1. Hypoglycemic result
Normal home-free management of Platycodon grandiflorum water or alcohol essence 200 mg/kg can reduce blood glucose, similar to that of tolbutamide. It additionally has hypoglycemic result on speculative tetrachloropyrimidine diabetic person rabbits, and can hinder the rise of food-induced blood glucose. The reduction of liver glycogen can additionally be recuperated after medicine, and the effect of alcohol extract is more powerful than that of water remove.
2. expectorant, antitussive result
Both Bellflower Remove and root water preparation can reduce the discharging of phenol red, and also have an extremely significant expectorant result. The primary reason is that the saponins consisted of in it boost the glossopharyngeal nerve suggestion when administered by mouth, which reflexively causes hypersecretion of the breathing system, dilutes the spit and also makes it simple to cough up. Platycodon saponins D and D3 may be effective ingredients for lowering phlegm. Researches have shown that platycodon saponin capsules have obvious anti-inflammatory, coughing, asthma and also expectorant results, as well as have certain precautionary and also healing results on persistent respiratory disease.
3. Anti-tumor and also anti-oxidation impacts
Platycodon grandiflorum root oil ether extract has anti-oxidation result, as well as the results of colorimetric test of tetramethylazozolium salt (MTT) reveal that the essence has strong cytotoxicity to human colon cancer cell HT-29, ileocecal cancer cells cell HRT-18, as well as liver cancer cells cell HepG2 in vitro. Researches have actually revealed that platycodon saponin D has the task of dramatically inhibiting the spreading of human breast cancer cells (MCF-7) and human severe promyelocytic leukemia cells (HL-60 cells). Its certain device of activity and also the structure-activity relationship of platycodon saponin antitumor task require refresher course. The remove of platycodon grandiflora has anti-oxidation and removes oxygen cost-free radicals, so it can be utilized in the development of anti-oxidation and anti-aging cosmetics; at the same time, the platycodon grandiflorum is utilized in the manufacturing of fragrance and also pigment compounds by acid electrolysis, which can be made use of in aesthetic manufacturing, which fulfills the requirement of green food, so it has high application worth. Recent researches have actually additionally revealed that the saponins of Platycodon grandiflorum can impact the lipid content in lotion and also liver, and also have the impact of reducing weight and also lipid.
4. Lower cholesterol
Bellflower Remove can enhance bile acid secretion, minimize cholesterol content in rat liver, as well as increase steroid excretion.
Bellflower Essence has a local irritability as well as a rather strong hemolytic result, with a hemolytic index of 887. As a result, it can only be taken orally, and can not be made use of as a shot. Dental management can trigger saponins to be hydrolyzed as well as damaged in the digestion system without hemolysis. Nonetheless, when taken orally in huge dosages, the stomach mucosa is boosted with saponins, which can cause nausea or vomiting as well as throwing up.
6. Anti-bacterial result
Platycodon grandiflorum water essence as well as preparation were diluted in test tubes at a proportion of 1:10 to hinder Epidermophyton flocculus in vitro. With the preparation 4.50% plate little groove approach, it has repressive result on Staphylococcus aureus, Salmonella typhi, Shigella flexneri, Pseudomonas aeruginosa and also Escherichia coli.
7. Sedative, analgesic as well as antipyretic impacts
Dental feeding of Bellflower Extract to animals has solid antipyretic and analgesic results. Inducing fever to computer mice with typhoid vaccination and gavage at 50-100 mg/kg can minimize the spontaneous task of computer mice, as well as has apparent antipyretic impact which can last for 3-4 hours. It has inhibitory result on the wriggling response caused by tail pushing technique and also intraperitoneal injection of acetic acid in computer mice, and can enhance the discomfort threshold of animals. Its activity intensity and analgesic effect amount pain killers as well as aminopyrine, as well as it can prolong the bedtime of cyclohexobarbital salt. Experiments of climbing up ladders, piercing holes, rotating rods and inclined planes in computer mice have actually confirmed that the unrefined product of Campanulaceae saponins has central repressive impacts such as sedation as well as analgesia.
8. Hinder gastric acid secretion as well as anti-ulcer impact
Bellflower Remove has the result of hindering the secretion of gastric juice and standing up to peptic ulcer. For rats with pylorus ligation, platycodon saponin was offered to the duodenum, which can lower the secretion of gastric juice and partially prevent the task of pepsin. Its inhibitory effect on experimental abscess resembles that of atropine. After the dosage is enhanced, it can entirely hinder the secretion of gastric juice and also the incident of ulcers. Continuous administration of platycodon saponins in rats additionally minimized the incident of acetic acid ulcers. The methanol cold saturate of bellflower likewise has anti-ulcer effect.
9. Anti-inflammatory and immune improving results
Bellflower Essence has anti-inflammatory result. Rats fed platycodon saponin have substantial anti-inflammatory impact on carrageenan foot swelling, cotton round granuloma as well as acetic acid swelling. It can additionally prevent adjuvant arthritis in rats as well as decrease capillary leaks in the structure in allergic mice. Researches have actually revealed that the administration of Platycodon grandiflora total saponins to rats can considerably enhance the content of ACTH and corticosterone in the blood, suggesting that its anti-inflammatory effect might be associated with the engagement of adrenal cortex hormonal agents. Additionally, crude platycodon saponins have a neighborhood stimulating result on the skin, which can improve the blood flow of inflammation, advertise the enhancement of swelling as well as the absorption of inflammation procedure. Platycodon grandiflorum has the effect of boosting immune function, and also its extract can inhibit the migration of leukocytes, enhance the bactericidal power of neutrophils, and increase the activity of lysozyme; crude saponins can also boost the phagocytosis of macrophages.
10. Other functions
Bellflower Essence has the impacts of reducing high blood pressure, reducing heart rate, and hindering respiration, and its antihypertensive result can not be antagonized by atropine and α as well as β blockers. It has anti-edema and also diuretic impacts on rats with congestive edema caused by reciprocal throaty blood vessel ligation. Furthermore, bellflower extract still has anti-allergic effect.