Baicalin Powder (Baicalin, BAI) is a flavonoid compound extracted from the dried root of the Chinese herbal medicine Scutellaria baicalensis. Numerous studies have shown that it has good anti-inflammatory and antioxidant effects. Zhuang Feng et al. (2020) showed that intramuscular injection of 50 mg/kg baicalin can effectively alleviate the elevated body temperature, abnormal changes in white blood cell count, decreased total platelet count, and liver and kidney function damage in piglets induced by LPS stimulation. Huang Peiyu et al. (2020) showed that baicalin can regulate the liver function of rats with hepatitis B by inhibiting the activation of NF-κB p65, reducing the inflammatory response, and inhibiting the apoptosis of liver cells. Cheng et al. (2017) showed that pretreatment with Baicalin Powder had a protective effect on lipopolysaccharide-induced liver inflammation by down-regulating the expression of TLR 4 and inhibiting the activation of NF-κB. Wang Hongyu et al. (2016) showed that Scutellaria baicalensis and its effective components have different degrees of antipyretic and anti-inflammatory effects, and can prevent the rise of body temperature and eliminate inflammation. class is the most obvious. Gao Guangwu et al. (2014) pointed out that Scutellaria baicalensis extract has good anti-inflammatory activity by taking carrageenan-induced rat foot swelling model, and its role may be to inhibit the formation of lipid peroxides and affect the release of inflammatory mediators.
Baicalin Powder also has good antioxidant capacity, can scavenge free radicals, and inhibit the activity of xanthine oxidase. Zhou Yinglu et al. (2018) showed that baicalin can alleviate the oxidative damage and apoptosis of mouse ovarian tissue under heat stress, and the mechanism may be because baicalin can enhance the antioxidant capacity of N2a/APPswe cells and promote the nuclear transfer of Nrf2 bit.