Zhishang Chemical

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Zhishang Chemical

Azone CAS 59227-89-3

Molecular Formula: C18H35NO

Formula Weight: 281.48

ZSpharmac: Azone Supplement

Product Name: Azone
CAS No: 59227-89-3
Purity: 99%

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Basic Info

Product Name:Azone
Other Names:Laurocapram
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colourless Oil
EINECS No.:261-668-9
Storage:Sealed in Dry,Room Temperature
Provide:Azone MSDS;
Azone COA

What is Azone?

Laureazone is a new type of skin penetrant first reported by American Stoughton in the early 1980s, and its chemical name is 1-n-dodecylazepan-2-one. Referred to as azone. Azone is a colorless, odorless, non-toxic and non-irritating oily transparent liquid at room temperature, with lubricity, easy coating and strong permeability. It is also a kind of organic chemicals with a wide range of uses, and its high-efficiency permeability-enhancing properties, non-toxic safety and other characteristics have increasingly attracted people’s attention. It has a permeation-enhancing effect on hydrophilic and hydrophobic compounds.

Azone Properties

Melting point -7°
Boiling point bp50m 160°
density 0.906-0.926
refractive index 1.470-1.473
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Oil
color Colourless


Azone Uses

  1. Azone is utilized as a penetrant, made use of in numerous lotions and hair products in cosmetics; utilized as an infiltration booster for exterior drug application and also massage therapy; utilized in pesticides, as a plant growth regulatory authority. Additionally, it can also be used as a tinting accelerator in the fields of natural leather and also printing and also dyeing.
  2. Azone is a brand-new kind of high-efficiency, risk-free as well as safe transdermal absorption booster, which has evident transdermal infiltration result on hydrophilic and also lipophilic medications. It can be widely made use of in medicine, cosmetics, pesticides, aerosols, printing as well as dyeing as well as oil expedition and various other industries. This product has the advantages of solid penetration, anemic, odor-free, non-toxic as well as non-irritating.
  3. Azone is utilized as a high-efficiency skin penetration booster for exterior medication, cosmetics and also as a surfactant.

Azone Promotes Penetration

Azone can increase the fluidity of lipids, thereby changing the permeability of the stratum corneum of the skin and reducing the diffusion resistance of drugs. The abdominal skin of the experimental mice was coated with the water extract of Bupleurum Jierefang plus 2% azone. After 8 hours, the mice were sacrificed. The ultrastructure of the coated skin was observed with a KYYY-1000B scanning electron microscope, and the stratum corneum cells were loose. It is slightly damaged, the cracks on the skin surface are increased, and the diameter of the follicle pores is widened, which is conducive to the penetration of drugs into the skin. Azone has different effects on the transdermal absorption of different drugs, and has different degrees of permeation-promoting effect on water-soluble drugs, while the permeation-promoting effect on some lipid-soluble drugs is not obvious, and may even have a negative effect. The usual concentration of azone is less than 10%, it is not that the higher the concentration, the stronger the effect of promoting transdermal absorption, and the opposite effect will be obtained if the dosage is too large. The optimal osmotic concentration is related to the physicochemical properties of the drug and the dosage form of the preparation.

1. Gel
Azone has strong permeation-promoting effect on water-soluble drugs, low toxicity and high safety, and is one of the most commonly used gel permeation enhancers. There are two types of azone on the market today: water-soluble and fat-soluble. The water-based gel matrix is ​​hydrophilic, so that the water-soluble azone can be easily distributed into the intercellular parts and exert its permeation-promoting effect. Too high azone concentration will increase the viscosity of the gel, which is not conducive to the transdermal absorption of the drug in the gel. In vitro studies of adding 2.0% or 3.0% azone to 3.0% chitosan gel of celecoxib showed that it had the best adhesion properties and mucosal retention time, but with the concentration of chitosan and azone increased, the amount of celecoxib delivered by oral administration decreased.

2. Cream
Azone is widely used as a penetration enhancer in creams. Fu Jiyu et al. [3] found that the penetration rate of ibuprofen cream samples with different concentrations of azone was generally greater than that of cream samples without azone; and when the concentration of azone was 3%, the ibuprofen The penetration rate was the highest, and the cumulative penetration rate in 12 h reached (48.8±7.62)%. Studies have shown that different concentrations of azone can promote the transdermal absorption of manidipine cream to a certain extent, and the order of its permeation-promoting effect within 24 hours is: 3% azone > 5% azone > 1% azone > Azone-free.

3. Patch
Patches are often used in Chinese medicine transdermal therapy, and select relevant parts or acupoints for transdermal administration. Investigate the permeation rate and total amount of tobemoside A in the Jingliukang plaster with the dosage of 0, 1%, 2% and 3% of azone. More, it is 4.5 to 4.9 times that of adding azone to 0, and adding 1% azone is the best. Under the action of different penetration enhancers, the transdermal penetration rate of 6-gingerol in the ginger gel patch was as follows: 4% azone>2% propylene glycol+2% azone>4% menthol>4% borneol>control, It is shown that the permeation-promoting effect of azone is the most significant; at the same time, after optimization, it is concluded that the permeation-promoting effect is: 6% azone>4%azone>2%azone>1%azone, and adding 4%~6% nitrogen The penetration rate of the drug in ketones is similar.

Preparation of Azone

1. Sodium hydride method
This method is the original process of producing azone. In toluene or petroleum ether solvent, caprolactam first reacts with sodium hydride to generate caprolactam sodium salt. Then, it undergoes condensation reaction with dropwise bromododecane under heating and stirring to obtain azone. All very active chemical reagents such as sodium hydride used in this method are expensive and dangerous to operate. Reference [2] uses sodium alkoxide instead of sodium hydride to improve the process, but still needs inert gas protection, solvent drying, etc. The reaction time is as long as 25 hours, and the yield is less than 50%.

2. Liquid-liquid phase transfer catalysis
This method is a synthetic method of caprolactam N-alkylation using NaOH aqueous solution as proton-removing agent, which is obtained by the reaction of caprolactam and bromopentyldodecane under the phase transfer catalyst of tetrabutylammonium bromide. The characteristics of this method are that the synthesis process is simple, no water-free operation is required, and the reaction conditions are easy to control. But the product yield is low and the reaction time is more than 10 hours. The effect of being soluble in water has side reactions, the amount of solvent is large, the amount of alkali is large, the post-processing is difficult, the equipment requirements are high, and it lacks certain competitiveness.

3. Solid-liquid phase transfer catalysis
The method utilizes KOH-K2CO3 double alkali instead of potassium hydroxide or sodium hydroxide as proton-removing agent, and tetrabutyl sodium bromide or polyethylene glycol as phase transfer catalyst. Caprolactam and bromododecane are reacted in toluene or ethane solvent to generate azone in one step with a yield of over 93%.

The reaction conditions are mild, no N 2 protection is required, and it is easy to operate, but it needs to be carried out in a non-aqueous solvent, and is a production process widely used in the domestic production of azone at present.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Azone Quotation