidation, remove free radicals, decrease blood cholesterol degrees, anti-tumor, anti-mutation and also various other results. Anthocyanins have excellent stability, good water solubility, high material, and also the features of all-natural pigments. Consequently, while playing a certain role in controling physiological features in the human body, Platycodon grandiflora anthocyanins can additionally be used for all-natural usage in food and beverages, etc pigment.

Bellflower Remove has anti-oxidation impact and eliminates oxygen totally free radicals, so it can be used in the advancement of anti-oxidation as well as anti-aging cosmetics; at the same time, making use of acid remedy electrolysis to prepare fragrance as well as pigment compounds can be used in cosmetics manufacturing, which meets the requirements of environment-friendly food, so it has High application value. Current research studies have actually also shown that the saponins of platycodon grandiflorum can affect the lipid web content in lotion as well as liver, and have the result of lowering weight and also lipid.

Chemical composition of Bellflower Extract

1. The main active ingredients of Bellflower Extract are saponins, and the saponins of Bellflower Extract are all oleanane-type pentacyclic triterpene derivatives, which can be divided into three categories: bellflower acids, bellflower diacids, and telegalic acids.
2. Flavonoids were earlier separated from the aerial part of Platycodon grandiflorum in the early 1980s to obtain 9 kinds of flavonoids, and an anthocyanin was isolated from its flower; recently, 4 kinds of flavonoids were isolated from the aerial part, and celery luteolin and luteolin; 5 kinds of flavonoids were isolated from its seeds, such as docetaxel, quercetin and so on. Natural flavonoids have small molecular weight, can be quickly absorbed by the human body, enter the blood and tissues, and then exhibit anti-fatigue, capillary expansion, anti-oxidation, anti-aging, anti-mutation, anti-tumor and other effects. Studies have shown that flavonoids have a strong ability to scavenge free radicals, superoxide and hydroxyl radicals, and inhibit lipid peroxidation.
3. The polysaccharides and anthocyanin platycodon polysaccharides were fractionated and purified by DEAE-cellulose, and the three polysaccharide single components PGPsI, PGPsII and PGPsIII were obtained, and their molecular weights were 2640, 89759 and 63453, which were analyzed by SephadexG-200 gel chromatography, The components identified by ultraviolet spectroscopy and iodine reaction are single, free of nucleic acid, protein and starch. Anthocyanins are glycosides formed by the combination of anthocyanins and sugars through glycosidic bonds. They mainly exist in flowers and fruits, making them appear in different colors such as red, purple red to blue. Bellflower Extract have good stability under most conditions, but in the presence of alkaline and oxidizing agents, the stability of Bellflower anthocyanins is poor. When the concentration was higher, the scavenging efficiency of Vc and platycodon anthocyanins on DPPH would increase exponentially.
4. Fatty acids and fatty oils 34 kinds of fatty acids were isolated and identified from the fatty oil of bellflower, including 15 kinds of unsaturated fatty acids, the main types were linoleic acid (42.79%), palmitoleic acid (0.30%), 11-eicosenoic acid (1.53%), linolenic acid (14.02%), etc.; 19 kinds of saturated fatty acids, the main types are palmitic acid (13.71%), stearic acid (1.36%), arachidic acid (0.79%), behenic acid (1.78%) , Lignoceric acid (1.38%), Hexacosanoic acid (3.14%), Octacosanoic acid (3.51%), etc.
5. Bellflower Extract Trace elements and amino acids contain Cu, Fe, Mn, Co, Zn, Cr, Mg, Ca, Sr, Li and other trace elements.
6. Bellflower Extract Contains a variety of amino acids, including 8 kinds of essential amino acids, accounting for 6.44% of the total amino acids. The total amino acid content is as high as 15.01%. Among them, уγ-aminobutyric acid is a neurotransmitter chemical substance that plays an important role in the energy metabolism of the human brain.
7. Others 12 kinds ofBellflower Extract compounds and their derivatives were identified from the aerial part of Bellflower root; two kinds of phenolic compounds with antioxidant activity were isolated from the petroleum ether extract of Bellflower root. In addition, Bellflower Extract also contains steroids (α-spinach, △7-stigmasterol, β-sitosterol, etc.), proteins, alkaloids, volatile oils and other chemical components.

Pharmacology of Bellflower Remove

1. Hypoglycemic result
Regular home-free administration of Platycodon grandiflorum water or alcohol essence 200 mg/kg can reduce blood glucose, similar to that of tolbutamide. It likewise has hypoglycemic effect on speculative tetrachloropyrimidine diabetic rabbits, as well as can inhibit the increase of food-induced blood glucose. The decrease of liver glycogen can also be recuperated after drug, and also the result of alcohol extract is stronger than that of water extract.
2. Expectorant, antitussive impact
The ethanol remove of Platycodon grandiflorum and origin water decoction can reduce the discharging of phenol red, and also have a really substantial expectorant effect. The primary reason is that the saponins consisted of in it stimulate the glossopharyngeal nerve idea when administered by mouth, which reflexively creates hypersecretion of the breathing system, waters down the spit and makes it simple to cough up. Platycodon saponins D and also D3 may be effective ingredients for minimizing phlegm. Researches have shown that platycodon saponin capsules have obvious anti-inflammatory, coughing, asthma and expectorant impacts, and also have certain precautionary as well as healing impacts on persistent respiratory disease.
3. Anti-tumor as well as anti-oxidation effects
Bellflower Remove has anti-oxidant effect, and the outcomes of the colorimetric test of tetramethylazolium salt (MTT) show that the extract has an anti-oxidant result on human colorectal cancer cells cell HT-29, ileocecal cancer cells cell HRT-18, and also liver cancer cell HepG2 artificial insemination. exhibit strong cytotoxicity. Researches have actually shown that platycodon saponin D has the task of substantially hindering the proliferation of human breast cancer cells (MCF-7) and human intense promyelocytic leukemia cells (HL-60 cells). Its specific system of action as well as the structure-activity relationship of platycodon saponin antitumor task require refresher course. Platycodon grandiflora polysaccharide has the capacity to feed on hydroxyl radicals and also superoxide anion radicals, and its scavenging ability has a noticeable dose-effect connection with the focus of polysaccharides. The focus of polysaccharides required to feed on 50% of hydroxyl radicals and also superoxide anion radicals is 0.06 mg/mL and 0.31 mg/mL.
4. Lower cholesterol
Bellflower Get rid of can increase bile acid secretion, reduce cholesterol content in rat liver, as well as boost steroid discharging.
5. Hemolysis
Bellflower Get rid of has a regional inflammation and a relatively strong hemolytic impact, with a hemolytic index of 887. Therefore, it can only be taken by mouth, and can not be utilized as an injection. Oral administration can trigger saponins to be hydrolyzed and destroyed in the digestive system tract without hemolysis. Nonetheless, when taken by mouth in large dosages, the gastric mucosa is boosted with saponins, which can trigger nausea or vomiting and vomiting.
6. Antibacterial result
Platycodon grandiflorum water extract and also preparation were weakened in test tubes at a proportion of 1:10 to hinder Epidermophyton flocculus in vitro. With the preparation 4.50% plate tiny groove method, it has repressive effect on Staphylococcus aureus, Salmonella typhi, Shigella flexneri, Pseudomonas aeruginosa and Escherichia coli.
7. Sedative, analgesic as well as antipyretic effects
Dental feeding of Bellflower Remove to animals has strong antipyretic and also analgesic effects. Utilizing typhoid vaccine to generate fever in mice and gavage with 50-100mg/ kg can decrease the spontaneous activity of computer mice, as well as has apparent antipyretic impact as well as It can last for 3-4 hrs. It has inhibitory impact on the wincing response triggered by tail pressing technique and intraperitoneal injection of acetic acid in computer mice, and can increase the pain threshold of animals. Sleep time with sodium perbital. Experiments of climbing up ladders, piercing holes, rotating rods and also inclined planes in mice verify that the crude item of Bellflower Remove has main repressive effects such as sedation and analgesia.
8. Prevent gastric acid secretion and also anti-ulcer impact
Platycodon grandiflorum crude saponins have the impact of inhibiting the secretion of gastric juice as well as resisting peptic ulcer. For rats with pylorus ligation, platycodon saponin was offered to the duodenum, which can minimize the secretion of stomach juice as well as partially prevent the task of pepsin. Its inhibitory impact on experimental ulcers is similar to that of atropine. After the dose is increased, it can completely hinder the secretion of gastric juice and also the incident of abscess. Continuous administration of platycodon saponins in rats also reduced the incident of acetic acid ulcers. The methanol cold soak of bellflower also has anti-ulcer result.
9. Anti-inflammatory and also immune improving impacts
Bellflower Eliminate has anti-inflammatory result. Rats fed platycodon saponin have considerable anti-inflammatory impact on carrageenan foot swelling, cotton ball granuloma as well as acetic acid swelling. It can likewise prevent adjuvant arthritis in rats and decrease capillary leaks in the structure in allergic computer mice. Studies have shown that the administration of Platycodon grandiflora complete saponins to rats can considerably enhance the web content of ACTH and also corticosterone in the blood, recommending that its anti-inflammatory result might be connected to the engagement of adrenal cortex hormones. Furthermore, unrefined platycodon saponins have a neighborhood stimulating effect on the skin, which can improve the blood flow of inflammation, advertise the enhancement of swelling and also the absorption of swelling procedure. Platycodon grandiflorum has the impact of enhancing immune function, and also its extract can hinder the movement of leukocytes, improve the bactericidal power of neutrophils, and also increase the activity of lysozyme; crude saponins can additionally enhance the phagocytosis of macrophages.
10. Other features
Platycodon saponins can reduce blood pressure, sluggish heart rate, as well as hinder respiration, and its antihypertensive impact can not be antagonized by atropine and α and also β blockers. It has anti-edema and diuretic effects on rats with congestive edema caused by reciprocal throaty blood vessel ligation. In addition, Bellflower Get rid of has anti-allergic impact.

Extraction Method of Bellflower Remove

Reflux method
Bellflower powder→add 7% sulfuric acid ethanol-water (1:3) mixed solution→heat to reflux for 3h→cool→trichloromethane extraction→combine the extracts→wash with water, discard the washing solution→dehydrate the chloroform with anhydrous sodium sulfate → Filtration → Evaporate the filtrate → Total saponins
alcohol extraction
Bellflower powder→add 95% ethanol→stand at room temperature for 1.5h→filter, take supernatant→rotary steam→obtain dark brown viscous liquid→dry at 105°C to constant weight→crude bellflower saponin.
hot water extraction
Bellflower powder→add distilled water→stand at room temperature for 1.5h→filter→distill→dark brown viscous liquid→dry at 105℃ to constant weight→crude bellflower saponin

Bellflower Remove Identification

Trait identification
The root is cylindrical or spindle-shaped, slightly twisted, occasionally branched, 6-25cm long, 0.5-2.5cm in diameter; the surface is off-white or light yellowish white, and there are half-moon-shaped stem scars on the upper rhizome (reed head), and horizontal stems on the root. There are irregular longitudinal wrinkles and grooves throughout, and there are transverse lenticel-like root scars. Hard and brittle, easy to break, the broken surface is slightly uneven, slightly granular, with radial fissures, the cortex is narrow, the cambium is prominent, light brown, and the xylem is off-white. No gas, taste slightly sweet and then bitter. It is better to have thick strips, white color, firm body and bitter taste.
Microscopic identification
Cross-section of platycodon root: the cork layer is yellow-brown, but most of it has been removed. The phloem is broad. The phloem rays on the outside are curved, the sieve tubes are mostly compressed and decadent, the milk ducts are scattered in groups, containing yellow-brown granules, and the milk ducts in the inner phloem are radially arranged in rows. The cambium forms a ring. The xylem rays are wide, the vessels are polygonal, single or several gather together, and are arranged radially. Slice directly with the dry product, seal in ethanol or dilute glycerol, and see the inulin crystals in the parenchyma cells. Powder: beige. (1) Too much inulin. The powder was installed with chloral hydrate solution (without heating), and the inulin clumps in the parenchyma cells were fan-shaped, and gradually melted after a long time. Using the Steiner’s solution or ethanol device, the inulin clumps are irregular and will not disappear after a long time. (2) Nodulated milk ducts, 14-25 μm in diameter, slightly thicker wall, connected to another milk duct by short cell chains on the side to form a network, the milk ducts contain small light yellow oil droplets and fine particles. (3) The diameter of the trapezoidal, reticulate and bordered pit vessels is 16-72 μm, and the vessel molecules are relatively short, some of which are only 96 μm long. There are also a few fine reticulated tracheocytes. (4) Wood parenchyma cells are rectangular in longitudinal Section, and the terminal wall is wavy and curved. In addition, the roots that have not been peeled off have cork cells, and some cells contain fine Square crystals of calcium oxalate.
Physical and chemical identification
Take 1g of the sample powder, extract it with an appropriate amount of methanol, spot the extract on a silica gel G plate, use ethyl acetate-methanol-water (14:3:3) as the developer, develop the color with concentrated sulfuric acid, and the saponin is yellow spot.

About Products:
If you need Bellflower Remove this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced Bellflower Remove manufacturer and supplier, ZSpharmac will provide Bellflower Remove raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.