Baicalin Powder (Baicalin, BAI) is a flavonoid compound extracted from the dried root of the Chinese herbal medicine Scutellaria baicalensis. Numerous studies have shown that it has good anti-inflammatory and antioxidant effects. Zhuang Feng et al. (2020) showed that intramuscular injection of 50 mg/kg baicalin can effectively alleviate the elevated body temperature, abnormal changes in white blood cell count, decreased total platelet count, and liver and kidney function damage in piglets induced by LPS stimulation. Huang Peiyu et al. (2020) showed that baicalin can regulate the liver function of rats with hepatitis B by inhibiting the activation of NF-κB p65, reducing the inflammatory response, and inhibiting the apoptosis of liver cells. Cheng et al. (2017) showed that pretreatment with Baicalin Powder had a protective effect on lipopolysaccharide-induced liver inflammation by down-regulating the expression of TLR 4 and inhibiting the activation of NF-κB. Wang Hongyu et al. (2016) showed that Scutellaria baicalensis and its effective components have different degrees of antipyretic and anti-inflammatory effects, and can prevent the rise of body temperature and eliminate inflammation. class is the most obvious. Gao Guangwu et al. (2014) pointed out that Scutellaria baicalensis extract has good anti-inflammatory activity by taking carrageenan-induced rat foot swelling model, and its role may be to inhibit the formation of lipid peroxides and affect the release of inflammatory mediators.
Baicalin Powder also has good antioxidant capacity, can scavenge free radicals, and inhibit the activity of xanthine oxidase. Zhou Yinglu et al. (2018) showed that baicalin can alleviate the oxidative damage and apoptosis of mouse ovarian tissue under heat stress, and the mechanism may be because baicalin can enhance the antioxidant capacity of N2a/APPswe cells and promote the nuclear transfer of Nrf2 bit.
Baicalin Powder has obvious antibacterial effect, and has inhibitory effect on Escherichia coli, Salmonella, Clostridium perfringens, Streptococcus, Candida and other Gram-positive and negative bacteria. Wang Liu et al. (2020) showed that baicalin can significantly inhibit the hemolysis of suis streptolysin when the concentration of baicalin is 32-64 μg/ml determined by in vitro microdilution method. Zhang Wei et al. (2018) showed that Scutellaria baicalensis extract can play a therapeutic role in Streptococcus suis infection by inhibiting the bioactivity of suis streptolysin (SLY). Wu et al. (2018) showed that baicalin significantly reduced body weight, serum TNF-α, IL-6 and LDH levels, and cecal bacterial load in mice challenged with Salmonella typhimurium. Liu Hao et al. (2017) showed that baicalin has obvious antibacterial effect on Escherichia coli, and its minimum inhibitory concentration is 6.25 mg/ml, which exerts antibacterial effect by increasing the permeability of E. coli cell membrane and cell wall. Yang et al. (2014) showed that baicalin can increase the apoptosis rate of Candida albicans. Qiu et al. (2012) Baicalin may reduce the number of Staphylococcus aureus carried in the lungs by inhibiting the activity of α-hemolysin.
In recent years, the antitumor effect of Baicalin Powder has attracted widespread attention. Zhang Di et al. (2020) showed that baicalin and baicalein have high activity on a variety of tumor cells, exert their effects through various pathways and targets, and have a broad anti-tumor spectrum, mainly concentrated in the digestive system, respiratory system and reproductive system tumor. Wang Tingting et al. (2019) showed that baicalin can have a significant inhibitory effect on tumor cells and has no obvious toxic and side effects on normal cells. Gao et al. (2018) showed that baicalin can inhibit the expression of NF-κB-p65 protein by inhibiting IκB kinase in vivo, reduce the secretion of TNF-α and IL-1β and reduce inflammation, thereby inhibiting the proliferation, invasion and metastasis of breast tumors.
Diuretic, cholesterol-lowering, anti-thrombotic, relieve asthma, purging fire and detoxification, hemostasis, anti-birth, anti-allergic and antispasmodic effects, also has a strong anti-cancer physiological effect.
As one of the main active ingredients of Scutellaria baicalensis, Baicalin Powder has many functions. In recent years, it has attracted the attention of practitioners in the feed industry and has become a hot research object of Chinese herbal medicine feed additives. However, baicalin is not included in the feed raw material catalogue, and only Scutellaria baicalensis extract powder is a Chinese herbal medicine additive approved by the Ministry of Agriculture that can be legally added to feed. I hope that more people can learn more about the application value of Baicalin Powder from the application of Scutellaria baicalin extract powder independently developed by Beijing Shengtaier in broiler and piglet feed, and continue to study the molecular mechanism of baicalin in the future. Improved pharmacokinetic profile contributes.
