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Bellflower Extract

Molecular Formula:  

Formula Weight: 0

ZSpharmac: Bellflower Extract Supplier

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Product Name: Bellflower Extract
CAS No:  
Purity: 99%

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Basic Info

Product Name:Bellflower Extract
Other Names:RADIX PLATYCODI Extract
CAS: 
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance: Colorless Liquid
EINECS No.: 
Storage:2-8°C
Provide:Bellflower Extract MSDS;
Bellflower Extract COA

What is Bellflower Extract?

Platycodon grandiflorum extract is the dried origin remove of Platycodon grandiflorum (Jacq.) A.DC. The primary energetic component is saponins, and also it also has flavonoids, polysaccharides and also anthocyanins, fatty acids and fatty oils, micronutrient as well as amino acids. Anthocyanins have anti-oxidation, get rid of cost-free radicals, minimize blood cholesterol degrees, anti-tumor, anti-mutation and also other effects. Anthocyanins have excellent security, excellent water solubility, high material, and also have the attributes of natural pigments. Therefore, while playing a particular function in managing physical functions in the body, platycodon anthocyanins can also be made use of as healthy food pigments in food and beverages.

Chemical Composition of Bellflower Extract

1. Campanulaceae saponins The main active ingredients of Campanulaceae are saponins, and the saponins of Campanulaceae are all oleanane-type pentacyclic triterpene derivatives, which can be divided into three categories: Campanulaceae acids, Campanulaceae diacids, and telegalic acids.
2. Flavonoids In the early 1980s, 9 kinds of flavonoids were isolated from the aerial part of platycodon grandiflorum, and an anthocyanidin was isolated from its flower; recently, 4 kinds of flavonoids were isolated from the aerial part, mainly apigenin and luteolin; 5 kinds of flavonoids were isolated from its seeds, such as docetaxel and quercetin. Natural flavonoids have small molecular weight, can be quickly absorbed by the human body, enter the blood and tissues, and then exhibit anti-fatigue, capillary expansion, anti-oxidation, anti-aging, anti-mutation, anti-tumor and other effects. Studies have shown that flavonoids have a strong ability to scavenge free radicals, superoxide and hydroxyl radicals, and inhibit lipid peroxidation.
3. The polysaccharides and anthocyanin platycodon polysaccharides were fractionated and purified by DEAE-cellulose, and the three polysaccharide single components PGPsI, PGPsII and PGPsIII were obtained, and their molecular weights were 2640, 89759 and 63453. The components were identified by SephadexG-200 gel chromatography, ultraviolet spectroscopy and iodine reaction, and did not contain nucleic acid, protein and starch. Anthocyanins are glycosides formed by the combination of anthocyanins and sugars through glycosidic bonds. They mainly exist in flowers and fruits, making them appear in different colors such as red, purple red to blue. Bellflower anthocyanins have good stability under most conditions, but in the presence of alkaline and oxidizing agents, the stability of Bellflower anthocyanins is poor. When the concentration was higher, the scavenging efficiency of Vc and platycodon anthocyanins on DPPH would increase exponentially.
4. Fatty acid and fatty oil 34 kinds of fatty acids were isolated and identified from Platycodon grandiflorum fatty oil, including 15 kinds of unsaturated fatty acids, the main types are linoleic acid (42.79%), palmitoleic acid (0.30%), 11-eicosenoic acid (1.53%), linolenic acid (14.02%), etc.; 19 kinds of saturated fatty acids, the main types are palmitic acid (13.71%), stearic acid (1.36%), arachidic acid (0.79%) %), behenic acid (1.78%), lignoceric acid (1.38%), hexacosanoic acid (3.14%), octacosanoic acid (3.51%), etc.
5. Trace elements and amino acids contain Cu, Fe, Mn, Co, Zn, Cr, Mg, Ca, Sr, Li and other trace elements.
6. Contains a variety of amino acids, including 8 kinds of essential amino acids, accounting for 6.44% of the total amino acids. The total amino acid content is as high as 15.01%. Among them, уγ-aminobutyric acid is a neurotransmitter chemical substance that plays an important role in the energy metabolism of the human brain.
7. Others 12 kinds of phenolic acid compounds and their derivatives were identified from the aerial part of Bellflower root; two kinds of phenolic compounds with antioxidant activity were isolated from the petroleum ether extract of Bellflower root. In addition, Campanulaceae also contains steroids (α-spinach, △7-stigmasterol, β-sitosterol, etc.), proteins, alkaloids, volatile oils and other chemical components.

Bellflower Extract Uses

1. Hypoglycemic result
Normal home-free management of Platycodon grandiflorum water or alcohol essence 200 mg/kg can reduce blood glucose, similar to that of tolbutamide. It additionally has hypoglycemic result on speculative tetrachloropyrimidine diabetic person rabbits, and can hinder the rise of food-induced blood glucose. The reduction of liver glycogen can additionally be recuperated after medicine, and the effect of alcohol extract is more powerful than that of water remove.

2. expectorant, antitussive result
Both Bellflower Remove and root water preparation can reduce the discharging of phenol red, and also have an extremely significant expectorant result. The primary reason is that the saponins consisted of in it boost the glossopharyngeal nerve suggestion when administered by mouth, which reflexively causes hypersecretion of the breathing system, dilutes the spit and also makes it simple to cough up. Platycodon saponins D and D3 may be effective ingredients for lowering phlegm. Researches have shown that platycodon saponin capsules have obvious anti-inflammatory, coughing, asthma and also expectorant results, as well as have certain precautionary and also healing results on persistent respiratory disease.

3. Anti-tumor and also anti-oxidation impacts
Platycodon grandiflorum root oil ether extract has anti-oxidation result, as well as the results of colorimetric test of tetramethylazozolium salt (MTT) reveal that the essence has strong cytotoxicity to human colon cancer cell HT-29, ileocecal cancer cells cell HRT-18, as well as liver cancer cells cell HepG2 in vitro. Researches have actually revealed that platycodon saponin D has the task of dramatically inhibiting the spreading of human breast cancer cells (MCF-7) and human severe promyelocytic leukemia cells (HL-60 cells). Its certain device of activity and also the structure-activity relationship of platycodon saponin antitumor task require refresher course. The remove of platycodon grandiflora has anti-oxidation and removes oxygen cost-free radicals, so it can be utilized in the development of anti-oxidation and anti-aging cosmetics; at the same time, the platycodon grandiflorum is utilized in the manufacturing of fragrance and also pigment compounds by acid electrolysis, which can be made use of in aesthetic manufacturing, which fulfills the requirement of green food, so it has high application worth. Recent researches have actually additionally revealed that the saponins of Platycodon grandiflorum can impact the lipid content in lotion and also liver, and also have the impact of reducing weight and also lipid.

4. Lower cholesterol
Bellflower Remove can enhance bile acid secretion, minimize cholesterol content in rat liver, as well as increase steroid excretion.

5. Hemolysis
Bellflower Essence has a local irritability as well as a rather strong hemolytic result, with a hemolytic index of 887. As a result, it can only be taken orally, and can not be made use of as a shot. Dental management can trigger saponins to be hydrolyzed as well as damaged in the digestion system without hemolysis. Nonetheless, when taken orally in huge dosages, the stomach mucosa is boosted with saponins, which can cause nausea or vomiting as well as throwing up.

6. Anti-bacterial result
Platycodon grandiflorum water essence as well as preparation were diluted in test tubes at a proportion of 1:10 to hinder Epidermophyton flocculus in vitro. With the preparation 4.50% plate little groove approach, it has repressive result on Staphylococcus aureus, Salmonella typhi, Shigella flexneri, Pseudomonas aeruginosa and also Escherichia coli.

7. Sedative, analgesic as well as antipyretic impacts
Dental feeding of Bellflower Extract to animals has solid antipyretic and analgesic results. Inducing fever to computer mice with typhoid vaccination and gavage at 50-100 mg/kg can minimize the spontaneous task of computer mice, as well as has apparent antipyretic impact which can last for 3-4 hours. It has inhibitory result on the wriggling response caused by tail pushing technique and also intraperitoneal injection of acetic acid in computer mice, and can enhance the discomfort threshold of animals. Its activity intensity and analgesic effect amount pain killers as well as aminopyrine, as well as it can prolong the bedtime of cyclohexobarbital salt. Experiments of climbing up ladders, piercing holes, rotating rods and inclined planes in computer mice have actually confirmed that the unrefined product of Campanulaceae saponins has central repressive impacts such as sedation as well as analgesia.

8. Hinder gastric acid secretion as well as anti-ulcer impact
Bellflower Remove has the result of hindering the secretion of gastric juice and standing up to peptic ulcer. For rats with pylorus ligation, platycodon saponin was offered to the duodenum, which can lower the secretion of gastric juice and partially prevent the task of pepsin. Its inhibitory effect on experimental abscess resembles that of atropine. After the dosage is enhanced, it can entirely hinder the secretion of gastric juice and also the incident of ulcers. Continuous administration of platycodon saponins in rats additionally minimized the incident of acetic acid ulcers. The methanol cold saturate of bellflower likewise has anti-ulcer effect.

9. Anti-inflammatory and immune improving results
Bellflower Essence has anti-inflammatory result. Rats fed platycodon saponin have substantial anti-inflammatory impact on carrageenan foot swelling, cotton round granuloma as well as acetic acid swelling. It can additionally prevent adjuvant arthritis in rats as well as decrease capillary leaks in the structure in allergic mice. Researches have actually revealed that the administration of Platycodon grandiflora total saponins to rats can considerably enhance the content of ACTH and corticosterone in the blood, suggesting that its anti-inflammatory effect might be associated with the engagement of adrenal cortex hormonal agents. Additionally, crude platycodon saponins have a neighborhood stimulating result on the skin, which can improve the blood flow of inflammation, advertise the enhancement of swelling as well as the absorption of inflammation procedure. Platycodon grandiflorum has the effect of boosting immune function, and also its extract can inhibit the migration of leukocytes, enhance the bactericidal power of neutrophils, and increase the activity of lysozyme; crude saponins can also boost the phagocytosis of macrophages.

10. Other functions
Bellflower Essence has the impacts of reducing high blood pressure, reducing heart rate, and hindering respiration, and its antihypertensive result can not be antagonized by atropine and α as well as β blockers. It has anti-edema and also diuretic impacts on rats with congestive edema caused by reciprocal throaty blood vessel ligation. Furthermore, bellflower extract still has anti-allergic effect.

Bellflower Extract Extraction Method

Reflux method
Bellflower powder→add 7% sulfuric acid ethanol-water (1:3) mixed solution→heat to reflux for 3h→cool→trichloromethane extraction→combine the extracts→wash with water, discard the washing solution→dehydrate the chloroform with anhydrous sodium sulfate → Filtration → Evaporate the filtrate → Total saponins
Alcohol extraction
Bellflower powder→add 95% ethanol→stand at room temperature for 1.5h→filter, take the supernatant→rotary steam→obtain dark brown viscous liquid→dry at 105°C to constant weight→crude bellflower saponin.
Hot water extraction
Bellflower powder→add distilled water→stand at room temperature for 1.5h→filter→distill→dark brown viscous liquid→dry at 105℃ to constant weight→crude bellflower saponin

Identification of Bellflower Extract

Trait identification
Root cylindrical or fusiform, slightly twisted, occasionally branched, 6-25cm long, 0.5-2.5cm in diameter; surface off-white or light yellow-white, with half-moon-shaped stem scars on the upper rhizome (reed head), horizontal stripes on the root, irregular longitudinal wrinkles and grooves throughout, and transverse lenticel-like root scars. Hard and brittle, easy to break, the broken surface is slightly uneven, slightly granular, with radial fissures, the cortex is narrow, the cambium is prominent, light brown, and the xylem is off-white. No gas, taste slightly sweet and then bitter. It is better to have thick strips, white color, firm body and bitter taste.
Microscopic identification
Cross-section of platycodon root: the cork layer is yellow-brown, but most of it has been removed. The phloem is broad. The phloem rays on the outside are curved, the sieve tubes are mostly compressed and decadent, the milk ducts are scattered in groups, containing yellow-brown granules, and the milk ducts are arranged in radial rows in the inner phloem. The cambium forms a ring. The xylem rays are wide, the vessels are polygonal, single or several gather together, and are arranged radially. Slice directly with the dry product, seal in ethanol or dilute glycerol, and see the inulin crystals in the parenchyma cells. Powder: beige. (1) Too much inulin. The powder was installed with chloral hydrate solution (without heating), and the inulin clumps in the parenchyma cells were fan-shaped, and gradually melted after a long time. Using the Steiner’s solution or ethanol device, the inulin clumps are irregular and will not disappear after a long time. (2) Nodulated milk ducts, 14-25 μm in diameter, slightly thicker wall, connected to another milk duct by short cell chains on the side to form a network, the milk ducts contain small light yellow oil droplets and fine particles. (3) The diameter of the trapezoidal, reticulate and bordered pit vessels is 16-72 μm, and the vessel molecules are relatively short, some of which are only 96 μm long. There are also a few fine reticulated tracheocytes. (4) Wood parenchyma cells are rectangular in longitudinal section, and the terminal wall is wavy and curved. In addition, the roots that have not been peeled off have cork cells, and some cells contain fine square crystals of calcium oxalate.
Physical and chemical identification
Take 1g of the sample powder, extract it with an appropriate amount of methanol, spot the extract on a silica gel G plate, use ethyl acetate-methanol-water (14:3:3) as the developer, develop the color with concentrated sulfuric acid, and saponins show yellow spots.

About Products:
If you need Bellflower Extract, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Bellflower Extract manufacturer and supplier, ZSpharmac will provide Bellflower Extract raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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